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Protein

Cyclin-dependent kinase-like 5

Gene

Cdkl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates phosphorylation of MECP2.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei135 – 1351Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. kinase activity Source: MGI
  4. protein kinase activity Source: MGI

GO - Biological processi

  1. neuron migration Source: Ensembl
  2. positive regulation of axon extension Source: Ensembl
  3. positive regulation of dendrite morphogenesis Source: Ensembl
  4. positive regulation of Rac GTPase activity Source: Ensembl
  5. protein autophosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 5 (EC:2.7.11.22)
Gene namesi
Name:Cdkl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1278336. Cdkl5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. dendrite cytoplasm Source: Ensembl
  3. dendritic growth cone Source: Ensembl
  4. nucleoplasm Source: MGI
  5. nucleus Source: MGI
  6. ruffle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938Cyclin-dependent kinase-like 5PRO_0000275897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei720 – 7201PhosphoserineBy similarity
Modified residuei761 – 7611PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UTQ8.
PaxDbiQ3UTQ8.
PRIDEiQ3UTQ8.

PTM databases

PhosphoSiteiQ3UTQ8.

Expressioni

Gene expression databases

BgeeiQ3UTQ8.
CleanExiMM_CDKL5.
ExpressionAtlasiQ3UTQ8. baseline and differential.
GenevestigatoriQ3UTQ8.

Interactioni

Subunit structurei

Interacts with MECP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3UTQ8.
SMRiQ3UTQ8. Positions 9-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 297285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi784 – 7896Poly-Lys

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiQ3UTQ8.
KOiK08824.
OMAiHMDGSHS.
OrthoDBiEOG7992PS.
TreeFamiTF101032.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UTQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN
60 70 80 90 100
EEVKETTLRE LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL
110 120 130 140 150
EEMPNGVPPE KVKSYIYQLI KAIHWCHKND IVHRDIKPEN LLISHNDVLK
160 170 180 190 200
LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK SVDMWSVGCI
210 220 230 240 250
LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP
260 270 280 290 300
AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ
310 320 330 340 350
RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS
360 370 380 390 400
VGLPRAEEGL PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN
410 420 430 440 450
NIPHLLSPKE AKSKTEFDFN IDTKPSEGPG TKYLKSSTRS QQNRHSFMES
460 470 480 490 500
SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP SYRTKAKSHG ALSDSKSVSN
510 520 530 540 550
LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT LLSPSGRNNR
560 570 580 590 600
NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS
610 620 630 640 650
PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG
660 670 680 690 700
EQLPPEMTVA RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN
710 720 730 740 750
RHLYNDPVPR RVGSFYRVPS PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS
760 770 780 790 800
KRQPGFDPWK SPENISHADQ LKEKEKQGFF RSMKKKKKKT QTVPNTDGPD
810 820 830 840 850
LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR KLLHLSSSTN
860 870 880 890 900
HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA
910 920 930
LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ
Length:938
Mass (Da):105,489
Last modified:October 11, 2005 - v1
Checksum:i3502580AF9A48DDD
GO
Isoform 2 (identifier: Q3UTQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.
     402-410: IPHLLSPKE → MPLIPASKK

Note: No experimental confirmation available.

Show »
Length:537
Mass (Da):59,784
Checksum:iB47FF2787C0E643E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 401401Missing in isoform 2. 1 PublicationVSP_022968Add
BLAST
Alternative sequencei402 – 4109IPHLLSPKE → MPLIPASKK in isoform 2. 1 PublicationVSP_022969

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052380 mRNA. Translation: BAC34965.1.
AK139220 mRNA. Translation: BAE23922.1.
BC042705 mRNA. Translation: AAH42705.1.
CCDSiCCDS53238.1. [Q3UTQ8-1]
RefSeqiNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
UniGeneiMm.443717.

Genome annotation databases

EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
GeneIDi382253.
KEGGimmu:382253.
UCSCiuc009utr.2. mouse. [Q3UTQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052380 mRNA. Translation: BAC34965.1.
AK139220 mRNA. Translation: BAE23922.1.
BC042705 mRNA. Translation: AAH42705.1.
CCDSiCCDS53238.1. [Q3UTQ8-1]
RefSeqiNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
UniGeneiMm.443717.

3D structure databases

ProteinModelPortaliQ3UTQ8.
SMRiQ3UTQ8. Positions 9-343.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ3UTQ8.

Proteomic databases

MaxQBiQ3UTQ8.
PaxDbiQ3UTQ8.
PRIDEiQ3UTQ8.

Protocols and materials databases

DNASUi382253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
GeneIDi382253.
KEGGimmu:382253.
UCSCiuc009utr.2. mouse. [Q3UTQ8-1]

Organism-specific databases

CTDi6792.
MGIiMGI:1278336. Cdkl5.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiQ3UTQ8.
KOiK08824.
OMAiHMDGSHS.
OrthoDBiEOG7992PS.
TreeFamiTF101032.

Miscellaneous databases

NextBioi403189.
PROiQ3UTQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UTQ8.
CleanExiMM_CDKL5.
ExpressionAtlasiQ3UTQ8. baseline and differential.
GenevestigatoriQ3UTQ8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-788 (ISOFORM 2).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCDKL5_MOUSE
AccessioniPrimary (citable) accession number: Q3UTQ8
Secondary accession number(s): Q05BK3, Q8BWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.