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Protein

Zinc transporter 10

Gene

Slc30a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 10
Short name:
ZnT-10
Alternative name(s):
Solute carrier family 30 member 10
Gene namesi
Name:Slc30a10
Synonyms:Znt10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685058. Slc30a10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 34ExtracellularSequence analysis3
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 81CytoplasmicSequence analysisAdd BLAST26
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 113ExtracellularSequence analysisAdd BLAST11
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 233CytoplasmicSequence analysisAdd BLAST99
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 270ExtracellularSequence analysisAdd BLAST16
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 470CytoplasmicSequence analysisAdd BLAST179

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003125811 – 470Zinc transporter 10Add BLAST470

Proteomic databases

PaxDbiQ3UVU3.
PeptideAtlasiQ3UVU3.
PRIDEiQ3UVU3.

PTM databases

iPTMnetiQ3UVU3.
PhosphoSitePlusiQ3UVU3.

Expressioni

Tissue specificityi

Specifically expressed in fetal liver and fetal brain.

Gene expression databases

BgeeiENSMUSG00000026614.
CleanExiMM_SLC30A10.
GenevisibleiQ3UVU3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053181.

Structurei

3D structure databases

ProteinModelPortaliQ3UVU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 248Poly-Val4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ3UVU3.
KOiK14697.
OMAiTIQFETL.
OrthoDBiEOG091G04DT.
PhylomeDBiQ3UVU3.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UVU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRYSGKTCR LLFMLVLTAA FFVAELVSGY LGNSIALLSD SFNMLSDLIS
60 70 80 90 100
LCVGLGSGYI ARRGPRGSSA TYGYVRAEVV GALSNAVFLT ALCFTIFVEA
110 120 130 140 150
VLRLARPERI DDPELVLIVG ALGLAVNVVG LLIFQDCGAC FSRCTRGRRT
160 170 180 190 200
RPSQQPSQGD PRGALGCPQE AATATAPGSG TAVTLRGSSA GRKQQEGATV
210 220 230 240 250
FSNVAGDSLN TENEPEETTK KEKKSEALNI RGVLLHVMGD ALGSVVVVIT
260 270 280 290 300
AIIFYVQPLR REDPCNWQCY IDPSLTVVMV IIILSSAFPL IKETAVILLQ
310 320 330 340 350
MVPKGVNMEE LMSQLSTVPG ISSVHEVHIW ELISGKIIAT LHIKHQKGTE
360 370 380 390 400
YQDASRKIRE IFHHAGIHNV TIQFETLDLK EALEQKDFLL TCSAPCITQS
410 420 430 440 450
CAKKLCCPPG TLPLALVNGC AEHNGRSSRE SYRSIEAPEV AIDVDGCPRE
460 470
QGQTLSKTQE RQHYENSTHF
Length:470
Mass (Da):50,911
Last modified:October 11, 2005 - v1
Checksum:iE2DF53D5890CEE2B
GO
Isoform 2 (identifier: Q3UVU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):25,934
Checksum:i01E92347C8F300F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339A → S in AAI08420 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298671 – 237Missing in isoform 2. 1 PublicationAdd BLAST237

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136932 mRNA. Translation: BAE23176.1.
BC108419 mRNA. Translation: AAI08420.1.
CCDSiCCDS15599.1. [Q3UVU3-1]
RefSeqiNP_001028458.1. NM_001033286.2. [Q3UVU3-1]
UniGeneiMm.227117.

Genome annotation databases

EnsembliENSMUST00000061093; ENSMUSP00000053181; ENSMUSG00000026614. [Q3UVU3-1]
GeneIDi226781.
KEGGimmu:226781.
UCSCiuc007dzk.1. mouse. [Q3UVU3-1]
uc007dzl.2. mouse. [Q3UVU3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136932 mRNA. Translation: BAE23176.1.
BC108419 mRNA. Translation: AAI08420.1.
CCDSiCCDS15599.1. [Q3UVU3-1]
RefSeqiNP_001028458.1. NM_001033286.2. [Q3UVU3-1]
UniGeneiMm.227117.

3D structure databases

ProteinModelPortaliQ3UVU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053181.

PTM databases

iPTMnetiQ3UVU3.
PhosphoSitePlusiQ3UVU3.

Proteomic databases

PaxDbiQ3UVU3.
PeptideAtlasiQ3UVU3.
PRIDEiQ3UVU3.

Protocols and materials databases

DNASUi226781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061093; ENSMUSP00000053181; ENSMUSG00000026614. [Q3UVU3-1]
GeneIDi226781.
KEGGimmu:226781.
UCSCiuc007dzk.1. mouse. [Q3UVU3-1]
uc007dzl.2. mouse. [Q3UVU3-2]

Organism-specific databases

CTDi55532.
MGIiMGI:2685058. Slc30a10.

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ3UVU3.
KOiK14697.
OMAiTIQFETL.
OrthoDBiEOG091G04DT.
PhylomeDBiQ3UVU3.
TreeFamiTF313924.

Miscellaneous databases

PROiQ3UVU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026614.
CleanExiMM_SLC30A10.
GenevisibleiQ3UVU3. MM.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT10_MOUSE
AccessioniPrimary (citable) accession number: Q3UVU3
Secondary accession number(s): Q32NY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.