Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3UVU3 (ZNT10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 10

Short name=ZnT-10
Alternative name(s):
Solute carrier family 30 member 10
Gene names
Name:Slc30a10
Synonyms:Znt10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in zinc transport out of the cell, being a zinc-efflux transporter By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Specifically expressed in fetal liver and fetal brain.

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandZinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processzinc ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncation transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3UVU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3UVU3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Zinc transporter 10
PRO_0000312581

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 343Extracellular Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 8126Cytoplasmic Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11311Extracellular Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 23399Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 27016Extracellular Potential
Transmembrane271 – 29121Helical; Potential
Topological domain292 – 470179Cytoplasmic Potential
Compositional bias245 – 2484Poly-Val

Natural variations

Alternative sequence1 – 237237Missing in isoform 2.
VSP_029867

Experimental info

Sequence conflict3391A → S in AAI08420. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: E2DF53D5890CEE2B

FASTA47050,911
        10         20         30         40         50         60 
MGRYSGKTCR LLFMLVLTAA FFVAELVSGY LGNSIALLSD SFNMLSDLIS LCVGLGSGYI 

        70         80         90        100        110        120 
ARRGPRGSSA TYGYVRAEVV GALSNAVFLT ALCFTIFVEA VLRLARPERI DDPELVLIVG 

       130        140        150        160        170        180 
ALGLAVNVVG LLIFQDCGAC FSRCTRGRRT RPSQQPSQGD PRGALGCPQE AATATAPGSG 

       190        200        210        220        230        240 
TAVTLRGSSA GRKQQEGATV FSNVAGDSLN TENEPEETTK KEKKSEALNI RGVLLHVMGD 

       250        260        270        280        290        300 
ALGSVVVVIT AIIFYVQPLR REDPCNWQCY IDPSLTVVMV IIILSSAFPL IKETAVILLQ 

       310        320        330        340        350        360 
MVPKGVNMEE LMSQLSTVPG ISSVHEVHIW ELISGKIIAT LHIKHQKGTE YQDASRKIRE 

       370        380        390        400        410        420 
IFHHAGIHNV TIQFETLDLK EALEQKDFLL TCSAPCITQS CAKKLCCPPG TLPLALVNGC 

       430        440        450        460        470 
AEHNGRSSRE SYRSIEAPEV AIDVDGCPRE QGQTLSKTQE RQHYENSTHF 

« Hide

Isoform 2 [UniParc].

Checksum: 01E92347C8F300F7
Show »

FASTA23325,934

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Diencephalon.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK136932 mRNA. Translation: BAE23176.1.
BC108419 mRNA. Translation: AAI08420.1.
RefSeqNP_001028458.1. NM_001033286.2.
UniGeneMm.227117.

3D structure databases

ProteinModelPortalQ3UVU3.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3UVU3.

Proteomic databases

PaxDbQ3UVU3.
PRIDEQ3UVU3.

Protocols and materials databases

DNASU226781.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061093; ENSMUSP00000053181; ENSMUSG00000026614. [Q3UVU3-1]
GeneID226781.
KEGGmmu:226781.
UCSCuc007dzk.1. mouse. [Q3UVU3-1]

Organism-specific databases

CTD55532.
MGIMGI:2685058. Slc30a10.

Phylogenomic databases

eggNOGCOG1230.
GeneTreeENSGT00550000074381.
HOGENOMHOG000166089.
HOVERGENHBG000588.
InParanoidQ3UVU3.
KOK14697.
OMAESYRSIE.
OrthoDBEOG7034GQ.
PhylomeDBQ3UVU3.
TreeFamTF313924.

Gene expression databases

BgeeQ3UVU3.
CleanExMM_SLC30A10.
GenevestigatorQ3UVU3.

Family and domain databases

Gene3D1.20.1510.10. 2 hits.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

NextBio378351.
PROQ3UVU3.
SOURCESearch...

Entry information

Entry nameZNT10_MOUSE
AccessionPrimary (citable) accession number: Q3UVU3
Secondary accession number(s): Q32NY2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot