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Q3UYC0

- PPM1H_MOUSE

UniProt

Q3UYC0 - PPM1H_MOUSE

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Protein
Protein phosphatase 1H
Gene
Ppm1h, Kiaa1157
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1H (EC:3.1.3.16)
Gene namesi
Name:Ppm1h
Synonyms:Kiaa1157
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2442087. Ppm1h.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Protein phosphatase 1H
PRO_0000286604Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine1 Publication
Modified residuei210 – 2101Phosphoserine By similarity
Modified residuei220 – 2201Phosphoserine By similarity
Modified residuei223 – 2231Phosphothreonine By similarity
Modified residuei421 – 4211Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UYC0.
PaxDbiQ3UYC0.
PRIDEiQ3UYC0.

PTM databases

PhosphoSiteiQ3UYC0.

Expressioni

Gene expression databases

ArrayExpressiQ3UYC0.
BgeeiQ3UYC0.
CleanExiMM_PPM1H.
GenevestigatoriQ3UYC0.

Interactioni

Protein-protein interaction databases

IntActiQ3UYC0. 2 interactions.
MINTiMINT-5174682.

Structurei

3D structure databases

ProteinModelPortaliQ3UYC0.
SMRiQ3UYC0. Positions 247-506.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini136 – 506371PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00530000063231.
HOVERGENiHBG105802.
InParanoidiQ3UYC0.
KOiK17503.
OMAiERTVYNI.
OrthoDBiEOG7F511J.
PhylomeDBiQ3UYC0.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UYC0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS    50
QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV 100
LTVKKKAGTI TSTPNRNSKR RSSLPNGEGL QLKENSESEG ISCHYWSLFD 150
GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL KNSAILPPTC LGEEPESTPA 200
HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV IGALESAFKE 250
MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP 300
MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR 350
DFNMTGWAYK TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD 400
SNIYIKPFLS SAPEVRVYDL SRYEHGADDV LILATDGLWD VLSNEEVAEA 450
ITQFLPNCDP DDPHRYTLAA QDLVMRARGV LKDRGWRISN DRLGSGDDIS 500
VYVIPLIHGN KLS 513
Length:513
Mass (Da):56,380
Last modified:October 11, 2005 - v1
Checksum:i27885A4519A0F0DB
GO
Isoform 2 (identifier: Q3UYC0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-469: YTLA → FVPL
     470-513: Missing.

Show »
Length:469
Mass (Da):51,514
Checksum:i741F0263D5BC28AD
GO

Sequence cautioni

The sequence BAD90185.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE29457.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE43270.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei466 – 4694YTLA → FVPL in isoform 2.
VSP_025121
Alternative sequencei470 – 51344Missing in isoform 2.
VSP_025122Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 934THNE → EVIP in AAH52910. 1 Publication
Sequence conflicti130 – 1301L → R in BAD90185. 1 Publication
Sequence conflicti168 – 1681H → P in AAH52910. 1 Publication
Sequence conflicti198 – 1981T → A in BAE43308. 1 Publication
Sequence conflicti260 – 2601S → G in BAE29457. 1 Publication
Sequence conflicti456 – 4561P → L in AAH52910. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029461 mRNA. Translation: BAE43270.1. Different initiation.
AK040194 mRNA. Translation: BAC30536.1.
AK040207 mRNA. Translation: BAE43308.1.
AK134804 mRNA. Translation: BAE22292.1.
AK150309 mRNA. Translation: BAE29457.1. Different initiation.
AK220260 mRNA. Translation: BAD90185.1. Different initiation.
BC052910 mRNA. Translation: AAH52910.1.
CCDSiCCDS48705.1. [Q3UYC0-1]
CCDS48706.1. [Q3UYC0-2]
RefSeqiNP_001103688.1. NM_001110218.1. [Q3UYC0-1]
NP_795893.2. NM_176919.4. [Q3UYC0-2]
UniGeneiMm.489703.

Genome annotation databases

EnsembliENSMUST00000067918; ENSMUSP00000066561; ENSMUSG00000034613. [Q3UYC0-1]
ENSMUST00000161487; ENSMUSP00000124982; ENSMUSG00000034613. [Q3UYC0-2]
GeneIDi319468.
KEGGimmu:319468.
UCSCiuc007hgf.2. mouse. [Q3UYC0-1]
uc007hgg.2. mouse. [Q3UYC0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK029461 mRNA. Translation: BAE43270.1 . Different initiation.
AK040194 mRNA. Translation: BAC30536.1 .
AK040207 mRNA. Translation: BAE43308.1 .
AK134804 mRNA. Translation: BAE22292.1 .
AK150309 mRNA. Translation: BAE29457.1 . Different initiation.
AK220260 mRNA. Translation: BAD90185.1 . Different initiation.
BC052910 mRNA. Translation: AAH52910.1 .
CCDSi CCDS48705.1. [Q3UYC0-1 ]
CCDS48706.1. [Q3UYC0-2 ]
RefSeqi NP_001103688.1. NM_001110218.1. [Q3UYC0-1 ]
NP_795893.2. NM_176919.4. [Q3UYC0-2 ]
UniGenei Mm.489703.

3D structure databases

ProteinModelPortali Q3UYC0.
SMRi Q3UYC0. Positions 247-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3UYC0. 2 interactions.
MINTi MINT-5174682.

PTM databases

PhosphoSitei Q3UYC0.

Proteomic databases

MaxQBi Q3UYC0.
PaxDbi Q3UYC0.
PRIDEi Q3UYC0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067918 ; ENSMUSP00000066561 ; ENSMUSG00000034613 . [Q3UYC0-1 ]
ENSMUST00000161487 ; ENSMUSP00000124982 ; ENSMUSG00000034613 . [Q3UYC0-2 ]
GeneIDi 319468.
KEGGi mmu:319468.
UCSCi uc007hgf.2. mouse. [Q3UYC0-1 ]
uc007hgg.2. mouse. [Q3UYC0-2 ]

Organism-specific databases

CTDi 57460.
MGIi MGI:2442087. Ppm1h.
Rougei Search...

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00530000063231.
HOVERGENi HBG105802.
InParanoidi Q3UYC0.
KOi K17503.
OMAi ERTVYNI.
OrthoDBi EOG7F511J.
PhylomeDBi Q3UYC0.
TreeFami TF314700.

Miscellaneous databases

ChiTaRSi PPM1H. mouse.
NextBioi 394782.
PROi Q3UYC0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UYC0.
Bgeei Q3UYC0.
CleanExi MM_PPM1H.
Genevestigatori Q3UYC0.

Family and domain databases

Gene3Di 3.60.40.10. 3 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 4 hits.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow, Head, Medulla oblongata and Thymus.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-513 (ISOFORM 1).
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPM1H_MOUSE
AccessioniPrimary (citable) accession number: Q3UYC0
Secondary accession number(s): Q3UD05
, Q3V3H5, Q3V3Y7, Q571C9, Q7TMU7, Q8BYE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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