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Protein

Delta-like protein

Gene

Jag1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Jag1Imported
ORF Names:mCG_128952Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1095416 Jag1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1068 – 1093HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501430923231 – 1218Delta-like proteinSequence analysisAdd BLAST1188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi187 ↔ 196PROSITE-ProRule annotation
Disulfide bondi200 ↔ 212PROSITE-ProRule annotation
Disulfide bondi220 ↔ 229PROSITE-ProRule annotation
Disulfide bondi253 ↔ 262PROSITE-ProRule annotation
Disulfide bondi324 ↔ 333PROSITE-ProRule annotation
Disulfide bondi362 ↔ 371PROSITE-ProRule annotation
Disulfide bondi400 ↔ 409PROSITE-ProRule annotation
Disulfide bondi438 ↔ 447PROSITE-ProRule annotation
Disulfide bondi454 ↔ 464PROSITE-ProRule annotation
Disulfide bondi475 ↔ 484PROSITE-ProRule annotation
Disulfide bondi513 ↔ 522PROSITE-ProRule annotation
Disulfide bondi551 ↔ 560PROSITE-ProRule annotation
Disulfide bondi617 ↔ 626PROSITE-ProRule annotation
Disulfide bondi655 ↔ 664PROSITE-ProRule annotation
Disulfide bondi693 ↔ 702PROSITE-ProRule annotation
Disulfide bondi731 ↔ 740PROSITE-ProRule annotation
Disulfide bondi770 ↔ 779PROSITE-ProRule annotation
Disulfide bondi808 ↔ 817PROSITE-ProRule annotation
Disulfide bondi846 ↔ 855PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRIDEiQ3UVN4

Expressioni

Gene expression databases

BgeeiENSMUSG00000027276
ExpressionAtlasiQ3UVN4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ3UVN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 229DSLInterPro annotationAdd BLAST45
Domaini230 – 263EGF-likeInterPro annotationAdd BLAST34
Domaini296 – 334EGF-likeInterPro annotationAdd BLAST39
Domaini336 – 372EGF-likeInterPro annotationAdd BLAST37
Domaini374 – 410EGF-likeInterPro annotationAdd BLAST37
Domaini412 – 448EGF-likeInterPro annotationAdd BLAST37
Domaini450 – 485EGF-likeInterPro annotationAdd BLAST36
Domaini487 – 523EGF-likeInterPro annotationAdd BLAST37
Domaini525 – 561EGF-likeInterPro annotationAdd BLAST37
Domaini586 – 627EGF-likeInterPro annotationAdd BLAST42
Domaini629 – 665EGF-likeInterPro annotationAdd BLAST37
Domaini667 – 703EGF-likeInterPro annotationAdd BLAST37
Domaini705 – 741EGF-likeInterPro annotationAdd BLAST37
Domaini744 – 780EGF-likeInterPro annotationAdd BLAST37
Domaini782 – 818EGF-likeInterPro annotationAdd BLAST37
Domaini820 – 856EGF-likeInterPro annotationAdd BLAST37

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
HOVERGENiHBG031645
KOiK06052
OMAiCLCETNW
OrthoDBiEOG091G0A88

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 11 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 4 hits

Sequencei

Sequence statusi: Complete.

Q3UVN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPRTRGRP GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ
60 70 80 90 100
NGNCCGGVRN PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP
110 120 130 140 150
VIGGNTFNLK ASRGNDRNRI VLPFSFAWPR SYTLLVEAWD SSNDTIQPDS
160 170 180 190 200
IIEKASHSGM INPSRQWQTL KQNTGIAHFE YQIRVTCDDH YYGFGCNKFC
210 220 230 240 250
RPRDDFFGHY ACDQNGNKTC MEGWMGPDCN KAICRQGCSP KHGSCKLPGD
260 270 280 290 300
CRCQYGWQGL YCDKCIPHPG CVHGTCNEPW QCLCETNWGG QLCDKDLNYC
310 320 330 340 350
GTHQPCLNRG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS
360 370 380 390 400
CKETSSGFEC ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC
410 420 430 440 450
PPQWTGKTCQ LDANECEAKP CVNARSCKNL IASYYCDCLP GWMGQNCDIN
460 470 480 490 500
INDCLGQCQN DASCRDLVNG YRCICPPGYA GDHCERDIDE CASNPCLNGG
510 520 530 540 550
HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC YNRASDYFCK
560 570 580 590 600
CPEDYEGKNC SHLKDHCRTT TCEVIDSCTV AMASNDTPEG VRYISSNVCG
610 620 630 640 650
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCKN GGTCIDGVNS
660 670 680 690 700
YKCICSDGWE GAHCENNIND CSQNPCHYGG TCRDLVNDFY CDCKNGWKGK
710 720 730 740 750
TCHSRDSQCD EATCNNGGTC YDEVDTFKCM CPGGWEGTTC NIARNSSCLP
760 770 780 790 800
NPCHNGGTCV VNGDSFTCVC KEGWEGPICT QNTNDCSPHP CYNSGTCVDG
810 820 830 840 850
DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN GYQCICPPGH
860 870 880 890 900
SGAKCHEVSG RSCITMGRVI LDGAKWDDDC NTCQCLNGRV ACSKVWCGPR
910 920 930 940 950
PCRLHKSHNE CPSGQSCIPV LDDQCFVRPC TGVGECRSSS LQPVKTKCTS
960 970 980 990 1000
DSYYQDNCAN ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI
1010 1020 1030 1040 1050
ACEPSLSANN EIHVAISAED IRDDGNPVKE ITDKIIDLVS KRDGNSSLIA
1060 1070 1080 1090 1100
AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA WVCCLVTAFY WCVRKRRKPS
1110 1120 1130 1140 1150
SHTHSAPEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE NKNSKMSKIR
1160 1170 1180 1190 1200
THNSEVEEDD MDKHQQKVRF AKQPVYTLVD REEKAPSGTP TKHPNWTNKQ
1210
DNRDLESAQS LNRMEYIV
Length:1,218
Mass (Da):134,164
Last modified:October 11, 2005 - v1
Checksum:i77739F8928BB793C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137092 mRNA Translation: BAE23235.1
CH466519 Genomic DNA Translation: EDL28396.1
RefSeqiNP_038850.1, NM_013822.5
UniGeneiMm.22398

Genome annotation databases

GeneIDi16449
KEGGimmu:16449

Similar proteinsi

Entry informationi

Entry nameiQ3UVN4_MOUSE
AccessioniPrimary (citable) accession number: Q3UVN4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health