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Q3UXV4

- Q3UXV4_MOUSE

UniProt

Q3UXV4 - Q3UXV4_MOUSE

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Protein

Serine/threonine-protein phosphatase

Gene

Ppp3cb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

GO - Molecular functioni

  1. protein serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. heart development Source: MGI
  2. locomotion involved in locomotory behavior Source: MGI
  3. negative regulation of T cell mediated cytotoxicity Source: MGI
  4. protein dephosphorylation Source: MGI
  5. regulation of gene expression Source: MGI
  6. response to cytokine Source: MGI
  7. T cell differentiation Source: MGI
  8. T cell homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation)
Gene namesi
Name:Ppp3cbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:107163. Ppp3cb.

PTM / Processingi

Proteomic databases

PRIDEiQ3UXV4.

Expressioni

Gene expression databases

GenevestigatoriQ3UXV4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022355.

Structurei

3D structure databases

ProteinModelPortaliQ3UXV4.
SMRiQ3UXV4. Positions 2-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000172699.
HOVERGENiHBG002819.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UXV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGIPRVDVL KNHLVKEGRV DEEIALRIIN EGAAILRREK TMIEVEAPIT
60 70 80 90 100
VCGDIHGQFF DLMKLFEVGG SPANTRYLFL GDYVDRGYFS IECVLYLWVL
110 120 130 140 150
KILYPSTLFL LRGNHECRHL TEYFTFKQEC KIKYSERVYE ACMEAFDSLP
160 170 180 190 200
LAALLNQQFL CVHGGLSPEI HTLDDIRRLY RFKEPPAFGP MCDLLWSDPS
210 220 230 240 250
EDFGNEKSQE HFSHNTVRGC SYFYNYPAVC EFLQNNNLLS IIRAHEAQDA
260 270 280 290 300
GYRMYRKSQT TGFPSLITIF SAPNYLDVYN NKAAVLKYEN NVMNIRQFNC
310 320 330 340 350
SPHPYWLPNF MDVFTWSLPF VGEKVTEMLV NVLSICSDDE LMTEGEDQFD
360 370 380 390 400
VGSAAARKEI IRNKIRAIGK MARVFSVLRE ESESVLTLKG LTPTGMLPSG
410 420 430 440 450
VLAGGRQTLQ SGNDVMQLAV PQMDWGTTHS FANNTHNACR ELLLLFSSCL

SS
Length:452
Mass (Da):51,446
Last modified:October 11, 2005 - v1
Checksum:i400A2BC70FF78751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135203 mRNA. Translation: BAE22459.1.
UniGeneiMm.274432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135203 mRNA. Translation: BAE22459.1 .
UniGenei Mm.274432.

3D structure databases

ProteinModelPortali Q3UXV4.
SMRi Q3UXV4. Positions 2-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022355.

Proteomic databases

PRIDEi Q3UXV4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:107163. Ppp3cb.

Phylogenomic databases

HOGENOMi HOG000172699.
HOVERGENi HBG002819.

Miscellaneous databases

ChiTaRSi Ppp3cb. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3UXV4.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.

Entry informationi

Entry nameiQ3UXV4_MOUSE
AccessioniPrimary (citable) accession number: Q3UXV4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)