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Protein

Probable G-protein coupled receptor 149

Gene

Gpr149

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

  • antral ovarian follicle growth Source: MGI
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
  • negative regulation of ovulation Source: MGI
  • neuropeptide signaling pathway Source: GO_Central
  • preantral ovarian follicle growth Source: MGI
  • synaptic transmission Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 149
Alternative name(s):
G-protein coupled receptor PGR10
Gene namesi
Name:Gpr149
Synonyms:Pgr10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2443628. Gpr149.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularSequence analysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini58 – 6912CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 11020ExtracellularSequence analysisAdd
BLAST
Transmembranei111 – 13323Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15623CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 19013ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 311100CytoplasmicSequence analysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini333 – 34311ExtracellularSequence analysisAdd
BLAST
Transmembranei344 – 36421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini365 – 732368CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Probable G-protein coupled receptor 149PRO_0000069627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3UVY1.
PaxDbiQ3UVY1.
PRIDEiQ3UVY1.

PTM databases

iPTMnetiQ3UVY1.
PhosphoSiteiQ3UVY1.

Expressioni

Gene expression databases

BgeeiQ3UVY1.
CleanExiMM_GPR149.
GenevisibleiQ3UVY1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060893.

Structurei

3D structure databases

ProteinModelPortaliQ3UVY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000003715.
HOGENOMiHOG000112771.
HOVERGENiHBG081566.
InParanoidiQ3UVY1.
KOiK08433.
OMAiHEDYYDD.
OrthoDBiEOG7QC7VP.
PhylomeDBiQ3UVY1.
TreeFamiTF331679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UVY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFLSNLTN DSNLWKASHN STETDLMNSP ATLTLSLFCL ICIMTLAALV
60 70 80 90 100
GSIFSLVSLL TMQYRTVLSI LVTSWSVDDL LSVLSVAIFM VLQWPKEAQG
110 120 130 140 150
YFQSLCTTSA LLYMCQGLSS NLKATLIVCY NFYTMNRTVE SQSSSWRLGQ
160 170 180 190 200
VLGVTLTVWA VSLLLASLPL CGWGVFVRTP WGCLTDCSSP YVLLLFAVYA
210 220 230 240 250
SAFGLLAVLS VPLTHQLLCS EEPLRLHANY QEISRGASTP GTPAAAGRVL
260 270 280 290 300
CLPPEDVEIP ALRCTGGCSP SSDVVFAPGQ PAASGAGAGR RENPGTPQGT
310 320 330 340 350
NSFPLSLAQK RFSLILALTK VILWLPMMIH MVVKHVVGFQ SLPVDMLSFL
360 370 380 390 400
LSLLASSVTP VFVLSKRWAH LPCGCIINCQ PDTYSVAFDG KKSKRKGFEF
410 420 430 440 450
NLSFQQSYGL YKIPHADCYD DDENSISYHN PKNYECEATK EPWGDNRSVF
460 470 480 490 500
NTITVEISTT PPLDSATLTG VHKCTNTDIP ESKQAMKEEK GAFSVKTESD
510 520 530 540 550
INYGETTSFE GPERRLSHEE NQKPDLSDWE WCRSKSERTP RQRSGGGLAI
560 570 580 590 600
PICAFQGTVS LQAPTGKTLS LSTYEVSAEG QKITPASKKI EVYRSKSVGH
610 620 630 640 650
EPNSEESPST FADTSVKIHL EVLEICDNDE ALDTVSIISN ISQSSTKVRS
660 670 680 690 700
PSLRYSRKEN RFVSCDLGET ASYSLFLPTS DPDGDINISI PDTVEAHRQN
710 720 730
SRRQHEERDG YQEEIQLLNK AYRKREAESK GD
Length:732
Mass (Da):80,520
Last modified:October 11, 2005 - v1
Checksum:iC5E762A8F3C2C98B
GO

Sequence cautioni

The sequence BAC33315.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391T → S in BAC33315 (PubMed:16141072).Curated
Sequence conflicti366 – 3661K → E in BAE38531 (PubMed:16141072).Curated
Sequence conflicti368 – 3681W → G in BAC33315 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035931 mRNA. Translation: BAC29247.1.
AK048373 mRNA. Translation: BAC33315.1. Different initiation.
AK136826 mRNA. Translation: BAE23138.1.
AK166029 mRNA. Translation: BAE38531.1.
AY255591 mRNA. Translation: AAO85103.1.
CCDSiCCDS17380.1.
RefSeqiNP_796320.2. NM_177346.4.
UniGeneiMm.95181.

Genome annotation databases

EnsembliENSMUST00000058535; ENSMUSP00000060893; ENSMUSG00000043441.
GeneIDi229357.
KEGGimmu:229357.
UCSCiuc008pjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035931 mRNA. Translation: BAC29247.1.
AK048373 mRNA. Translation: BAC33315.1. Different initiation.
AK136826 mRNA. Translation: BAE23138.1.
AK166029 mRNA. Translation: BAE38531.1.
AY255591 mRNA. Translation: AAO85103.1.
CCDSiCCDS17380.1.
RefSeqiNP_796320.2. NM_177346.4.
UniGeneiMm.95181.

3D structure databases

ProteinModelPortaliQ3UVY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060893.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ3UVY1.
PhosphoSiteiQ3UVY1.

Proteomic databases

MaxQBiQ3UVY1.
PaxDbiQ3UVY1.
PRIDEiQ3UVY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058535; ENSMUSP00000060893; ENSMUSG00000043441.
GeneIDi229357.
KEGGimmu:229357.
UCSCiuc008pjo.1. mouse.

Organism-specific databases

CTDi344758.
MGIiMGI:2443628. Gpr149.

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000003715.
HOGENOMiHOG000112771.
HOVERGENiHBG081566.
InParanoidiQ3UVY1.
KOiK08433.
OMAiHEDYYDD.
OrthoDBiEOG7QC7VP.
PhylomeDBiQ3UVY1.
TreeFamiTF331679.

Miscellaneous databases

PROiQ3UVY1.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UVY1.
CleanExiMM_GPR149.
GenevisibleiQ3UVY1. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Diencephalon, Head and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-327.
  3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGP149_MOUSE
AccessioniPrimary (citable) accession number: Q3UVY1
Secondary accession number(s): Q3TMB1
, Q80T52, Q8BXA3, Q8BZC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.