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Protein

Ankyrin repeat domain-containing protein 13C

Gene

Ankrd13c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 13C
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2139746. Ankrd13c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406461 – 541Ankyrin repeat domain-containing protein 13CAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UX43.
PRIDEiQ3UX43.

PTM databases

iPTMnetiQ3UX43.
PhosphoSitePlusiQ3UX43.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039988.
CleanExiMM_ANKRD13C.
ExpressionAtlasiQ3UX43. baseline and differential.
GenevisibleiQ3UX43. MM.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ3UX43.
SMRiQ3UX43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 142ANK 1Add BLAST32
Repeati143 – 172ANK 2Add BLAST30
Repeati176 – 205ANK 3Add BLAST30

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0522. Eukaryota.
ENOG410XNMS. LUCA.
GeneTreeiENSGT00410000025381.
HOGENOMiHOG000007095.
HOVERGENiHBG079639.
InParanoidiQ3UX43.
OMAiSPNTISW.
OrthoDBiEOG091G06FU.
PhylomeDBiQ3UX43.
TreeFamiTF314176.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR021832. ANKRD13.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PANTHERiPTHR12447. PTHR12447. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF11904. GPCR_chapero_1. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UX43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGEKIRSLR RDHKPSKEDG DVLEPCEEEA TAALGGAFTG GRSGPGGSGK
60 70 80 90 100
GGKACHKIFS HHHRLQLKAP AVPGPGVPAP PQHNAVTATC PAPACLGGSN
110 120 130 140 150
PALVADGGGC PSLYPVHECV FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL
160 170 180 190 200
AVMLGNKECA HLLLAHNAPV KVKNAQGWSP LAEAISYGDR QMITALLRKL
210 220 230 240 250
KQQSRESVGE KRPRLLKALK ELGDFYLELH WDFQSWVPLL SRILPSDACK
260 270 280 290 300
IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV
310 320 330 340 350
YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK
360 370 380 390 400
TERVGNFLAD FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGSLA
410 420 430 440 450
EQSFEPVRRQ SLTPPPQNTI TWEEYISAEN GKAPHLGREL VCKESKKTFK
460 470 480 490 500
ATVAMSQEFP LGIESLLNVL EVIAPFKHFN KLREFVQMKL PPGFPVKLDI
510 520 530 540
PVFPTITATV TFQEFRCDEF DGSIFAIPED YKEDPSRFPD L
Length:541
Mass (Da):60,150
Last modified:June 27, 2006 - v2
Checksum:iF270FA45C62F2A7F
GO
Isoform 2 (identifier: Q3UX43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-249: VPLLSRILPSDAC → GKSVLRFIIKVQL
     250-541: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):26,807
Checksum:i71D1BF484626E8EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69 – 111APAVP…GGGCP → VSSEALARGAGERWLRRVFP SEEEAAAAAPGVVRSWSLEL RLS in BAE22720 (Ref. 2) CuratedAdd BLAST43

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019409237 – 249VPLLS…PSDAC → GKSVLRFIIKVQL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_019410250 – 541Missing in isoform 2. 1 PublicationAdd BLAST292

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135906 mRNA. Translation: BAE22720.1.
BY751496 mRNA. No translation available.
CH466532 Genomic DNA. Translation: EDL11855.1.
BC065088 mRNA. Translation: AAH65088.1.
BC138991 mRNA. Translation: AAI38992.1.
BC138992 mRNA. Translation: AAI38993.1.
CCDSiCCDS17933.1. [Q3UX43-1]
RefSeqiNP_001013828.1. NM_001013806.1. [Q3UX43-1]
UniGeneiMm.265806.

Genome annotation databases

EnsembliENSMUST00000040787; ENSMUSP00000038662; ENSMUSG00000039988. [Q3UX43-1]
ENSMUST00000164582; ENSMUSP00000125831; ENSMUSG00000039988. [Q3UX43-1]
GeneIDi433667.
KEGGimmu:433667.
UCSCiuc008rvk.1. mouse. [Q3UX43-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135906 mRNA. Translation: BAE22720.1.
BY751496 mRNA. No translation available.
CH466532 Genomic DNA. Translation: EDL11855.1.
BC065088 mRNA. Translation: AAH65088.1.
BC138991 mRNA. Translation: AAI38992.1.
BC138992 mRNA. Translation: AAI38993.1.
CCDSiCCDS17933.1. [Q3UX43-1]
RefSeqiNP_001013828.1. NM_001013806.1. [Q3UX43-1]
UniGeneiMm.265806.

3D structure databases

ProteinModelPortaliQ3UX43.
SMRiQ3UX43.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3UX43.
PhosphoSitePlusiQ3UX43.

Proteomic databases

PaxDbiQ3UX43.
PRIDEiQ3UX43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040787; ENSMUSP00000038662; ENSMUSG00000039988. [Q3UX43-1]
ENSMUST00000164582; ENSMUSP00000125831; ENSMUSG00000039988. [Q3UX43-1]
GeneIDi433667.
KEGGimmu:433667.
UCSCiuc008rvk.1. mouse. [Q3UX43-1]

Organism-specific databases

CTDi81573.
MGIiMGI:2139746. Ankrd13c.

Phylogenomic databases

eggNOGiKOG0522. Eukaryota.
ENOG410XNMS. LUCA.
GeneTreeiENSGT00410000025381.
HOGENOMiHOG000007095.
HOVERGENiHBG079639.
InParanoidiQ3UX43.
OMAiSPNTISW.
OrthoDBiEOG091G06FU.
PhylomeDBiQ3UX43.
TreeFamiTF314176.

Miscellaneous databases

ChiTaRSiAnkrd13c. mouse.
PROiQ3UX43.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039988.
CleanExiMM_ANKRD13C.
ExpressionAtlasiQ3UX43. baseline and differential.
GenevisibleiQ3UX43. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR021832. ANKRD13.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PANTHERiPTHR12447. PTHR12447. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF11904. GPCR_chapero_1. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN13C_MOUSE
AccessioniPrimary (citable) accession number: Q3UX43
Secondary accession number(s): B2RST2, Q6P1G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.