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Protein

STE20-related kinase adapter protein alpha

Gene

Strada

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiR-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-related kinase adapter protein alpha
Short name:
STRAD alpha
Alternative name(s):
STE20-related adapter protein
Gene namesi
Name:Strada
Synonyms:Lyk5, Strad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919399. Strada.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600371 – 431STE20-related kinase adapter protein alphaAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei419Phosphothreonine; by LKB1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UUJ4.
PeptideAtlasiQ3UUJ4.
PRIDEiQ3UUJ4.

PTM databases

iPTMnetiQ3UUJ4.
PhosphoSitePlusiQ3UUJ4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069631.
CleanExiMM_2610019A05RIK.
ExpressionAtlasiQ3UUJ4. baseline and differential.
GenevisibleiQ3UUJ4. MM.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UUJ4. 2 interactors.
MINTiMINT-4126430.
STRINGi10090.ENSMUSP00000007444.

Structurei

3D structure databases

ProteinModelPortaliQ3UUJ4.
SMRiQ3UUJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 379Protein kinasePROSITE-ProRule annotationAdd BLAST311

Domaini

The protein kinase domain is predicted to be catalytically inactive.Sequence analysis

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
GeneTreeiENSGT00860000133680.
HOGENOMiHOG000237355.
HOVERGENiHBG055069.
InParanoidiQ3UUJ4.
KOiK08271.
OMAiQEIMSSF.
OrthoDBiEOG091G0E7D.
PhylomeDBiQ3UUJ4.
TreeFamiTF319817.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q3UUJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLVSKPER IRRWVSEKFI VEGLRDLELF GEQPPGDTRR KANEASSESI
60 70 80 90 100
ASFSKPEMMS SFLPEGGCYE LLTIIGKGFE DLMTVNLARY KPTGEYVTVR
110 120 130 140 150
RINLEACSNE MVTFLQGELH VSKLFSHPNI VPYRATFIAD NELWVVTSFM
160 170 180 190 200
AYGSAKDLIG THFMDGMNEL AIAYILQGVL KALDYIHHMG YVHRSVKASH
210 220 230 240 250
ILISTDGKVY LSGLRSNLSM ISHGQRQRAV HDFPKYSIKV LPWLSPEVLQ
260 270 280 290 300
QNLQGYDAKS DIYSVGITAC ELANGHVPFK DMPATQMLLE KLNGTVPCLL
310 320 330 340 350
DTSTIPAEEL TMSPSRSIAN PGLNDSLAAG SLRPSNGDSP SHPYHRTFSP
360 370 380 390 400
HFHNFVEQCL QRNPDARPNA STLLNHSFFK QIKRRASEAL PELLRPVTPI
410 420 430
TNFEGSQSQD HSGIFGLVTN LEDLEVDDWE F
Length:431
Mass (Da):48,236
Last modified:October 11, 2005 - v1
Checksum:i6E4B14CC9B2B1D7D
GO
Isoform 21 Publication (identifier: Q3UUJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-41: Missing.
     370-381: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:382
Mass (Da):42,454
Checksum:i9EFCD966627136AA
GO
Isoform 32 Publications (identifier: Q3UUJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-41: Missing.

Show »
Length:394
Mass (Da):43,829
Checksum:iC743BFE801ADDB8D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0522175 – 41Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST37
Alternative sequenceiVSP_052218370 – 381Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341872 mRNA. Translation: AAQ24157.1.
AY341878 mRNA. Translation: AAQ24162.1.
AK011451 mRNA. Translation: BAB27626.1.
AK138358 mRNA. Translation: BAE23631.1.
BC058517 mRNA. Translation: AAH58517.1.
CCDSiCCDS25550.1. [Q3UUJ4-3]
CCDS56816.1. [Q3UUJ4-1]
RefSeqiNP_001239377.1. NM_001252448.1. [Q3UUJ4-1]
NP_001239378.1. NM_001252449.1. [Q3UUJ4-2]
NP_082402.1. NM_028126.3. [Q3UUJ4-3]
XP_006534358.1. XM_006534295.1. [Q3UUJ4-3]
XP_011247572.1. XM_011249270.1. [Q3UUJ4-1]
UniGeneiMm.403722.

Genome annotation databases

EnsembliENSMUST00000007444; ENSMUSP00000007444; ENSMUSG00000069631. [Q3UUJ4-1]
ENSMUST00000103072; ENSMUSP00000099361; ENSMUSG00000069631. [Q3UUJ4-3]
GeneIDi72149.
KEGGimmu:72149.
UCSCiuc007lyf.2. mouse. [Q3UUJ4-3]
uc007lyg.2. mouse. [Q3UUJ4-1]
uc011ygi.2. mouse. [Q3UUJ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341872 mRNA. Translation: AAQ24157.1.
AY341878 mRNA. Translation: AAQ24162.1.
AK011451 mRNA. Translation: BAB27626.1.
AK138358 mRNA. Translation: BAE23631.1.
BC058517 mRNA. Translation: AAH58517.1.
CCDSiCCDS25550.1. [Q3UUJ4-3]
CCDS56816.1. [Q3UUJ4-1]
RefSeqiNP_001239377.1. NM_001252448.1. [Q3UUJ4-1]
NP_001239378.1. NM_001252449.1. [Q3UUJ4-2]
NP_082402.1. NM_028126.3. [Q3UUJ4-3]
XP_006534358.1. XM_006534295.1. [Q3UUJ4-3]
XP_011247572.1. XM_011249270.1. [Q3UUJ4-1]
UniGeneiMm.403722.

3D structure databases

ProteinModelPortaliQ3UUJ4.
SMRiQ3UUJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UUJ4. 2 interactors.
MINTiMINT-4126430.
STRINGi10090.ENSMUSP00000007444.

PTM databases

iPTMnetiQ3UUJ4.
PhosphoSitePlusiQ3UUJ4.

Proteomic databases

PaxDbiQ3UUJ4.
PeptideAtlasiQ3UUJ4.
PRIDEiQ3UUJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007444; ENSMUSP00000007444; ENSMUSG00000069631. [Q3UUJ4-1]
ENSMUST00000103072; ENSMUSP00000099361; ENSMUSG00000069631. [Q3UUJ4-3]
GeneIDi72149.
KEGGimmu:72149.
UCSCiuc007lyf.2. mouse. [Q3UUJ4-3]
uc007lyg.2. mouse. [Q3UUJ4-1]
uc011ygi.2. mouse. [Q3UUJ4-2]

Organism-specific databases

CTDi92335.
MGIiMGI:1919399. Strada.

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
GeneTreeiENSGT00860000133680.
HOGENOMiHOG000237355.
HOVERGENiHBG055069.
InParanoidiQ3UUJ4.
KOiK08271.
OMAiQEIMSSF.
OrthoDBiEOG091G0E7D.
PhylomeDBiQ3UUJ4.
TreeFamiTF319817.

Enzyme and pathway databases

ReactomeiR-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.

Miscellaneous databases

PROiQ3UUJ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069631.
CleanExiMM_2610019A05RIK.
ExpressionAtlasiQ3UUJ4. baseline and differential.
GenevisibleiQ3UUJ4. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTRAA_MOUSE
AccessioniPrimary (citable) accession number: Q3UUJ4
Secondary accession number(s): Q6VEU7, Q9D0G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: October 11, 2005
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.