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Q3UXB2

- Q3UXB2_MOUSE

UniProt

Q3UXB2 - Q3UXB2_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene
Bmp6
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. BMP receptor binding Source: MGI
  2. protein binding Source: MGI
  3. protein heterodimerization activity Source: MGI

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. cell differentiation Source: MGI
  3. cellular response to mechanical stimulus Source: Ensembl
  4. endochondral ossification Source: MGI
  5. growth Source: InterPro
  6. immune response Source: Ensembl
  7. male genitalia development Source: MGI
  8. osteoblast differentiation Source: MGI
  9. positive regulation of aldosterone biosynthetic process Source: Ensembl
  10. positive regulation of aldosterone secretion Source: Ensembl
  11. positive regulation of bone mineralization Source: Ensembl
  12. positive regulation of chondrocyte differentiation Source: Ensembl
  13. positive regulation of epithelial cell proliferation Source: Ensembl
  14. positive regulation of neuron differentiation Source: MGI
  15. positive regulation of osteoblast differentiation Source: Ensembl
  16. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  17. response to activity Source: Ensembl
  18. response to glucocorticoid Source: Ensembl
  19. response to iron ion Source: Ensembl
  20. response to magnesium ion Source: Ensembl
  21. response to retinoic acid Source: Ensembl
  22. SMAD protein signal transduction Source: Ensembl
  23. type B pancreatic cell development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Bmp6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88182. Bmp6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
  3. membrane-bounded vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ3UXB2.
BgeeiQ3UXB2.
GenevestigatoriQ3UXB2.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG004860.
InParanoidiQ3UXB2.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 2 hits.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3UXB2-1 [UniParc]FASTAAdd to Basket

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AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ    50
PPVLPPQQQQ QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA 100
SEGVGQEPGS HGGASSSQLR QPSPGAAHSL NRKSLLAPGP GGGASPLTSA 150
QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR HHKEFKFNLS QIPEGEAVTA 200
AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL DTRVVWASEE 250
GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY 300
DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY 350
NGSELKTACK KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM 400
NATNHAIVQT LVHLMNPEYV PKPCCAPTKL NAISVLYFDD NSNVILKKYR 450
NMVVRACGCH 460
Length:460
Mass (Da):51,300
Last modified:October 11, 2005 - v1
Checksum:iC74C18E2AC1D6170
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135770 mRNA. Translation: BAE22651.1.
UniGeneiMm.385759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135770 mRNA. Translation: BAE22651.1 .
UniGenei Mm.385759.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:88182. Bmp6.

Phylogenomic databases

HOVERGENi HBG004860.
InParanoidi Q3UXB2.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UXB2.
Bgeei Q3UXB2.
Genevestigatori Q3UXB2.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 2 hits.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.

Entry informationi

Entry nameiQ3UXB2_MOUSE
AccessioniPrimary (citable) accession number: Q3UXB2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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