Q3UXE9 (Q3UXE9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 EMBL CAM19379.1

Submitted name:
Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (P55) EMBL EDL30611.1

Gene names

Name:	Pik3r3 MGI 109277 EMBL EDL30611.1
ORF Names:	mCG_19660 EMBL EDL30611.1, RP23-276M23.4-001 EMBL CAM19379.1

Organism

Mus musculus (Mouse) EMBL BAE22614.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Kinase EMBL CAM19379.1 Transferase
Gene Ontology (GO)
Biological process	insulin receptor signaling pathway Inferred from direct assay. Source: MGI
Cellular component	phosphatidylinositol 3-kinase complex Inferred from physical interaction. Source: MGI
Molecular function	1-phosphatidylinositol-3-kinase regulator activity Inferred from direct assay. Source: MGI kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3UXE9 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 97A01A0DFAAC661F	FASTA	461	54,474
	10 20 30 40 50 60 MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTPAVT NGMKDSFISL 70 80 90 100 110 120 QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG 130 140 150 160 170 180 KYGFSEPLTF TSVVELINHY HHESLAQYNP KLDVKLTYPV SRFQQDQLVK EDNIDAVGKN 190 200 210 220 230 240 LQEFHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY 250 260 270 280 290 300 IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKLRLEQD LKKQALDNRE IDKKMNSIKP 310 320 330 340 350 360 DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKNEDSDES YFINEEDENL PHYDEKTWFV 370 380 390 400 410 420 EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN 430 440 450 460 LYSSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPTLC R

References

[1]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed: 16141073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[2]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed: 11076861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[3]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL30611.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[5]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed: 10349636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[6]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed: 11042159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[7]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[8]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[9]	Tracey A. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22614.1. Tissue: Head EMBL BAE21116.1 and In vitro fertilized eggs EMBL BAE22614.1.
[11]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL30611.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK132341 mRNA. Translation: BAE21116.1. AK135693 mRNA. Translation: BAE22614.1. AL670603 Genomic DNA. Translation: CAM19379.1. CH466552 Genomic DNA. Translation: EDL30611.1.
IPI	IPI00131170.
RefSeq	NP_853616.1. NM_181585.5.
UniGene	Mm.253819.
3D structure databases
ProteinModelPortal	Q3UXE9.
SMR	Q3UXE9. Positions 4-455.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3UXE9.
Proteomic databases
PRIDE	Q3UXE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	18710.
KEGG	mmu:18710.
UCSC	uc008ugm.1. mouse.
Organism-specific databases
CTD	8503.
MGI	MGI:109277. Pik3r3.
Phylogenomic databases
HOVERGEN	HBG082100.
InParanoid	Q3UXE9.
OMA	ETYFINE.
PhylomeDB	Q3UXE9.
Gene expression databases
ArrayExpress	Q3UXE9.
Bgee	Q3UXE9.
Genevestigator	Q3UXE9.
Family and domain databases
InterPro	IPR001720. PI3kinase_P85. IPR000980. SH2. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 2 hits.
KO	K02649.
PANTHER	PTHR10155. PI3kinase_P85. 1 hit.
Pfam	PF00017. SH2. 2 hits. [Graphical view]
PRINTS	PR00678. PI3KINASEP85. PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 2 hits. [Graphical view]
PROSITE	PS50001. SH2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	294789.
SOURCE	Search...

Entry information

Entry name

Q3UXE9_MOUSE

Accession

Primary (citable) accession number: Q3UXE9

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)