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Q3UTR7

- Q3UTR7_MOUSE

UniProt

Q3UTR7 - Q3UTR7_MOUSE

Protein
Submitted name:

Angiotensinogen

Gene

Agt

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetyltransferase activator activity Source: Ensembl
    2. serine-type endopeptidase inhibitor activity Source: RefGenome
    3. type 1 angiotensin receptor binding Source: MGI
    4. type 2 angiotensin receptor binding Source: MGI

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: MGI
    2. activation of phospholipase C activity Source: Ensembl
    3. aging Source: Ensembl
    4. angiotensin-mediated drinking behavior Source: Ensembl
    5. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
    6. artery smooth muscle contraction Source: Ensembl
    7. astrocyte activation Source: MGI
    8. blood vessel development Source: MGI
    9. brain renin-angiotensin system Source: MGI
    10. branching involved in ureteric bud morphogenesis Source: MGI
    11. catenin import into nucleus Source: Ensembl
    12. cell growth involved in cardiac muscle cell development Source: Ensembl
    13. cell-matrix adhesion Source: MGI
    14. cellular response to mechanical stimulus Source: Ensembl
    15. cellular sodium ion homeostasis Source: Ensembl
    16. cytokine secretion Source: Ensembl
    17. drinking behavior Source: MGI
    18. ERK1 and ERK2 cascade Source: Ensembl
    19. establishment of blood-nerve barrier Source: MGI
    20. excretion Source: MGI
    21. extracellular matrix organization Source: MGI
    22. fibroblast proliferation Source: Ensembl
    23. G-protein coupled receptor signaling pathway Source: Ensembl
    24. hormone metabolic process Source: MGI
    25. kidney development Source: MGI
    26. negative regulation of angiogenesis Source: Ensembl
    27. negative regulation of cell growth Source: Ensembl
    28. negative regulation of cell proliferation Source: MGI
    29. negative regulation of endopeptidase activity Source: RefGenome
    30. negative regulation of neuron apoptotic process Source: MGI
    31. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
    32. negative regulation of tissue remodeling Source: Ensembl
    33. ovarian follicle rupture Source: MGI
    34. peristalsis Source: MGI
    35. positive regulation of activation of JAK2 kinase activity Source: Ensembl
    36. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    37. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    38. positive regulation of cholesterol esterification Source: Ensembl
    39. positive regulation of endothelial cell migration Source: Ensembl
    40. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    41. positive regulation of extracellular matrix constituent secretion Source: Ensembl
    42. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    43. positive regulation of fatty acid biosynthetic process Source: MGI
    44. positive regulation of fibroblast proliferation Source: Ensembl
    45. positive regulation of gene expression Source: MGI
    46. positive regulation of MAPK cascade Source: MGI
    47. positive regulation of multicellular organism growth Source: MGI
    48. positive regulation of organ growth Source: MGI
    49. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    50. positive regulation of protein tyrosine kinase activity Source: Ensembl
    51. positive regulation of renal sodium excretion Source: Ensembl
    52. positive regulation of superoxide anion generation Source: Ensembl
    53. positive regulation of transcription, DNA-templated Source: Ensembl
    54. regulation of apoptotic process Source: MGI
    55. regulation of blood pressure Source: MGI
    56. regulation of calcium ion transport Source: Ensembl
    57. regulation of gene expression Source: MGI
    58. regulation of inflammatory response Source: MGI
    59. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    60. regulation of norepinephrine secretion Source: Ensembl
    61. regulation of proteolysis Source: RefGenome
    62. regulation of renal output by angiotensin Source: MGI
    63. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
    64. renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: MGI
    65. renin-angiotensin regulation of aldosterone production Source: MGI
    66. response to cold Source: MGI
    67. response to muscle activity involved in regulation of muscle adaptation Source: Ensembl
    68. response to salt stress Source: MGI
    69. smooth muscle cell differentiation Source: MGI
    70. smooth muscle cell proliferation Source: MGI
    71. stress-activated MAPK cascade Source: Ensembl
    72. uterine smooth muscle contraction Source: Ensembl
    73. vasodilation Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196539. Metabolism of Angiotensinogen to Angiotensins.
    REACT_198602. PPARA activates gene expression.
    REACT_207651. G alpha (q) signalling events.

    Protein family/group databases

    MEROPSiI04.953.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    AngiotensinogenImported
    Gene namesi
    Name:AgtImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:87963. Agt.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ3UTR7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000066488.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117773.
    HOGENOMiHOG000033941.
    HOVERGENiHBG004233.
    InParanoidiQ3UTR7.
    KOiK09821.
    OMAiRFMQAVT.
    OrthoDBiEOG7QK0BN.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR000227. Angiotensinogen.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    PRINTSiPR00654. ANGIOTENSNGN.
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3UTR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRSEMTPTG AGLKATIFCI LTWVSLTAGD RVYIHPFHLL YHNKSTCAQL    50
    ENPSVETLPE STFEPVPIQA KTSPVNEKTL HDQLVLAAEK LEDEDRKRAA 100
    QVAMIANFVG FRMYKMLNEA GSGASGAILS PPALFGTLVS FYLGSLDPTA 150
    SQLQTLLDVP VKEGDCTSRL DGHKVLAALR AIQGLLVTQG GSSSQTPLLQ 200
    SIVVGLFTAP GFRLKHSFVQ SLALFTPALF PRSLDLSTDP VLATEKINRF 250
    IKAVTGWKMN LPLEGVSTDS TLLFNTYVHF QGTMRGFSQL PGVHEFWVDN 300
    SISVSVPMIS GTGNFQHWSD TQNNFSVTCV PLGERATLLL IQPHCTSDLD 350
    RVEALIFRND LLTWIENPPP RAIRLTLPQL EIRGSYNLQD LLAEDKLPTL 400
    LGAEANLNNI GDTNPRVGEV LNSILLELKA GEEEQPTTSV QQPGSPEALD 450
    VTLSSPFLFA IYEQDSGTLH FLGRVNNPQS VV 482
    Length:482
    Mass (Da):52,670
    Last modified:October 11, 2005 - v1
    Checksum:iDC4633B4020178C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126930 Genomic DNA. No translation available.
    AK139179 mRNA. Translation: BAE23913.1.
    RefSeqiNP_031454.3. NM_007428.3.
    UniGeneiMm.301626.

    Genome annotation databases

    EnsembliENSMUST00000063278; ENSMUSP00000066488; ENSMUSG00000031980.
    GeneIDi11606.
    KEGGimmu:11606.
    UCSCiuc009nxe.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126930 Genomic DNA. No translation available.
    AK139179 mRNA. Translation: BAE23913.1 .
    RefSeqi NP_031454.3. NM_007428.3.
    UniGenei Mm.301626.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000066488.

    Protein family/group databases

    MEROPSi I04.953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063278 ; ENSMUSP00000066488 ; ENSMUSG00000031980 .
    GeneIDi 11606.
    KEGGi mmu:11606.
    UCSCi uc009nxe.1. mouse.

    Organism-specific databases

    CTDi 183.
    MGIi MGI:87963. Agt.

    Phylogenomic databases

    GeneTreei ENSGT00750000117773.
    HOGENOMi HOG000033941.
    HOVERGENi HBG004233.
    InParanoidi Q3UTR7.
    KOi K09821.
    OMAi RFMQAVT.
    OrthoDBi EOG7QK0BN.
    TreeFami TF343201.

    Enzyme and pathway databases

    Reactomei REACT_196539. Metabolism of Angiotensinogen to Angiotensins.
    REACT_198602. PPARA activates gene expression.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 279140.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q3UTR7.

    Family and domain databases

    InterProi IPR000227. Angiotensinogen.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    PRINTSi PR00654. ANGIOTENSNGN.
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ3UTR7_MOUSE
    AccessioniPrimary (citable) accession number: Q3UTR7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3