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Q3UTQ8 (CDKL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase-like 5

EC=2.7.11.22
Gene names
Name:Cdkl5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length938 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates phosphorylation of MECP2 By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with MECP2 By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3UTQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3UTQ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.
     402-410: IPHLLSPKE → MPLIPASKK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 938938Cyclin-dependent kinase-like 5
PRO_0000275897

Regions

Domain13 – 297285Protein kinase
Nucleotide binding19 – 279ATP By similarity
Compositional bias784 – 7896Poly-Lys

Sites

Active site1351Proton acceptor By similarity
Binding site421ATP By similarity

Amino acid modifications

Modified residue4071Phosphoserine By similarity
Modified residue7201Phosphoserine By similarity
Modified residue7611Phosphoserine By similarity

Natural variations

Alternative sequence1 – 401401Missing in isoform 2.
VSP_022968
Alternative sequence402 – 4109IPHLLSPKE → MPLIPASKK in isoform 2.
VSP_022969

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 3502580AF9A48DDD

FASTA938105,489
        10         20         30         40         50         60 
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 

        70         80         90        100        110        120 
LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 

       130        140        150        160        170        180 
KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 

       190        200        210        220        230        240 
ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 

       250        260        270        280        290        300 
NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 

       310        320        330        340        350        360 
RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS VGLPRAEEGL 

       370        380        390        400        410        420 
PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN NIPHLLSPKE AKSKTEFDFN 

       430        440        450        460        470        480 
IDTKPSEGPG TKYLKSSTRS QQNRHSFMES SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP 

       490        500        510        520        530        540 
SYRTKAKSHG ALSDSKSVSN LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT 

       550        560        570        580        590        600 
LLSPSGRNNR NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 

       610        620        630        640        650        660 
PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 

       670        680        690        700        710        720 
RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 

       730        740        750        760        770        780 
PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS KRQPGFDPWK SPENISHADQ LKEKEKQGFF 

       790        800        810        820        830        840 
RSMKKKKKKT QTVPNTDGPD LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR 

       850        860        870        880        890        900 
KLLHLSSSTN HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA 

       910        920        930 
LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ 

« Hide

Isoform 2 [UniParc].

Checksum: B47FF2787C0E643E
Show »

FASTA53759,784

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Cerebellum and Heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-788 (ISOFORM 2).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK052380 mRNA. Translation: BAC34965.1.
AK139220 mRNA. Translation: BAE23922.1.
BC042705 mRNA. Translation: AAH42705.1.
CCDSCCDS53238.1. [Q3UTQ8-1]
RefSeqNP_001019795.1. NM_001024624.2. [Q3UTQ8-1]
UniGeneMm.443717.

3D structure databases

ProteinModelPortalQ3UTQ8.
SMRQ3UTQ8. Positions 9-343.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ3UTQ8.

Proteomic databases

PaxDbQ3UTQ8.
PRIDEQ3UTQ8.

Protocols and materials databases

DNASU382253.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292. [Q3UTQ8-1]
GeneID382253.
KEGGmmu:382253.
UCSCuc009utr.2. mouse. [Q3UTQ8-1]

Organism-specific databases

CTD6792.
MGIMGI:1278336. Cdkl5.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000115348.
HOGENOMHOG000049181.
HOVERGENHBG050863.
InParanoidQ3UTQ8.
KOK08824.
OMAQPGSTSK.
OrthoDBEOG7992PS.
TreeFamTF101032.

Gene expression databases

BgeeQ3UTQ8.
CleanExMM_CDKL5.
GenevestigatorQ3UTQ8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio403189.
PROQ3UTQ8.
SOURCESearch...

Entry information

Entry nameCDKL5_MOUSE
AccessionPrimary (citable) accession number: Q3UTQ8
Secondary accession number(s): Q05BK3, Q8BWI8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot