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Protein
Submitted name:

Uncharacterized protein

Gene

Adcy8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:Adcy8Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1341110. Adcy8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei181 – 200HelicalSequence analysisAdd BLAST20
Transmembranei212 – 230HelicalSequence analysisAdd BLAST19
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Transmembranei268 – 285HelicalSequence analysisAdd BLAST18
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei714 – 731HelicalSequence analysisAdd BLAST18
Transmembranei737 – 759HelicalSequence analysisAdd BLAST23
Transmembranei780 – 796HelicalSequence analysisAdd BLAST17
Transmembranei828 – 848HelicalSequence analysisAdd BLAST21
Transmembranei868 – 884HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ3UUN2.
PaxDbiQ3UUN2.
PeptideAtlasiQ3UUN2.
PRIDEiQ3UUN2.

Expressioni

Gene expression databases

GenevisibleiQ3UUN2. MM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini412 – 539Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini950 – 1090Guanylate cyclaseInterPro annotationAdd BLAST141

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili898 – 921Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
HOVERGENiHBG050458.
KOiK08048.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiView protein in InterPro
IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR032628. AC_N.
IPR030672. Adcy.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
PfamiView protein in Pfam
PF16214. AC_N. 1 hit.
PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
PIRSFiPIRSF039050. Ade_cyc. 2 hits.
SMARTiView protein in SMART
SM00044. CYCc. 2 hits.
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiView protein in PROSITE
PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

Q3UUN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSDVHCLS GSEELYTIQP TPPAGDDGSG SRPQRLLWQT AVRHITEQRF
60 70 80 90 100
IHGHRGGGGG GVSRKASNPA GSGPNHHAPQ LSSDSVLPLY SLGPGERAHN
110 120 130 140 150
TGGTKVFPER SGSGSASGSG GGGDLGFLHL DCAPSNSDFF LNGGYSYRGV
160 170 180 190 200
IFPTLRNSFK SRDLERLYQR YFLGQRRKSE VVMNVLDVLT KLTLLVLHLS
210 220 230 240 250
LASAPMDPLK GILLGFFTGI EVVICALVVV RKDNTSHTYL QYSGVVTWVA
260 270 280 290 300
MTTQILAAGL GYGLLGDGIG YVLFTLFATY SMLPLPLTWA ILAGLGTSLL
310 320 330 340 350
QVTLQVLIPR LAVFSINQVL AQVVLFMCMN TAGIFISYLS DRAQRQAFLE
360 370 380 390 400
TRRCVEARLR LETENQRQER LVLSVLPRFV VLEMINDMTN VEDEHLQHQF
410 420 430 440 450
HRIYIHRYEN VSILFADVKG FTNLSTTLSA QELVRMLNEL FARFDRLAHE
460 470 480 490 500
HHCLRIKILG DCYYCVSGLP EPRRDHAHCC VEMGLSMIKT IRFVRSRTKH
510 520 530 540 550
DVDMRIGIHS GSVLCGVLGL RKWQFDVWSW DVDIANKLES GGIPGRIHIS
560 570 580 590 600
KATLDCLNGD YNVEEGHGKE RNEFLRKHNI ETYLIKQPEE SLLCLPEDIV
610 620 630 640 650
KESVSCSDRR NSGATFTEGS WSPELPFDNI VGKQNTLAAL TRNSINLLPN
660 670 680 690 700
HLAQALHVQS GPEEINKRIE HTIDLRSGDK LRREHIKPFS LMFKDSSLEH
710 720 730 740 750
KYSQMRDEVF KSNLVCAFIV LLFITAIQSL LPSSRLMPMT IQFSILIMLH
760 770 780 790 800
SALVLITTAE DYKCLPLILR KTCCWINETY LARNVIIFAS ILINFLGAVL
810 820 830 840 850
NIYFVFTGVL AMVTCAVFLR LNSVLKLAVL LIMIAIYALL TETIYAGLFL
860 870 880 890 900
SYDNLNHSGE DFLGTKEASL LLMAMFLLAV FYHGQQLEYT ARLDFLWRVQ
910 920 930 940 950
AKEEINEMKE LREHNENMLR NILPSHVARH FLEKDRDNEE LYSQSYDAVG
960 970 980 990 1000
VMFASIPGFA DFYSQTEMNN QGVECLRLLN EIIADFDELL GEDRFQDIEK
1010 1020 1030 1040 1050
IKTIGSTYMA VSGLSPEKQQ CEDKWGHLCA LADFSLALTE SIQEINKHSF
1060 1070 1080 1090 1100
NNFELRIGIS HGSVVAGVIG AKKPQYDIWG KTVNLASRMD STGVSGRIQV
1110 1120
PEETYLILKD QGFAFDYRGE IYVKGIS
Length:1,127
Mass (Da):126,469
Last modified:October 11, 2005 - v1
Checksum:iC541A9C8DD80688D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1127Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138244 mRNA. Translation: BAE23593.1.
RefSeqiNP_001278832.1. NM_001291903.1.
NP_033753.2. NM_009623.2.
UniGeneiMm.1425.

Genome annotation databases

GeneIDi11514.
KEGGimmu:11514.

Similar proteinsi

Entry informationi

Entry nameiQ3UUN2_MOUSE
AccessioniPrimary (citable) accession number: Q3UUN2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)