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Q3UXB2

- Q3UXB2_MOUSE

UniProt

Q3UXB2 - Q3UXB2_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Bmp6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. BMP receptor binding Source: MGI
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI

    GO - Biological processi

    1. BMP signaling pathway Source: MGI
    2. cell differentiation Source: MGI
    3. cellular response to mechanical stimulus Source: Ensembl
    4. endochondral ossification Source: MGI
    5. growth Source: InterPro
    6. immune response Source: Ensembl
    7. male genitalia development Source: MGI
    8. osteoblast differentiation Source: MGI
    9. positive regulation of aldosterone biosynthetic process Source: Ensembl
    10. positive regulation of aldosterone secretion Source: Ensembl
    11. positive regulation of bone mineralization Source: Ensembl
    12. positive regulation of chondrocyte differentiation Source: Ensembl
    13. positive regulation of epithelial cell proliferation Source: Ensembl
    14. positive regulation of neuron differentiation Source: MGI
    15. positive regulation of osteoblast differentiation Source: Ensembl
    16. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    17. response to activity Source: Ensembl
    18. response to glucocorticoid Source: Ensembl
    19. response to iron ion Source: Ensembl
    20. response to magnesium ion Source: Ensembl
    21. response to retinoic acid Source: Ensembl
    22. SMAD protein signal transduction Source: Ensembl
    23. type B pancreatic cell development Source: Ensembl

    Keywords - Molecular functioni

    Growth factorUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Bmp6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88182. Bmp6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl
    3. membrane-bounded vesicle Source: Ensembl

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UXB2.
    BgeeiQ3UXB2.
    GenevestigatoriQ3UXB2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG004860.
    InParanoidiQ3UXB2.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 2 hits.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3UXB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ    50
    PPVLPPQQQQ QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA 100
    SEGVGQEPGS HGGASSSQLR QPSPGAAHSL NRKSLLAPGP GGGASPLTSA 150
    QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS QIPEGEAVTA 200
    AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE 250
    GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY 300
    DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY 350
    NGSELKTACK KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM 400
    NATNHAIVQT LVHLMNPEYV PKPCCAPTKL NAISVLYFDD NSNVILKKYR 450
    NMVVRACGCH 460
    Length:460
    Mass (Da):51,300
    Last modified:October 11, 2005 - v1
    Checksum:iC74C18E2AC1D6170
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135770 mRNA. Translation: BAE22651.1.
    UniGeneiMm.385759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135770 mRNA. Translation: BAE22651.1 .
    UniGenei Mm.385759.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:88182. Bmp6.

    Phylogenomic databases

    HOVERGENi HBG004860.
    InParanoidi Q3UXB2.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UXB2.
    Bgeei Q3UXB2.
    Genevestigatori Q3UXB2.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 2 hits.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: In vitro fertilized eggsImported.

    Entry informationi

    Entry nameiQ3UXB2_MOUSE
    AccessioniPrimary (citable) accession number: Q3UXB2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)