Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q3UU35 (OVOS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ovostatin homolog
Gene names
Name:Ovos
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1456 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]

Ontologies

Keywords
   Cellular componentSecreted
   DomainBait region
Signal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of endopeptidase activity

Inferred from electronic annotation. Source: GOC

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 14561437Ovostatin homolog
PRO_0000318967

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation8681N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict11271E → G in BAE23794. Ref.1
Sequence conflict12921S → C in BAE23794. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q3UU35 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 3A0535BDBEA59979

FASTA1,456162,340
        10         20         30         40         50         60 
MVPTILLSAL LLHFTDVVAA EPRYILWVSS VVQRFSSEKA CLHLLNLNES VSLSVTLEYD 

        70         80         90        100        110        120 
GSSTTIFDQP VDEGNFYACA DFKVSQMSSE QLAFVALLVQ GNTLKISERR SVAIAAEENA 

       130        140        150        160        170        180 
TFVQTDTPVH KPGDTVHFRV VTLNIWLKPV DDLYPLITVQ DPQSNVIFQW INVTTFRNIT 

       190        200        210        220        230        240 
QLSFQLTPEP ILGDYTIVIK TQSGTTVMDH FTVNRDVLPK FEVELTAPET ITIADSQFQM 

       250        260        270        280        290        300 
VTCAKYTYGQ PVQGKAQIKV CRELFSPAHC ESNENEICEQ FTVQLKDGCA SHIINTKVFQ 

       310        320        330        340        350        360 
LDRSGLFMTL NVNEVVTESG TGVQMSKTHS VFITSVLGTV SFENMDPFYR RGITYFGTLK 

       370        380        390        400        410        420 
FSGPNNTPLV DKLLQLELDG KPVGNYTTDE NGEARFSINT SEIFGAQISL KAVYVRPRSC 

       430        440        450        460        470        480 
HRSSWLSPEY LDAYFSASRF YSQTSSFTKI ILEPKQLPCD QEKMFSVLYS LNPEAYKEAS 

       490        500        510        520        530        540 
DVTFFYLVMV RGGISRSGQK QVRVQAWNGN FSFPISINAD LAPSADLFVY TLHPSGEIVA 

       550        560        570        580        590        600 
DNVRLQIEKC FKNKVSINFS RDKDLPGSNT SVHLQAAPDS FCALRAVDKS ALLLNHGQEM 

       610        620        630        640        650        660 
TPESVYFTLP YIHQYGYFYN GLNLDDQQAE PCIPQKDLFY NGLYYTPTGN IWDGDLSNLL 

       670        680        690        700        710        720 
SNMGLKIFTN LHYRKPEVCS SQENQPLLRT FDHPNERIMM YGGGAPPSSA FHDSVDSISH 

       730        740        750        760        770        780 
AKVAIKETVR TNFPRTWIWN LVSVDSSGTA NVSFLVPDTI TQWEASAFCV NGNAGFGISP 

       790        800        810        820        830        840 
KVSLQISQPF FVEVTSPFSV VRSEQSDMVV TVFNYLTTCV EISVQLEASE NYEASINTQR 

       850        860        870        880        890        900 
NTDSEVLQAG EQKTYVWTII PKTLGKVNVT VVATSKQSRA CPNDASKEQD VHWKDTVVKT 

       910        920        930        940        950        960 
MLVEAEGIEK EATQSFLICP KGTKASKQTL LELPSNVVEG SVRSFVTIVG DILGVAMQNL 

       970        980        990       1000       1010       1020 
ESLLQMPYGC GEQNIAQLAS DVYILDYLKA TDQLTEELKS KAQRLLSNGY QNHLSFKNYD 

      1030       1040       1050       1060       1070       1080 
GSYDVFCQSN QEGSTWLSAL SFKTVEKMKE YIFIEETVPK QTLIWLVKKQ KSNGCFRRDE 

      1090       1100       1110       1120       1130       1140 
KHVDTAQEGR EGDQEDIALT AYVVGVFLEV GLNASFPALR NGLYCLEEAF SNGVTNGYTQ 

      1150       1160       1170       1180       1190       1200 
AILAYVFALA GKEQQAKSLL SILDKSATKT NNMIYWERDE KPETDNSPSF IPSALSGETE 

      1210       1220       1230       1240       1250       1260 
KTCYVLLAVL SQDTQDLDYA SKIVQWLAQR MNSHGGFSAM QDTTVCLLAL TQYMKLTGSN 

      1270       1280       1290       1300       1310       1320 
PQNTITLSSE ESEEVFYVNR NKRLLVQHSK VSKGHQQYTV DVEGDGCSFI QATLRYNVPL 

      1330       1340       1350       1360       1370       1380 
PKEASGFSLS VKTGKSNSSD EFQTKFELTV TLTYTGARES SVTVLVDVKM LSGFTPVVSS 

      1390       1400       1410       1420       1430       1440 
TEELKFNSQV TKTDIKNGHV LFYLENVPKE ATSLTFSIEQ TNHVANIQPA PVTVYSYEKG 

      1450 
EYAFDSYNIN SISDSQ

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK138836 mRNA. Translation: BAE23794.1.
AC123060 Genomic DNA. No translation available.
IPIIPI00169490.
RefSeqNP_001001179.2. NM_001001179.3.
UniGeneMm.259234.

3D structure databases

HSSPHSSP built from PDB template 1BV8 based on UniProtKB P01023.
ProteinModelPortalQ3UU35.
SMRQ3UU35. Positions 94-609, 730-1455.
ModBaseSearch...

Protein family/group databases

MEROPSI39.002.

PTM databases

PhosphoSiteQ3UU35.

Proteomic databases

PRIDEQ3UU35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060574; ENSMUSP00000059426; ENSMUSG00000047228.
GeneID232400.
KEGGmmu:232400.
UCSCuc009eeh.2. mouse.

Organism-specific databases

MGIMGI:3039594. BC048546.

Phylogenomic databases

eggNOGCOG2373.
GeneTreeENSGT00560000076685.
HOGENOMHOG000220939.
HOVERGENHBG000039.
InParanoidQ3UU35.
OMAMNSHGGF.
OrthoDBEOG4WSW8S.

Gene expression databases

ArrayExpressQ3UU35.
BgeeQ3UU35.
CleanExMM_BC048546.
GenevestigatorQ3UU35.

Family and domain databases

Gene3D2.60.40.690. 1 hit.
InterProIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMSSF49410. AM_receptor_bind. 1 hit.
SSF48239. Terp_cyc_toroid. 1 hit.
PROSITEPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio381079.
SOURCESearch...

Entry information

Entry nameOVOS_MOUSE
AccessionPrimary (citable) accession number: Q3UU35
Secondary accession number(s): E9QMV5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 28, 2011
Last modified: May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents