Q3UYH7 (ARBK2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
September 21, 2011.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Beta-adrenergic receptor kinase 2 Short name=Beta-ARK-2 EC=2.7.11.15 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 688 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. |
| Catalytic activity | ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 PH domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activityInferred from direct assay. Source: MGI beta-adrenergic receptor kinase activityInferred from electronic annotation. Source: EC signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 688 | 688 | Beta-adrenergic receptor kinase 2 | PRO_0000260828 | |||||
Regions | |||||||||
| Domain | 54 – 175 | 122 | RGS | ||||||
| Domain | 191 – 453 | 263 | Protein kinase | ||||||
| Domain | 454 – 521 | 68 | AGC-kinase C-terminal | ||||||
| Domain | 558 – 652 | 95 | PH | ||||||
| Nucleotide binding | 197 – 205 | 9 | ATP By similarity | ||||||
| Region | 1 – 190 | 190 | N-terminal | ||||||
Sites | |||||||||
| Active site | 317 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 220 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Medulla oblongata. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK134672 mRNA. Translation: BAE22235.1. |
| IPI | IPI00622878. |
| RefSeq | NP_796052.2. NM_177078.3. |
| UniGene | Mm.285619. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2BCJ based on UniProtKB P21146. |
| ProteinModelPortal | Q3UYH7. |
| SMR | Q3UYH7. Positions 28-667. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3UYH7. |
PTM databases | |
| PhosphoSite | Q3UYH7. |
Proteomic databases | |
| PRIDE | Q3UYH7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 320129. |
| KEGG | mmu:320129. |
| UCSC | uc008ytt.1. mouse. |
Organism-specific databases | |
| CTD | 157. |
| MGI | MGI:87941. Adrbk2. |
Phylogenomic databases | |
| eggNOG | roNOG09946. |
| HOGENOM | HBG443643. |
| HOVERGEN | HBG050559. |
| InParanoid | Q3UYH7. |
| OrthoDB | EOG4W3SMD. |
Gene expression databases | |
| ArrayExpress | Q3UYH7. |
| Bgee | Q3UYH7. |
| CleanEx | MM_ADRBK2. |
| Genevestigator | Q3UYH7. |
| GermOnline | ENSMUSG00000042249. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR017442. Se/Thr_kinase-like_dom. IPR002290. Ser/Thr_kinase_dom. [Graphical view] |
| Gene3D | G3DSA:2.30.29.30. PH_type. 1 hit. |
| Pfam | PF00169. PH. 1 hit. PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view] |
| PRINTS | PR00717. GPCRKINASE. |
| SMART | SM00233. PH. 1 hit. SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit. |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50132. RGS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 396088. |
| SOURCE | Search... |
Entry information
| Entry name | ARBK2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q3UYH7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with