Serine/threonine-protein phosphatase - Mus musculus (Mouse)

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Unreviewed, UniProtKB/TrEMBL Q3UXV4 (Q3UXV4_MOUSE)

Last modified February 9, 2010. Version 38. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase RuleBase RU004273V0
EC=3.1.3.16 RuleBase RU004273V0

Gene names

Name:

Ppp3cb MGI 107163

Organism

Mus musculus (Mouse) EMBL BAE22459.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A phosphoprotein + H₂O = a protein + phosphate. RuleBase RU004273V0
Sequence similarities	Belongs to the PPP phosphatase family.

Ontologies

Keywords
Ligand	Iron RuleBase RU004273V0
Molecular function	Hydrolase Spearmint SPM006186 RuleBase RU004273V0
Gene Ontology (GO)
Biological process	T cell differentiation Inferred from mutant phenotype. Source: MGI T cell homeostasis Inferred from mutant phenotype. Source: MGI heart development Inferred from mutant phenotype. Source: MGI muscle homeostasis Inferred from electronic annotation. Source: Compara negative regulation of T cell mediated cytotoxicity Inferred from mutant phenotype. Source: MGI protein amino acid dephosphorylation Inferred from mutant phenotype. Source: MGI regulation of gene expression Inferred from mutant phenotype. Source: MGI response to amphetamine Inferred from electronic annotation. Source: Compara response to cytokine stimulus Inferred from mutant phenotype. Source: MGI
Cellular component	insoluble fraction Inferred from electronic annotation. Source: Compara soluble fraction Inferred from electronic annotation. Source: Compara
Molecular function	calcium-dependent protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein heterodimerization activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q3UXV4-1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 400A2BC70FF78751
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452

51,446

        10         20         30         40         50         60 
MDGIPRVDVL KNHLVKEGRV DEEIALRIIN EGAAILRREK TMIEVEAPIT VCGDIHGQFF 

        70         80         90        100        110        120 
DLMKLFEVGG SPANTRYLFL GDYVDRGYFS IECVLYLWVL KILYPSTLFL LRGNHECRHL 

       130        140        150        160        170        180 
TEYFTFKQEC KIKYSERVYE ACMEAFDSLP LAALLNQQFL CVHGGLSPEI HTLDDIRRLY 

       190        200        210        220        230        240 
RFKEPPAFGP MCDLLWSDPS EDFGNEKSQE HFSHNTVRGC SYFYNYPAVC EFLQNNNLLS 

       250        260        270        280        290        300 
IIRAHEAQDA GYRMYRKSQT TGFPSLITIF SAPNYLDVYN NKAAVLKYEN NVMNIRQFNC 

       310        320        330        340        350        360 
SPHPYWLPNF MDVFTWSLPF VGEKVTEMLV NVLSICSDDE LMTEGEDQFD VGSAAARKEI 

       370        380        390        400        410        420 
IRNKIRAIGK MARVFSVLRE ESESVLTLKG LTPTGMLPSG VLAGGRQTLQ SGNDVMQLAV 

       430        440        450 
PQMDWGTTHS FANNTHNACR ELLLLFSSCL SS

References

[1]

"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.

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Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAE22459.1.
Tissue: Wolffian duct includes surrounding region EMBL BAE22459.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK135203 mRNA. Translation: BAE22459.1.
IPI	IPI00654325.
UniGene	Mm.274432
3D structure databases
SMR	Q3UXV4. Positions 2-336.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3UXV4.
Proteomic databases
PRIDE	Q3UXV4.
Genome annotation databases
Ensembl	ENSMUST00000022355; ENSMUSP00000022355; ENSMUSG00000021816; Mus musculus. [Genome view]
UCSC	uc007sjz.1. mouse.
Organism-specific databases
MGI	MGI:107163. Ppp3cb.
Phylogenomic databases
HOVERGEN	Q3UXV4.
InParanoid	Q3UXV4.
PhylomeDB	Q3UXV4.
Gene expression databases
ArrayExpress	Q3UXV4.
Bgee	Q3UXV4.
Genevestigator	Q3UXV4.
Family and domain databases
InterPro	IPR004843. M-pesterase. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
PANTHER	PTHR11668. T_phtase_apaH. 1 hit.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q3UXV4_MOUSE

Accession

Primary (citable) accession number: Q3UXV4

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information