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Q3UXL4

- KIZ_MOUSE

UniProt

Q3UXL4 - KIZ_MOUSE

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Protein

Centrosomal protein kizuna

Gene

Kiz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.By similarity

GO - Biological processi

  1. spindle organization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein kizuna
Alternative name(s):
Polo-like kinase 1 substrate 1
Gene namesi
Name:Kiz
Synonyms:Gm114, Plk1s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2684960. Kiz.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity
Note: Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome- surrounding area in a microtubule-independent and dependent manner, respectively.By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Centrosomal protein kizunaPRO_0000301852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei391 – 3911Phosphothreonine; by PLK1By similarity
Modified residuei667 – 6671PhosphoserineBy similarity
Modified residuei670 – 6701PhosphoserineBy similarity
Modified residuei672 – 6721PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Thr-391 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ3UXL4.

PTM databases

PhosphoSiteiQ3UXL4.

Expressioni

Gene expression databases

BgeeiQ3UXL4.
ExpressionAtlasiQ3UXL4. baseline and differential.
GenevestigatoriQ3UXL4.

Interactioni

Subunit structurei

Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.By similarity

Protein-protein interaction databases

IntActiQ3UXL4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ3UXL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 5729Sequence AnalysisAdd
BLAST
Coiled coili102 – 13231Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the kizuna family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG25010.
GeneTreeiENSGT00390000010121.
HOGENOMiHOG000060289.
InParanoidiQ3UXL4.
KOiK16539.
OMAiSRGLYQP.
OrthoDBiEOG7H791X.
PhylomeDBiQ3UXL4.
TreeFamiTF336086.

Family and domain databases

InterProiIPR026742. Centrosomal_kizuma.
[Graphical view]
PANTHERiPTHR16299. PTHR16299. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UXL4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRGRGGGGG GLRQASATSA PLASPSYYER VGQLQQALRD SEKKRLDLED
60 70 80 90 100
KLYEYNKSDK CRAKLKCAKL KKYLKEVCES ERRAQVRNQG YLKKFECVQT
110 120 130 140 150
YVEHLTTNTE KLQKLKTEYE AEVKRMRLLS KDSLGMSDED GAKDAVQAGI
160 170 180 190 200
NSGTAMSRGL YQPATIFMGR QMSAISSIED FSTELKSNQP TKNFSISDPH
210 220 230 240 250
SHQQTAQSSC VTDSCVVQTN GDTQCLNKSD KIHGKTSLQT GEKAPVTSYV
260 270 280 290 300
LSAEEQTHCL EIGSSTQHSK SNLSEGRKSA ELHSSLQERL SPENSITDLK
310 320 330 340 350
CDSSSRSEGS DREILTQEHI EVREERAGPL VPMMAASEHC TSAKKWAGEK
360 370 380 390 400
HSAWEASSDD LDHGDSKSQK AVLKHEEEQE EGSSCSSSDL TVSVSEDDLI
410 420 430 440 450
LESLAALSNP GAKMAGKDGM QALRAAHTEP RQDSLFTEYV LQTQSFPDSK
460 470 480 490 500
REPSPDSPRQ PEKVPDCHLL KTRGQCMKEH DNSLKEEATT LLKKVLTEEC
510 520 530 540 550
DHRSAIHSNE SSCSMPSILN DNNGIKEAKP ALRLNSVLTR EQEVSSGCGD
560 570 580 590 600
ESKEESIAAA PGTGHREADL VPSELFQFSL GAAMKETKAY QLLKKSTLQD
610 620 630 640 650
NSNQAEERFE SQFSGLDIGG SMFTTKTAHK IASEASFSSS EGSPLSRHES
660 670 680 690
KRDPVTTIKS NAFWGESDDS NSEIEAALRP RDHDMPDDFD DFYDT
Length:695
Mass (Da):76,542
Last modified:October 11, 2005 - v1
Checksum:i71DDC7CB94FD6EBF
GO

Sequence cautioni

The sequence CAM27275.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135486 mRNA. Translation: BAE22549.1.
AL929215 Genomic DNA. Translation: CAM27275.1. Sequence problems.
AL929215 Genomic DNA. Translation: CAM27276.1.
BC150844 mRNA. Translation: AAI50845.1.
BC150845 mRNA. Translation: AAI50846.1.
CCDSiCCDS16832.1.
RefSeqiNP_001028470.1. NM_001033298.3.
UniGeneiMm.292352.

Genome annotation databases

EnsembliENSMUST00000099278; ENSMUSP00000096884; ENSMUSG00000074749.
GeneIDi228730.
KEGGimmu:228730.
UCSCiuc008mso.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135486 mRNA. Translation: BAE22549.1 .
AL929215 Genomic DNA. Translation: CAM27275.1 . Sequence problems.
AL929215 Genomic DNA. Translation: CAM27276.1 .
BC150844 mRNA. Translation: AAI50845.1 .
BC150845 mRNA. Translation: AAI50846.1 .
CCDSi CCDS16832.1.
RefSeqi NP_001028470.1. NM_001033298.3.
UniGenei Mm.292352.

3D structure databases

ProteinModelPortali Q3UXL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q3UXL4. 1 interaction.

PTM databases

PhosphoSitei Q3UXL4.

Proteomic databases

PRIDEi Q3UXL4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099278 ; ENSMUSP00000096884 ; ENSMUSG00000074749 .
GeneIDi 228730.
KEGGi mmu:228730.
UCSCi uc008mso.1. mouse.

Organism-specific databases

CTDi 55857.
MGIi MGI:2684960. Kiz.

Phylogenomic databases

eggNOGi NOG25010.
GeneTreei ENSGT00390000010121.
HOGENOMi HOG000060289.
InParanoidi Q3UXL4.
KOi K16539.
OMAi SRGLYQP.
OrthoDBi EOG7H791X.
PhylomeDBi Q3UXL4.
TreeFami TF336086.

Miscellaneous databases

ChiTaRSi PLK1S1. mouse.
NextBioi 379092.
PROi Q3UXL4.
SOURCEi Search...

Gene expression databases

Bgeei Q3UXL4.
ExpressionAtlasi Q3UXL4. baseline and differential.
Genevestigatori Q3UXL4.

Family and domain databases

InterProi IPR026742. Centrosomal_kizuma.
[Graphical view ]
PANTHERi PTHR16299. PTHR16299. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Muellerian duct.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 73-82; 76-87 AND 132-158, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiKIZ_MOUSE
AccessioniPrimary (citable) accession number: Q3UXL4
Secondary accession number(s): A2AUS7, B2RX19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3