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Q3UYC0

- PPM1H_MOUSE

UniProt

Q3UYC0 - PPM1H_MOUSE

Protein

Protein phosphatase 1H

Gene

Ppm1h

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1H (EC:3.1.3.16)
    Gene namesi
    Name:Ppm1h
    Synonyms:Kiaa1157
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:2442087. Ppm1h.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Protein phosphatase 1HPRO_0000286604Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231Phosphoserine1 Publication
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei220 – 2201PhosphoserineBy similarity
    Modified residuei223 – 2231PhosphothreonineBy similarity
    Modified residuei421 – 4211PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ3UYC0.
    PaxDbiQ3UYC0.
    PRIDEiQ3UYC0.

    PTM databases

    PhosphoSiteiQ3UYC0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UYC0.
    BgeeiQ3UYC0.
    CleanExiMM_PPM1H.
    GenevestigatoriQ3UYC0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ3UYC0. 2 interactions.
    MINTiMINT-5174682.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UYC0.
    SMRiQ3UYC0. Positions 247-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini136 – 506371PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00530000063231.
    HOVERGENiHBG105802.
    InParanoidiQ3UYC0.
    KOiK17503.
    OMAiERTVYNI.
    OrthoDBiEOG7F511J.
    PhylomeDBiQ3UYC0.
    TreeFamiTF314700.

    Family and domain databases

    Gene3Di3.60.40.10. 3 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 4 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UYC0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS    50
    QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV 100
    LTVKKKAGTI TSTPNRNSKR RSSLPNGEGL QLKENSESEG ISCHYWSLFD 150
    GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL KNSAILPPTC LGEEPESTPA 200
    HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV IGALESAFKE 250
    MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP 300
    MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR 350
    DFNMTGWAYK TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD 400
    SNIYIKPFLS SAPEVRVYDL SRYEHGADDV LILATDGLWD VLSNEEVAEA 450
    ITQFLPNCDP DDPHRYTLAA QDLVMRARGV LKDRGWRISN DRLGSGDDIS 500
    VYVIPLIHGN KLS 513
    Length:513
    Mass (Da):56,380
    Last modified:October 11, 2005 - v1
    Checksum:i27885A4519A0F0DB
    GO
    Isoform 2 (identifier: Q3UYC0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         466-469: YTLA → FVPL
         470-513: Missing.

    Show »
    Length:469
    Mass (Da):51,514
    Checksum:i741F0263D5BC28AD
    GO

    Sequence cautioni

    The sequence BAD90185.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE29457.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE43270.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 934THNE → EVIP in AAH52910. (PubMed:15489334)Curated
    Sequence conflicti130 – 1301L → R in BAD90185. 1 PublicationCurated
    Sequence conflicti168 – 1681H → P in AAH52910. (PubMed:15489334)Curated
    Sequence conflicti198 – 1981T → A in BAE43308. (PubMed:16141072)Curated
    Sequence conflicti260 – 2601S → G in BAE29457. (PubMed:16141072)Curated
    Sequence conflicti456 – 4561P → L in AAH52910. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei466 – 4694YTLA → FVPL in isoform 2. 1 PublicationVSP_025121
    Alternative sequencei470 – 51344Missing in isoform 2. 1 PublicationVSP_025122Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029461 mRNA. Translation: BAE43270.1. Different initiation.
    AK040194 mRNA. Translation: BAC30536.1.
    AK040207 mRNA. Translation: BAE43308.1.
    AK134804 mRNA. Translation: BAE22292.1.
    AK150309 mRNA. Translation: BAE29457.1. Different initiation.
    AK220260 mRNA. Translation: BAD90185.1. Different initiation.
    BC052910 mRNA. Translation: AAH52910.1.
    CCDSiCCDS48705.1. [Q3UYC0-1]
    CCDS48706.1. [Q3UYC0-2]
    RefSeqiNP_001103688.1. NM_001110218.1. [Q3UYC0-1]
    NP_795893.2. NM_176919.4. [Q3UYC0-2]
    UniGeneiMm.489703.

    Genome annotation databases

    EnsembliENSMUST00000067918; ENSMUSP00000066561; ENSMUSG00000034613. [Q3UYC0-1]
    ENSMUST00000161487; ENSMUSP00000124982; ENSMUSG00000034613. [Q3UYC0-2]
    GeneIDi319468.
    KEGGimmu:319468.
    UCSCiuc007hgf.2. mouse. [Q3UYC0-1]
    uc007hgg.2. mouse. [Q3UYC0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK029461 mRNA. Translation: BAE43270.1 . Different initiation.
    AK040194 mRNA. Translation: BAC30536.1 .
    AK040207 mRNA. Translation: BAE43308.1 .
    AK134804 mRNA. Translation: BAE22292.1 .
    AK150309 mRNA. Translation: BAE29457.1 . Different initiation.
    AK220260 mRNA. Translation: BAD90185.1 . Different initiation.
    BC052910 mRNA. Translation: AAH52910.1 .
    CCDSi CCDS48705.1. [Q3UYC0-1 ]
    CCDS48706.1. [Q3UYC0-2 ]
    RefSeqi NP_001103688.1. NM_001110218.1. [Q3UYC0-1 ]
    NP_795893.2. NM_176919.4. [Q3UYC0-2 ]
    UniGenei Mm.489703.

    3D structure databases

    ProteinModelPortali Q3UYC0.
    SMRi Q3UYC0. Positions 247-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3UYC0. 2 interactions.
    MINTi MINT-5174682.

    PTM databases

    PhosphoSitei Q3UYC0.

    Proteomic databases

    MaxQBi Q3UYC0.
    PaxDbi Q3UYC0.
    PRIDEi Q3UYC0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067918 ; ENSMUSP00000066561 ; ENSMUSG00000034613 . [Q3UYC0-1 ]
    ENSMUST00000161487 ; ENSMUSP00000124982 ; ENSMUSG00000034613 . [Q3UYC0-2 ]
    GeneIDi 319468.
    KEGGi mmu:319468.
    UCSCi uc007hgf.2. mouse. [Q3UYC0-1 ]
    uc007hgg.2. mouse. [Q3UYC0-2 ]

    Organism-specific databases

    CTDi 57460.
    MGIi MGI:2442087. Ppm1h.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00530000063231.
    HOVERGENi HBG105802.
    InParanoidi Q3UYC0.
    KOi K17503.
    OMAi ERTVYNI.
    OrthoDBi EOG7F511J.
    PhylomeDBi Q3UYC0.
    TreeFami TF314700.

    Miscellaneous databases

    ChiTaRSi PPM1H. mouse.
    NextBioi 394782.
    PROi Q3UYC0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UYC0.
    Bgeei Q3UYC0.
    CleanExi MM_PPM1H.
    Genevestigatori Q3UYC0.

    Family and domain databases

    Gene3Di 3.60.40.10. 3 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Bone marrow, Head, Medulla oblongata and Thymus.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreatic islet.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-513 (ISOFORM 1).
      Strain: C57BL/6NCr.
      Tissue: Hematopoietic stem cell.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPPM1H_MOUSE
    AccessioniPrimary (citable) accession number: Q3UYC0
    Secondary accession number(s): Q3UD05
    , Q3V3H5, Q3V3Y7, Q571C9, Q7TMU7, Q8BYE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3