Pik3r3

Functionⁱ

GO - Molecular functionⁱ

kinase activity Source: UniProtKB-KW
phosphatidylinositol 3-kinase regulator activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

positive regulation of glucose import in response to insulin stimulus Source: AgBase

Complete GO annotation...

Keywordsⁱ

Molecular function	KinaseImported, Transferase

Molecular function

KinaseImported, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (P55)Imported Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Pik3r3Imported ORF Names:mCG_19660Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Subcellular locationⁱ

GO - Cellular componentⁱ

phosphatidylinositol 3-kinase complex Source: InterPro

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028698.
ExpressionAtlasⁱ	Q3UXE9. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q3UXE9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	65 – 160	SH2InterPro annotationAdd BLAST		96
Domainⁱ	358 – 452	SH2InterPro annotationAdd BLAST		95

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	181 – 208	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG4637. Eukaryota. ENOG410XP6R. LUCA.
HOVERGENⁱ	HBG082100.
KEGG Orthology (KO) More...KOⁱ	K02649.
OMAⁱ	ETYFINE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C3Z.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09930. SH2_cSH2_p85_like. 1 hit. cd09942. SH2_nSH2_p85_like. 1 hit.
Gene3Dⁱ	3.30.505.10. 2 hits.
InterProⁱ	View protein in InterPro IPR032498. PI3K_P85_iSH2. IPR001720. PI3kinase_P85. IPR035020. PI3kinase_P85_cSH2. IPR035022. PI3kinase_P85_nSH2. IPR000980. SH2.
PANTHERⁱ	PTHR10155. PTHR10155. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16454. PI3K_P85_iSH2. 1 hit. PF00017. SH2. 2 hits.
PRINTSⁱ	PR00401. SH2DOMAIN.
SMARTⁱ	View protein in SMART SM00252. SH2. 2 hits.
SUPFAMⁱ	SSF55550. SSF55550. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50001. SH2. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UXE9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTPAVT 
        60         70         80         90        100
NGMKDSFISL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY 
       110        120        130        140        150
TLTLRKGGNN KLIKIYHRDG KYGFSEPLTF TSVVELINHY HHESLAQYNP 
       160        170        180        190        200
KLDVKLTYPV SRFQQDQLVK EDNIDAVGKN LQEFHSQYQE KSKEYDRLYE 
       210        220        230        240        250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKDY IERFRREGNE 
       260        270        280        290        300
KEIERIMMNY DKLKSRLGEI HDSKLRLEQD LKKQALDNRE IDKKMNSIKP 
       310        320        330        340        350
DLIQLRKIRD QHLVWLNHRG VRQRRLNAWL GIKNEDSDES YFINEEDENL 
       360        370        380        390        400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE 
       410        420        430        440        450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY 
       460 
PVHAQMPTLC R

Length:461

Mass (Da):54,474

Last modified:October 11, 2005 - v1

Checksum:ⁱ97A01A0DFAAC661F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK132341 mRNA. Translation: BAE21116.1. AK135693 mRNA. Translation: BAE22614.1. CH466552 Genomic DNA. Translation: EDL30611.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_853616.1. NM_181585.5. XP_017175528.1. XM_017320039.1. XP_017175529.1. XM_017320040.1.
UniGeneⁱ	Mm.253819.

Genome annotation databases

GeneIDⁱ	18710.
KEGGⁱ	mmu:18710.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK132341 mRNA. Translation: BAE21116.1. AK135693 mRNA. Translation: BAE22614.1. CH466552 Genomic DNA. Translation: EDL30611.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_853616.1. NM_181585.5. XP_017175528.1. XM_017320039.1. XP_017175529.1. XM_017320040.1.
UniGeneⁱ	Mm.253819.

3D structure databases

SMRⁱ	Q3UXE9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	18710.
KEGGⁱ	mmu:18710.

Organism-specific databases

CTDⁱ	8503.

CTDⁱ

8503.

Phylogenomic databases

eggNOGⁱ	KOG4637. Eukaryota. ENOG410XP6R. LUCA.
HOVERGENⁱ	HBG082100.
KEGG Orthology (KO) More...KOⁱ	K02649.
OMAⁱ	ETYFINE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C3Z.

Gene expression databases

Bgeeⁱ	ENSMUSG00000028698.
ExpressionAtlasⁱ	Q3UXE9. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09930. SH2_cSH2_p85_like. 1 hit. cd09942. SH2_nSH2_p85_like. 1 hit.
Gene3Dⁱ	3.30.505.10. 2 hits.
InterProⁱ	View protein in InterPro IPR032498. PI3K_P85_iSH2. IPR001720. PI3kinase_P85. IPR035020. PI3kinase_P85_cSH2. IPR035022. PI3kinase_P85_nSH2. IPR000980. SH2.
PANTHERⁱ	PTHR10155. PTHR10155. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16454. PI3K_P85_iSH2. 1 hit. PF00017. SH2. 2 hits.
PRINTSⁱ	PR00401. SH2DOMAIN.
SMARTⁱ	View protein in SMART SM00252. SH2. 2 hits.
SUPFAMⁱ	SSF55550. SSF55550. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50001. SH2. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UXE9_MOUSE
Accessionⁱ	Q3UXE9Primary (citable) accession number: Q3UXE9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q3UXE9 (Q3UXE9_MOUSE)

Your basket is currently empty.

Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (P55)

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UXE9 (Q3UXE9_MOUSE)

Your basket is currently empty.

Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (P55)

Pik3r3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ