Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KH homology domain-containing protein 1A

Gene

Khdc1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has pro-apoptotic activity.1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI
  • poly(U) RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
KH homology domain-containing protein 1A
Alternative name(s):
Nur77 downstream gene 1 protein
Gene namesi
Name:Khdc1a
Synonyms:Ndg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2676610. Khdc1a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166KH homology domain-containing protein 1APRO_0000311433Add
BLAST

Proteomic databases

PaxDbiQ3UWR2.
PRIDEiQ3UWR2.

Expressioni

Inductioni

By NR4A1/NUR77.1 Publication

Gene expression databases

BgeeiQ3UWR2.
CleanExiMM_KHDC1A.
GenevisibleiQ3UWR2. MM.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085749.

Structurei

3D structure databases

ProteinModelPortaliQ3UWR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 7860KH; atypicalAdd
BLAST

Sequence similaritiesi

Belongs to the KHDC1 family.Curated
Contains 1 KH domain.Curated

Phylogenomic databases

eggNOGiENOG410J7N5. Eukaryota.
ENOG4111ED1. LUCA.
GeneTreeiENSGT00390000008575.
HOGENOMiHOG000037926.
HOVERGENiHBG056258.
InParanoidiQ3UWR2.
OMAiCIEVNSH.
OrthoDBiEOG7T7GVB.
PhylomeDBiQ3UWR2.
TreeFamiTF337964.

Family and domain databases

InterProiIPR031952. MOEP19_KH-like.
[Graphical view]
PfamiPF16005. MOEP19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UWR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLRRKGWW NVPDYFHSPL VFDMEEDKED YIFGPHDEYL HTLEVHSNTL
60 70 80 90 100
IQLERWFTPT GQTRVTVVGP LKARLWVMDM IRKVGSKNNL DQIKGKMMLL
110 120 130 140 150
QIRDHPLRDR DLELHPESGS SLWITTMNDT TFVEVPHFLR FPLTVAWLFC
160
GFVRILGIHN FADLHW
Length:166
Mass (Da):19,690
Last modified:October 11, 2005 - v1
Checksum:iBB4FC5FD844145F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211V → A in AAP51210 (PubMed:14657025).Curated
Sequence conflicti28 – 281K → R in AAP51210 (PubMed:14657025).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238603 mRNA. Translation: AAP51210.1.
AK136166 mRNA. Translation: BAE22852.1.
CCDSiCCDS14848.1.
RefSeqiNP_899145.2. NM_183322.2.
XP_006495609.1. XM_006495546.1.
UniGeneiMm.26006.

Genome annotation databases

EnsembliENSMUST00000088407; ENSMUSP00000085749; ENSMUSG00000067750.
GeneIDi368204.
KEGGimmu:368204.
UCSCiuc007aln.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY238603 mRNA. Translation: AAP51210.1.
AK136166 mRNA. Translation: BAE22852.1.
CCDSiCCDS14848.1.
RefSeqiNP_899145.2. NM_183322.2.
XP_006495609.1. XM_006495546.1.
UniGeneiMm.26006.

3D structure databases

ProteinModelPortaliQ3UWR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085749.

Proteomic databases

PaxDbiQ3UWR2.
PRIDEiQ3UWR2.

Protocols and materials databases

DNASUi368204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088407; ENSMUSP00000085749; ENSMUSG00000067750.
GeneIDi368204.
KEGGimmu:368204.
UCSCiuc007aln.1. mouse.

Organism-specific databases

CTDi368204.
MGIiMGI:2676610. Khdc1a.

Phylogenomic databases

eggNOGiENOG410J7N5. Eukaryota.
ENOG4111ED1. LUCA.
GeneTreeiENSGT00390000008575.
HOGENOMiHOG000037926.
HOVERGENiHBG056258.
InParanoidiQ3UWR2.
OMAiCIEVNSH.
OrthoDBiEOG7T7GVB.
PhylomeDBiQ3UWR2.
TreeFamiTF337964.

Miscellaneous databases

NextBioi400948.
PROiQ3UWR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UWR2.
CleanExiMM_KHDC1A.
GenevisibleiQ3UWR2. MM.

Family and domain databases

InterProiIPR031952. MOEP19_KH-like.
[Graphical view]
PfamiPF16005. MOEP19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor."
    Rajpal A., Cho Y.A., Yelent B., Koza-Taylor P.H., Li D., Chen E., Whang M., Kang C., Turi T.G., Winoto A.
    EMBO J. 22:6526-6536(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKHD1A_MOUSE
AccessioniPrimary (citable) accession number: Q3UWR2
Secondary accession number(s): Q7TNM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.