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Protein

Protein Niban

Gene

Fam129a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response.1 Publication

GO - Biological processi

  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • response to endoplasmic reticulum stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Niban1 Publication
Alternative name(s):
Protein FAM129A
Gene namesi
Name:Fam129a
Synonyms:Niban
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2137237. Fam129a.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

No obvious phenotypic abnormalities but mice show increased phosphorylation of Eif2a and decreased phosphorylation of Eif4ebp1 and Rps6kb1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 926925Protein NibanPRO_0000355583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei578 – 5781PhosphoserineCombined sources
Modified residuei581 – 5811PhosphoserineCombined sources
Modified residuei595 – 5951PhosphoserineCombined sources
Modified residuei601 – 6011PhosphoserineCombined sources
Modified residuei640 – 6401PhosphoserineBy similarity
Modified residuei699 – 6991PhosphoserineBy similarity
Modified residuei755 – 7551PhosphoserineBy similarity
Modified residuei923 – 9231PhosphoserineBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ3UW53.
MaxQBiQ3UW53.
PaxDbiQ3UW53.
PeptideAtlasiQ3UW53.
PRIDEiQ3UW53.

PTM databases

iPTMnetiQ3UW53.
PhosphoSiteiQ3UW53.

Expressioni

Inductioni

By endoplasmic reticulum stress-inducing agents such as tunicamycin and thapsigargin in liver, kidney and cerebrum.1 Publication

Gene expression databases

BgeeiENSMUSG00000026483.
ExpressionAtlasiQ3UW53. baseline and differential.
GenevisibleiQ3UW53. MM.

Interactioni

Protein-protein interaction databases

BioGridi211004. 1 interaction.
IntActiQ3UW53. 2 interactions.
MINTiMINT-4129357.
STRINGi10090.ENSMUSP00000115822.

Structurei

3D structure databases

ProteinModelPortaliQ3UW53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Niban family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000113785.
HOVERGENiHBG108186.
InParanoidiQ3UW53.
OMAiEDEYNLL.
OrthoDBiEOG091G02BX.
PhylomeDBiQ3UW53.
TreeFamiTF333351.

Family and domain databases

InterProiIPR026088. Niban-like.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UW53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGSASSQLD EGKCAYIRGK TEASIKNFSP YYSRQYSVAF CNHVRSEVEQ
60 70 80 90 100
QRDLTSQFLK TKPPLEPGTV LYEAELSQFA EDIRKWKDRY IVIKNDFAVE
110 120 130 140 150
SYESKEAYQR GAVPKSRILP AGGKVLTSEE EYSLLSDKHF PDPTASSEKN
160 170 180 190 200
SQPFVLLPKA FPVYLWQPYL RHGYFCFHEA AEQQKFSALL NDCIRHLNHD
210 220 230 240 250
YMKQTTFEAQ AFLEAVQFFR QEKGHYGSWE MTTGDEVQVL SKLVMEELLP
260 270 280 290 300
TLQTDLLPKL KGKKNDRKRA WFGLLEEAYN LVQHQVSEGL NALKEECRAL
310 320 330 340 350
TKDLEGTIRS DMDQIVTSKN FLTGKIRAMV AQPAEQCCGE SVQPFLASIL
360 370 380 390 400
EELMGPVSSG FSEVRALFEK EVDELSQSFH ATQDSAQLKE GLQQLMKLPL
410 420 430 440 450
DSVKMEPCYT KVTLLPERLL DLQSRFRFPH VDLVVQRTQN YMQELMENAV
460 470 480 490 500
FTFEQLLSPY LQGEASRIPV AIEKVKLRVL KQYDYDSSTI RKKIFQEALI
510 520 530 540 550
QITLPTVQKA LASTCKPELQ KYEQFIFADH TNMIHVENVY EEILYEILLD
560 570 580 590 600
ETLKVITEAA ILKKHNLFED NMALPSESVS SLTDLKTAMG SNQASPARRV
610 620 630 640 650
SAILPGAPDN ELPSNEVFQE PEEKKEQPGV PGSLAISASS CPSGGDGQVS
660 670 680 690 700
VDHSAGGPLT VENTAGPLSS HLSEVEAGGT LKDEEPTCQS PEPSAVPGSL
710 720 730 740 750
KELKKLLTVT VSVESAPVVE NDIHNGTPVP QENIKEEESK IHPEASHPAA
760 770 780 790 800
IQQDSCEERE VREKEAQPLE AEAPGVDLGI LPEGRGSTSQ STSGGLTENT
810 820 830 840 850
SCPGPIEEPF EAQEPAEKVL PAIVSTEDSP QAGGEAEHSV TVTPQEDATL
860 870 880 890 900
SSNPICPMES NEVAQASGDQ EVLGGEDSSA LGMDTEQVND THEHACQWLV
910 920
EDTLSTDILA VHDFDVSSPE QPSEEW
Length:926
Mass (Da):102,649
Last modified:December 16, 2008 - v2
Checksum:iD41F603AF127673C
GO

Sequence cautioni

The sequence AAH21332 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH58234 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI37844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB17052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC26641 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 43GGS → ASA in BAB17052 (PubMed:11011112).Curated
Sequence conflicti437 – 4371R → G in AAH21332 (PubMed:15489334).Curated
Sequence conflicti608 – 6081P → Q in BAE41736 (PubMed:16141072).Curated
Sequence conflicti651 – 6511V → E in AAH21332 (PubMed:15489334).Curated
Sequence conflicti680 – 6801T → S in AAH21332 (PubMed:15489334).Curated
Sequence conflicti693 – 6931P → S in AAH21332 (PubMed:15489334).Curated
Sequence conflicti705 – 7051K → E in AAH21332 (PubMed:15489334).Curated
Sequence conflicti911 – 9111V → L in BAE23066 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029847 mRNA. Translation: BAC26641.1. Sequence problems.
AK136597 mRNA. Translation: BAE23066.1.
AK170347 mRNA. Translation: BAE41736.1.
BC021332 mRNA. Translation: AAH21332.1. Sequence problems.
BC058234 mRNA. Translation: AAH58234.2. Different initiation.
BC137843 mRNA. Translation: AAI37844.1. Different initiation.
AB049355 mRNA. Translation: BAB17052.1. Different initiation.
CCDSiCCDS48393.1.
RefSeqiNP_071301.2. NM_022018.3.
XP_006529839.1. XM_006529776.2.
UniGeneiMm.157700.
Mm.482559.

Genome annotation databases

EnsembliENSMUST00000148810; ENSMUSP00000115822; ENSMUSG00000026483.
GeneIDi63913.
KEGGimmu:63913.
UCSCiuc007cyz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029847 mRNA. Translation: BAC26641.1. Sequence problems.
AK136597 mRNA. Translation: BAE23066.1.
AK170347 mRNA. Translation: BAE41736.1.
BC021332 mRNA. Translation: AAH21332.1. Sequence problems.
BC058234 mRNA. Translation: AAH58234.2. Different initiation.
BC137843 mRNA. Translation: AAI37844.1. Different initiation.
AB049355 mRNA. Translation: BAB17052.1. Different initiation.
CCDSiCCDS48393.1.
RefSeqiNP_071301.2. NM_022018.3.
XP_006529839.1. XM_006529776.2.
UniGeneiMm.157700.
Mm.482559.

3D structure databases

ProteinModelPortaliQ3UW53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211004. 1 interaction.
IntActiQ3UW53. 2 interactions.
MINTiMINT-4129357.
STRINGi10090.ENSMUSP00000115822.

PTM databases

iPTMnetiQ3UW53.
PhosphoSiteiQ3UW53.

Proteomic databases

EPDiQ3UW53.
MaxQBiQ3UW53.
PaxDbiQ3UW53.
PeptideAtlasiQ3UW53.
PRIDEiQ3UW53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000148810; ENSMUSP00000115822; ENSMUSG00000026483.
GeneIDi63913.
KEGGimmu:63913.
UCSCiuc007cyz.2. mouse.

Organism-specific databases

CTDi116496.
MGIiMGI:2137237. Fam129a.

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000113785.
HOVERGENiHBG108186.
InParanoidiQ3UW53.
OMAiEDEYNLL.
OrthoDBiEOG091G02BX.
PhylomeDBiQ3UW53.
TreeFamiTF333351.

Miscellaneous databases

PROiQ3UW53.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026483.
ExpressionAtlasiQ3UW53. baseline and differential.
GenevisibleiQ3UW53. MM.

Family and domain databases

InterProiIPR026088. Niban-like.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIBAN_MOUSE
AccessioniPrimary (citable) accession number: Q3UW53
Secondary accession number(s): A0PJB3
, Q3TD68, Q6PE79, Q9ESL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Niban' means 'second' in Japanese.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.