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Q3UTQ8

- CDKL5_MOUSE

UniProt

Q3UTQ8 - CDKL5_MOUSE

Protein

Cyclin-dependent kinase-like 5

Gene

Cdkl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Mediates phosphorylation of MECP2.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei135 – 1351Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. kinase activity Source: MGI

    GO - Biological processi

    1. neuron migration Source: Ensembl
    2. positive regulation of axon extension Source: Ensembl
    3. positive regulation of dendrite morphogenesis Source: Ensembl
    4. positive regulation of Rac GTPase activity Source: Ensembl
    5. protein autophosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 5 (EC:2.7.11.22)
    Gene namesi
    Name:Cdkl5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1278336. Cdkl5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. dendrite cytoplasm Source: Ensembl
    2. dendritic growth cone Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. ruffle membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 938938Cyclin-dependent kinase-like 5PRO_0000275897Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei407 – 4071PhosphoserineBy similarity
    Modified residuei720 – 7201PhosphoserineBy similarity
    Modified residuei761 – 7611PhosphoserineBy similarity

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ3UTQ8.
    PRIDEiQ3UTQ8.

    PTM databases

    PhosphoSiteiQ3UTQ8.

    Expressioni

    Gene expression databases

    BgeeiQ3UTQ8.
    CleanExiMM_CDKL5.
    GenevestigatoriQ3UTQ8.

    Interactioni

    Subunit structurei

    Interacts with MECP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ3UTQ8.
    SMRiQ3UTQ8. Positions 9-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 297285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi784 – 7896Poly-Lys

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000115348.
    HOGENOMiHOG000049181.
    HOVERGENiHBG050863.
    InParanoidiQ3UTQ8.
    KOiK08824.
    OMAiQPGSTSK.
    OrthoDBiEOG7992PS.
    TreeFamiTF101032.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q3UTQ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN    50
    EEVKETTLRE LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL 100
    EEMPNGVPPE KVKSYIYQLI KAIHWCHKND IVHRDIKPEN LLISHNDVLK 150
    LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK SVDMWSVGCI 200
    LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP 250
    AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300
    RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS 350
    VGLPRAEEGL PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN 400
    NIPHLLSPKE AKSKTEFDFN IDTKPSEGPG TKYLKSSTRS QQNRHSFMES 450
    SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP SYRTKAKSHG ALSDSKSVSN 500
    LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT LLSPSGRNNR 550
    NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600
    PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG 650
    EQLPPEMTVA RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN 700
    RHLYNDPVPR RVGSFYRVPS PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS 750
    KRQPGFDPWK SPENISHADQ LKEKEKQGFF RSMKKKKKKT QTVPNTDGPD 800
    LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR KLLHLSSSTN 850
    HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA 900
    LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ 938
    Length:938
    Mass (Da):105,489
    Last modified:October 11, 2005 - v1
    Checksum:i3502580AF9A48DDD
    GO
    Isoform 2 (identifier: Q3UTQ8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-401: Missing.
         402-410: IPHLLSPKE → MPLIPASKK

    Note: No experimental confirmation available.

    Show »
    Length:537
    Mass (Da):59,784
    Checksum:iB47FF2787C0E643E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 401401Missing in isoform 2. 1 PublicationVSP_022968Add
    BLAST
    Alternative sequencei402 – 4109IPHLLSPKE → MPLIPASKK in isoform 2. 1 PublicationVSP_022969

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052380 mRNA. Translation: BAC34965.1.
    AK139220 mRNA. Translation: BAE23922.1.
    BC042705 mRNA. Translation: AAH42705.1.
    CCDSiCCDS53238.1. [Q3UTQ8-1]
    RefSeqiNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
    UniGeneiMm.443717.

    Genome annotation databases

    EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
    GeneIDi382253.
    KEGGimmu:382253.
    UCSCiuc009utr.2. mouse. [Q3UTQ8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK052380 mRNA. Translation: BAC34965.1 .
    AK139220 mRNA. Translation: BAE23922.1 .
    BC042705 mRNA. Translation: AAH42705.1 .
    CCDSi CCDS53238.1. [Q3UTQ8-1 ]
    RefSeqi NP_001019795.1. NM_001024624.2. [Q3UTQ8-1 ]
    UniGenei Mm.443717.

    3D structure databases

    ProteinModelPortali Q3UTQ8.
    SMRi Q3UTQ8. Positions 9-343.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q3UTQ8.

    Proteomic databases

    PaxDbi Q3UTQ8.
    PRIDEi Q3UTQ8.

    Protocols and materials databases

    DNASUi 382253.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087104 ; ENSMUSP00000084342 ; ENSMUSG00000031292 . [Q3UTQ8-1 ]
    GeneIDi 382253.
    KEGGi mmu:382253.
    UCSCi uc009utr.2. mouse. [Q3UTQ8-1 ]

    Organism-specific databases

    CTDi 6792.
    MGIi MGI:1278336. Cdkl5.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000115348.
    HOGENOMi HOG000049181.
    HOVERGENi HBG050863.
    InParanoidi Q3UTQ8.
    KOi K08824.
    OMAi QPGSTSK.
    OrthoDBi EOG7992PS.
    TreeFami TF101032.

    Miscellaneous databases

    NextBioi 403189.
    PROi Q3UTQ8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3UTQ8.
    CleanExi MM_CDKL5.
    Genevestigatori Q3UTQ8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-788 (ISOFORM 2).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCDKL5_MOUSE
    AccessioniPrimary (citable) accession number: Q3UTQ8
    Secondary accession number(s): Q05BK3, Q8BWI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3