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Protein

Beta-adrenergic receptor kinase 2

Gene

Adrbk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Catalytic activityi

ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei317Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.15. 3474.
ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-adrenergic receptor kinase 2 (EC:2.7.11.15)
Short name:
Beta-ARK-2
Gene namesi
Name:Adrbk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87941. Adrbk2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002608281 – 688Beta-adrenergic receptor kinase 2Add BLAST688

Post-translational modificationi

Ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ3UYH7.
PaxDbiQ3UYH7.
PeptideAtlasiQ3UYH7.
PRIDEiQ3UYH7.

PTM databases

iPTMnetiQ3UYH7.
PhosphoSitePlusiQ3UYH7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042249.
CleanExiMM_ADRBK2.
ExpressionAtlasiQ3UYH7. baseline and differential.
GenevisibleiQ3UYH7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3UYH7. 1 interactor.
STRINGi10090.ENSMUSP00000070445.

Structurei

3D structure databases

ProteinModelPortaliQ3UYH7.
SMRiQ3UYH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 175RGSPROSITE-ProRule annotationAdd BLAST122
Domaini191 – 453Protein kinasePROSITE-ProRule annotationAdd BLAST263
Domaini454 – 521AGC-kinase C-terminalAdd BLAST68
Domaini558 – 652PHPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190N-terminalAdd BLAST190

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00860000133699.
HOGENOMiHOG000006742.
HOVERGENiHBG050559.
InParanoidiQ3UYH7.
KOiK00910.
OMAiDHVQTHL.
OrthoDBiEOG091G0AEI.
TreeFamiTF313940.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UYH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLEAVLAD VSYLMAMEKS KTAPAARASK KVVLPEPSIR SVMQRYLAER
60 70 80 90 100
NEITFDKIFN QKIGFLLFKD FCLNEIGEAV PQVKFYEEIK EYEKLDNEED
110 120 130 140 150
RLRRSRQMYD AYIMRELLSS THQFSKQAVE HVQSHLSKKQ VTATLFQPYI
160 170 180 190 200
EEICESLRGD IFQKFMESDK FTRFCQWKNV ELNIHLSMND FSVHRIIGRG
210 220 230 240 250
GFGEVYGCRK ADTGKMYAMK CLDKKRVKMK QGETLALNER IMLSLVSTGD
260 270 280 290 300
CPFIVCMTYA FHTPDKLCFI LDLMNGGDMH YHLSQHGVFS EKEMRFYASE
310 320 330 340 350
IILGLEHMHT CFVVYRDLKP ANILLDEYGH VRISDLGLAC DFSKKKPHAS
360 370 380 390 400
VGTHGYMAPE VLQKGTCYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH
410 420 430 440 450
EIDRMTLTVN VQLPDAFSPE LRSLLEGLLQ RDVSQRLGCG GGGARELKEH
460 470 480 490 500
IFFKGIDWQH VYLRKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD
510 520 530 540 550
CDQDLYKNFP LVISERWQQE VVETIYDAVN ADTDKIEARR KAKNKQLGQE
560 570 580 590 600
EDYAMGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQSL
610 620 630 640 650
LTMEQIMSVE ETQIKDRKCI LLRIKGGKQF VLQCESDPEF AQWLKELTCT
660 670 680
FNEAQRLLRR APKFLNKPRA AILEFSKPPL CHRNSSGL
Length:688
Mass (Da):79,657
Last modified:February 22, 2012 - v2
Checksum:i9E587AE1BBA41EAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319K → N in BAE22235 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134672 mRNA. Translation: BAE22235.1.
AC107631 Genomic DNA. No translation available.
CCDSiCCDS19545.1.
RefSeqiNP_001272735.1. NM_001285806.1.
NP_796052.2. NM_177078.4.
UniGeneiMm.285619.

Genome annotation databases

EnsembliENSMUST00000065167; ENSMUSP00000070445; ENSMUSG00000042249.
GeneIDi320129.
KEGGimmu:320129.
UCSCiuc008ytt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134672 mRNA. Translation: BAE22235.1.
AC107631 Genomic DNA. No translation available.
CCDSiCCDS19545.1.
RefSeqiNP_001272735.1. NM_001285806.1.
NP_796052.2. NM_177078.4.
UniGeneiMm.285619.

3D structure databases

ProteinModelPortaliQ3UYH7.
SMRiQ3UYH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UYH7. 1 interactor.
STRINGi10090.ENSMUSP00000070445.

PTM databases

iPTMnetiQ3UYH7.
PhosphoSitePlusiQ3UYH7.

Proteomic databases

MaxQBiQ3UYH7.
PaxDbiQ3UYH7.
PeptideAtlasiQ3UYH7.
PRIDEiQ3UYH7.

Protocols and materials databases

DNASUi320129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065167; ENSMUSP00000070445; ENSMUSG00000042249.
GeneIDi320129.
KEGGimmu:320129.
UCSCiuc008ytt.2. mouse.

Organism-specific databases

CTDi320129.
MGIiMGI:87941. Adrbk2.

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00860000133699.
HOGENOMiHOG000006742.
HOVERGENiHBG050559.
InParanoidiQ3UYH7.
KOiK00910.
OMAiDHVQTHL.
OrthoDBiEOG091G0AEI.
TreeFamiTF313940.

Enzyme and pathway databases

BRENDAi2.7.11.15. 3474.
ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiAdrbk2. mouse.
PROiQ3UYH7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042249.
CleanExiMM_ADRBK2.
ExpressionAtlasiQ3UYH7. baseline and differential.
GenevisibleiQ3UYH7. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARBK2_MOUSE
AccessioniPrimary (citable) accession number: Q3UYH7
Secondary accession number(s): F8VPM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 22, 2012
Last modified: November 30, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.