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Protein

KH homology domain-containing protein 1A

Gene

Khdc1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has pro-apoptotic activity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI
  • poly(U) RNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
KH homology domain-containing protein 1A
Alternative name(s):
Nur77 downstream gene 1 protein
Gene namesi
Name:Khdc1a
Synonyms:Ndg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2676610 Khdc1a

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003114331 – 166KH homology domain-containing protein 1AAdd BLAST166

Proteomic databases

PaxDbiQ3UWR2
PRIDEiQ3UWR2

Expressioni

Inductioni

By NR4A1/NUR77.1 Publication

Gene expression databases

BgeeiENSMUSG00000067750
CleanExiMM_KHDC1A
GenevisibleiQ3UWR2 MM

Interactioni

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085749

Structurei

3D structure databases

ProteinModelPortaliQ3UWR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 78KH; atypicalAdd BLAST60

Sequence similaritiesi

Belongs to the KHDC1 family.Curated

Phylogenomic databases

eggNOGiENOG410J7N5 Eukaryota
ENOG4111ED1 LUCA
GeneTreeiENSGT00390000008575
HOGENOMiHOG000037926
HOVERGENiHBG056258
InParanoidiQ3UWR2
OrthoDBiEOG091G0ZT4
PhylomeDBiQ3UWR2
TreeFamiTF337964

Family and domain databases

CDDicd12795 FILIA_N_like, 1 hit
Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR036612 KH_dom_type_1_sf
IPR031952 MOEP19_KH-like
PfamiView protein in Pfam
PF16005 MOEP19, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UWR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLRRKGWW NVPDYFHSPL VFDMEEDKED YIFGPHDEYL HTLEVHSNTL
60 70 80 90 100
IQLERWFTPT GQTRVTVVGP LKARLWVMDM IRKVGSKNNL DQIKGKMMLL
110 120 130 140 150
QIRDHPLRDR DLELHPESGS SLWITTMNDT TFVEVPHFLR FPLTVAWLFC
160
GFVRILGIHN FADLHW
Length:166
Mass (Da):19,690
Last modified:October 11, 2005 - v1
Checksum:iBB4FC5FD844145F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21V → A in AAP51210 (PubMed:14657025).Curated1
Sequence conflicti28K → R in AAP51210 (PubMed:14657025).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238603 mRNA Translation: AAP51210.1
AK136166 mRNA Translation: BAE22852.1
CCDSiCCDS14848.1
RefSeqiNP_899145.2, NM_183322.2
UniGeneiMm.26006

Genome annotation databases

EnsembliENSMUST00000088407; ENSMUSP00000085749; ENSMUSG00000067750
GeneIDi368204
KEGGimmu:368204
UCSCiuc007aln.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKHD1A_MOUSE
AccessioniPrimary (citable) accession number: Q3UWR2
Secondary accession number(s): Q7TNM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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