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Q3UVU3

- ZNT10_MOUSE

UniProt

Q3UVU3 - ZNT10_MOUSE

Protein

Zinc transporter 10

Gene

Slc30a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    May be involved in zinc transport out of the cell, being a zinc-efflux transporter.By similarity

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 10
    Short name:
    ZnT-10
    Alternative name(s):
    Solute carrier family 30 member 10
    Gene namesi
    Name:Slc30a10
    Synonyms:Znt10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2685058. Slc30a10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Zinc transporter 10PRO_0000312581Add
    BLAST

    Proteomic databases

    PaxDbiQ3UVU3.
    PRIDEiQ3UVU3.

    PTM databases

    PhosphoSiteiQ3UVU3.

    Expressioni

    Tissue specificityi

    Specifically expressed in fetal liver and fetal brain.

    Gene expression databases

    BgeeiQ3UVU3.
    CleanExiMM_SLC30A10.
    GenevestigatoriQ3UVU3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UVU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 343ExtracellularSequence Analysis
    Topological domaini56 – 8126CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11311ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 23399CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 27016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 470179CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi245 – 2484Poly-Val

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    GeneTreeiENSGT00550000074381.
    HOGENOMiHOG000166089.
    HOVERGENiHBG000588.
    InParanoidiQ3UVU3.
    KOiK14697.
    OMAiTIQFETL.
    OrthoDBiEOG7034GQ.
    PhylomeDBiQ3UVU3.
    TreeFamiTF313924.

    Family and domain databases

    Gene3Di1.20.1510.10. 2 hits.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UVU3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRYSGKTCR LLFMLVLTAA FFVAELVSGY LGNSIALLSD SFNMLSDLIS    50
    LCVGLGSGYI ARRGPRGSSA TYGYVRAEVV GALSNAVFLT ALCFTIFVEA 100
    VLRLARPERI DDPELVLIVG ALGLAVNVVG LLIFQDCGAC FSRCTRGRRT 150
    RPSQQPSQGD PRGALGCPQE AATATAPGSG TAVTLRGSSA GRKQQEGATV 200
    FSNVAGDSLN TENEPEETTK KEKKSEALNI RGVLLHVMGD ALGSVVVVIT 250
    AIIFYVQPLR REDPCNWQCY IDPSLTVVMV IIILSSAFPL IKETAVILLQ 300
    MVPKGVNMEE LMSQLSTVPG ISSVHEVHIW ELISGKIIAT LHIKHQKGTE 350
    YQDASRKIRE IFHHAGIHNV TIQFETLDLK EALEQKDFLL TCSAPCITQS 400
    CAKKLCCPPG TLPLALVNGC AEHNGRSSRE SYRSIEAPEV AIDVDGCPRE 450
    QGQTLSKTQE RQHYENSTHF 470
    Length:470
    Mass (Da):50,911
    Last modified:October 11, 2005 - v1
    Checksum:iE2DF53D5890CEE2B
    GO
    Isoform 2 (identifier: Q3UVU3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-237: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:233
    Mass (Da):25,934
    Checksum:i01E92347C8F300F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti339 – 3391A → S in AAI08420. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 237237Missing in isoform 2. 1 PublicationVSP_029867Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK136932 mRNA. Translation: BAE23176.1.
    BC108419 mRNA. Translation: AAI08420.1.
    CCDSiCCDS15599.1. [Q3UVU3-1]
    RefSeqiNP_001028458.1. NM_001033286.2. [Q3UVU3-1]
    UniGeneiMm.227117.

    Genome annotation databases

    EnsembliENSMUST00000061093; ENSMUSP00000053181; ENSMUSG00000026614. [Q3UVU3-1]
    GeneIDi226781.
    KEGGimmu:226781.
    UCSCiuc007dzk.1. mouse. [Q3UVU3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK136932 mRNA. Translation: BAE23176.1 .
    BC108419 mRNA. Translation: AAI08420.1 .
    CCDSi CCDS15599.1. [Q3UVU3-1 ]
    RefSeqi NP_001028458.1. NM_001033286.2. [Q3UVU3-1 ]
    UniGenei Mm.227117.

    3D structure databases

    ProteinModelPortali Q3UVU3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3UVU3.

    Proteomic databases

    PaxDbi Q3UVU3.
    PRIDEi Q3UVU3.

    Protocols and materials databases

    DNASUi 226781.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061093 ; ENSMUSP00000053181 ; ENSMUSG00000026614 . [Q3UVU3-1 ]
    GeneIDi 226781.
    KEGGi mmu:226781.
    UCSCi uc007dzk.1. mouse. [Q3UVU3-1 ]

    Organism-specific databases

    CTDi 55532.
    MGIi MGI:2685058. Slc30a10.

    Phylogenomic databases

    eggNOGi COG1230.
    GeneTreei ENSGT00550000074381.
    HOGENOMi HOG000166089.
    HOVERGENi HBG000588.
    InParanoidi Q3UVU3.
    KOi K14697.
    OMAi TIQFETL.
    OrthoDBi EOG7034GQ.
    PhylomeDBi Q3UVU3.
    TreeFami TF313924.

    Miscellaneous databases

    NextBioi 378351.
    PROi Q3UVU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UVU3.
    CleanExi MM_SLC30A10.
    Genevestigatori Q3UVU3.

    Family and domain databases

    Gene3Di 1.20.1510.10. 2 hits.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Diencephalon.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiZNT10_MOUSE
    AccessioniPrimary (citable) accession number: Q3UVU3
    Secondary accession number(s): Q32NY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3