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Protein

Beta-adrenergic receptor kinase 2

Gene

Adrbk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

Catalytic activityi

ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei317Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.15 3474
ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-adrenergic receptor kinase 2 (EC:2.7.11.15)
Short name:
Beta-ARK-2
Gene namesi
Name:Adrbk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87941 Adrbk2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002608281 – 688Beta-adrenergic receptor kinase 2Add BLAST688

Post-translational modificationi

Ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ3UYH7
PaxDbiQ3UYH7
PeptideAtlasiQ3UYH7
PRIDEiQ3UYH7

PTM databases

iPTMnetiQ3UYH7
PhosphoSitePlusiQ3UYH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000042249
CleanExiMM_ADRBK2
ExpressionAtlasiQ3UYH7 baseline and differential
GenevisibleiQ3UYH7 MM

Interactioni

Protein-protein interaction databases

BioGridi235781, 1 interactor
IntActiQ3UYH7, 1 interactor
STRINGi10090.ENSMUSP00000070445

Structurei

3D structure databases

ProteinModelPortaliQ3UYH7
SMRiQ3UYH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 175RGSPROSITE-ProRule annotationAdd BLAST122
Domaini191 – 453Protein kinasePROSITE-ProRule annotationAdd BLAST263
Domaini454 – 521AGC-kinase C-terminalAdd BLAST68
Domaini558 – 652PHPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190N-terminalAdd BLAST190

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00860000133699
HOGENOMiHOG000006742
HOVERGENiHBG050559
InParanoidiQ3UYH7
KOiK00910
OMAiPLCHRNS
OrthoDBiEOG091G0AEI
TreeFamiTF313940

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UYH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLEAVLAD VSYLMAMEKS KTAPAARASK KVVLPEPSIR SVMQRYLAER
60 70 80 90 100
NEITFDKIFN QKIGFLLFKD FCLNEIGEAV PQVKFYEEIK EYEKLDNEED
110 120 130 140 150
RLRRSRQMYD AYIMRELLSS THQFSKQAVE HVQSHLSKKQ VTATLFQPYI
160 170 180 190 200
EEICESLRGD IFQKFMESDK FTRFCQWKNV ELNIHLSMND FSVHRIIGRG
210 220 230 240 250
GFGEVYGCRK ADTGKMYAMK CLDKKRVKMK QGETLALNER IMLSLVSTGD
260 270 280 290 300
CPFIVCMTYA FHTPDKLCFI LDLMNGGDMH YHLSQHGVFS EKEMRFYASE
310 320 330 340 350
IILGLEHMHT CFVVYRDLKP ANILLDEYGH VRISDLGLAC DFSKKKPHAS
360 370 380 390 400
VGTHGYMAPE VLQKGTCYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH
410 420 430 440 450
EIDRMTLTVN VQLPDAFSPE LRSLLEGLLQ RDVSQRLGCG GGGARELKEH
460 470 480 490 500
IFFKGIDWQH VYLRKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD
510 520 530 540 550
CDQDLYKNFP LVISERWQQE VVETIYDAVN ADTDKIEARR KAKNKQLGQE
560 570 580 590 600
EDYAMGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQSL
610 620 630 640 650
LTMEQIMSVE ETQIKDRKCI LLRIKGGKQF VLQCESDPEF AQWLKELTCT
660 670 680
FNEAQRLLRR APKFLNKPRA AILEFSKPPL CHRNSSGL
Length:688
Mass (Da):79,657
Last modified:February 22, 2012 - v2
Checksum:i9E587AE1BBA41EAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319K → N in BAE22235 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134672 mRNA Translation: BAE22235.1
AC107631 Genomic DNA No translation available.
CCDSiCCDS19545.1
RefSeqiNP_001272735.1, NM_001285806.1
NP_796052.2, NM_177078.4
UniGeneiMm.285619

Genome annotation databases

EnsembliENSMUST00000065167; ENSMUSP00000070445; ENSMUSG00000042249
GeneIDi320129
KEGGimmu:320129
UCSCiuc008ytt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiARBK2_MOUSE
AccessioniPrimary (citable) accession number: Q3UYH7
Secondary accession number(s): F8VPM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 22, 2012
Last modified: March 28, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health