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Protein
Submitted name:

Putative uncharacterized protein

Gene

Parp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • base-excision repair Source: MGI
  • behavioral response to cocaine Source: MGI
  • cellular response to insulin stimulus Source: MGI
  • cellular response to oxidative stress Source: MGI
  • cellular response to superoxide Source: MGI
  • DNA metabolic process Source: MGI
  • DNA repair Source: MGI
  • double-strand break repair Source: MGI
  • mitochondrial DNA metabolic process Source: MGI
  • mitochondrial DNA repair Source: MGI
  • mitochondrion organization Source: MGI
  • protein ADP-ribosylation Source: MGI
  • protein modification process Source: MGI
  • protein poly-ADP-ribosylation Source: MGI
  • regulation of growth rate Source: MGI
  • regulation of single strand break repair Source: MGI
  • telomere maintenance Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_326745. POLB-Dependent Long Patch Base Excision Repair.
REACT_337844. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_360954. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Parp1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1340806. Parp1.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: MGI
  • mitochondrion Source: MGI
  • nuclear envelope Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein complex Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ3UX06.

Expressioni

Gene expression databases

BgeeiQ3UX06.
ExpressionAtlasiQ3UX06. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027777.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG088594.

Family and domain databases

Gene3Di3.30.1740.10. 2 hits.
InterProiIPR008288. NAD_ADPRT.
IPR001510. Znf_PARP.
[Graphical view]
PANTHERiPTHR15447:SF13. PTHR15447:SF13. 1 hit.
PfamiPF00645. zf-PARP. 2 hits.
[Graphical view]
PROSITEiPS00347. PARP_ZN_FINGER_1. 2 hits.
PS50064. PARP_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3UX06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEASERLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH
60 70 80 90 100
WYHFSCFWKV GHSIRQPDVE VDGFSELRWD DQQKVKKTAE AGGVAGKGQD
110 120 130 140 150
GSGGKAEKTL GDFLAEYAKS NRSMCKGCLE KIEKGQMRLS KKMVDPEKPQ
160 170 180 190
LGMIDRWYHP TCFVKKRDEL GFRPEYSASQ LKGFSLLSAE
Length:190
Mass (Da):21,473
Last modified:October 11, 2005 - v1
Checksum:iFC5CB732F65A33F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei190 – 1901Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135977 mRNA. Translation: BAE22758.1.
UniGeneiMm.277779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135977 mRNA. Translation: BAE22758.1.
UniGeneiMm.277779.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027777.

Proteomic databases

PRIDEiQ3UX06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1340806. Parp1.

Phylogenomic databases

HOVERGENiHBG088594.

Enzyme and pathway databases

ReactomeiREACT_326745. POLB-Dependent Long Patch Base Excision Repair.
REACT_337844. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_360954. SUMOylation of DNA damage response and repair proteins.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3UX06.
ExpressionAtlasiQ3UX06. baseline and differential.

Family and domain databases

Gene3Di3.30.1740.10. 2 hits.
InterProiIPR008288. NAD_ADPRT.
IPR001510. Znf_PARP.
[Graphical view]
PANTHERiPTHR15447:SF13. PTHR15447:SF13. 1 hit.
PfamiPF00645. zf-PARP. 2 hits.
[Graphical view]
PROSITEiPS00347. PARP_ZN_FINGER_1. 2 hits.
PS50064. PARP_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: In vitro fertilized eggsImported.

Entry informationi

Entry nameiQ3UX06_MOUSE
AccessioniPrimary (citable) accession number: Q3UX06
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.