Tiam1

Functionⁱ

GO - Molecular functionⁱ

Rho guanyl-nucleotide exchange factor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

activation of GTPase activity Source: InterPro
intracellular signal transduction Source: InterPro
regulation of Rho protein signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation

Molecular function

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Tiam1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103306. Tiam1.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q3UVX2.
PeptideAtlas More...PeptideAtlasⁱ	Q3UVX2.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q3UVX2. MM.

Genevisibleⁱ

Q3UVX2. MM.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	71 – 265	DH (DBL-homology)InterPro annotationAdd BLAST		195

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
HOVERGENⁱ	HBG058074.
KEGG Orthology (KO) More...KOⁱ	K05731.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UVX2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSLWKIKRK PRVESDRAGD SLYRTLHLST EQVAAFCRSL HEMSPSDSSP 
        60         70         80         90        100
SPQDATSPQL ATTRQLSDAD KLRKVICELL ETERTYVKDL NCLMERYLKP 
       110        120        130        140        150
LQKETFLTQD ELDVLFGNLT EMVEFQVEFL KTLEDGVRLV PDLEKLEKVD 
       160        170        180        190        200
QFKKVLFSLG GSFLYYADRF KLYSAFCASH TKVPKVLVKA KTDTAFKAFL 
       210        220        230        240        250
DAQNPRQQHS STLESYLIKP IQRVLKYPLL LRELFALTDA ESEEHYHLDV 
       260        270        280        290        300
AIKTMNKVAS HINEMQKIHE EFGAVFDQLI AEQTGEKKEV ADLSMGDLLL 
       310        320        330        340        350
HTSVIWLNPP ASLGKWKKEP ELAAFVFKTA VVLVYKDGSK QKKKLVGSHR 
       360        370        380        390        400
LSIYEEWDPF RFRHMVPTEA LQVRALPSAD AEANAACEIV HVKSESEGRP 
       410        420        430        440        450
ERVFHLCCSS PESRKDFLKS VHSILRDKHR RQLLKTESLP SAQQYVPFGG 
       460        470        480        490        500
KRLCALKGAR PAMSRAVSAP SKSLGRRRRR LARNRFTIDS DAISASSPEK 
       510        520        530        540        550
EPQQPAGGGD TDRWVEEQFD LAQYEEQDDI KETDILSDDD EFCESLKGAS 
       560        570        580        590        600
VDRDLQEQLQ AASISQRARG RRTLDSHASR MTQLKKQAAL SGINGGLESA 
       610        620 
SEEVIWVRRE DFAPSRKLNT EI

Length:622

Mass (Da):70,606

Last modified:October 11, 2005 - v1

Checksum:ⁱ7E1E90ADD0FC0825

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK136856 mRNA. Translation: BAE23147.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_001139359.1. NM_001145887.1. NP_033410.2. NM_009384.3.
UniGeneⁱ	Mm.310902.

Genome annotation databases

GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK136856 mRNA. Translation: BAE23147.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_001139359.1. NM_001145887.1. NP_033410.2. NM_009384.3.
UniGeneⁱ	Mm.310902.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3UVX2.
PeptideAtlas More...PeptideAtlasⁱ	Q3UVX2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.

Organism-specific databases

CTDⁱ	7074.
MGIⁱ	MGI:103306. Tiam1.

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
HOVERGENⁱ	HBG058074.
KEGG Orthology (KO) More...KOⁱ	K05731.

Miscellaneous databases

ChiTaRSⁱ	Tiam1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Genevisibleⁱ	Q3UVX2. MM.

Genevisibleⁱ

Q3UVX2. MM.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3UVX2_MOUSE
Accessionⁱ	Q3UVX2Primary (citable) accession number: Q3UVX2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q3UVX2 (Q3UVX2_MOUSE)

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Putative uncharacterized protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UVX2 (Q3UVX2_MOUSE)

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Putative uncharacterized protein

Tiam1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ