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Q3UXL4

- KIZ_MOUSE

UniProt

Q3UXL4 - KIZ_MOUSE

Protein

Centrosomal protein kizuna

Gene

Kiz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole By similarity.By similarity

    GO - Biological processi

    1. spindle organization Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein kizuna
    Alternative name(s):
    Polo-like kinase 1 substrate 1
    Gene namesi
    Name:Kiz
    Synonyms:Gm114, Plk1s1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2684960. Kiz.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome- surrounding area in a microtubule-independent and dependent manner, respectively By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Centrosomal protein kizunaPRO_0000301852Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei391 – 3911Phosphothreonine; by PLK1By similarity
    Modified residuei667 – 6671PhosphoserineBy similarity
    Modified residuei670 – 6701PhosphoserineBy similarity
    Modified residuei672 – 6721PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ3UXL4.

    PTM databases

    PhosphoSiteiQ3UXL4.

    Expressioni

    Gene expression databases

    BgeeiQ3UXL4.
    GenevestigatoriQ3UXL4.

    Interactioni

    Subunit structurei

    Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.By similarity

    Protein-protein interaction databases

    IntActiQ3UXL4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UXL4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 5729Sequence AnalysisAdd
    BLAST
    Coiled coili102 – 13231Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the kizuna family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG25010.
    GeneTreeiENSGT00390000010121.
    HOGENOMiHOG000060289.
    InParanoidiB2RX19.
    KOiK16539.
    OMAiSRGLYQP.
    OrthoDBiEOG7H791X.
    PhylomeDBiQ3UXL4.
    TreeFamiTF336086.

    Family and domain databases

    InterProiIPR026742. Centrosomal_kizuma.
    [Graphical view]
    PANTHERiPTHR16299. PTHR16299. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3UXL4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRGRGGGGG GLRQASATSA PLASPSYYER VGQLQQALRD SEKKRLDLED    50
    KLYEYNKSDK CRAKLKCAKL KKYLKEVCES ERRAQVRNQG YLKKFECVQT 100
    YVEHLTTNTE KLQKLKTEYE AEVKRMRLLS KDSLGMSDED GAKDAVQAGI 150
    NSGTAMSRGL YQPATIFMGR QMSAISSIED FSTELKSNQP TKNFSISDPH 200
    SHQQTAQSSC VTDSCVVQTN GDTQCLNKSD KIHGKTSLQT GEKAPVTSYV 250
    LSAEEQTHCL EIGSSTQHSK SNLSEGRKSA ELHSSLQERL SPENSITDLK 300
    CDSSSRSEGS DREILTQEHI EVREERAGPL VPMMAASEHC TSAKKWAGEK 350
    HSAWEASSDD LDHGDSKSQK AVLKHEEEQE EGSSCSSSDL TVSVSEDDLI 400
    LESLAALSNP GAKMAGKDGM QALRAAHTEP RQDSLFTEYV LQTQSFPDSK 450
    REPSPDSPRQ PEKVPDCHLL KTRGQCMKEH DNSLKEEATT LLKKVLTEEC 500
    DHRSAIHSNE SSCSMPSILN DNNGIKEAKP ALRLNSVLTR EQEVSSGCGD 550
    ESKEESIAAA PGTGHREADL VPSELFQFSL GAAMKETKAY QLLKKSTLQD 600
    NSNQAEERFE SQFSGLDIGG SMFTTKTAHK IASEASFSSS EGSPLSRHES 650
    KRDPVTTIKS NAFWGESDDS NSEIEAALRP RDHDMPDDFD DFYDT 695
    Length:695
    Mass (Da):76,542
    Last modified:October 11, 2005 - v1
    Checksum:i71DDC7CB94FD6EBF
    GO

    Sequence cautioni

    The sequence CAM27275.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135486 mRNA. Translation: BAE22549.1.
    AL929215 Genomic DNA. Translation: CAM27275.1. Sequence problems.
    AL929215 Genomic DNA. Translation: CAM27276.1.
    BC150844 mRNA. Translation: AAI50845.1.
    BC150845 mRNA. Translation: AAI50846.1.
    CCDSiCCDS16832.1.
    RefSeqiNP_001028470.1. NM_001033298.3.
    UniGeneiMm.292352.

    Genome annotation databases

    EnsembliENSMUST00000099278; ENSMUSP00000096884; ENSMUSG00000074749.
    GeneIDi228730.
    KEGGimmu:228730.
    UCSCiuc008mso.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135486 mRNA. Translation: BAE22549.1 .
    AL929215 Genomic DNA. Translation: CAM27275.1 . Sequence problems.
    AL929215 Genomic DNA. Translation: CAM27276.1 .
    BC150844 mRNA. Translation: AAI50845.1 .
    BC150845 mRNA. Translation: AAI50846.1 .
    CCDSi CCDS16832.1.
    RefSeqi NP_001028470.1. NM_001033298.3.
    UniGenei Mm.292352.

    3D structure databases

    ProteinModelPortali Q3UXL4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q3UXL4. 1 interaction.

    PTM databases

    PhosphoSitei Q3UXL4.

    Proteomic databases

    PRIDEi Q3UXL4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099278 ; ENSMUSP00000096884 ; ENSMUSG00000074749 .
    GeneIDi 228730.
    KEGGi mmu:228730.
    UCSCi uc008mso.1. mouse.

    Organism-specific databases

    CTDi 55857.
    MGIi MGI:2684960. Kiz.

    Phylogenomic databases

    eggNOGi NOG25010.
    GeneTreei ENSGT00390000010121.
    HOGENOMi HOG000060289.
    InParanoidi B2RX19.
    KOi K16539.
    OMAi SRGLYQP.
    OrthoDBi EOG7H791X.
    PhylomeDBi Q3UXL4.
    TreeFami TF336086.

    Miscellaneous databases

    ChiTaRSi PLK1S1. mouse.
    NextBioi 379092.
    PROi Q3UXL4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UXL4.
    Genevestigatori Q3UXL4.

    Family and domain databases

    InterProi IPR026742. Centrosomal_kizuma.
    [Graphical view ]
    PANTHERi PTHR16299. PTHR16299. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Muellerian duct.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 73-82; 76-87 AND 132-158, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiKIZ_MOUSE
    AccessioniPrimary (citable) accession number: Q3UXL4
    Secondary accession number(s): A2AUS7, B2RX19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3