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Protein
Submitted name:

Angiotensinogen

Gene

Agt

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central
  • sodium channel regulator activity Source: MGI
  • type 1 angiotensin receptor binding Source: MGI
  • type 2 angiotensin receptor binding Source: MGI

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: MGI
  • activation of phospholipase C activity Source: Ensembl
  • aging Source: Ensembl
  • angiotensin-mediated drinking behavior Source: Ensembl
  • angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure Source: MGI
  • artery smooth muscle contraction Source: Ensembl
  • astrocyte activation Source: MGI
  • blood vessel development Source: MGI
  • brain renin-angiotensin system Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • catenin import into nucleus Source: Ensembl
  • cell growth involved in cardiac muscle cell development Source: Ensembl
  • cell-matrix adhesion Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • cellular sodium ion homeostasis Source: Ensembl
  • cytokine secretion Source: Ensembl
  • drinking behavior Source: MGI
  • ERK1 and ERK2 cascade Source: Ensembl
  • establishment of blood-nerve barrier Source: MGI
  • excretion Source: MGI
  • extracellular matrix organization Source: MGI
  • female pregnancy Source: Ensembl
  • fibroblast proliferation Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: MGI
  • hormone metabolic process Source: MGI
  • kidney development Source: MGI
  • negative regulation of angiogenesis Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of endopeptidase activity Source: GO_Central
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • negative regulation of tissue remodeling Source: Ensembl
  • ovarian follicle rupture Source: MGI
  • peristalsis Source: MGI
  • positive regulation of activation of JAK2 kinase activity Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: MGI
  • positive regulation of cardiac muscle hypertrophy Source: Ensembl
  • positive regulation of cellular protein metabolic process Source: MGI
  • positive regulation of cholesterol esterification Source: MGI
  • positive regulation of endothelial cell migration Source: MGI
  • positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
  • positive regulation of extracellular matrix constituent secretion Source: Ensembl
  • positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of fatty acid biosynthetic process Source: MGI
  • positive regulation of fibroblast proliferation Source: Ensembl
  • positive regulation of gap junction assembly Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of membrane hyperpolarization Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • positive regulation of nitric oxide biosynthetic process Source: Ensembl
  • positive regulation of organ growth Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein kinase C activity Source: MGI
  • positive regulation of protein tyrosine kinase activity Source: MGI
  • positive regulation of renal sodium excretion Source: Ensembl
  • positive regulation of superoxide anion generation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of vasodilation Source: Ensembl
  • regulation of apoptotic process Source: MGI
  • regulation of blood pressure Source: MGI
  • regulation of calcium ion transport Source: Ensembl
  • regulation of cardiac conduction Source: MGI
  • regulation of extracellular matrix assembly Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of inflammatory response Source: MGI
  • regulation of long-term neuronal synaptic plasticity Source: Ensembl
  • regulation of norepinephrine secretion Source: Ensembl
  • regulation of renal output by angiotensin Source: MGI
  • regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
  • regulation of transmission of nerve impulse Source: Ensembl
  • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: MGI
  • renal system process Source: MGI
  • renin-angiotensin regulation of aldosterone production Source: MGI
  • response to cold Source: MGI
  • response to muscle activity involved in regulation of muscle adaptation Source: Ensembl
  • response to salt stress Source: MGI
  • smooth muscle cell differentiation Source: MGI
  • smooth muscle cell proliferation Source: MGI
  • stress-activated MAPK cascade Source: Ensembl
  • uterine smooth muscle contraction Source: Ensembl
  • vasodilation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_281604. Metabolism of Angiotensinogen to Angiotensins.
REACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Protein family/group databases

MEROPSiI04.953.

Names & Taxonomyi

Protein namesi
Submitted name:
AngiotensinogenImported
Gene namesi
Name:AgtImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:87963. Agt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066488.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117773.
HOGENOMiHOG000033941.
HOVERGENiHBG004233.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG7QK0BN.
TreeFamiTF343201.

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UTR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRSEMTPTG AGLKATIFCI LTWVSLTAGD RVYIHPFHLL YHNKSTCAQL
60 70 80 90 100
ENPSVETLPE STFEPVPIQA KTSPVNEKTL HDQLVLAAEK LEDEDRKRAA
110 120 130 140 150
QVAMIANFVG FRMYKMLNEA GSGASGAILS PPALFGTLVS FYLGSLDPTA
160 170 180 190 200
SQLQTLLDVP VKEGDCTSRL DGHKVLAALR AIQGLLVTQG GSSSQTPLLQ
210 220 230 240 250
SIVVGLFTAP GFRLKHSFVQ SLALFTPALF PRSLDLSTDP VLATEKINRF
260 270 280 290 300
IKAVTGWKMN LPLEGVSTDS TLLFNTYVHF QGTMRGFSQL PGVHEFWVDN
310 320 330 340 350
SISVSVPMIS GTGNFQHWSD TQNNFSVTCV PLGERATLLL IQPHCTSDLD
360 370 380 390 400
RVEALIFRND LLTWIENPPP RAIRLTLPQL EIRGSYNLQD LLAEDKLPTL
410 420 430 440 450
LGAEANLNNI GDTNPRVGEV LNSILLELKA GEEEQPTTSV QQPGSPEALD
460 470 480
VTLSSPFLFA IYEQDSGTLH FLGRVNNPQS VV
Length:482
Mass (Da):52,670
Last modified:October 11, 2005 - v1
Checksum:iDC4633B4020178C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126930 Genomic DNA. No translation available.
AK139179 mRNA. Translation: BAE23913.1.
RefSeqiNP_031454.3. NM_007428.3.
UniGeneiMm.301626.

Genome annotation databases

EnsembliENSMUST00000063278; ENSMUSP00000066488; ENSMUSG00000031980.
GeneIDi11606.
KEGGimmu:11606.
UCSCiuc009nxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126930 Genomic DNA. No translation available.
AK139179 mRNA. Translation: BAE23913.1.
RefSeqiNP_031454.3. NM_007428.3.
UniGeneiMm.301626.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066488.

Protein family/group databases

MEROPSiI04.953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063278; ENSMUSP00000066488; ENSMUSG00000031980.
GeneIDi11606.
KEGGimmu:11606.
UCSCiuc009nxe.1. mouse.

Organism-specific databases

CTDi183.
MGIiMGI:87963. Agt.

Phylogenomic databases

GeneTreeiENSGT00750000117773.
HOGENOMiHOG000033941.
HOVERGENiHBG004233.
KOiK09821.
OMAiRFMQAVT.
OrthoDBiEOG7QK0BN.
TreeFamiTF343201.

Enzyme and pathway databases

ReactomeiREACT_281604. Metabolism of Angiotensinogen to Angiotensins.
REACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi279140.
SOURCEiSearch...

Family and domain databases

InterProiIPR000227. Angiotensinogen.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00654. ANGIOTENSNGN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: CerebellumImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ3UTR7_MOUSE
AccessioniPrimary (citable) accession number: Q3UTR7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.