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Protein

Centrosomal protein kizuna

Gene

Kiz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein kizuna
Alternative name(s):
Polo-like kinase 1 substrate 1
Gene namesi
Name:Kiz
Synonyms:Gm114, Plk1s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684960. Kiz.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018521 – 695Centrosomal protein kizunaAdd BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391Phosphothreonine; by PLK1By similarity1
Modified residuei667PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei672PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UXL4.
PaxDbiQ3UXL4.
PeptideAtlasiQ3UXL4.
PRIDEiQ3UXL4.

PTM databases

iPTMnetiQ3UXL4.
PhosphoSitePlusiQ3UXL4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000074749.
ExpressionAtlasiQ3UXL4. baseline and differential.
GenevisibleiQ3UXL4. MM.

Interactioni

Subunit structurei

Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UXL4. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ3UXL4.
SMRiQ3UXL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 57Sequence analysisAdd BLAST29
Coiled coili102 – 132Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the kizuna family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK70. Eukaryota.
ENOG4111S83. LUCA.
GeneTreeiENSGT00390000010121.
HOGENOMiHOG000060289.
InParanoidiQ3UXL4.
KOiK16539.
OMAiQPATIFM.
OrthoDBiEOG091G18TL.
PhylomeDBiQ3UXL4.
TreeFamiTF336086.

Family and domain databases

InterProiView protein in InterPro
IPR026742. Centrosomal_kizuma.
PANTHERiPTHR16299. PTHR16299. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3UXL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGRGGGGG GLRQASATSA PLASPSYYER VGQLQQALRD SEKKRLDLED
60 70 80 90 100
KLYEYNKSDK CRAKLKCAKL KKYLKEVCES ERRAQVRNQG YLKKFECVQT
110 120 130 140 150
YVEHLTTNTE KLQKLKTEYE AEVKRMRLLS KDSLGMSDED GAKDAVQAGI
160 170 180 190 200
NSGTAMSRGL YQPATIFMGR QMSAISSIED FSTELKSNQP TKNFSISDPH
210 220 230 240 250
SHQQTAQSSC VTDSCVVQTN GDTQCLNKSD KIHGKTSLQT GEKAPVTSYV
260 270 280 290 300
LSAEEQTHCL EIGSSTQHSK SNLSEGRKSA ELHSSLQERL SPENSITDLK
310 320 330 340 350
CDSSSRSEGS DREILTQEHI EVREERAGPL VPMMAASEHC TSAKKWAGEK
360 370 380 390 400
HSAWEASSDD LDHGDSKSQK AVLKHEEEQE EGSSCSSSDL TVSVSEDDLI
410 420 430 440 450
LESLAALSNP GAKMAGKDGM QALRAAHTEP RQDSLFTEYV LQTQSFPDSK
460 470 480 490 500
REPSPDSPRQ PEKVPDCHLL KTRGQCMKEH DNSLKEEATT LLKKVLTEEC
510 520 530 540 550
DHRSAIHSNE SSCSMPSILN DNNGIKEAKP ALRLNSVLTR EQEVSSGCGD
560 570 580 590 600
ESKEESIAAA PGTGHREADL VPSELFQFSL GAAMKETKAY QLLKKSTLQD
610 620 630 640 650
NSNQAEERFE SQFSGLDIGG SMFTTKTAHK IASEASFSSS EGSPLSRHES
660 670 680 690
KRDPVTTIKS NAFWGESDDS NSEIEAALRP RDHDMPDDFD DFYDT
Length:695
Mass (Da):76,542
Last modified:October 11, 2005 - v1
Checksum:i71DDC7CB94FD6EBF
GO

Sequence cautioni

The sequence CAM27275 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135486 mRNA. Translation: BAE22549.1.
AL929215 Genomic DNA. Translation: CAM27275.1. Sequence problems.
AL929215 Genomic DNA. Translation: CAM27276.1.
BC150844 mRNA. Translation: AAI50845.1.
BC150845 mRNA. Translation: AAI50846.1.
CCDSiCCDS16832.1.
RefSeqiNP_001028470.1. NM_001033298.3.
UniGeneiMm.292352.

Genome annotation databases

EnsembliENSMUST00000099278; ENSMUSP00000096884; ENSMUSG00000074749.
GeneIDi228730.
KEGGimmu:228730.
UCSCiuc008mso.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiKIZ_MOUSE
AccessioniPrimary (citable) accession number: Q3UXL4
Secondary accession number(s): A2AUS7, B2RX19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families