Q3UX61 (NAA11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-alpha-acetyltransferase 11
EC=2.3.1.88

Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
NatA catalytic subunit

Gene names

Name:	Naa11
Synonyms:	Ard1b, Ard2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In complex with NAA15, displays alpha (N-terminal) acetyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Subunit structure	Interacts with NAA15 and HIF1A By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the acetyltransferase family. ARD1 subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Acyltransferase Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide alpha-N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	N-alpha-acetyltransferase 11		PRO_0000305010
Regions
	Domain	1 – 152	152	N-acetyltransferase
	Region	1 – 58	58	Interaction with NAA15 By similarity
Amino acid modifications
	Modified residue	136	1	N6-acetyllysine By similarity
Experimental info
	Sequence conflict	141	1	G → V in BAE21577. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q3UX61 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 93DE5F40D09EED20	FASTA	218	24,671
	10 20 30 40 50 60 MNIRNARPDD LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDEDG KIVGYVLAKM 70 80 90 100 110 120 EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFGAKYVSLH VRKSNRAALH 130 140 150 160 170 180 LYSNTLNFQV SEVEPKYYAD GEDAYAMKRD LSQMTDELRR QLVLKKNRYV VLGSEETQGG 190 200 210 TLPDAGEACL PKNPTSKDSG SSDSTDVQDS SEDLDSIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Egg and Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase." Arnesen T., Betts M.J., Pendino F., Liberles D.A., Anderson D., Caro J., Kong X., Varhaug J.E., Lillehaug J.R. BMC Biochem. 7:13-13(2006) [PubMed: 16638120] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK133248 mRNA. Translation: BAE21577.1. AK135863 mRNA. Translation: BAE22702.1. BC145776 mRNA. Translation: AAI45777.1.
IPI	IPI00130894.
RefSeq	NP_001028363.1. NM_001033191.2.
UniGene	Mm.11746.
3D structure databases
ProteinModelPortal	Q3UX61.
SMR	Q3UX61. Positions 1-150.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3UX61.
PTM databases
PhosphoSite	Q3UX61.
Proteomic databases
PRIDE	Q3UX61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000060265; ENSMUSP00000057336; ENSMUSG00000046000.
GeneID	97243.
KEGG	mmu:97243.
NMPDR	fig|10090.3.peg.11932.
Organism-specific databases
CTD	84779.
MGI	MGI:2141314. Naa11.
Phylogenomic databases
eggNOG	roNOG08307.
GeneTree	ENSGT00550000074803.
HOGENOM	HBG742014.
HOVERGEN	HBG050561.
InParanoid	Q3UX61.
OMA	VEDAYAM.
OrthoDB	EOG4Z0B6F.
PhylomeDB	Q3UX61.
Gene expression databases
ArrayExpress	Q3UX61.
Bgee	Q3UX61.
CleanEx	MM_ARD1B.
Genevestigator	Q3UX61.
Family and domain databases
InterPro	IPR000182. AcTrfase_GCN5-related_dom. IPR016181. Acyl_CoA_acyltransferase. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
KO	K00670.
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	352667.
SOURCE	Search...

Entry information

Entry name

NAA11_MOUSE

Accession

Primary (citable) accession number: Q3UX61
Secondary accession number(s): Q3V0C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 11, 2005
Last modified:	November 16, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program