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Protein

Calpain-13

Gene

Capn13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911By similarity
Active sitei247 – 2471By similarity
Active sitei271 – 2711By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-13 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 13
Short name:
CANP 13
Gene namesi
Name:Capn13
Synonyms:Gm943
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2685789. Capn13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Calpain-13PRO_0000259583Add
BLAST

Proteomic databases

MaxQBiQ3UW68.
PaxDbiQ3UW68.
PRIDEiQ3UW68.

PTM databases

PhosphoSiteiQ3UW68.

Expressioni

Gene expression databases

BgeeiQ3UW68.
CleanExiMM_CAPN13.
GenevisibleiQ3UW68. MM.

Interactioni

Protein-protein interaction databases

BioGridi237788. 1 interaction.
STRINGi10090.ENSMUSP00000092832.

Structurei

3D structure databases

ProteinModelPortaliQ3UW68.
SMRiQ3UW68. Positions 8-665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 329300Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini534 – 56936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini632 – 66534EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
KOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ3UW68.
KOiK08581.
OMAiLTEMEWM.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ3UW68.
TreeFamiTF314748.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR029544. CANP13/Calpain-C.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF282. PTHR10183:SF282. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UW68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHDAETSVV KFKNQDFRTL RDHCLSRGQL FIDDTFPAAA SSIGEKLLRG
60 70 80 90 100
KHLSKLEWKR PTSKDLPFYP PHFILEGASR FDIHQGIAGD CWFLAALGSL
110 120 130 140 150
TQNPQCLQKI LMDQSYSHQY AGIFQFRFWQ CGQWVEVVID DQLPVIGDNF
160 170 180 190 200
LFVHPRGGNK EFWPCLMEKA YAKLLGSYSQ LHYGYLPDAL VDLTGGVVTI
210 220 230 240 250
INLHSSPFDL LTTVKTAIQA GSMVACATEN GLTEEAKVME NGLVSQHAYT
260 270 280 290 300
VTGAEKIQYQ GRWEDIIRLW NPWGKTEWKG RWKDGSKEWR ETHDPRKSQL
310 320 330 340 350
YENKEDGEFW MSCQDFQENF SCLFICNQIP ITMDHGVTPN ESWRQMRFTN
360 370 380 390 400
QVISRNRAGG HGRDMQYVFS VQEHTAGNNV VVAFTIMPQS LNTEEERFPL
410 420 430 440 450
QFQVFKVPQF QNVQGRLPPA FFSPFRSAAQ GTKYVSKCNF TKSFHLNPGT
460 470 480 490 500
YVVVTTANGK EVEFLLRIFL KMPDKHRDPS SNFNLRALKE SLPENGSRNS
510 520 530 540 550
ISYTYMDQGL DIDATQLQSL LNQEFLTGPP GDTFSLDQCQ SIMALMDLKV
560 570 580 590 600
NGRLDQEEFA RLRSRLIHCQ HIFQSIQRRP GVLLSSDLWK VIENTDFLVG
610 620 630 640 650
IFISSELLSL MALRYSDSSG RVSFPTLVCF LIRLETMAKA FRNLSKDGKG
660
IYLTETEWMN LVMYS
Length:665
Mass (Da):76,049
Last modified:October 11, 2005 - v1
Checksum:i7C1AA17FD2D14D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136569 mRNA. Translation: BAE23051.1.
BC147510 mRNA. Translation: AAI47511.1.
BC147512 mRNA. Translation: AAI47513.1.
CCDSiCCDS37690.1.
RefSeqiNP_001028616.1. NM_001033444.2.
UniGeneiMm.81496.

Genome annotation databases

EnsembliENSMUST00000095208; ENSMUSP00000092832; ENSMUSG00000043705.
GeneIDi381122.
KEGGimmu:381122.
UCSCiuc008dnj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136569 mRNA. Translation: BAE23051.1.
BC147510 mRNA. Translation: AAI47511.1.
BC147512 mRNA. Translation: AAI47513.1.
CCDSiCCDS37690.1.
RefSeqiNP_001028616.1. NM_001033444.2.
UniGeneiMm.81496.

3D structure databases

ProteinModelPortaliQ3UW68.
SMRiQ3UW68. Positions 8-665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237788. 1 interaction.
STRINGi10090.ENSMUSP00000092832.

Protein family/group databases

MEROPSiC02.020.

PTM databases

PhosphoSiteiQ3UW68.

Proteomic databases

MaxQBiQ3UW68.
PaxDbiQ3UW68.
PRIDEiQ3UW68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095208; ENSMUSP00000092832; ENSMUSG00000043705.
GeneIDi381122.
KEGGimmu:381122.
UCSCiuc008dnj.1. mouse.

Organism-specific databases

CTDi92291.
MGIiMGI:2685789. Capn13.

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
KOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ3UW68.
KOiK08581.
OMAiLTEMEWM.
OrthoDBiEOG7RV9FM.
PhylomeDBiQ3UW68.
TreeFamiTF314748.

Miscellaneous databases

PROiQ3UW68.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UW68.
CleanExiMM_CAPN13.
GenevisibleiQ3UW68. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR029544. CANP13/Calpain-C.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF282. PTHR10183:SF282. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCAN13_MOUSE
AccessioniPrimary (citable) accession number: Q3UW68
Secondary accession number(s): B2RW21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.