Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3UU35

- OVOS_MOUSE

UniProt

Q3UU35 - OVOS_MOUSE

Protein

Ovostatin homolog

Gene

Ovos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI39.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovostatin homolog
    Gene namesi
    Name:Ovos
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:3039594. BC048546.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 14561437Ovostatin homologPRO_0000318967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ3UU35.
    PRIDEiQ3UU35.

    PTM databases

    PhosphoSiteiQ3UU35.

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UU35.
    BgeeiQ3UU35.
    CleanExiMM_BC048546.
    GenevestigatoriQ3UU35.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UU35.
    SMRiQ3UU35. Positions 94-609, 730-1455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Bait region, Signal

    Phylogenomic databases

    eggNOGiCOG2373.
    GeneTreeiENSGT00740000115177.
    HOGENOMiHOG000220939.
    HOVERGENiHBG000039.
    InParanoidiQ3UU35.
    OMAiRKPEVCS.
    OrthoDBiEOG7DJSKB.
    TreeFamiTF313285.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProiIPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3UU35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPTILLSAL LLHFTDVVAA EPRYILWVSS VVQRFSSEKA CLHLLNLNES     50
    VSLSVTLEYD GSSTTIFDQP VDEGNFYACA DFKVSQMSSE QLAFVALLVQ 100
    GNTLKISERR SVAIAAEENA TFVQTDTPVH KPGDTVHFRV VTLNIWLKPV 150
    DDLYPLITVQ DPQSNVIFQW INVTTFRNIT QLSFQLTPEP ILGDYTIVIK 200
    TQSGTTVMDH FTVNRDVLPK FEVELTAPET ITIADSQFQM VTCAKYTYGQ 250
    PVQGKAQIKV CRELFSPAHC ESNENEICEQ FTVQLKDGCA SHIINTKVFQ 300
    LDRSGLFMTL NVNEVVTESG TGVQMSKTHS VFITSVLGTV SFENMDPFYR 350
    RGITYFGTLK FSGPNNTPLV DKLLQLELDG KPVGNYTTDE NGEARFSINT 400
    SEIFGAQISL KAVYVRPRSC HRSSWLSPEY LDAYFSASRF YSQTSSFTKI 450
    ILEPKQLPCD QEKMFSVLYS LNPEAYKEAS DVTFFYLVMV RGGISRSGQK 500
    QVRVQAWNGN FSFPISINAD LAPSADLFVY TLHPSGEIVA DNVRLQIEKC 550
    FKNKVSINFS RDKDLPGSNT SVHLQAAPDS FCALRAVDKS ALLLNHGQEM 600
    TPESVYFTLP YIHQYGYFYN GLNLDDQQAE PCIPQKDLFY NGLYYTPTGN 650
    IWDGDLSNLL SNMGLKIFTN LHYRKPEVCS SQENQPLLRT FDHPNERIMM 700
    YGGGAPPSSA FHDSVDSISH AKVAIKETVR TNFPRTWIWN LVSVDSSGTA 750
    NVSFLVPDTI TQWEASAFCV NGNAGFGISP KVSLQISQPF FVEVTSPFSV 800
    VRSEQSDMVV TVFNYLTTCV EISVQLEASE NYEASINTQR NTDSEVLQAG 850
    EQKTYVWTII PKTLGKVNVT VVATSKQSRA CPNDASKEQD VHWKDTVVKT 900
    MLVEAEGIEK EATQSFLICP KGTKASKQTL LELPSNVVEG SVRSFVTIVG 950
    DILGVAMQNL ESLLQMPYGC GEQNIAQLAS DVYILDYLKA TDQLTEELKS 1000
    KAQRLLSNGY QNHLSFKNYD GSYDVFCQSN QEGSTWLSAL SFKTVEKMKE 1050
    YIFIEETVPK QTLIWLVKKQ KSNGCFRRDE KHVDTAQEGR EGDQEDIALT 1100
    AYVVGVFLEV GLNASFPALR NGLYCLEEAF SNGVTNGYTQ AILAYVFALA 1150
    GKEQQAKSLL SILDKSATKT NNMIYWERDE KPETDNSPSF IPSALSGETE 1200
    KTCYVLLAVL SQDTQDLDYA SKIVQWLAQR MNSHGGFSAM QDTTVCLLAL 1250
    TQYMKLTGSN PQNTITLSSE ESEEVFYVNR NKRLLVQHSK VSKGHQQYTV 1300
    DVEGDGCSFI QATLRYNVPL PKEASGFSLS VKTGKSNSSD EFQTKFELTV 1350
    TLTYTGARES SVTVLVDVKM LSGFTPVVSS TEELKFNSQV TKTDIKNGHV 1400
    LFYLENVPKE ATSLTFSIEQ TNHVANIQPA PVTVYSYEKG EYAFDSYNIN 1450
    SISDSQ 1456
    Length:1,456
    Mass (Da):162,340
    Last modified:June 28, 2011 - v2
    Checksum:i3A0535BDBEA59979
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1127 – 11271E → G in BAE23794. (PubMed:16141072)Curated
    Sequence conflicti1292 – 12921S → C in BAE23794. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK138836 mRNA. Translation: BAE23794.1.
    AC123060 Genomic DNA. No translation available.
    CCDSiCCDS39651.1.
    RefSeqiNP_001001179.2. NM_001001179.3.
    XP_006506095.1. XM_006506032.1.
    UniGeneiMm.259234.

    Genome annotation databases

    EnsembliENSMUST00000060574; ENSMUSP00000059426; ENSMUSG00000047228.
    GeneIDi232400.
    KEGGimmu:232400.
    UCSCiuc009eeh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK138836 mRNA. Translation: BAE23794.1 .
    AC123060 Genomic DNA. No translation available.
    CCDSi CCDS39651.1.
    RefSeqi NP_001001179.2. NM_001001179.3.
    XP_006506095.1. XM_006506032.1.
    UniGenei Mm.259234.

    3D structure databases

    ProteinModelPortali Q3UU35.
    SMRi Q3UU35. Positions 94-609, 730-1455.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I39.002.

    PTM databases

    PhosphoSitei Q3UU35.

    Proteomic databases

    MaxQBi Q3UU35.
    PRIDEi Q3UU35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060574 ; ENSMUSP00000059426 ; ENSMUSG00000047228 .
    GeneIDi 232400.
    KEGGi mmu:232400.
    UCSCi uc009eeh.2. mouse.

    Organism-specific databases

    MGIi MGI:3039594. BC048546.

    Phylogenomic databases

    eggNOGi COG2373.
    GeneTreei ENSGT00740000115177.
    HOGENOMi HOG000220939.
    HOVERGENi HBG000039.
    InParanoidi Q3UU35.
    OMAi RKPEVCS.
    OrthoDBi EOG7DJSKB.
    TreeFami TF313285.

    Miscellaneous databases

    NextBioi 381079.
    PROi Q3UU35.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UU35.
    Bgeei Q3UU35.
    CleanExi MM_BC048546.
    Genevestigatori Q3UU35.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    2.60.40.690. 1 hit.
    InterProi IPR009048. A-macroglobulin_rcpt-bd.
    IPR011626. A2M_comp.
    IPR002890. A2M_N.
    IPR011625. A2M_N_2.
    IPR014756. Ig_E-set.
    IPR001599. Macroglobln_a2.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00207. A2M. 1 hit.
    PF07678. A2M_comp. 1 hit.
    PF01835. A2M_N. 1 hit.
    PF07703. A2M_N_2. 1 hit.
    PF07677. A2M_recep. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    SSF49410. SSF49410. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiOVOS_MOUSE
    AccessioniPrimary (citable) accession number: Q3UU35
    Secondary accession number(s): E9QMV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3