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Protein

Protein phosphatase 1H

Gene

Ppm1h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1H (EC:3.1.3.16)
Gene namesi
Name:Ppm1h
Synonyms:Kiaa1157
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2442087. Ppm1h.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Protein phosphatase 1HPRO_0000286604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine1 Publication
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei223 – 2231PhosphothreonineBy similarity
Modified residuei421 – 4211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UYC0.
PaxDbiQ3UYC0.
PRIDEiQ3UYC0.

PTM databases

PhosphoSiteiQ3UYC0.

Expressioni

Gene expression databases

BgeeiQ3UYC0.
CleanExiMM_PPM1H.
ExpressionAtlasiQ3UYC0. baseline and differential.
GenevisibleiQ3UYC0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3UYC0. 2 interactions.
MINTiMINT-5174682.
STRINGi10090.ENSMUSP00000066561.

Structurei

3D structure databases

ProteinModelPortaliQ3UYC0.
SMRiQ3UYC0. Positions 247-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 506430PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00530000063231.
HOVERGENiHBG105802.
InParanoidiQ3UYC0.
KOiK17503.
OMAiGYAECVN.
OrthoDBiEOG7F511J.
PhylomeDBiQ3UYC0.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UYC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS
60 70 80 90 100
QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV
110 120 130 140 150
LTVKKKAGTI TSTPNRNSKR RSSLPNGEGL QLKENSESEG ISCHYWSLFD
160 170 180 190 200
GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL KNSAILPPTC LGEEPESTPA
210 220 230 240 250
HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV IGALESAFKE
260 270 280 290 300
MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP
310 320 330 340 350
MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR
360 370 380 390 400
DFNMTGWAYK TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD
410 420 430 440 450
SNIYIKPFLS SAPEVRVYDL SRYEHGADDV LILATDGLWD VLSNEEVAEA
460 470 480 490 500
ITQFLPNCDP DDPHRYTLAA QDLVMRARGV LKDRGWRISN DRLGSGDDIS
510
VYVIPLIHGN KLS
Length:513
Mass (Da):56,380
Last modified:October 11, 2005 - v1
Checksum:i27885A4519A0F0DB
GO
Isoform 2 (identifier: Q3UYC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-469: YTLA → FVPL
     470-513: Missing.

Show »
Length:469
Mass (Da):51,514
Checksum:i741F0263D5BC28AD
GO

Sequence cautioni

The sequence BAD90185.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE29457.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE43270.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 934THNE → EVIP in AAH52910 (PubMed:15489334).Curated
Sequence conflicti130 – 1301L → R in BAD90185 (Ref. 2) Curated
Sequence conflicti168 – 1681H → P in AAH52910 (PubMed:15489334).Curated
Sequence conflicti198 – 1981T → A in BAE43308 (PubMed:16141072).Curated
Sequence conflicti260 – 2601S → G in BAE29457 (PubMed:16141072).Curated
Sequence conflicti456 – 4561P → L in AAH52910 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei466 – 4694YTLA → FVPL in isoform 2. 1 PublicationVSP_025121
Alternative sequencei470 – 51344Missing in isoform 2. 1 PublicationVSP_025122Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029461 mRNA. Translation: BAE43270.1. Different initiation.
AK040194 mRNA. Translation: BAC30536.1.
AK040207 mRNA. Translation: BAE43308.1.
AK134804 mRNA. Translation: BAE22292.1.
AK150309 mRNA. Translation: BAE29457.1. Different initiation.
AK220260 mRNA. Translation: BAD90185.1. Different initiation.
BC052910 mRNA. Translation: AAH52910.1.
CCDSiCCDS48705.1. [Q3UYC0-1]
CCDS48706.1. [Q3UYC0-2]
RefSeqiNP_001103688.1. NM_001110218.1. [Q3UYC0-1]
NP_795893.2. NM_176919.4. [Q3UYC0-2]
UniGeneiMm.489703.

Genome annotation databases

EnsembliENSMUST00000067918; ENSMUSP00000066561; ENSMUSG00000034613. [Q3UYC0-1]
ENSMUST00000161487; ENSMUSP00000124982; ENSMUSG00000034613. [Q3UYC0-2]
GeneIDi319468.
KEGGimmu:319468.
UCSCiuc007hgf.2. mouse. [Q3UYC0-1]
uc007hgg.2. mouse. [Q3UYC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029461 mRNA. Translation: BAE43270.1. Different initiation.
AK040194 mRNA. Translation: BAC30536.1.
AK040207 mRNA. Translation: BAE43308.1.
AK134804 mRNA. Translation: BAE22292.1.
AK150309 mRNA. Translation: BAE29457.1. Different initiation.
AK220260 mRNA. Translation: BAD90185.1. Different initiation.
BC052910 mRNA. Translation: AAH52910.1.
CCDSiCCDS48705.1. [Q3UYC0-1]
CCDS48706.1. [Q3UYC0-2]
RefSeqiNP_001103688.1. NM_001110218.1. [Q3UYC0-1]
NP_795893.2. NM_176919.4. [Q3UYC0-2]
UniGeneiMm.489703.

3D structure databases

ProteinModelPortaliQ3UYC0.
SMRiQ3UYC0. Positions 247-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UYC0. 2 interactions.
MINTiMINT-5174682.
STRINGi10090.ENSMUSP00000066561.

PTM databases

PhosphoSiteiQ3UYC0.

Proteomic databases

MaxQBiQ3UYC0.
PaxDbiQ3UYC0.
PRIDEiQ3UYC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067918; ENSMUSP00000066561; ENSMUSG00000034613. [Q3UYC0-1]
ENSMUST00000161487; ENSMUSP00000124982; ENSMUSG00000034613. [Q3UYC0-2]
GeneIDi319468.
KEGGimmu:319468.
UCSCiuc007hgf.2. mouse. [Q3UYC0-1]
uc007hgg.2. mouse. [Q3UYC0-2]

Organism-specific databases

CTDi57460.
MGIiMGI:2442087. Ppm1h.
RougeiSearch...

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00530000063231.
HOVERGENiHBG105802.
InParanoidiQ3UYC0.
KOiK17503.
OMAiGYAECVN.
OrthoDBiEOG7F511J.
PhylomeDBiQ3UYC0.
TreeFamiTF314700.

Miscellaneous databases

ChiTaRSiPpm1h. mouse.
NextBioi394782.
PROiQ3UYC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UYC0.
CleanExiMM_PPM1H.
ExpressionAtlasiQ3UYC0. baseline and differential.
GenevisibleiQ3UYC0. MM.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Head, Medulla oblongata and Thymus.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-513 (ISOFORM 1).
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPM1H_MOUSE
AccessioniPrimary (citable) accession number: Q3UYC0
Secondary accession number(s): Q3UD05
, Q3V3H5, Q3V3Y7, Q571C9, Q7TMU7, Q8BYE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.