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Q3UTQ8

- CDKL5_MOUSE

UniProt

Q3UTQ8 - CDKL5_MOUSE

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Protein

Cyclin-dependent kinase-like 5

Gene

Cdkl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates phosphorylation of MECP2.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei135 – 1351Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. kinase activity Source: MGI

GO - Biological processi

  1. neuron migration Source: Ensembl
  2. positive regulation of axon extension Source: Ensembl
  3. positive regulation of dendrite morphogenesis Source: Ensembl
  4. positive regulation of Rac GTPase activity Source: Ensembl
  5. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 5 (EC:2.7.11.22)
Gene namesi
Name:Cdkl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1278336. Cdkl5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. dendrite cytoplasm Source: Ensembl
  2. dendritic growth cone Source: Ensembl
  3. nucleus Source: UniProtKB-KW
  4. ruffle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 938938Cyclin-dependent kinase-like 5PRO_0000275897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei720 – 7201PhosphoserineBy similarity
Modified residuei761 – 7611PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UTQ8.
PaxDbiQ3UTQ8.
PRIDEiQ3UTQ8.

PTM databases

PhosphoSiteiQ3UTQ8.

Expressioni

Gene expression databases

BgeeiQ3UTQ8.
CleanExiMM_CDKL5.
ExpressionAtlasiQ3UTQ8. baseline and differential.
GenevestigatoriQ3UTQ8.

Interactioni

Subunit structurei

Interacts with MECP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3UTQ8.
SMRiQ3UTQ8. Positions 9-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 297285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi784 – 7896Poly-Lys

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiQ3UTQ8.
KOiK08824.
OMAiQPGSTSK.
OrthoDBiEOG7992PS.
TreeFamiTF101032.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UTQ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN
60 70 80 90 100
EEVKETTLRE LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL
110 120 130 140 150
EEMPNGVPPE KVKSYIYQLI KAIHWCHKND IVHRDIKPEN LLISHNDVLK
160 170 180 190 200
LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK SVDMWSVGCI
210 220 230 240 250
LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP
260 270 280 290 300
AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ
310 320 330 340 350
RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS
360 370 380 390 400
VGLPRAEEGL PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN
410 420 430 440 450
NIPHLLSPKE AKSKTEFDFN IDTKPSEGPG TKYLKSSTRS QQNRHSFMES
460 470 480 490 500
SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP SYRTKAKSHG ALSDSKSVSN
510 520 530 540 550
LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT LLSPSGRNNR
560 570 580 590 600
NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS
610 620 630 640 650
PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG
660 670 680 690 700
EQLPPEMTVA RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN
710 720 730 740 750
RHLYNDPVPR RVGSFYRVPS PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS
760 770 780 790 800
KRQPGFDPWK SPENISHADQ LKEKEKQGFF RSMKKKKKKT QTVPNTDGPD
810 820 830 840 850
LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR KLLHLSSSTN
860 870 880 890 900
HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA
910 920 930
LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ
Length:938
Mass (Da):105,489
Last modified:October 11, 2005 - v1
Checksum:i3502580AF9A48DDD
GO
Isoform 2 (identifier: Q3UTQ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.
     402-410: IPHLLSPKE → MPLIPASKK

Note: No experimental confirmation available.

Show »
Length:537
Mass (Da):59,784
Checksum:iB47FF2787C0E643E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 401401Missing in isoform 2. 1 PublicationVSP_022968Add
BLAST
Alternative sequencei402 – 4109IPHLLSPKE → MPLIPASKK in isoform 2. 1 PublicationVSP_022969

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052380 mRNA. Translation: BAC34965.1.
AK139220 mRNA. Translation: BAE23922.1.
BC042705 mRNA. Translation: AAH42705.1.
CCDSiCCDS53238.1. [Q3UTQ8-1]
RefSeqiNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
UniGeneiMm.443717.

Genome annotation databases

EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
GeneIDi382253.
KEGGimmu:382253.
UCSCiuc009utr.2. mouse. [Q3UTQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK052380 mRNA. Translation: BAC34965.1 .
AK139220 mRNA. Translation: BAE23922.1 .
BC042705 mRNA. Translation: AAH42705.1 .
CCDSi CCDS53238.1. [Q3UTQ8-1 ]
RefSeqi NP_001019795.1. NM_001024624.2. [Q3UTQ8-1 ]
UniGenei Mm.443717.

3D structure databases

ProteinModelPortali Q3UTQ8.
SMRi Q3UTQ8. Positions 9-343.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q3UTQ8.

Proteomic databases

MaxQBi Q3UTQ8.
PaxDbi Q3UTQ8.
PRIDEi Q3UTQ8.

Protocols and materials databases

DNASUi 382253.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087104 ; ENSMUSP00000084342 ; ENSMUSG00000031292 . [Q3UTQ8-1 ]
GeneIDi 382253.
KEGGi mmu:382253.
UCSCi uc009utr.2. mouse. [Q3UTQ8-1 ]

Organism-specific databases

CTDi 6792.
MGIi MGI:1278336. Cdkl5.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119242.
HOGENOMi HOG000049181.
HOVERGENi HBG050863.
InParanoidi Q3UTQ8.
KOi K08824.
OMAi QPGSTSK.
OrthoDBi EOG7992PS.
TreeFami TF101032.

Miscellaneous databases

NextBioi 403189.
PROi Q3UTQ8.
SOURCEi Search...

Gene expression databases

Bgeei Q3UTQ8.
CleanExi MM_CDKL5.
ExpressionAtlasi Q3UTQ8. baseline and differential.
Genevestigatori Q3UTQ8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-788 (ISOFORM 2).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCDKL5_MOUSE
AccessioniPrimary (citable) accession number: Q3UTQ8
Secondary accession number(s): Q05BK3, Q8BWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3