Q3UTR7 (Q3UTR7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Angiotensinogen Ensembl ENSMUSP00000066488

Gene names

Name:

Agt Ensembl ENSMUSP00000066488 MGI 87963

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the serpin family. RuleBase RU000411

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara activation of NF-kappaB-inducing kinase activity Inferred from direct assay PubMed 19404405. Source: MGI activation of phospholipase C activity Inferred from electronic annotation. Source: Compara aging Inferred from electronic annotation. Source: Compara angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Inferred from direct assay PubMed 10425188. Source: MGI angiotensin-mediated drinking behavior Inferred from electronic annotation. Source: Compara artery smooth muscle contraction Inferred from electronic annotation. Source: Compara astrocyte activation Inferred from mutant phenotype PubMed 9734405. Source: MGI blood vessel development Inferred from mutant phenotype PubMed 8675666PubMed 9466969. Source: MGI brain renin-angiotensin system Inferred from direct assay PubMed 15499027PubMed 9878677. Source: MGI branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 12657564. Source: MGI catenin import into nucleus Inferred from electronic annotation. Source: Compara cell growth involved in cardiac muscle cell development Inferred from electronic annotation. Source: Compara cell-matrix adhesion Inferred from mutant phenotype PubMed 9734405. Source: MGI cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara cellular sodium ion homeostasis Inferred from electronic annotation. Source: Compara cytokine secretion Inferred from electronic annotation. Source: Compara drinking behavior Inferred from mutant phenotype PubMed 9852267. Source: MGI establishment of blood-nerve barrier Inferred from mutant phenotype PubMed 9734405. Source: MGI excretion Inferred from mutant phenotype PubMed 9557921. Source: MGI extracellular matrix organization Inferred from mutant phenotype PubMed 9734405. Source: MGI fibroblast proliferation Inferred from electronic annotation. Source: Compara hormone metabolic process Inferred from mutant phenotype PubMed 12660889. Source: MGI induction of apoptosis Inferred from electronic annotation. Source: Compara kidney development Inferred from mutant phenotype PubMed 8675666PubMed 9466969. Source: MGI negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from mutant phenotype PubMed 10318840PubMed 11606482PubMed 8675666. Source: MGI negative regulation of nerve growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 9310306. Source: MGI negative regulation of tissue remodeling Inferred from electronic annotation. Source: Compara ovarian follicle rupture Inferred from mutant phenotype PubMed 11384650. Source: MGI peristalsis Inferred from mutant phenotype PubMed 9788961. Source: MGI positive regulation of MAPK cascade Inferred from mutant phenotype PubMed 9196031. Source: MGI positive regulation of activation of JAK2 kinase activity Inferred from electronic annotation. Source: Compara positive regulation of branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle hypertrophy Inferred from electronic annotation. Source: Compara positive regulation of cholesterol esterification Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell migration Inferred from electronic annotation. Source: Compara positive regulation of epidermal growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of extracellular matrix constituent secretion Inferred from electronic annotation. Source: Compara positive regulation of fatty acid biosynthetic process Inferred from mutant phenotype PubMed 11606482. Source: MGI positive regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from direct assay PubMed 19404405. Source: MGI positive regulation of multicellular organism growth Inferred from mutant phenotype PubMed 12660889. Source: MGI positive regulation of organ growth Inferred from direct assay PubMed 16374517. Source: MGI positive regulation of phosphatidylinositol 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of protein tyrosine kinase activity Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of superoxide anion generation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of calcium ion transport Inferred from electronic annotation. Source: Compara regulation of inflammatory response Inferred from direct assay PubMed 19404405. Source: MGI regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of norepinephrine secretion Inferred from electronic annotation. Source: Compara regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of renal output by angiotensin Inferred from mutant phenotype PubMed 11606482PubMed 9507198PubMed 9852267. Source: MGI renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Inferred from mutant phenotype PubMed 11606482. Source: MGI renin-angiotensin regulation of aldosterone production Inferred from mutant phenotype PubMed 10076178PubMed 9852267. Source: MGI response to cold Inferred from mutant phenotype PubMed 12574102. Source: MGI response to muscle activity involved in regulation of muscle adaptation Inferred from electronic annotation. Source: Compara response to salt stress Inferred from mutant phenotype PubMed 9557921. Source: MGI smooth muscle cell differentiation Inferred from direct assay PubMed 9788961. Source: MGI smooth muscle cell proliferation Inferred from direct assay PubMed 9788961. Source: MGI stress-activated MAPK cascade Inferred from electronic annotation. Source: Compara vasodilation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic part Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay PubMed 10425188PubMed 11606482PubMed 7989296. Source: MGI
Molecular_function	acetyltransferase activator activity Inferred from electronic annotation. Source: Compara serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome type 1 angiotensin receptor binding Inferred from direct assay PubMed 9878677. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q3UTR7 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: DC4633B4020178C9	FASTA	482	52,670
	10 20 30 40 50 60 MHRSEMTPTG AGLKATIFCI LTWVSLTAGD RVYIHPFHLL YHNKSTCAQL ENPSVETLPE 70 80 90 100 110 120 STFEPVPIQA KTSPVNEKTL HDQLVLAAEK LEDEDRKRAA QVAMIANFVG FRMYKMLNEA 130 140 150 160 170 180 GSGASGAILS PPALFGTLVS FYLGSLDPTA SQLQTLLDVP VKEGDCTSRL DGHKVLAALR 190 200 210 220 230 240 AIQGLLVTQG GSSSQTPLLQ SIVVGLFTAP GFRLKHSFVQ SLALFTPALF PRSLDLSTDP 250 260 270 280 290 300 VLATEKINRF IKAVTGWKMN LPLEGVSTDS TLLFNTYVHF QGTMRGFSQL PGVHEFWVDN 310 320 330 340 350 360 SISVSVPMIS GTGNFQHWSD TQNNFSVTCV PLGERATLLL IQPHCTSDLD RVEALIFRND 370 380 390 400 410 420 LLTWIENPPP RAIRLTLPQL EIRGSYNLQD LLAEDKLPTL LGAEANLNNI GDTNPRVGEV 430 440 450 460 470 480 LNSILLELKA GEEEQPTTSV QQPGSPEALD VTLSSPFLFA IYEQDSGTLH FLGRVNNPQS VV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE23913.1. Tissue: Cerebellum EMBL BAE23913.1.
[9]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000066488.
[10]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000066488.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC126930 Genomic DNA. No translation available. AK139179 mRNA. Translation: BAE23913.1.
IPI	IPI00654069.
RefSeq	NP_031454.3. NM_007428.3.
UniGene	Mm.301626.
3D structure databases
SMR	Q3UTR7. Positions 30-479.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000066488.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000063278; ENSMUSP00000066488; ENSMUSG00000031980.
GeneID	11606.
KEGG	mmu:11606.
UCSC	uc009nxe.1. mouse.
Organism-specific databases
CTD	183.
MGI	MGI:87963. Agt.
Phylogenomic databases
GeneTree	ENSGT00690000102272.
HOGENOM	HOG000033941.
HOVERGEN	HBG004233.
InParanoid	Q3UTR7.
KO	K09821.
OMA	TYVHFQG.
Gene expression databases
Genevestigator	Q3UTR7.
Family and domain databases
InterPro	IPR000227. Angiotensngn. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
PRINTS	PR00654. ANGIOTENSNGN.
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
ProtoNet	Search...
Other
NextBio	279140.
SOURCE	Search...

Entry information

Entry name

Q3UTR7_MOUSE

Accession

Primary (citable) accession number: Q3UTR7

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)