Q3UXB2 (Q3UXB2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE22651.1

Gene names

Name:

Bmp6 MGI 88182

Organism

Mus musculus (Mouse) EMBL BAE22651.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	460 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS015615
Molecular function	Growth factor RuleBase RU000354 SAAS SAAS015615
PTM	Disulfide bond SAAS SAAS015615
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay PubMed 14623234PubMed 19852960. Source: MGI SMAD protein signal transduction Inferred from electronic annotation. Source: Compara endochondral ossification Inferred from mutant phenotype PubMed 9664685. Source: MGI growth Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: Compara male genitalia development Inferred from genetic interaction PubMed 9664685. Source: MGI osteoblast differentiation Inferred from genetic interaction PubMed 16109715. Source: MGI positive regulation of aldosterone biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from direct assay PubMed 9786991. Source: MGI positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to retinoic acid Inferred from electronic annotation. Source: Compara type B pancreatic cell development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara membrane-bounded vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	BMP receptor binding Inferred from sequence orthology PubMed 7811286. Source: MGI protein heterodimerization activity Inferred from sequence orthology PubMed 7811286. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE22651.1

Sequences

	Sequence		Length	Mass (Da)
	Q3UXB2 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: C74C18E2AC1D6170	FASTA	460	51,300
	10 20 30 40 50 60 AEQPPPQSSS SGFLYRRLKT HEKREMQKEI LSVLGLPHRP RPLHGLQQPQ PPVLPPQQQQ 70 80 90 100 110 120 QQQQQQTARE EPPPGRLKSA PLFMLDLYNA LSNDDEEDGA SEGVGQEPGS HGGASSSQLR 130 140 150 160 170 180 QPSPGAAHSL NRKSLLAPGP GGGASPLTSA QDSAFLNDAD MVMSFVNLVE YDKEFSPHQR 190 200 210 220 230 240 HHKEFKFNLS QIPEGEAVTA AEFRVYKDCV VGSFKNQTFL ISIYQVLQEH QHRDSDLFLL 250 260 270 280 290 300 DTRVVWASEE GWLEFDITAT SNLWVVTPQH NMGLQLSVVT RDGLHVNPRA AGLVGRDGPY 310 320 330 340 350 360 DKQPFMVAFF KVSEVHVRTT RSASSRRRQQ SRNRSTQSQD VSRGSGSSDY NGSELKTACK 370 380 390 400 410 420 KHELYVSFQD LGWQDWIIAP KGYAANYCDG ECSFPLNAHM NATNHAIVQT LVHLMNPEYV 430 440 450 460 PKPCCAPTKL NAISVLYFDD NSNVILKKYR NMVVRACGCH

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE22651.1. Tissue: In vitro fertilized eggs EMBL BAE22651.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK135770 mRNA. Translation: BAE22651.1.
IPI	IPI00989072.
UniGene	Mm.385759.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:88182. Bmp6.
Phylogenomic databases
HOVERGEN	HBG004860.
InParanoid	Q3UXB2.
Gene expression databases
ArrayExpress	Q3UXB2.
Bgee	Q3UXB2.
Genevestigator	Q3UXB2.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q3UXB2_MOUSE

Accession

Primary (citable) accession number: Q3UXB2

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)