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Q3UU35

- OVOS_MOUSE

UniProt

Q3UU35 - OVOS_MOUSE

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Protein

Ovostatin homolog

Gene

Ovos

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI39.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovostatin homolog
Gene namesi
Name:Ovos
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:3039594. BC048546.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 14561437Ovostatin homologPRO_0000318967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi868 – 8681N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3UU35.
PRIDEiQ3UU35.

PTM databases

PhosphoSiteiQ3UU35.

Expressioni

Gene expression databases

BgeeiQ3UU35.
CleanExiMM_BC048546.
ExpressionAtlasiQ3UU35. baseline and differential.
GenevestigatoriQ3UU35.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3UU35.
SMRiQ3UU35. Positions 94-609, 730-1455.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiCOG2373.
GeneTreeiENSGT00760000118982.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
InParanoidiQ3UU35.
OMAiRKPEVCS.
OrthoDBiEOG7DJSKB.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UU35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPTILLSAL LLHFTDVVAA EPRYILWVSS VVQRFSSEKA CLHLLNLNES
60 70 80 90 100
VSLSVTLEYD GSSTTIFDQP VDEGNFYACA DFKVSQMSSE QLAFVALLVQ
110 120 130 140 150
GNTLKISERR SVAIAAEENA TFVQTDTPVH KPGDTVHFRV VTLNIWLKPV
160 170 180 190 200
DDLYPLITVQ DPQSNVIFQW INVTTFRNIT QLSFQLTPEP ILGDYTIVIK
210 220 230 240 250
TQSGTTVMDH FTVNRDVLPK FEVELTAPET ITIADSQFQM VTCAKYTYGQ
260 270 280 290 300
PVQGKAQIKV CRELFSPAHC ESNENEICEQ FTVQLKDGCA SHIINTKVFQ
310 320 330 340 350
LDRSGLFMTL NVNEVVTESG TGVQMSKTHS VFITSVLGTV SFENMDPFYR
360 370 380 390 400
RGITYFGTLK FSGPNNTPLV DKLLQLELDG KPVGNYTTDE NGEARFSINT
410 420 430 440 450
SEIFGAQISL KAVYVRPRSC HRSSWLSPEY LDAYFSASRF YSQTSSFTKI
460 470 480 490 500
ILEPKQLPCD QEKMFSVLYS LNPEAYKEAS DVTFFYLVMV RGGISRSGQK
510 520 530 540 550
QVRVQAWNGN FSFPISINAD LAPSADLFVY TLHPSGEIVA DNVRLQIEKC
560 570 580 590 600
FKNKVSINFS RDKDLPGSNT SVHLQAAPDS FCALRAVDKS ALLLNHGQEM
610 620 630 640 650
TPESVYFTLP YIHQYGYFYN GLNLDDQQAE PCIPQKDLFY NGLYYTPTGN
660 670 680 690 700
IWDGDLSNLL SNMGLKIFTN LHYRKPEVCS SQENQPLLRT FDHPNERIMM
710 720 730 740 750
YGGGAPPSSA FHDSVDSISH AKVAIKETVR TNFPRTWIWN LVSVDSSGTA
760 770 780 790 800
NVSFLVPDTI TQWEASAFCV NGNAGFGISP KVSLQISQPF FVEVTSPFSV
810 820 830 840 850
VRSEQSDMVV TVFNYLTTCV EISVQLEASE NYEASINTQR NTDSEVLQAG
860 870 880 890 900
EQKTYVWTII PKTLGKVNVT VVATSKQSRA CPNDASKEQD VHWKDTVVKT
910 920 930 940 950
MLVEAEGIEK EATQSFLICP KGTKASKQTL LELPSNVVEG SVRSFVTIVG
960 970 980 990 1000
DILGVAMQNL ESLLQMPYGC GEQNIAQLAS DVYILDYLKA TDQLTEELKS
1010 1020 1030 1040 1050
KAQRLLSNGY QNHLSFKNYD GSYDVFCQSN QEGSTWLSAL SFKTVEKMKE
1060 1070 1080 1090 1100
YIFIEETVPK QTLIWLVKKQ KSNGCFRRDE KHVDTAQEGR EGDQEDIALT
1110 1120 1130 1140 1150
AYVVGVFLEV GLNASFPALR NGLYCLEEAF SNGVTNGYTQ AILAYVFALA
1160 1170 1180 1190 1200
GKEQQAKSLL SILDKSATKT NNMIYWERDE KPETDNSPSF IPSALSGETE
1210 1220 1230 1240 1250
KTCYVLLAVL SQDTQDLDYA SKIVQWLAQR MNSHGGFSAM QDTTVCLLAL
1260 1270 1280 1290 1300
TQYMKLTGSN PQNTITLSSE ESEEVFYVNR NKRLLVQHSK VSKGHQQYTV
1310 1320 1330 1340 1350
DVEGDGCSFI QATLRYNVPL PKEASGFSLS VKTGKSNSSD EFQTKFELTV
1360 1370 1380 1390 1400
TLTYTGARES SVTVLVDVKM LSGFTPVVSS TEELKFNSQV TKTDIKNGHV
1410 1420 1430 1440 1450
LFYLENVPKE ATSLTFSIEQ TNHVANIQPA PVTVYSYEKG EYAFDSYNIN

SISDSQ
Length:1,456
Mass (Da):162,340
Last modified:June 28, 2011 - v2
Checksum:i3A0535BDBEA59979
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1127 – 11271E → G in BAE23794. (PubMed:16141072)Curated
Sequence conflicti1292 – 12921S → C in BAE23794. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138836 mRNA. Translation: BAE23794.1.
AC123060 Genomic DNA. No translation available.
CCDSiCCDS39651.1.
RefSeqiNP_001001179.2. NM_001001179.3.
XP_006506095.1. XM_006506032.1.
UniGeneiMm.259234.

Genome annotation databases

EnsembliENSMUST00000060574; ENSMUSP00000059426; ENSMUSG00000047228.
GeneIDi232400.
KEGGimmu:232400.
UCSCiuc009eeh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138836 mRNA. Translation: BAE23794.1 .
AC123060 Genomic DNA. No translation available.
CCDSi CCDS39651.1.
RefSeqi NP_001001179.2. NM_001001179.3.
XP_006506095.1. XM_006506032.1.
UniGenei Mm.259234.

3D structure databases

ProteinModelPortali Q3UU35.
SMRi Q3UU35. Positions 94-609, 730-1455.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I39.002.

PTM databases

PhosphoSitei Q3UU35.

Proteomic databases

MaxQBi Q3UU35.
PRIDEi Q3UU35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060574 ; ENSMUSP00000059426 ; ENSMUSG00000047228 .
GeneIDi 232400.
KEGGi mmu:232400.
UCSCi uc009eeh.2. mouse.

Organism-specific databases

MGIi MGI:3039594. BC048546.

Phylogenomic databases

eggNOGi COG2373.
GeneTreei ENSGT00760000118982.
HOGENOMi HOG000220939.
HOVERGENi HBG000039.
InParanoidi Q3UU35.
OMAi RKPEVCS.
OrthoDBi EOG7DJSKB.
TreeFami TF313285.

Miscellaneous databases

NextBioi 381079.
PROi Q3UU35.
SOURCEi Search...

Gene expression databases

Bgeei Q3UU35.
CleanExi MM_BC048546.
ExpressionAtlasi Q3UU35. baseline and differential.
Genevestigatori Q3UU35.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiOVOS_MOUSE
AccessioniPrimary (citable) accession number: Q3UU35
Secondary accession number(s): E9QMV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3