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Q3UU35

- OVOS_MOUSE

UniProt

Q3UU35 - OVOS_MOUSE

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Protein
Ovostatin homolog
Gene
Ovos
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism By similarity.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI39.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Ovostatin homolog
Gene namesi
Name:Ovos
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:3039594. BC048546.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 14561437Ovostatin homolog
PRO_0000318967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi868 – 8681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3UU35.
PRIDEiQ3UU35.

PTM databases

PhosphoSiteiQ3UU35.

Expressioni

Gene expression databases

ArrayExpressiQ3UU35.
BgeeiQ3UU35.
CleanExiMM_BC048546.
GenevestigatoriQ3UU35.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ3UU35.
SMRiQ3UU35. Positions 94-609, 730-1455.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

eggNOGiCOG2373.
GeneTreeiENSGT00740000115177.
HOGENOMiHOG000220939.
HOVERGENiHBG000039.
InParanoidiQ3UU35.
OMAiRKPEVCS.
OrthoDBiEOG7DJSKB.
TreeFamiTF313285.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UU35-1 [UniParc]FASTAAdd to Basket

« Hide

MVPTILLSAL LLHFTDVVAA EPRYILWVSS VVQRFSSEKA CLHLLNLNES     50
VSLSVTLEYD GSSTTIFDQP VDEGNFYACA DFKVSQMSSE QLAFVALLVQ 100
GNTLKISERR SVAIAAEENA TFVQTDTPVH KPGDTVHFRV VTLNIWLKPV 150
DDLYPLITVQ DPQSNVIFQW INVTTFRNIT QLSFQLTPEP ILGDYTIVIK 200
TQSGTTVMDH FTVNRDVLPK FEVELTAPET ITIADSQFQM VTCAKYTYGQ 250
PVQGKAQIKV CRELFSPAHC ESNENEICEQ FTVQLKDGCA SHIINTKVFQ 300
LDRSGLFMTL NVNEVVTESG TGVQMSKTHS VFITSVLGTV SFENMDPFYR 350
RGITYFGTLK FSGPNNTPLV DKLLQLELDG KPVGNYTTDE NGEARFSINT 400
SEIFGAQISL KAVYVRPRSC HRSSWLSPEY LDAYFSASRF YSQTSSFTKI 450
ILEPKQLPCD QEKMFSVLYS LNPEAYKEAS DVTFFYLVMV RGGISRSGQK 500
QVRVQAWNGN FSFPISINAD LAPSADLFVY TLHPSGEIVA DNVRLQIEKC 550
FKNKVSINFS RDKDLPGSNT SVHLQAAPDS FCALRAVDKS ALLLNHGQEM 600
TPESVYFTLP YIHQYGYFYN GLNLDDQQAE PCIPQKDLFY NGLYYTPTGN 650
IWDGDLSNLL SNMGLKIFTN LHYRKPEVCS SQENQPLLRT FDHPNERIMM 700
YGGGAPPSSA FHDSVDSISH AKVAIKETVR TNFPRTWIWN LVSVDSSGTA 750
NVSFLVPDTI TQWEASAFCV NGNAGFGISP KVSLQISQPF FVEVTSPFSV 800
VRSEQSDMVV TVFNYLTTCV EISVQLEASE NYEASINTQR NTDSEVLQAG 850
EQKTYVWTII PKTLGKVNVT VVATSKQSRA CPNDASKEQD VHWKDTVVKT 900
MLVEAEGIEK EATQSFLICP KGTKASKQTL LELPSNVVEG SVRSFVTIVG 950
DILGVAMQNL ESLLQMPYGC GEQNIAQLAS DVYILDYLKA TDQLTEELKS 1000
KAQRLLSNGY QNHLSFKNYD GSYDVFCQSN QEGSTWLSAL SFKTVEKMKE 1050
YIFIEETVPK QTLIWLVKKQ KSNGCFRRDE KHVDTAQEGR EGDQEDIALT 1100
AYVVGVFLEV GLNASFPALR NGLYCLEEAF SNGVTNGYTQ AILAYVFALA 1150
GKEQQAKSLL SILDKSATKT NNMIYWERDE KPETDNSPSF IPSALSGETE 1200
KTCYVLLAVL SQDTQDLDYA SKIVQWLAQR MNSHGGFSAM QDTTVCLLAL 1250
TQYMKLTGSN PQNTITLSSE ESEEVFYVNR NKRLLVQHSK VSKGHQQYTV 1300
DVEGDGCSFI QATLRYNVPL PKEASGFSLS VKTGKSNSSD EFQTKFELTV 1350
TLTYTGARES SVTVLVDVKM LSGFTPVVSS TEELKFNSQV TKTDIKNGHV 1400
LFYLENVPKE ATSLTFSIEQ TNHVANIQPA PVTVYSYEKG EYAFDSYNIN 1450
SISDSQ 1456
Length:1,456
Mass (Da):162,340
Last modified:June 28, 2011 - v2
Checksum:i3A0535BDBEA59979
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1127 – 11271E → G in BAE23794. 1 Publication
Sequence conflicti1292 – 12921S → C in BAE23794. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK138836 mRNA. Translation: BAE23794.1.
AC123060 Genomic DNA. No translation available.
CCDSiCCDS39651.1.
RefSeqiNP_001001179.2. NM_001001179.3.
XP_006506095.1. XM_006506032.1.
UniGeneiMm.259234.

Genome annotation databases

EnsembliENSMUST00000060574; ENSMUSP00000059426; ENSMUSG00000047228.
GeneIDi232400.
KEGGimmu:232400.
UCSCiuc009eeh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK138836 mRNA. Translation: BAE23794.1 .
AC123060 Genomic DNA. No translation available.
CCDSi CCDS39651.1.
RefSeqi NP_001001179.2. NM_001001179.3.
XP_006506095.1. XM_006506032.1.
UniGenei Mm.259234.

3D structure databases

ProteinModelPortali Q3UU35.
SMRi Q3UU35. Positions 94-609, 730-1455.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I39.002.

PTM databases

PhosphoSitei Q3UU35.

Proteomic databases

MaxQBi Q3UU35.
PRIDEi Q3UU35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060574 ; ENSMUSP00000059426 ; ENSMUSG00000047228 .
GeneIDi 232400.
KEGGi mmu:232400.
UCSCi uc009eeh.2. mouse.

Organism-specific databases

MGIi MGI:3039594. BC048546.

Phylogenomic databases

eggNOGi COG2373.
GeneTreei ENSGT00740000115177.
HOGENOMi HOG000220939.
HOVERGENi HBG000039.
InParanoidi Q3UU35.
OMAi RKPEVCS.
OrthoDBi EOG7DJSKB.
TreeFami TF313285.

Miscellaneous databases

NextBioi 381079.
PROi Q3UU35.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UU35.
Bgeei Q3UU35.
CleanExi MM_BC048546.
Genevestigatori Q3UU35.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiOVOS_MOUSE
AccessioniPrimary (citable) accession number: Q3UU35
Secondary accession number(s): E9QMV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi