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Q3UV55

- NR1D1_MOUSE

UniProt

Q3UV55 - NR1D1_MOUSE

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Protein

Nuclear receptor subfamily 1 group D member 1

Gene
Nr1d1, Ear1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner.17 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei419 – 4191Heme By similarity
Binding sitei603 – 6031Heme By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi130 – 20677Nuclear receptorAdd
BLAST
Zinc fingeri133 – 15321NR C4-typeAdd
BLAST
Zinc fingeri170 – 19425NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. DNA binding Source: MGI
  3. heme binding Source: Ensembl
  4. protein binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. steroid hormone receptor activity Source: InterPro
  7. transcription corepressor binding Source: UniProtKB
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. circadian regulation of gene expression Source: UniProtKB
  4. circadian rhythm Source: UniProtKB
  5. circadian temperature homeostasis Source: UniProtKB
  6. glycogen biosynthetic process Source: UniProtKB
  7. negative regulation of receptor biosynthetic process Source: Ensembl
  8. negative regulation of toll-like receptor 4 signaling pathway Source: Ensembl
  9. negative regulation of transcription, DNA-templated Source: UniProtKB
  10. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. positive regulation of bile acid biosynthetic process Source: UniProtKB
  12. positive regulation of transcription, DNA-templated Source: UniProtKB
  13. proteasomal protein catabolic process Source: UniProtKB
  14. regulation of cholesterol homeostasis Source: UniProtKB
  15. regulation of circadian rhythm Source: UniProtKB
  16. regulation of fat cell differentiation Source: UniProtKB
  17. regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  18. regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  19. regulation of lipid metabolic process Source: UniProtKB
  20. regulation of transcription, DNA-templated Source: MGI
  21. regulation of type B pancreatic cell proliferation Source: UniProtKB
  22. response to leptin Source: UniProtKB
  23. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor, Repressor

Keywords - Biological processi

Biological rhythms, Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Heme, Iron, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_118837. Rora activates circadian gene expression.
REACT_198351. RORA activates circadian gene expression.
REACT_198352. REV-ERBA represses gene expression.
REACT_198602. PPARA activates gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_24972. Circadian Clock.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 1 group D member 1
Alternative name(s):
Rev-erbA-alpha
V-erbA-related protein 1
Short name:
EAR-1
Gene namesi
Name:Nr1d1
Synonyms:Ear1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2444210. Nr1d1.

Subcellular locationi

Nucleus. Cytoplasm. Cell projectiondendrite. Cell projectiondendritic spine
Note: Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. dendrite Source: UniProtKB
  3. dendritic spine Source: UniProtKB
  4. nuclear chromatin Source: Ensembl
  5. nucleoplasm Source: Reactome
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display increased cold tolerance, higher oxygen consumption rates, enhanced brown adipose tissue metabolic capacity, maintenance of higher body temperature throughout the light phase and increased glucose uptake only during the day. They also show retinal abnormalities such as pan-retinal spotting and decreased response to light and decreased bile acid accumulation. Double knockout for NR1D1 and PER2 show a significantly shorter period length compared with wild type or single knockouts for both genes. 50% of double knockouts animals show a stable circadian throughout at least 5 weeks in constant darckness. The other 50% of animals lose their circadian rhythmicity when held in constant darkness for an average of 21 days. Animals have blunted steady-state levels of glycogen in the liver in spite of normal patterns of food consumption.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi456 – 4561K → A: Reduces interaction with PER2 by 60%. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Nuclear receptor subfamily 1 group D member 1PRO_0000311182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551Phosphoserine; by GSK3-beta By similarity
Modified residuei59 – 591Phosphoserine; by GSK3-beta By similarity
Modified residuei192 – 1921N6-acetyllysine; by KAT5 By similarity
Modified residuei193 – 1931N6-acetyllysine; by KAT5 By similarity

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3UV55.
PRIDEiQ3UV55.

PTM databases

PhosphoSiteiQ3UV55.

Expressioni

Tissue specificityi

Expressed during adipocyte differentiation (at protein level). Expressed in skeletal muscle, bladder, lumbar spinal cord, pancreatic islets and hypothalamus. Expressed in developing and adult retina. In the adult retina, predominantly expressed in the outer nuclear layer, where rod and cone cells reside, and also localized to the ganglion cell layer.7 Publications

Developmental stagei

During development at embryonic day E18.5, expressed in the outer neuroblastic layer of the retina where developing postmitotic photoreceptors and retinal progenitors reside (at protein level).1 Publication

Inductioni

Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. In bladder smooth muscle cells, pancreas and lumbar spinal cord, exhibits night/day variations with a peak time at circadian time (CT) 4-12 and a trough at CT16-24.4 Publications

Gene expression databases

BgeeiQ3UV55.
CleanExiMM_NR1D1.
GenevestigatoriQ3UV55.

Interactioni

Subunit structurei

Binds DNA as a monomer or a homodimer. Interacts with NR2E3 and ZNHIT1. Interacts with C1D and SP1. Interacts with OPHN1 (via C-terminus). Interacts with PER2; the interaction associates PER2 to ARNTL promoter region. Interacts with CRY1.5 Publications

Protein-protein interaction databases

BioGridi229856. 1 interaction.
DIPiDIP-59440N.

Structurei

3D structure databases

ProteinModelPortaliQ3UV55.
SMRiQ3UV55. Positions 128-614.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 129129ModulatingAdd
BLAST
Regioni49 – 285237Crucial for activation of GJA1Add
BLAST
Regioni207 – 28579HingeAdd
BLAST
Regioni286 – 615330Ligand-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 9416Poly-SerAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri133 – 15321NR C4-typeAdd
BLAST
Zinc fingeri170 – 19425NR C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG324222.
GeneTreeiENSGT00740000114909.
HOGENOMiHOG000261691.
HOVERGENiHBG106790.
InParanoidiQ3UV55.
KOiK03728.
OMAiGTSPGNF.
OrthoDBiEOG776SQ0.
PhylomeDBiQ3UV55.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UV55-1 [UniParc]FASTAAdd to Basket

« Hide

MTTLDSNNNT GGVITYIGSS GSSPSRTSPE SLYSDSSNGS FQSLTQGCPT    50
YFPPSPTGSL TQDPARSFGS APPSLSDDSS PSSASSSSSS SSSSFYNGSP 100
PGSLQVAMED SSRVSPSKGT SNITKLNGMV LLCKVCGDVA SGFHYGVHAC 150
EGCKGFFRRS IQQNIQYKRC LKNENCSIVR INRNRCQQCR FKKCLSVGMS 200
RDAVRFGRIP KREKQRMLAE MQSAMNLANN QLSSLCPLET SPTPHPTSGS 250
MGPSPPPAPA PTPLVGFSQF PQQLTPPRSP SPEPTMEDVI SQVARAHREI 300
FTYAHDKLGT SPGNFNANHA SGSPSATTPH RWESQGCPSA PNDNNLLAAQ 350
RHNEALNGLR QGPSSYPPTW PSGPTHHSCH QPNSNGHRLC PTHVYSAPEG 400
EAPANSLRQG NTKNVLLACP MNMYPHGRSG RTVQEIWEDF SMSFTPAVRE 450
VVEFAKHIPG FRDLSQHDQV TLLKAGTFEV LMVRFASLFN VKDQTVMFLS 500
RTTYSLQELG AMGMGDLLNA MFDFSEKLNS LALTEEELGL FTAVVLVSAD 550
RSGMENSASV EQLQETLLRA LRALVLKNRP SETSRFTKLL LKLPDLRTLN 600
NMHSEKLLSF RVDAQ 615
Length:615
Mass (Da):66,802
Last modified:October 11, 2005 - v1
Checksum:iFFEC491B616BB326
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361S → R in CAA59997. 1 Publication
Sequence conflicti40 – 401S → R in CAA59997. 1 Publication
Sequence conflicti84 – 841A → T in BAE27164. 1 Publication
Sequence conflicti84 – 841A → T in AAH08989. 1 Publication
Sequence conflicti440 – 4401F → L in BAE27164. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK137398 mRNA. Translation: BAE23342.1.
AK137582 mRNA. Translation: BAE23418.1.
AK146430 mRNA. Translation: BAE27164.1.
AK154931 mRNA. Translation: BAE32932.1.
AK155597 mRNA. Translation: BAE33339.1.
AL590963 Genomic DNA. Translation: CAM46187.1.
BC008989 mRNA. Translation: AAH08989.1.
AF291821 mRNA. Translation: AAG01345.1.
X86010 mRNA. Translation: CAA59997.1.
AY336125 Genomic DNA. Translation: AAS48348.1.
CCDSiCCDS25363.1.
PIRiS52813.
RefSeqiNP_663409.2. NM_145434.4.
UniGeneiMm.390397.

Genome annotation databases

EnsembliENSMUST00000064941; ENSMUSP00000069505; ENSMUSG00000020889.
GeneIDi217166.
KEGGimmu:217166.
UCSCiuc007lhh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK137398 mRNA. Translation: BAE23342.1 .
AK137582 mRNA. Translation: BAE23418.1 .
AK146430 mRNA. Translation: BAE27164.1 .
AK154931 mRNA. Translation: BAE32932.1 .
AK155597 mRNA. Translation: BAE33339.1 .
AL590963 Genomic DNA. Translation: CAM46187.1 .
BC008989 mRNA. Translation: AAH08989.1 .
AF291821 mRNA. Translation: AAG01345.1 .
X86010 mRNA. Translation: CAA59997.1 .
AY336125 Genomic DNA. Translation: AAS48348.1 .
CCDSi CCDS25363.1.
PIRi S52813.
RefSeqi NP_663409.2. NM_145434.4.
UniGenei Mm.390397.

3D structure databases

ProteinModelPortali Q3UV55.
SMRi Q3UV55. Positions 128-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229856. 1 interaction.
DIPi DIP-59440N.

PTM databases

PhosphoSitei Q3UV55.

Proteomic databases

PaxDbi Q3UV55.
PRIDEi Q3UV55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064941 ; ENSMUSP00000069505 ; ENSMUSG00000020889 .
GeneIDi 217166.
KEGGi mmu:217166.
UCSCi uc007lhh.1. mouse.

Organism-specific databases

CTDi 9572.
MGIi MGI:2444210. Nr1d1.

Phylogenomic databases

eggNOGi NOG324222.
GeneTreei ENSGT00740000114909.
HOGENOMi HOG000261691.
HOVERGENi HBG106790.
InParanoidi Q3UV55.
KOi K03728.
OMAi GTSPGNF.
OrthoDBi EOG776SQ0.
PhylomeDBi Q3UV55.
TreeFami TF328382.

Enzyme and pathway databases

Reactomei REACT_118837. Rora activates circadian gene expression.
REACT_198351. RORA activates circadian gene expression.
REACT_198352. REV-ERBA represses gene expression.
REACT_198602. PPARA activates gene expression.
REACT_198620. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
REACT_24972. Circadian Clock.

Miscellaneous databases

NextBioi 375617.
PROi Q3UV55.
SOURCEi Search...

Gene expression databases

Bgeei Q3UV55.
CleanExi MM_NR1D1.
Genevestigatori Q3UV55.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J, DBA/2 and NOD.
    Tissue: Bone and Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Sadek M.M., Chen Y., Elbrecht A.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-186.
    Strain: BALB/c.
    Tissue: Liver.
  5. Chomez P., Vennstrom B.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-55.
    Strain: BALB/c.
    Tissue: Skeletal muscle.
  6. "The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker."
    Triqueneaux G., Thenot S., Kakizawa T., Antoch M.P., Safi R., Takahashi J.S., Delaunay F., Laudet V.
    J. Mol. Endocrinol. 33:585-608(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
    Strain: C57BL/6N.
  7. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
    Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
    Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C1D.
  8. "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
    Curtis A.M., Seo S.B., Westgate E.J., Rudic R.D., Smyth E.M., Chakravarti D., FitzGerald G.A., McNamara P.
    J. Biol. Chem. 279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  9. Cited for: FUNCTION.
  10. "Bifunctional role of Rev-erbalpha in adipocyte differentiation."
    Wang J., Lazar M.A.
    Mol. Cell. Biol. 28:2213-2220(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, PROTEASOMAL DEGRADATION.
  11. "Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms."
    Liu A.C., Tran H.G., Zhang E.E., Priest A.A., Welsh D.K., Kay S.A.
    PLoS Genet. 4:E1000023-E1000023(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha."
    Wu N., Yin L., Hanniman E.A., Joshi S., Lazar M.A.
    Genes Dev. 23:2201-2209(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis."
    Le Martelot G., Claudel T., Gatfield D., Schaad O., Kornmann B., Lo Sasso G., Moschetta A., Schibler U.
    PLoS Biol. 7:E1000181-E1000181(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
    Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
    Genes Dev. 24:345-357(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH PER2, DISRUPTION PHENOTYPE, MUTAGENESIS OF LYS-456.
  15. "A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha."
    Valnegri P., Khelfaoui M., Dorseuil O., Bassani S., Lagneaux C., Gianfelice A., Benfante R., Chelly J., Billuart P., Sala C., Passafaro M.
    Nat. Neurosci. 14:1293-1301(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH OPHN1, PROTEASOMAL DEGRADATION, TISSUE SPECIFICITY.
  16. "Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
    Lamia K.A., Papp S.J., Yu R.T., Barish G.D., Uhlenhaut N.H., Jonker J.W., Downes M., Evans R.M.
    Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PER2.
  17. "Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina."
    Mollema N.J., Yuan Y., Jelcick A.S., Sachs A.J., von Alpen D., Schorderet D., Escher P., Haider N.B.
    PLoS ONE 6:E17494-E17494(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  18. "The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet."
    Vieira E., Marroqui L., Batista T.M., Caballero-Garrido E., Carneiro E.M., Boschero A.C., Nadal A., Quesada I.
    Endocrinology 153:592-601(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  19. "Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function."
    Bugge A., Feng D., Everett L.J., Briggs E.R., Mullican S.E., Wang F., Jager J., Lazar M.A.
    Genes Dev. 26:657-667(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm."
    Negoro H., Kanematsu A., Doi M., Suadicani S.O., Matsuo M., Imamura M., Okinami T., Nishikawa N., Oura T., Matsui S., Seo K., Tainaka M., Urabe S., Kiyokage E., Todo T., Okamura H., Tabata Y., Ogawa O.
    Nat. Commun. 3:809-809(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SP1, INDUCTION.
  21. "The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines."
    Gibbs J.E., Blaikley J., Beesley S., Matthews L., Simpson K.D., Boyce S.H., Farrow S.N., Else K.J., Singh D., Ray D.W., Loudon A.S.
    Proc. Natl. Acad. Sci. U.S.A. 109:582-587(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  22. "High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice."
    Barclay J.L., Shostak A., Leliavski A., Tsang A.H., Johren O., Muller-Fielitz H., Landgraf D., Naujokat N., van der Horst G.T., Oster H.
    Am. J. Physiol. 304:E1053-E1063(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  23. "Role of Rev-erbalpha domains for transactivation of the connexin43 promoter with Sp1."
    Negoro H., Okinami T., Kanematsu A., Imamura M., Tabata Y., Ogawa O.
    FEBS Lett. 587:98-103(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  24. "Transcription factor NF-Y is a functional regulator of the transcription of core clock gene Bmal1."
    Xiao J., Zhou Y., Lai H., Lei S., Chi L.H., Mo X.
    J. Biol. Chem. 288:31930-31936(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  25. "Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy."
    Woldt E., Sebti Y., Solt L.A., Duhem C., Lancel S., Eeckhoute J., Hesselink M.K., Paquet C., Delhaye S., Shin Y., Kamenecka T.M., Schaart G., Lefebvre P., Neviere R., Burris T.P., Schrauwen P., Staels B., Duez H.
    Nat. Med. 19:1039-1046(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  26. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  27. Cited for: FUNCTION.
  28. "Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells."
    Vieira E., Marroqui L., Figueroa A.L., Merino B., Fernandez-Ruiz R., Nadal A., Burris T.P., Gomis R., Quesada I.
    PLoS ONE 8:E69939-E69939(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  29. "Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice."
    Noh J.Y., Han D.H., Kim M.H., Ko I.G., Kim S.E., Park N., Kyoung Choe H., Kim K.H., Kim K., Kim C.J., Cho S.
    Exp. Mol. Med. 46:E81-E81(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNR1D1_MOUSE
AccessioniPrimary (citable) accession number: Q3UV55
Secondary accession number(s): Q3UJJ1
, Q62171, Q6EEZ6, Q922A5, Q9ESY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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