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Q3UXL4 (KIZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centrosomal protein kizuna
Alternative name(s):
Polo-like kinase 1 substrate 1
Gene names
Name:Plk1s1
Synonyms:Gm114, Kiz
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole By similarity.

Subunit structure

Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2 By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome- surrounding area in a microtubule-independent and dependent manner, respectively By similarity.

Post-translational modification

Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization By similarity.

Sequence similarities

Belongs to the kizuna family.

Sequence caution

The sequence CAM27275.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695Centrosomal protein kizuna
PRO_0000301852

Regions

Coiled coil29 – 5729 Potential
Coiled coil102 – 13231 Potential

Amino acid modifications

Modified residue3911Phosphothreonine; by PLK1 By similarity
Modified residue6671Phosphoserine By similarity
Modified residue6701Phosphoserine By similarity
Modified residue6721Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3UXL4 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 71DDC7CB94FD6EBF

FASTA69576,542
        10         20         30         40         50         60 
MPRGRGGGGG GLRQASATSA PLASPSYYER VGQLQQALRD SEKKRLDLED KLYEYNKSDK 

        70         80         90        100        110        120 
CRAKLKCAKL KKYLKEVCES ERRAQVRNQG YLKKFECVQT YVEHLTTNTE KLQKLKTEYE 

       130        140        150        160        170        180 
AEVKRMRLLS KDSLGMSDED GAKDAVQAGI NSGTAMSRGL YQPATIFMGR QMSAISSIED 

       190        200        210        220        230        240 
FSTELKSNQP TKNFSISDPH SHQQTAQSSC VTDSCVVQTN GDTQCLNKSD KIHGKTSLQT 

       250        260        270        280        290        300 
GEKAPVTSYV LSAEEQTHCL EIGSSTQHSK SNLSEGRKSA ELHSSLQERL SPENSITDLK 

       310        320        330        340        350        360 
CDSSSRSEGS DREILTQEHI EVREERAGPL VPMMAASEHC TSAKKWAGEK HSAWEASSDD 

       370        380        390        400        410        420 
LDHGDSKSQK AVLKHEEEQE EGSSCSSSDL TVSVSEDDLI LESLAALSNP GAKMAGKDGM 

       430        440        450        460        470        480 
QALRAAHTEP RQDSLFTEYV LQTQSFPDSK REPSPDSPRQ PEKVPDCHLL KTRGQCMKEH 

       490        500        510        520        530        540 
DNSLKEEATT LLKKVLTEEC DHRSAIHSNE SSCSMPSILN DNNGIKEAKP ALRLNSVLTR 

       550        560        570        580        590        600 
EQEVSSGCGD ESKEESIAAA PGTGHREADL VPSELFQFSL GAAMKETKAY QLLKKSTLQD 

       610        620        630        640        650        660 
NSNQAEERFE SQFSGLDIGG SMFTTKTAHK IASEASFSSS EGSPLSRHES KRDPVTTIKS 

       670        680        690 
NAFWGESDDS NSEIEAALRP RDHDMPDDFD DFYDT 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Muellerian duct.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 73-82; 76-87 AND 132-158, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK135486 mRNA. Translation: BAE22549.1.
AL929215 Genomic DNA. Translation: CAM27275.1. Sequence problems.
AL929215 Genomic DNA. Translation: CAM27276.1.
BC150844 mRNA. Translation: AAI50845.1.
BC150845 mRNA. Translation: AAI50846.1.
RefSeqNP_001028470.1. NM_001033298.3.
UniGeneMm.292352.

3D structure databases

ProteinModelPortalQ3UXL4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ3UXL4. 1 interaction.

PTM databases

PhosphoSiteQ3UXL4.

Proteomic databases

PRIDEQ3UXL4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099278; ENSMUSP00000096884; ENSMUSG00000074749.
GeneID228730.
KEGGmmu:228730.
UCSCuc008mso.1. mouse.

Organism-specific databases

CTD55857.
MGIMGI:2684960. Plk1s1.

Phylogenomic databases

eggNOGNOG25010.
GeneTreeENSGT00390000010121.
HOGENOMHOG000060289.
InParanoidB2RX19.
KOK16539.
OMASRGLYQP.
OrthoDBEOG7H791X.
PhylomeDBQ3UXL4.
TreeFamTF336086.

Gene expression databases

BgeeQ3UXL4.
GenevestigatorQ3UXL4.

Family and domain databases

InterProIPR026742. Centrosomal_kizuma.
[Graphical view]
PANTHERPTHR16299. PTHR16299. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPLK1S1. mouse.
NextBio379092.
PROQ3UXL4.
SOURCESearch...

Entry information

Entry nameKIZ_MOUSE
AccessionPrimary (citable) accession number: Q3UXL4
Secondary accession number(s): A2AUS7, B2RX19
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot