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Q3UXB2 (Q3UXB2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Bmp6 MGI 88182
OrganismMus musculus (Mouse) EMBL BAE22651.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length460 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
   Cellular componentSecreted SAAS SAAS001839
   Molecular functionGrowth factor RuleBase RU000354 SAAS SAAS001839
   PTMDisulfide bond SAAS SAAS001839
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 14623234PubMed 19852960. Source: MGI

SMAD protein signal transduction

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from mutant phenotype PubMed 14623245. Source: MGI

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

endochondral ossification

Inferred from mutant phenotype PubMed 9664685. Source: MGI

growth

Inferred from electronic annotation. Source: InterPro

immune response

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from genetic interaction PubMed 9664685. Source: MGI

osteoblast differentiation

Inferred from genetic interaction PubMed 16109715. Source: MGI

positive regulation of aldosterone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of aldosterone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of bone mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from direct assay PubMed 9786991. Source: MGI

positive regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to iron ion

Inferred from electronic annotation. Source: Ensembl

response to magnesium ion

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

type B pancreatic cell development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionBMP receptor binding

Inferred from sequence orthology PubMed 7811286. Source: MGI

protein heterodimerization activity

Inferred from sequence orthology PubMed 7811286. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE22651.1

Sequences

Sequence LengthMass (Da)Tools
Q3UXB2 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: C74C18E2AC1D6170

FASTA46051,300
        10         20         30         40         50         60 
AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ PPVLPPQQQQ 

        70         80         90        100        110        120 
QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA SEGVGQEPGS HGGASSSQLR 

       130        140        150        160        170        180 
QPSPGAAHSL NRKSLLAPGP GGGASPLTSA QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR 

       190        200        210        220        230        240 
HHKEFKFNLS QIPEGEAVTA AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL 

       250        260        270        280        290        300 
DTRVVWASEE GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY 

       310        320        330        340        350        360 
DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY NGSELKTACK 

       370        380        390        400        410        420 
KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM NATNHAIVQT LVHLMNPEYV 

       430        440        450        460 
PKPCCAPTKL NAISVLYFDD NSNVILKKYR NMVVRACGCH 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE22651.1.
Tissue: In vitro fertilized eggs EMBL BAE22651.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK135770 mRNA. Translation: BAE22651.1.
UniGeneMm.385759.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:88182. Bmp6.

Phylogenomic databases

HOVERGENHBG004860.
InParanoidQ3UXB2.

Gene expression databases

ArrayExpressQ3UXB2.
BgeeQ3UXB2.
GenevestigatorQ3UXB2.

Family and domain databases

InterProIPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 2 hits.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ3UXB2_MOUSE
AccessionPrimary (citable) accession number: Q3UXB2
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)