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Protein

P2X purinoceptor

Gene

P2rx5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorUniRule annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-418346. Platelet homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx5Imported
ORF Names:mCG_125429Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2137026. P2rx5.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5020HelicalUniRule annotationAdd
BLAST
Transmembranei340 – 36223HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of nuclear inner membrane Source: GO_Central
  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

PhosphoSiteiQ3UYI1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005950.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006104.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOVERGENiHBG053086.
KOiK05219.
OMAiAGAFFCD.
OrthoDBiEOG091G0A2U.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003048. P2X5_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF12. PTHR10125:SF12. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UYI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQAAWKGFV LSLFDYKTAK FVVAKSKKVG LLYRVLQLTI LLYLLIWVFL
60 70 80 90 100
IKKSYQDIDT SLQSAVVTKV KGVAYTNTTM LGERLWDVAD FVIPSQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQGICAE REGIPDGECS EDTDCHAGES VVAGHGLKTG
160 170 180 190 200
RCLRVGNSTR GTCEIFAWCP VETKSMPTDP LLKDAEGFTI FIKNFIRFPK
210 220 230 240 250
FNFSKANVLE TGNKHFLKTC HFSSTNLYCP IFRLGSIVRW AGADFQDIAL
260 270 280 290 300
KGGVIGIHIE WDCDLDKAAS HCNPHYYFNR LDNKHTQSIS SGYNFRFARY
310 320 330 340 350
YRDPHGVEFR DLMKAYGIRF DVIVNGKAGK FSIIPTVINI GSGLALMGAG
360 370 380 390 400
AFFCDLVLIY LIRKSEFYRD KKFEKVRGQK EEDNVEVEAN EMEQELPEDK
410 420 430 440 450
PLERVHQDEQ ALELAQSGRK QNSNCQVLFE PARSGLQENA FVNMKPSQIL

QTVKT
Length:455
Mass (Da):51,362
Last modified:February 5, 2008 - v1
Checksum:i16C126E191CBECB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670399 Genomic DNA. No translation available.
AK134662 mRNA. Translation: BAE22231.1.
CH466596 Genomic DNA. Translation: EDL12711.1.
RefSeqiNP_201578.2. NM_033321.3.
UniGeneiMm.156893.

Genome annotation databases

EnsembliENSMUST00000006104; ENSMUSP00000006104; ENSMUSG00000005950.
GeneIDi94045.
KEGGimmu:94045.
UCSCiuc007kaa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670399 Genomic DNA. No translation available.
AK134662 mRNA. Translation: BAE22231.1.
CH466596 Genomic DNA. Translation: EDL12711.1.
RefSeqiNP_201578.2. NM_033321.3.
UniGeneiMm.156893.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006104.

PTM databases

PhosphoSiteiQ3UYI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006104; ENSMUSP00000006104; ENSMUSG00000005950.
GeneIDi94045.
KEGGimmu:94045.
UCSCiuc007kaa.2. mouse.

Organism-specific databases

CTDi5026.
MGIiMGI:2137026. P2rx5.

Phylogenomic databases

eggNOGiENOG410IFJF. Eukaryota.
ENOG410XR0C. LUCA.
GeneTreeiENSGT00390000016028.
HOVERGENiHBG053086.
KOiK05219.
OMAiAGAFFCD.
OrthoDBiEOG091G0A2U.
TreeFamiTF328633.

Enzyme and pathway databases

ReactomeiR-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-418346. Platelet homeostasis.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005950.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003048. P2X5_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF12. PTHR10125:SF12. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PIRSFiPIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSiPR01312. P2X5RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UYI1_MOUSE
AccessioniPrimary (citable) accession number: Q3UYI1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.