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Protein

O-acetyl-ADP-ribose deacetylase MACROD2

Gene

Macrod2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
O-acetyl-ADP-ribose deacetylase MACROD2 (EC:3.2.2.-, EC:3.5.1.-)
Alternative name(s):
MACRO domain-containing protein 2
[Protein ADP-ribosylglutamate] hydrolase
Gene namesi
Name:Macrod2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1920149. Macrod2.

Subcellular locationi

  • Nucleus By similarity

  • Note: Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003004621 – 475O-acetyl-ADP-ribose deacetylase MACROD2Add BLAST475

Proteomic databases

MaxQBiQ3UYG8.
PaxDbiQ3UYG8.
PeptideAtlasiQ3UYG8.
PRIDEiQ3UYG8.

PTM databases

iPTMnetiQ3UYG8.
PhosphoSitePlusiQ3UYG8.

Expressioni

Tissue specificityi

Expressed in the kidney.1 Publication

Developmental stagei

At 12.5 dpc, expressed in the neural tube and in the dorsal root and cranial ganglia. At 14.5 dpc, expressed in metanephric glomeruli, but not in the medullary region of the kidney, in the epithelium lining the gut, the stomach and the seminiferous tubules, as well as in lung. Expression is maintained in the dorsal root and cranial ganglia. In the cranial region, up-regulated in the epithelial and mesenchymal components of the tooth bud, in the epithelium lining the primitive nasal cavity, the vestibulocochlear and cochlear ducts and in the cranial ganglia. At 16.5 dpc, expression is maintained in kidney and lung. Detected in the papilla of the whisker follicle. In the eye, highly expressed in the cuboid epithelium of the lens and the inner nuclear (neuroblastic) layer of the retina. Expression begins in the brain, in particular the ventricular zone, and in the heart. At 18.5 dpc, expression is maintained in the brain, including the subventricular zone of striatum and olfactory lobe, the cortical plate, the cerebellar primordium and the inferior colliculus of the tectum. At this stage, the expression in the heart is 45 times lower than in the brain. At birth, still detectable in the metanephric glomeruli, but not in the adrenal gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000068205.
CleanExiMM_MACROD2.
ExpressionAtlasiQ3UYG8. baseline and differential.

Interactioni

Subunit structurei

Interacts with ADP-ribosylated PARP1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077174.

Structurei

3D structure databases

ProteinModelPortaliQ3UYG8.
SMRiQ3UYG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 240MacroPROSITE-ProRule annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 79Substrate bindingBy similarity3
Regioni90 – 92Substrate bindingBy similarity3
Regioni97 – 102Substrate bindingBy similarity6
Regioni185 – 191Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 9Poly-Lys4

Sequence similaritiesi

Contains 1 Macro domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00520000055566.
HOGENOMiHOG000231859.
HOVERGENiHBG099716.
InParanoidiQ3UYG8.
OMAiWLAKNHQ.
OrthoDBiEOG091G0NNH.
PhylomeDBiQ3UYG8.
TreeFamiTF341440.

Family and domain databases

InterProiIPR002589. Macro_dom.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UYG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPSNKKKKV WREEKERLLK MTLEERRKEY IRDYVSLSTI LSWKEEMKSK
60 70 80 90 100
GQNDEENTQE APQMKKSLSE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG
110 120 130 140 150
VDGCIHRAAG PCLLAECRNL NGCETGHAKI TCGYDLPAKY VIHTVGPIAR
160 170 180 190 200
GHINGSHKED LANCYQSSLK LVKENNLRSV AFPCISTGIY GFPNEPAAVI
210 220 230 240 250
ALGTIKEWLA KNHQEVDRII FCVFLEVDFK IYKKKMNEFF PVDDNNEGTD
260 270 280 290 300
ADMKEDSEGP EPKGLSPPHK KSKAKKPESS KDSSEDESGP EEKQTAEEME
310 320 330 340 350
GQSQEAGGLR FLLRNLLGLI HRDGVNTTPV PSPASEDKAE VHKDEDSAKD
360 370 380 390 400
DNTVKDSDMT NHSVCDQELP NGQENDSAKS EGKTEAESPS SSMETEDLSP
410 420 430 440 450
NQEDAAIVEQ PEVIPLIDDQ EAQEGGEAQG KDAPAVFAES QGSSEAENTS
460 470
GPDVDMNSQV DGVNEPTESL QEDLQ
Length:475
Mass (Da):52,145
Last modified:October 11, 2005 - v1
Checksum:i47D6AE85DF7FF08A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134694 mRNA. Translation: BAE22244.1.
AL731795
, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM14291.1.
AL929027
, AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929443 Genomic DNA. Translation: CAM17747.1.
AL844562
, AL731795, AL837516, AL844582, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM18117.1.
AL844582
, AL731795, AL837516, AL844562, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM18237.1.
AL837516
, AL731795, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM18246.1.
AL845530
, AL731795, AL837516, AL844562, AL844582, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM19545.1.
AL929443
, AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027 Genomic DNA. Translation: CAM25240.1.
AL928823
, AL731795, AL837516, AL844562, AL844582, AL845530, AL929027, AL929443 Genomic DNA. Translation: CAM25366.1.
CCDSiCCDS50733.1.
RefSeqiNP_001013824.2. NM_001013802.3.
UniGeneiMm.229466.

Genome annotation databases

EnsembliENSMUST00000078027; ENSMUSP00000077174; ENSMUSG00000068205.
ENSMUST00000110064; ENSMUSP00000105691; ENSMUSG00000068205.
GeneIDi72899.
KEGGimmu:72899.
UCSCiuc008mpv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134694 mRNA. Translation: BAE22244.1.
AL731795
, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM14291.1.
AL929027
, AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929443 Genomic DNA. Translation: CAM17747.1.
AL844562
, AL731795, AL837516, AL844582, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM18117.1.
AL844582
, AL731795, AL837516, AL844562, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM18237.1.
AL837516
, AL731795, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM18246.1.
AL845530
, AL731795, AL837516, AL844562, AL844582, AL928823, AL929027, AL929443 Genomic DNA. Translation: CAM19545.1.
AL929443
, AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027 Genomic DNA. Translation: CAM25240.1.
AL928823
, AL731795, AL837516, AL844562, AL844582, AL845530, AL929027, AL929443 Genomic DNA. Translation: CAM25366.1.
CCDSiCCDS50733.1.
RefSeqiNP_001013824.2. NM_001013802.3.
UniGeneiMm.229466.

3D structure databases

ProteinModelPortaliQ3UYG8.
SMRiQ3UYG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077174.

PTM databases

iPTMnetiQ3UYG8.
PhosphoSitePlusiQ3UYG8.

Proteomic databases

MaxQBiQ3UYG8.
PaxDbiQ3UYG8.
PeptideAtlasiQ3UYG8.
PRIDEiQ3UYG8.

Protocols and materials databases

DNASUi72899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078027; ENSMUSP00000077174; ENSMUSG00000068205.
ENSMUST00000110064; ENSMUSP00000105691; ENSMUSG00000068205.
GeneIDi72899.
KEGGimmu:72899.
UCSCiuc008mpv.1. mouse.

Organism-specific databases

CTDi140733.
MGIiMGI:1920149. Macrod2.

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00520000055566.
HOGENOMiHOG000231859.
HOVERGENiHBG099716.
InParanoidiQ3UYG8.
OMAiWLAKNHQ.
OrthoDBiEOG091G0NNH.
PhylomeDBiQ3UYG8.
TreeFamiTF341440.

Miscellaneous databases

ChiTaRSiMacrod2. mouse.
PROiQ3UYG8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068205.
CleanExiMM_MACROD2.
ExpressionAtlasiQ3UYG8. baseline and differential.

Family and domain databases

InterProiIPR002589. Macro_dom.
[Graphical view]
PfamiPF01661. Macro. 1 hit.
[Graphical view]
SMARTiSM00506. A1pp. 1 hit.
[Graphical view]
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMACD2_MOUSE
AccessioniPrimary (citable) accession number: Q3UYG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.