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Protein

Integrin beta-2-like protein

Gene

Itgb2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-2-like protein
Alternative name(s):
Protein pactolus
Gene namesi
Name:Itgb2lImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1277979. Itgb2l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 671649ExtracellularSequence analysisAdd
BLAST
Transmembranei672 – 69221HelicalSequence analysisAdd
BLAST
Topological domaini693 – 73846CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: Ensembl
  • extracellular exosome Source: Ensembl
  • integrin alphaL-beta2 complex Source: Ensembl
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display normal neutrophil maturation and function including appropriate migration into sites of inflammation and response to bacterial infection. Following inflammatory stimulus in the peritoneal cavity, they display decreased levels of Cxcl13 due to the migration of resident Cxcl13-expressing macrophages from the peritoneal cavity during the inflammatory response.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 738716Integrin beta-2-like proteinPRO_0000278124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 419By similarity
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi33 ↔ 43By similarity
Disulfide bondi36 ↔ 73By similarity
Disulfide bondi46 ↔ 62By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi218 ↔ 258By similarity
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi358 ↔ 372By similarity
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi417 ↔ 421By similarity
Disulfide bondi439 ↔ 478By similarity
Disulfide bondi444 ↔ 453By similarity
Disulfide bondi455 ↔ 469By similarity
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi484 ↔ 489By similarity
Disulfide bondi486 ↔ 521By similarity
Disulfide bondi491 ↔ 506By similarity
Disulfide bondi508 ↔ 513By similarity
Disulfide bondi529 ↔ 534By similarity
Disulfide bondi531 ↔ 562By similarity
Disulfide bondi536 ↔ 545By similarity
Disulfide bondi547 ↔ 554By similarity
Disulfide bondi568 ↔ 573By similarity
Disulfide bondi575 ↔ 584By similarity
Disulfide bondi594 ↔ 603By similarity
Disulfide bondi600 ↔ 664By similarity
Glycosylationi627 – 6271N-linked (GlcNAc...)Sequence analysis
Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3UV74.
PaxDbiQ3UV74.
PRIDEiQ3UV74.

PTM databases

iPTMnetiQ3UV74.

Expressioni

Tissue specificityi

Expressed predominantly in maturing and mature neutrophils.1 Publication

Gene expression databases

BgeeiQ3UV74.
CleanExiMM_ITGB2L.
ExpressionAtlasiQ3UV74. baseline and differential.
GenevisibleiQ3UV74. MM.

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Unlike integrin beta chains, no alpha chain partner has yet been found.Curated2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000161.

Structurei

Secondary structure

1
738
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi127 – 1348Combined sources
Helixi137 – 1393Combined sources
Turni140 – 1423Combined sources
Helixi143 – 16018Combined sources
Beta strandi164 – 17411Combined sources
Beta strandi176 – 1849Combined sources
Helixi186 – 1949Combined sources
Beta strandi202 – 2065Combined sources
Helixi208 – 21710Combined sources
Helixi219 – 2224Combined sources
Beta strandi226 – 2349Combined sources
Helixi244 – 2485Combined sources
Beta strandi260 – 2656Combined sources
Helixi266 – 2694Combined sources
Helixi276 – 28611Combined sources
Beta strandi289 – 2957Combined sources
Helixi296 – 30813Combined sources
Beta strandi313 – 3197Combined sources
Helixi322 – 33312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IUENMR-A124-335[»]
ProteinModelPortaliQ3UV74.
SMRiQ3UV74. Positions 23-605.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3UV74.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 7451PSISequence analysisAdd
BLAST
Domaini126 – 329204VWFASequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the integrin beta chain family.Sequence analysis
Contains 1 PSI domain.Sequence analysis
Contains 1 VWFA domain.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiQ3UV74.
KOiK06464.
OrthoDBiEOG7T7GSB.
PhylomeDBiQ3UV74.
TreeFamiTF105392.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PfamiPF00362. Integrin_beta. 2 hits.
[Graphical view]
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 3 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q3UV74-1) [UniParc]FASTAAdd to basket

Also known as: A1 Publication

, Membrane-bound1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGQCTLLPV LAGLLSLESA LSQLCTKDNV STCQDCIRSG PSCAWCQKLN
60 70 80 90 100
FTGRGEPDSV RCDTPEQLLL KGCTSEYLVD PKSLAESQED KERDQRQLSP
110 120 130 140 150
RNVTVFLRPG QAATFKVDFQ RTQDNSVDLY FLMGLSGSAQ GHLSNVQTLG
160 170 180 190 200
SDLLKALNEI SRSGRIGFGS IVNMTFQHIL KLTADSSQFQ RELRKQLVSG
210 220 230 240 250
KLATPKGQLD AVVQVAICLG EIGWRNGTRF LVLVTDNDFH LAKDKTLGTR
260 270 280 290 300
QNTSDGRCHL DDGMYRSRGE PDYQSVVQLA SKLAENNIQP IFVVPSRMVK
310 320 330 340 350
TYEKLTTFIP KLTIGELSDD SSNVAQLIRN AYSKLSSIVV LNHSTIPSIL
360 370 380 390 400
KVTYDSYCSN GTSNPGKPSG DCSGVQINDQ VTFQVNITAS ECFREQFFFI
410 420 430 440 450
QALGFMDSVT VRVLPLCECQ CQEQSQHHSL CGGKGAMECG ICRCNSGYAG
460 470 480 490 500
KNCECQTQGP SSQDLEGSCR KDNSSIMCSG LGDCICGQCE CHTSDIPNKE
510 520 530 540 550
IYGQYCECNN VNCERYDGQV CGGPERGHCS CGRCFCRYGF VGSACQCRMS
560 570 580 590 600
TSGCLNNRMV ECSGHGRCYC NRCLCDPGYQ PPLCEKRPGY FHRCSEYYSC
610 620 630 640 650
ARCLKDNSAI KCRECWNLLF SNTPFSNKTC MTERDSEGCW TTYTLYQPDQ
660 670 680 690 700
SDINSIYIKE SLVCAEISNT TILLGVIVGV LLAVIFLLVY CMVYLKGTQK
710 720 730
AAKLPRKGGA QSTLAQQPHF QEPHHVEPVW NQERQGTQ
Length:738
Mass (Da):81,547
Last modified:October 11, 2005 - v1
Checksum:iCCAA3138FEFF0D5A
GO
Isoform 21 Publication (identifier: Q3UV74-2) [UniParc]FASTAAdd to basket

Also known as: B1 Publication

, Truncated1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     525-540: ERGHCSCGRCFCRYGF → ASWAQPASAGCPLQAV
     541-738: Missing.

Show »
Length:540
Mass (Da):58,892
Checksum:i73ADCB17A9533ED9
GO
Isoform 31 Publication (identifier: Q3UV74-3) [UniParc]FASTAAdd to basket

Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     432-490: GGKGAMECGI...LGDCICGQCE → LQEDESWQPR...GVQWPWSMLL
     491-738: Missing.

Show »
Length:490
Mass (Da):54,554
Checksum:iD6869101C85F9F75
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti509 – 5091N → D in AAC25502 (PubMed:9535848).Curated
Sequence conflicti509 – 5091N → D in AAI13143 (PubMed:15489334).Curated
Sequence conflicti710 – 7101A → V in AAC25502 (PubMed:9535848).Curated

Polymorphismi

Strain C57BL/6 preferentially expresses isoform 1 while strains BALB/c and C3H/HeJ preferentially express isoform 2. This is due to a single nucleotide difference at the second splice acceptor site in exon 13 which results in production of isoform 2 when this splice site is used in strains BALB/c and C3H/HeJ.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti539 – 5391G → S in strain: BALB/c and C3H/HeJ. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei432 – 49059GGKGA…CGQCE → LQEDESWQPRLFSRKRPLLL WPMLLSLQLRGLSLPVPDVH FRLSEQQDGGVQWPWSMLL in isoform 3. 1 PublicationVSP_052319Add
BLAST
Alternative sequencei491 – 738248Missing in isoform 3. 1 PublicationVSP_052320Add
BLAST
Alternative sequencei525 – 54016ERGHC…CRYGF → ASWAQPASAGCPLQAV in isoform 2. 1 PublicationVSP_052321Add
BLAST
Alternative sequencei541 – 738198Missing in isoform 2. 1 PublicationVSP_052322Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051367 mRNA. Translation: AAC25502.1.
AK137534 mRNA. Translation: BAE23399.1.
BC113142 mRNA. Translation: AAI13143.1.
CCDSiCCDS28358.1. [Q3UV74-1]
RefSeqiNP_032431.2. NM_008405.3. [Q3UV74-1]
UniGeneiMm.12872.

Genome annotation databases

EnsembliENSMUST00000000161; ENSMUSP00000000161; ENSMUSG00000000157. [Q3UV74-1]
ENSMUST00000131567; ENSMUSP00000114497; ENSMUSG00000000157. [Q3UV74-2]
GeneIDi16415.
KEGGimmu:16415.
UCSCiuc008adb.1. mouse. [Q3UV74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051367 mRNA. Translation: AAC25502.1.
AK137534 mRNA. Translation: BAE23399.1.
BC113142 mRNA. Translation: AAI13143.1.
CCDSiCCDS28358.1. [Q3UV74-1]
RefSeqiNP_032431.2. NM_008405.3. [Q3UV74-1]
UniGeneiMm.12872.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IUENMR-A124-335[»]
ProteinModelPortaliQ3UV74.
SMRiQ3UV74. Positions 23-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000161.

PTM databases

iPTMnetiQ3UV74.

Proteomic databases

MaxQBiQ3UV74.
PaxDbiQ3UV74.
PRIDEiQ3UV74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000161; ENSMUSP00000000161; ENSMUSG00000000157. [Q3UV74-1]
ENSMUST00000131567; ENSMUSP00000114497; ENSMUSG00000000157. [Q3UV74-2]
GeneIDi16415.
KEGGimmu:16415.
UCSCiuc008adb.1. mouse. [Q3UV74-1]

Organism-specific databases

CTDi16415.
MGIiMGI:1277979. Itgb2l.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiQ3UV74.
KOiK06464.
OrthoDBiEOG7T7GSB.
PhylomeDBiQ3UV74.
TreeFamiTF105392.

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.

Miscellaneous databases

EvolutionaryTraceiQ3UV74.
PROiQ3UV74.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UV74.
CleanExiMM_ITGB2L.
ExpressionAtlasiQ3UV74. baseline and differential.
GenevisibleiQ3UV74. MM.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR015812. Integrin_bsu.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR032695. Integrin_dom.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PfamiPF00362. Integrin_beta. 2 hits.
[Graphical view]
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 3 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow."
    Chen Y., Garrison S., Weis J.J., Weis J.H.
    J. Biol. Chem. 273:8711-8718(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION.
    Strain: Swiss Webster / NIHImported.
    Tissue: Bone marrowImported.
  2. "Genomic organization, chromosomal localization, and transcriptional variants of the murine Pactolus gene."
    Margraf R.L., Chen Y., Garrison S., Weis J.J., Weis J.H.
    Mamm. Genome 10:1075-1081(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Strain: 129/Sv1 Publication.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6JImported.
    Tissue: BoneImported.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Functional characterization of pactolus, a beta-integrin-like protein preferentially expressed by neutrophils."
    Garrison S., Hojgaard A., Patillo D., Weis J.J., Weis J.H.
    J. Biol. Chem. 276:35500-35511(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, POLYMORPHISM, VARIANT SER-539.
  6. "Surface translocation of pactolus is induced by cell activation and death, but is not required for neutrophil migration and function."
    Garrison S., Hojgaard A., Margraf R., Weis J.J., Weis J.H.
    J. Immunol. 171:6795-6806(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  7. "Altered localization of CXCL13 expressing cells in mice deficient in pactolus following an inflammatory stimulus."
    Hojgaard A., Close R., Dunn D.M., Weiss R.B., Weis J.J., Weis J.H.
    Immunology 119:212-223(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  8. "Pactolus I-domain: functional switching of the Rossmann fold."
    Sen M., Legge G.B.
    Proteins 68:626-635(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 124-335, SUBUNIT.

Entry informationi

Entry nameiITB2L_MOUSE
AccessioniPrimary (citable) accession number: Q3UV74
Secondary accession number(s): O88424, Q2KHL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2005
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The human orthologous protein seems not to exist.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.