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Q3UTR7

- Q3UTR7_MOUSE

UniProt

Q3UTR7 - Q3UTR7_MOUSE

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Protein
Submitted name:

Angiotensinogen

Gene

Agt

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome
  2. type 1 angiotensin receptor binding Source: MGI
  3. type 2 angiotensin receptor binding Source: MGI

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: MGI
  2. activation of phospholipase C activity Source: Ensembl
  3. aging Source: Ensembl
  4. angiotensin-mediated drinking behavior Source: Ensembl
  5. angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  6. artery smooth muscle contraction Source: Ensembl
  7. astrocyte activation Source: MGI
  8. blood vessel development Source: MGI
  9. brain renin-angiotensin system Source: MGI
  10. branching involved in ureteric bud morphogenesis Source: MGI
  11. catenin import into nucleus Source: Ensembl
  12. cell growth involved in cardiac muscle cell development Source: Ensembl
  13. cell-matrix adhesion Source: MGI
  14. cellular response to mechanical stimulus Source: Ensembl
  15. cellular sodium ion homeostasis Source: Ensembl
  16. cytokine secretion Source: Ensembl
  17. drinking behavior Source: MGI
  18. ERK1 and ERK2 cascade Source: Ensembl
  19. establishment of blood-nerve barrier Source: MGI
  20. excretion Source: MGI
  21. extracellular matrix organization Source: MGI
  22. fibroblast proliferation Source: Ensembl
  23. G-protein coupled receptor signaling pathway Source: Ensembl
  24. hormone metabolic process Source: MGI
  25. kidney development Source: MGI
  26. negative regulation of angiogenesis Source: Ensembl
  27. negative regulation of cell growth Source: Ensembl
  28. negative regulation of cell proliferation Source: MGI
  29. negative regulation of endopeptidase activity Source: RefGenome
  30. negative regulation of neuron apoptotic process Source: MGI
  31. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  32. negative regulation of tissue remodeling Source: Ensembl
  33. ovarian follicle rupture Source: MGI
  34. peristalsis Source: MGI
  35. positive regulation of activation of JAK2 kinase activity Source: Ensembl
  36. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  37. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  38. positive regulation of cholesterol esterification Source: Ensembl
  39. positive regulation of endothelial cell migration Source: Ensembl
  40. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  41. positive regulation of extracellular matrix constituent secretion Source: Ensembl
  42. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  43. positive regulation of fatty acid biosynthetic process Source: MGI
  44. positive regulation of fibroblast proliferation Source: Ensembl
  45. positive regulation of gene expression Source: MGI
  46. positive regulation of MAPK cascade Source: MGI
  47. positive regulation of multicellular organism growth Source: MGI
  48. positive regulation of organ growth Source: MGI
  49. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  50. positive regulation of protein tyrosine kinase activity Source: Ensembl
  51. positive regulation of renal sodium excretion Source: Ensembl
  52. positive regulation of superoxide anion generation Source: Ensembl
  53. positive regulation of transcription, DNA-templated Source: Ensembl
  54. regulation of apoptotic process Source: MGI
  55. regulation of blood pressure Source: MGI
  56. regulation of calcium ion transport Source: Ensembl
  57. regulation of gene expression Source: MGI
  58. regulation of inflammatory response Source: MGI
  59. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  60. regulation of norepinephrine secretion Source: Ensembl
  61. regulation of proteolysis Source: RefGenome
  62. regulation of renal output by angiotensin Source: MGI
  63. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
  64. renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: MGI
  65. renin-angiotensin regulation of aldosterone production Source: MGI
  66. response to cold Source: MGI
  67. response to muscle activity involved in regulation of muscle adaptation Source: Ensembl
  68. response to salt stress Source: MGI
  69. smooth muscle cell differentiation Source: MGI
  70. smooth muscle cell proliferation Source: MGI
  71. stress-activated MAPK cascade Source: Ensembl
  72. uterine smooth muscle contraction Source: Ensembl
  73. vasodilation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196539. Metabolism of Angiotensinogen to Angiotensins.
REACT_198602. PPARA activates gene expression.
REACT_207651. G alpha (q) signalling events.

Protein family/group databases

MEROPSiI04.953.

Names & Taxonomyi

Protein namesi
Submitted name:
AngiotensinogenImported
Gene namesi
Name:AgtImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:87963. Agt.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ3UTR7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066488.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117773.
HOGENOMiHOG000033941.
HOVERGENiHBG004233.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG7QK0BN.
TreeFamiTF343201.

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UTR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRSEMTPTG AGLKATIFCI LTWVSLTAGD RVYIHPFHLL YHNKSTCAQL
60 70 80 90 100
ENPSVETLPE STFEPVPIQA KTSPVNEKTL HDQLVLAAEK LEDEDRKRAA
110 120 130 140 150
QVAMIANFVG FRMYKMLNEA GSGASGAILS PPALFGTLVS FYLGSLDPTA
160 170 180 190 200
SQLQTLLDVP VKEGDCTSRL DGHKVLAALR AIQGLLVTQG GSSSQTPLLQ
210 220 230 240 250
SIVVGLFTAP GFRLKHSFVQ SLALFTPALF PRSLDLSTDP VLATEKINRF
260 270 280 290 300
IKAVTGWKMN LPLEGVSTDS TLLFNTYVHF QGTMRGFSQL PGVHEFWVDN
310 320 330 340 350
SISVSVPMIS GTGNFQHWSD TQNNFSVTCV PLGERATLLL IQPHCTSDLD
360 370 380 390 400
RVEALIFRND LLTWIENPPP RAIRLTLPQL EIRGSYNLQD LLAEDKLPTL
410 420 430 440 450
LGAEANLNNI GDTNPRVGEV LNSILLELKA GEEEQPTTSV QQPGSPEALD
460 470 480
VTLSSPFLFA IYEQDSGTLH FLGRVNNPQS VV
Length:482
Mass (Da):52,670
Last modified:October 11, 2005 - v1
Checksum:iDC4633B4020178C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126930 Genomic DNA. No translation available.
AK139179 mRNA. Translation: BAE23913.1.
RefSeqiNP_031454.3. NM_007428.3.
UniGeneiMm.301626.

Genome annotation databases

EnsembliENSMUST00000063278; ENSMUSP00000066488; ENSMUSG00000031980.
GeneIDi11606.
KEGGimmu:11606.
UCSCiuc009nxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126930 Genomic DNA. No translation available.
AK139179 mRNA. Translation: BAE23913.1 .
RefSeqi NP_031454.3. NM_007428.3.
UniGenei Mm.301626.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000066488.

Protein family/group databases

MEROPSi I04.953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063278 ; ENSMUSP00000066488 ; ENSMUSG00000031980 .
GeneIDi 11606.
KEGGi mmu:11606.
UCSCi uc009nxe.1. mouse.

Organism-specific databases

CTDi 183.
MGIi MGI:87963. Agt.

Phylogenomic databases

GeneTreei ENSGT00750000117773.
HOGENOMi HOG000033941.
HOVERGENi HBG004233.
KOi K09821.
OMAi RFMQAVT.
OrthoDBi EOG7QK0BN.
TreeFami TF343201.

Enzyme and pathway databases

Reactomei REACT_196539. Metabolism of Angiotensinogen to Angiotensins.
REACT_198602. PPARA activates gene expression.
REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 279140.
SOURCEi Search...

Gene expression databases

Genevestigatori Q3UTR7.

Family and domain databases

InterProi IPR000227. Angiotensinogen.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00654. ANGIOTENSNGN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UTR7_MOUSE
AccessioniPrimary (citable) accession number: Q3UTR7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3