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Protein

Zinc transporter 10

Gene

Slc30a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.By similarity

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. manganese ion transport Source: UniProtKB
  2. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 10
Short name:
ZnT-10
Alternative name(s):
Solute carrier family 30 member 10
Gene namesi
Name:Slc30a10
Synonyms:Znt10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685058. Slc30a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 343ExtracellularSequence Analysis
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Topological domaini56 – 8126CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 11311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 23399CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 27016ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 470179CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Zinc transporter 10PRO_0000312581Add
BLAST

Proteomic databases

PaxDbiQ3UVU3.
PRIDEiQ3UVU3.

PTM databases

PhosphoSiteiQ3UVU3.

Expressioni

Tissue specificityi

Specifically expressed in fetal liver and fetal brain.

Gene expression databases

BgeeiQ3UVU3.
CleanExiMM_SLC30A10.
GenevestigatoriQ3UVU3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 2484Poly-Val

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ3UVU3.
KOiK14697.
OMAiHEVHVWE.
OrthoDBiEOG7034GQ.
PhylomeDBiQ3UVU3.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UVU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRYSGKTCR LLFMLVLTAA FFVAELVSGY LGNSIALLSD SFNMLSDLIS
60 70 80 90 100
LCVGLGSGYI ARRGPRGSSA TYGYVRAEVV GALSNAVFLT ALCFTIFVEA
110 120 130 140 150
VLRLARPERI DDPELVLIVG ALGLAVNVVG LLIFQDCGAC FSRCTRGRRT
160 170 180 190 200
RPSQQPSQGD PRGALGCPQE AATATAPGSG TAVTLRGSSA GRKQQEGATV
210 220 230 240 250
FSNVAGDSLN TENEPEETTK KEKKSEALNI RGVLLHVMGD ALGSVVVVIT
260 270 280 290 300
AIIFYVQPLR REDPCNWQCY IDPSLTVVMV IIILSSAFPL IKETAVILLQ
310 320 330 340 350
MVPKGVNMEE LMSQLSTVPG ISSVHEVHIW ELISGKIIAT LHIKHQKGTE
360 370 380 390 400
YQDASRKIRE IFHHAGIHNV TIQFETLDLK EALEQKDFLL TCSAPCITQS
410 420 430 440 450
CAKKLCCPPG TLPLALVNGC AEHNGRSSRE SYRSIEAPEV AIDVDGCPRE
460 470
QGQTLSKTQE RQHYENSTHF
Length:470
Mass (Da):50,911
Last modified:October 11, 2005 - v1
Checksum:iE2DF53D5890CEE2B
GO
Isoform 2 (identifier: Q3UVU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.

Note: No experimental confirmation available.

Show »
Length:233
Mass (Da):25,934
Checksum:i01E92347C8F300F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391A → S in AAI08420 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 237237Missing in isoform 2. 1 PublicationVSP_029867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136932 mRNA. Translation: BAE23176.1.
BC108419 mRNA. Translation: AAI08420.1.
CCDSiCCDS15599.1. [Q3UVU3-1]
RefSeqiNP_001028458.1. NM_001033286.2. [Q3UVU3-1]
UniGeneiMm.227117.

Genome annotation databases

EnsembliENSMUST00000061093; ENSMUSP00000053181; ENSMUSG00000026614. [Q3UVU3-1]
GeneIDi226781.
KEGGimmu:226781.
UCSCiuc007dzk.1. mouse. [Q3UVU3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136932 mRNA. Translation: BAE23176.1.
BC108419 mRNA. Translation: AAI08420.1.
CCDSiCCDS15599.1. [Q3UVU3-1]
RefSeqiNP_001028458.1. NM_001033286.2. [Q3UVU3-1]
UniGeneiMm.227117.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3UVU3.

Proteomic databases

PaxDbiQ3UVU3.
PRIDEiQ3UVU3.

Protocols and materials databases

DNASUi226781.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061093; ENSMUSP00000053181; ENSMUSG00000026614. [Q3UVU3-1]
GeneIDi226781.
KEGGimmu:226781.
UCSCiuc007dzk.1. mouse. [Q3UVU3-1]

Organism-specific databases

CTDi55532.
MGIiMGI:2685058. Slc30a10.

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ3UVU3.
KOiK14697.
OMAiHEVHVWE.
OrthoDBiEOG7034GQ.
PhylomeDBiQ3UVU3.
TreeFamiTF313924.

Miscellaneous databases

NextBioi378351.
PROiQ3UVU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UVU3.
CleanExiMM_SLC30A10.
GenevestigatoriQ3UVU3.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZNT10_MOUSE
AccessioniPrimary (citable) accession number: Q3UVU3
Secondary accession number(s): Q32NY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.