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Protein
Submitted name:

Putative uncharacterized protein

Gene

Cacna1f

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: GO_Central
  2. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. axonogenesis Source: MGI
  2. calcium ion import Source: GO_Central
  3. cellular calcium ion homeostasis Source: MGI
  4. dendrite morphogenesis Source: MGI
  5. detection of light stimulus involved in visual perception Source: MGI
  6. membrane depolarization during action potential Source: GO_Central
  7. regulation of T cell receptor signaling pathway Source: InterPro
  8. retina development in camera-type eye Source: MGI
  9. T cell homeostasis Source: InterPro
  10. visual perception Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Cacna1fImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: MGI
  2. membrane Source: MGI
  3. neuronal cell body Source: MGI
  4. plasma membrane Source: GO_Central
  5. voltage-gated calcium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ3UWK7.
ExpressionAtlasiQ3UWK7. baseline and differential.
GenevestigatoriQ3UWK7.

Structurei

3D structure databases

ProteinModelPortaliQ3UWK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR030157. VDCC_L_a1F.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF184. PTHR10037:SF184. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3UWK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TVALAMQHYE QTAPFNYAMD ILNMVFTGLF TIEMVLKIIA FKPKHYFADA
60 70 80 90 100
WNTFDALIVV GSVVDIAVTE VNSSEDSSRI SITFFRLFRV MRLVKLLSKG
110 120 130 140 150
EGIRTLLWTF IKSFQALPYV ALLIAMIFFI YAVIGMQMFG KVALQDGTQI
160 170 180 190 200
NRNNNFQTFP QAVLLLFRCA TGEAWQEIML ASLPGNRCDP ESDFGPGEEF
210 220 230 240 250
TCGSSFAIVY FISFFMLCAF LIINLFVAVI MDNFDYLTRD WSILGPHHLD
260 270 280 290 300
EFKRIWSEYD PGAKGRIKHL DVVALLRRIQ PPLGFGKLCP HRVACKRLVA
310 320 330 340 350
MNVPLNSDGT VTFNATLFAL VRTSLKIKTE GNLDQANQEL RMVIKKIWKR
360 370 380 390 400
IKQKLLDEVI PPPDEEEVTV GKFYATFLIQ DYFRKFRRRK EKGLLGREAP
410 420 430 440 450
TSTSSALQAG LRSLQDLGPE IRQALTYDTE EEEEEEEAVG QEAEEEEAEN
460 470 480 490 500
NPEPYKDSID SQPQSRWNSR ISVSLPVKEK LPDSLSTGPS DDDGLAPNSR
510 520 530 540 550
QPSVIQAGSQ PHRRSSGVFM FTIPEEGSIQ LKGTQGQDNQ NEEQEVPDWT
560 570 580 590 600
PDLDEQAGTP SNPVLLPPHW SQQHVNGHHV PRRRLLPPTP AGRKPSFTIQ
610 620 630 640 650
CLQRQGSCED LPIPGTYHRG RTSGPSRAQG SWAAPPQKGR LLYAPLLLVE
660 670 680 690 700
ESTVGEGYLG KLGGPLRTFT CLQVPGAHPN PSHRKRGSAD SLVEAVLISE
710 720 730 740 750
GLGLFAQDPR FVALAKQEIA DACHLTLDEM DSAASDLLAQ RTTSLYSDEE
760 770
SILSRFDEED LGDEMACVHA L
Length:771
Mass (Da):86,181
Last modified:October 11, 2005 - v1
Checksum:iA8FF82DE900412FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136273 mRNA. Translation: BAE22907.1.
UniGeneiMm.289647.

Genome annotation databases

UCSCiuc012hei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136273 mRNA. Translation: BAE22907.1.
UniGeneiMm.289647.

3D structure databases

ProteinModelPortaliQ3UWK7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc012hei.1. mouse.

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ3UWK7.
ExpressionAtlasiQ3UWK7. baseline and differential.
GenevestigatoriQ3UWK7.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR030157. VDCC_L_a1F.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF184. PTHR10037:SF184. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.

Entry informationi

Entry nameiQ3UWK7_MOUSE
AccessioniPrimary (citable) accession number: Q3UWK7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.