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Protein

Leucine-rich repeat-containing G-protein coupled receptor 6

Gene

Lgr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-4641263. Regulation of FZD by ubiquitination.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing G-protein coupled receptor 6
Gene namesi
Name:Lgr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2441805. Lgr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 567543ExtracellularSequence analysisAdd
BLAST
Transmembranei568 – 58821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini589 – 59810CytoplasmicSequence analysis
Transmembranei599 – 61921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini620 – 64425ExtracellularSequence analysisAdd
BLAST
Transmembranei645 – 66521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini666 – 68722CytoplasmicSequence analysisAdd
BLAST
Transmembranei688 – 70821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini709 – 72719ExtracellularSequence analysisAdd
BLAST
Transmembranei728 – 74821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini749 – 77426CytoplasmicSequence analysisAdd
BLAST
Transmembranei775 – 79521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini796 – 80914ExtracellularSequence analysisAdd
BLAST
Transmembranei810 – 83021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini831 – 967137CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 967945Leucine-rich repeat-containing G-protein coupled receptor 6PRO_0000303884Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi642 ↔ 717By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ3UVD5.
MaxQBiQ3UVD5.
PaxDbiQ3UVD5.
PRIDEiQ3UVD5.

PTM databases

PhosphoSiteiQ3UVD5.

Expressioni

Tissue specificityi

Specifically expressed in multipotent stem cells in the epidermis.1 Publication

Developmental stagei

Expressed in the earliest embryonic hair placodes. In adult hair follicles, present in a region directly above the follicle bulge. Specifically present in prenatal cells establishing the hair follicle, sebaceous gland and interfollicular epidermis. Postnatally, present in cells generating sebaceous gland and interfollicular epidermis.1 Publication

Gene expression databases

BgeeiQ3UVD5.
ExpressionAtlasiQ3UVD5. baseline and differential.
GenevisibleiQ3UVD5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ3UVD5. 1 interaction.
STRINGi10090.ENSMUSP00000035444.

Structurei

3D structure databases

ProteinModelPortaliQ3UVD5.
SMRiQ3UVD5. Positions 34-558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6641LRRNTAdd
BLAST
Repeati91 – 11222LRR 1Add
BLAST
Repeati115 – 13622LRR 2Add
BLAST
Repeati139 – 16022LRR 3Add
BLAST
Repeati163 – 18624LRR 4Add
BLAST
Repeati187 – 20822LRR 5Add
BLAST
Repeati211 – 23222LRR 6Add
BLAST
Repeati235 – 25622LRR 7Add
BLAST
Repeati258 – 27922LRR 8Add
BLAST
Repeati282 – 30221LRR 9Add
BLAST
Repeati303 – 32523LRR 10Add
BLAST
Repeati329 – 35022LRR 11Add
BLAST
Repeati353 – 37422LRR 12Add
BLAST
Repeati375 – 39622LRR 13Add
BLAST
Repeati399 – 42022LRR 14Add
BLAST
Repeati423 – 44321LRR 15Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi503 – 5064Poly-Glu

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiQ3UVD5.
KOiK08399.
OMAiAFQFLPK.
OrthoDBiEOG7DNNTF.
PhylomeDBiQ3UVD5.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UVD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSPPGLLAL WLCAVLCASA RAGSDPQPGP GRPACPAPCH CQEDGIMLSA
60 70 80 90 100
DCSELGLSVV PADLDPLTAY LDLSMNNLTE LQPGLFHHLR FLEELRLSGN
110 120 130 140 150
HLSHIPGQAF SGLHSLKILM LQSNQLRGIP AEALWELPSL QSLRLDANLI
160 170 180 190 200
SLVPERSFEG LSSLRHLWLD DNALTEIPVR ALNNLPALQA MTLALNHIRH
210 220 230 240 250
IPDYAFQNLT SLVVLHLHNN RIQHVGTHSF EGLHNLETLD LNYNELQEFP
260 270 280 290 300
LAIRTLGRLQ ELGFHNNNIK AIPEKAFMGS PLLQTIHFYD NPIQFVGRSA
310 320 330 340 350
FQYLSKLHTL SLNGATDIQE FPDLKGTTSL EILTLTRAGI RLLPPGVCQQ
360 370 380 390 400
LPRLRILELS HNQIEELPSL HRCQKLEEIG LRHNRIKEIG ADTFSQLGSL
410 420 430 440 450
QALDLSWNAI RAIHPEAFST LRSLVKLDLT DNQLTTLPLA GLGGLMHLKL
460 470 480 490 500
KGNLALSQAF SKDSFPKLRI LEVPYAYQCC AYGICASFFK TSGQWQAEDF
510 520 530 540 550
HPEEEEAPKR PLGLLAGQAE NHYDLDLDEL QMGTEDSKPH PSVQCSPVPG
560 570 580 590 600
PFKPCEHLFE SWGIRLAVWA IVLLSVLCNG LVLLTVFASG PSPLSPVKLV
610 620 630 640 650
VGAMAGANAL SGISCGLLAS VDALTYGQFA EYGARWESGL GCQATGFLAV
660 670 680 690 700
LGSEASVLLL TLAAVQCSIS VTCVRAYGKA PSPGSVRAGA LGCLALAGLA
710 720 730 740 750
AALPLASVGE YGASPLCLPY APPEGRPAAL GFAVALVMMN SLCFLVVAGA
760 770 780 790 800
YIKLYCDLPR GDFEAVWDCA MVRHVAWLIF ADGLLYCPVA FLSFASMLGL
810 820 830 840 850
FPVTPEAVKS VLLVVLPLPA CLNPLLYLLF NPHFRDDLRR LWPSPRSPGP
860 870 880 890 900
LAYAAAGELE KSSCDSTQAL VAFSDVDLIL EASEAGQPPG LETYGFPSVT
910 920 930 940 950
LISRHQPGAT RLEGNHFVES DGTKFGNPQP PMKGELLLKA EGATLAGCGS
960
SVGGALWPSG SLFASHL
Length:967
Mass (Da):104,267
Last modified:October 11, 2005 - v1
Checksum:i06FE0A7E7FA5083B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221A → G in AAI41211 (PubMed:15489334).Curated
Sequence conflicti280 – 2801S → N in AAI41211 (PubMed:15489334).Curated
Sequence conflicti540 – 5401H → N in AAH26896 (PubMed:15489334).Curated
Sequence conflicti540 – 5401H → N in AAI41211 (PubMed:15489334).Curated
Sequence conflicti611 – 6111S → T in AAH26896 (PubMed:15489334).Curated
Sequence conflicti611 – 6111S → T in AAI41211 (PubMed:15489334).Curated
Sequence conflicti918 – 9181V → I in AAH26896 (PubMed:15489334).Curated
Sequence conflicti918 – 9181V → I in AAI41211 (PubMed:15489334).Curated
Sequence conflicti952 – 9521V → M in AAH26896 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137380 mRNA. Translation: BAE23335.1.
GL456086 Genomic DNA. No translation available.
BC026896 mRNA. Translation: AAH26896.1.
BC141210 mRNA. Translation: AAI41211.1.
AY255562 mRNA. Translation: AAO85074.1.
CCDSiCCDS15314.1.
RefSeqiNP_001028581.1. NM_001033409.3.
UniGeneiMm.279594.

Genome annotation databases

EnsembliENSMUST00000044828; ENSMUSP00000035444; ENSMUSG00000042793.
GeneIDi329252.
KEGGimmu:329252.
UCSCiuc007csq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137380 mRNA. Translation: BAE23335.1.
GL456086 Genomic DNA. No translation available.
BC026896 mRNA. Translation: AAH26896.1.
BC141210 mRNA. Translation: AAI41211.1.
AY255562 mRNA. Translation: AAO85074.1.
CCDSiCCDS15314.1.
RefSeqiNP_001028581.1. NM_001033409.3.
UniGeneiMm.279594.

3D structure databases

ProteinModelPortaliQ3UVD5.
SMRiQ3UVD5. Positions 34-558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UVD5. 1 interaction.
STRINGi10090.ENSMUSP00000035444.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ3UVD5.

Proteomic databases

EPDiQ3UVD5.
MaxQBiQ3UVD5.
PaxDbiQ3UVD5.
PRIDEiQ3UVD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044828; ENSMUSP00000035444; ENSMUSG00000042793.
GeneIDi329252.
KEGGimmu:329252.
UCSCiuc007csq.1. mouse.

Organism-specific databases

CTDi59352.
MGIiMGI:2441805. Lgr6.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
InParanoidiQ3UVD5.
KOiK08399.
OMAiAFQFLPK.
OrthoDBiEOG7DNNTF.
PhylomeDBiQ3UVD5.
TreeFamiTF316814.

Enzyme and pathway databases

ReactomeiR-MMU-4641263. Regulation of FZD by ubiquitination.

Miscellaneous databases

PROiQ3UVD5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UVD5.
ExpressionAtlasiQ3UVD5. baseline and differential.
GenevisibleiQ3UVD5. MM.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 14 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 748-909.
  5. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiLGR6_MOUSE
AccessioniPrimary (citable) accession number: Q3UVD5
Secondary accession number(s): B2RUL8, Q80UB8, Q8R301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.