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Q3UXV4

- Q3UXV4_MOUSE

UniProt

Q3UXV4 - Q3UXV4_MOUSE

Protein

Serine/threonine-protein phosphatase

Gene

Ppp3cb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

    GO - Molecular functioni

    1. protein serine/threonine phosphatase activity Source: MGI

    GO - Biological processi

    1. heart development Source: MGI
    2. locomotion involved in locomotory behavior Source: MGI
    3. negative regulation of T cell mediated cytotoxicity Source: MGI
    4. protein dephosphorylation Source: MGI
    5. regulation of gene expression Source: MGI
    6. response to cytokine Source: MGI
    7. T cell differentiation Source: MGI
    8. T cell homeostasis Source: MGI

    Keywords - Molecular functioni

    HydrolaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
    Gene namesi
    Name:Ppp3cbImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:107163. Ppp3cb.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ3UXV4.

    Expressioni

    Gene expression databases

    GenevestigatoriQ3UXV4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022355.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UXV4.
    SMRiQ3UXV4. Positions 2-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000172699.
    HOVERGENiHBG002819.
    InParanoidiQ3UXV4.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3UXV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGIPRVDVL KNHLVKEGRV DEEIALRIIN EGAAILRREK TMIEVEAPIT    50
    VCGDIHGQFF DLMKLFEVGG SPANTRYLFL GDYVDRGYFS IECVLYLWVL 100
    KILYPSTLFL LRGNHECRHL TEYFTFKQEC KIKYSERVYE ACMEAFDSLP 150
    LAALLNQQFL CVHGGLSPEI HTLDDIRRLY RFKEPPAFGP MCDLLWSDPS 200
    EDFGNEKSQE HFSHNTVRGC SYFYNYPAVC EFLQNNNLLS IIRAHEAQDA 250
    GYRMYRKSQT TGFPSLITIF SAPNYLDVYN NKAAVLKYEN NVMNIRQFNC 300
    SPHPYWLPNF MDVFTWSLPF VGEKVTEMLV NVLSICSDDE LMTEGEDQFD 350
    VGSAAARKEI IRNKIRAIGK MARVFSVLRE ESESVLTLKG LTPTGMLPSG 400
    VLAGGRQTLQ SGNDVMQLAV PQMDWGTTHS FANNTHNACR ELLLLFSSCL 450
    SS 452
    Length:452
    Mass (Da):51,446
    Last modified:October 11, 2005 - v1
    Checksum:i400A2BC70FF78751
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135203 mRNA. Translation: BAE22459.1.
    UniGeneiMm.274432.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135203 mRNA. Translation: BAE22459.1 .
    UniGenei Mm.274432.

    3D structure databases

    ProteinModelPortali Q3UXV4.
    SMRi Q3UXV4. Positions 2-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022355.

    Proteomic databases

    PRIDEi Q3UXV4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:107163. Ppp3cb.

    Phylogenomic databases

    HOGENOMi HOG000172699.
    HOVERGENi HBG002819.
    InParanoidi Q3UXV4.

    Miscellaneous databases

    ChiTaRSi PPP3CB. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3UXV4.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Wolffian duct includes surrounding regionImported.

    Entry informationi

    Entry nameiQ3UXV4_MOUSE
    AccessioniPrimary (citable) accession number: Q3UXV4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)