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Protein

Cyclin-dependent kinase-like 5

Gene

Cdkl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates phosphorylation of MECP2.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei135Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 5 (EC:2.7.11.22)
Gene namesi
Name:Cdkl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1278336. Cdkl5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002758971 – 938Cyclin-dependent kinase-like 5Add BLAST938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineCombined sources1
Modified residuei479PhosphoserineBy similarity1
Modified residuei720PhosphoserineBy similarity1
Modified residuei761PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UTQ8.
PeptideAtlasiQ3UTQ8.
PRIDEiQ3UTQ8.

PTM databases

iPTMnetiQ3UTQ8.
PhosphoSitePlusiQ3UTQ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031292.
CleanExiMM_CDKL5.
ExpressionAtlasiQ3UTQ8. baseline and differential.

Interactioni

Subunit structurei

Interacts with MECP2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084342.

Structurei

3D structure databases

ProteinModelPortaliQ3UTQ8.
SMRiQ3UTQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi784 – 789Poly-Lys6

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiQ3UTQ8.
KOiK08824.
TreeFamiTF101032.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UTQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN
60 70 80 90 100
EEVKETTLRE LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL
110 120 130 140 150
EEMPNGVPPE KVKSYIYQLI KAIHWCHKND IVHRDIKPEN LLISHNDVLK
160 170 180 190 200
LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK SVDMWSVGCI
210 220 230 240 250
LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP
260 270 280 290 300
AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ
310 320 330 340 350
RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS
360 370 380 390 400
VGLPRAEEGL PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN
410 420 430 440 450
NIPHLLSPKE AKSKTEFDFN IDTKPSEGPG TKYLKSSTRS QQNRHSFMES
460 470 480 490 500
SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP SYRTKAKSHG ALSDSKSVSN
510 520 530 540 550
LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT LLSPSGRNNR
560 570 580 590 600
NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS
610 620 630 640 650
PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG
660 670 680 690 700
EQLPPEMTVA RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN
710 720 730 740 750
RHLYNDPVPR RVGSFYRVPS PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS
760 770 780 790 800
KRQPGFDPWK SPENISHADQ LKEKEKQGFF RSMKKKKKKT QTVPNTDGPD
810 820 830 840 850
LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR KLLHLSSSTN
860 870 880 890 900
HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA
910 920 930
LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ
Length:938
Mass (Da):105,489
Last modified:October 11, 2005 - v1
Checksum:i3502580AF9A48DDD
GO
Isoform 2 (identifier: Q3UTQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.
     402-410: IPHLLSPKE → MPLIPASKK

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):59,784
Checksum:iB47FF2787C0E643E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229681 – 401Missing in isoform 2. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_022969402 – 410IPHLLSPKE → MPLIPASKK in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052380 mRNA. Translation: BAC34965.1.
AK139220 mRNA. Translation: BAE23922.1.
BC042705 mRNA. Translation: AAH42705.1.
CCDSiCCDS53238.1. [Q3UTQ8-1]
RefSeqiNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
UniGeneiMm.443717.

Genome annotation databases

EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
GeneIDi382253.
KEGGimmu:382253.
UCSCiuc009utr.2. mouse. [Q3UTQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052380 mRNA. Translation: BAC34965.1.
AK139220 mRNA. Translation: BAE23922.1.
BC042705 mRNA. Translation: AAH42705.1.
CCDSiCCDS53238.1. [Q3UTQ8-1]
RefSeqiNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
UniGeneiMm.443717.

3D structure databases

ProteinModelPortaliQ3UTQ8.
SMRiQ3UTQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084342.

PTM databases

iPTMnetiQ3UTQ8.
PhosphoSitePlusiQ3UTQ8.

Proteomic databases

PaxDbiQ3UTQ8.
PeptideAtlasiQ3UTQ8.
PRIDEiQ3UTQ8.

Protocols and materials databases

DNASUi382253.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
GeneIDi382253.
KEGGimmu:382253.
UCSCiuc009utr.2. mouse. [Q3UTQ8-1]

Organism-specific databases

CTDi6792.
MGIiMGI:1278336. Cdkl5.

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOGENOMiHOG000049181.
HOVERGENiHBG050863.
InParanoidiQ3UTQ8.
KOiK08824.
TreeFamiTF101032.

Miscellaneous databases

PROiQ3UTQ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031292.
CleanExiMM_CDKL5.
ExpressionAtlasiQ3UTQ8. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL5_MOUSE
AccessioniPrimary (citable) accession number: Q3UTQ8
Secondary accession number(s): Q05BK3, Q8BWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.