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Protein

Leucine-rich repeat-containing G-protein coupled receptor 6

Gene

Lgr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-4641263. Regulation of FZD by ubiquitination.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing G-protein coupled receptor 6
Gene namesi
Name:Lgr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2441805. Lgr6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 567ExtracellularSequence analysisAdd BLAST543
Transmembranei568 – 588Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini589 – 598CytoplasmicSequence analysis10
Transmembranei599 – 619Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini620 – 644ExtracellularSequence analysisAdd BLAST25
Transmembranei645 – 665Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini666 – 687CytoplasmicSequence analysisAdd BLAST22
Transmembranei688 – 708Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini709 – 727ExtracellularSequence analysisAdd BLAST19
Transmembranei728 – 748Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini749 – 774CytoplasmicSequence analysisAdd BLAST26
Transmembranei775 – 795Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini796 – 809ExtracellularSequence analysisAdd BLAST14
Transmembranei810 – 830Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini831 – 967CytoplasmicSequence analysisAdd BLAST137

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000030388423 – 967Leucine-rich repeat-containing G-protein coupled receptor 6Add BLAST945

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi642 ↔ 717By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3UVD5.
PRIDEiQ3UVD5.

PTM databases

PhosphoSitePlusiQ3UVD5.

Expressioni

Tissue specificityi

Specifically expressed in multipotent stem cells in the epidermis.1 Publication

Developmental stagei

Expressed in the earliest embryonic hair placodes. In adult hair follicles, present in a region directly above the follicle bulge. Specifically present in prenatal cells establishing the hair follicle, sebaceous gland and interfollicular epidermis. Postnatally, present in cells generating sebaceous gland and interfollicular epidermis.1 Publication

Gene expression databases

BgeeiENSMUSG00000042793.
ExpressionAtlasiQ3UVD5. baseline and differential.
GenevisibleiQ3UVD5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3UVD5. 1 interactor.
STRINGi10090.ENSMUSP00000035444.

Structurei

3D structure databases

ProteinModelPortaliQ3UVD5.
SMRiQ3UVD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 66LRRNTAdd BLAST41
Repeati91 – 112LRR 1Add BLAST22
Repeati115 – 136LRR 2Add BLAST22
Repeati139 – 160LRR 3Add BLAST22
Repeati163 – 186LRR 4Add BLAST24
Repeati187 – 208LRR 5Add BLAST22
Repeati211 – 232LRR 6Add BLAST22
Repeati235 – 256LRR 7Add BLAST22
Repeati258 – 279LRR 8Add BLAST22
Repeati282 – 302LRR 9Add BLAST21
Repeati303 – 325LRR 10Add BLAST23
Repeati329 – 350LRR 11Add BLAST22
Repeati353 – 374LRR 12Add BLAST22
Repeati375 – 396LRR 13Add BLAST22
Repeati399 – 420LRR 14Add BLAST22
Repeati423 – 443LRR 15Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi503 – 506Poly-Glu4

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiQ3UVD5.
KOiK08399.
OMAiAFQFLPK.
OrthoDBiEOG091G0QA0.
PhylomeDBiQ3UVD5.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UVD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSPPGLLAL WLCAVLCASA RAGSDPQPGP GRPACPAPCH CQEDGIMLSA
60 70 80 90 100
DCSELGLSVV PADLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN
110 120 130 140 150
HLSHIPGQAF SGLHSLKILM LQSNQLRGIP AEALWELPSL QSLRLDANLI
160 170 180 190 200
SLVPERSFEG LSSLRHLWLD DNALTEIPVR ALNNLPALQA MTLALNHIRH
210 220 230 240 250
IPDYAFQNLT SLVVLHLHNN RIQHVGTHSF EGLHNLETLD LNYNELQEFP
260 270 280 290 300
LAIRTLGRLQ ELGFHNNNIK AIPEKAFMGS PLLQTIHFYD NPIQFVGRSA
310 320 330 340 350
FQYLSKLHTL SLNGATDIQE FPDLKGTTSL EILTLTRAGI RLLPPGVCQQ
360 370 380 390 400
LPRLRILELS HNQIEELPSL HRCQKLEEIG LRHNRIKEIG ADTFSQLGSL
410 420 430 440 450
QALDLSWNAI RAIHPEAFST LRSLVKLDLT DNQLTTLPLA GLGGLMHLKL
460 470 480 490 500
KGNLALSQAF SKDSFPKLRI LEVPYAYQCC AYGICASFFK TSGQWQAEDF
510 520 530 540 550
HPEEEEAPKR PLGLLAGQAE NHYDLDLDEL QMGTEDSKPH PSVQCSPVPG
560 570 580 590 600
PFKPCEHLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFASG PSPLSPVKLV
610 620 630 640 650
VGAMAGANAL SGISCGLLAS VDALTYGQFA EYGARWESGL GCQATGFLAV
660 670 680 690 700
LGSEASVLLL TLAAVQCSIS VTCVRAYGKA PSPGSVRAGA LGCLALAGLA
710 720 730 740 750
AALPLASVGE YGASPLCLPY APPEGRPAAL GFAVALVMMN SLCFLVVAGA
760 770 780 790 800
YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF ADGLLYCPVA FLSFASMLGL
810 820 830 840 850
FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR LWPSPRSPGP
860 870 880 890 900
LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGQPPG LETYGFPSVT
910 920 930 940 950
LISRHQPGAT RLEGNHFVES DGTKFGNPQP PMKGELLLKA EGATLAGCGS
960
SVGGALWPSG SLFASHL
Length:967
Mass (Da):104,267
Last modified:October 11, 2005 - v1
Checksum:i06FE0A7E7FA5083B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22A → G in AAI41211 (PubMed:15489334).Curated1
Sequence conflicti280S → N in AAI41211 (PubMed:15489334).Curated1
Sequence conflicti540H → N in AAH26896 (PubMed:15489334).Curated1
Sequence conflicti540H → N in AAI41211 (PubMed:15489334).Curated1
Sequence conflicti611S → T in AAH26896 (PubMed:15489334).Curated1
Sequence conflicti611S → T in AAI41211 (PubMed:15489334).Curated1
Sequence conflicti918V → I in AAH26896 (PubMed:15489334).Curated1
Sequence conflicti918V → I in AAI41211 (PubMed:15489334).Curated1
Sequence conflicti952V → M in AAH26896 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137380 mRNA. Translation: BAE23335.1.
GL456086 Genomic DNA. No translation available.
BC026896 mRNA. Translation: AAH26896.1.
BC141210 mRNA. Translation: AAI41211.1.
AY255562 mRNA. Translation: AAO85074.1.
CCDSiCCDS15314.1.
RefSeqiNP_001028581.1. NM_001033409.3.
UniGeneiMm.279594.

Genome annotation databases

EnsembliENSMUST00000044828; ENSMUSP00000035444; ENSMUSG00000042793.
GeneIDi329252.
KEGGimmu:329252.
UCSCiuc007csq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137380 mRNA. Translation: BAE23335.1.
GL456086 Genomic DNA. No translation available.
BC026896 mRNA. Translation: AAH26896.1.
BC141210 mRNA. Translation: AAI41211.1.
AY255562 mRNA. Translation: AAO85074.1.
CCDSiCCDS15314.1.
RefSeqiNP_001028581.1. NM_001033409.3.
UniGeneiMm.279594.

3D structure databases

ProteinModelPortaliQ3UVD5.
SMRiQ3UVD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UVD5. 1 interactor.
STRINGi10090.ENSMUSP00000035444.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ3UVD5.

Proteomic databases

PaxDbiQ3UVD5.
PRIDEiQ3UVD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044828; ENSMUSP00000035444; ENSMUSG00000042793.
GeneIDi329252.
KEGGimmu:329252.
UCSCiuc007csq.1. mouse.

Organism-specific databases

CTDi59352.
MGIiMGI:2441805. Lgr6.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiQ3UVD5.
KOiK08399.
OMAiAFQFLPK.
OrthoDBiEOG091G0QA0.
PhylomeDBiQ3UVD5.
TreeFamiTF316814.

Enzyme and pathway databases

ReactomeiR-MMU-4641263. Regulation of FZD by ubiquitination.

Miscellaneous databases

PROiQ3UVD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042793.
ExpressionAtlasiQ3UVD5. baseline and differential.
GenevisibleiQ3UVD5. MM.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLGR6_MOUSE
AccessioniPrimary (citable) accession number: Q3UVD5
Secondary accession number(s): B2RUL8, Q80UB8, Q8R301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.