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Protein

Cyclin-dependent kinase-like 5

Gene

Cdkl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates phosphorylation of MECP2. May regulate ciliogenesis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei135Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 5Curated (EC:2.7.11.22)
Gene namesi
Name:Cdkl5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1278336 Cdkl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002758971 – 938Cyclin-dependent kinase-like 5Add BLAST938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei407PhosphoserineCombined sources1
Modified residuei479PhosphoserineBy similarity1
Modified residuei720PhosphoserineBy similarity1
Modified residuei761PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UTQ8
PeptideAtlasiQ3UTQ8
PRIDEiQ3UTQ8

PTM databases

iPTMnetiQ3UTQ8
PhosphoSitePlusiQ3UTQ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000031292
CleanExiMM_CDKL5
ExpressionAtlasiQ3UTQ8 baseline and differential

Interactioni

Subunit structurei

Interacts with MECP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084342

Structurei

3D structure databases

ProteinModelPortaliQ3UTQ8
SMRiQ3UTQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 297Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi784 – 789Poly-Lys6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
GeneTreeiENSGT00830000128262
HOGENOMiHOG000049181
HOVERGENiHBG050863
InParanoidiQ3UTQ8
KOiK08824
TreeFamiTF101032

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UTQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN
60 70 80 90 100
EEVKETTLRE LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL
110 120 130 140 150
EEMPNGVPPE KVKSYIYQLI KAIHWCHKND IVHRDIKPEN LLISHNDVLK
160 170 180 190 200
LCDFGFARNL SEGNNANYTE YVATRWYRSP ELLLGAPYGK SVDMWSVGCI
210 220 230 240 250
LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS NPRFHGLRFP
260 270 280 290 300
AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ
310 320 330 340 350
RLLDRSPSRS TKRKPYHVES STLSNRNQST KGAALQTHHR SNSKDIQNLS
360 370 380 390 400
VGLPRAEEGL PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN
410 420 430 440 450
NIPHLLSPKE AKSKTEFDFN IDTKPSEGPG TKYLKSSTRS QQNRHSFMES
460 470 480 490 500
SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP SYRTKAKSHG ALSDSKSVSN
510 520 530 540 550
LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT LLSPSGRNNR
560 570 580 590 600
NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS
610 620 630 640 650
PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS IGQGMAARAN SLQLLSPQPG
660 670 680 690 700
EQLPPEMTVA RPSVKESSRE GASSFHTRQK SEGGVYHDPH SDDGTAPKEN
710 720 730 740 750
RHLYNDPVPR RVGSFYRVPS PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS
760 770 780 790 800
KRQPGFDPWK SPENISHADQ LKEKEKQGFF RSMKKKKKKT QTVPNTDGPD
810 820 830 840 850
LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQSQPLKSLR KLLHLSSSTN
860 870 880 890 900
HPASSDPRFQ PLTAQQAKNS FSEIRIHPLS QATGGSSNIR QEPTPKGRPA
910 920 930
LQLPGSSLLR YNGWKHSRSR SSQPDEVIFL ASHEKWKQ
Length:938
Mass (Da):105,489
Last modified:October 11, 2005 - v1
Checksum:i3502580AF9A48DDD
GO
Isoform 2 (identifier: Q3UTQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.
     402-410: IPHLLSPKE → MPLIPASKK

Note: No experimental confirmation available.
Show »
Length:537
Mass (Da):59,784
Checksum:iB47FF2787C0E643E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229681 – 401Missing in isoform 2. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_022969402 – 410IPHLLSPKE → MPLIPASKK in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052380 mRNA Translation: BAC34965.1
AK139220 mRNA Translation: BAE23922.1
BC042705 mRNA Translation: AAH42705.1
CCDSiCCDS53238.1 [Q3UTQ8-1]
RefSeqiNP_001019795.1, NM_001024624.2 [Q3UTQ8-1]
UniGeneiMm.443717

Genome annotation databases

EnsembliENSMUST00000087104; ENSMUSP00000084342; ENSMUSG00000031292 [Q3UTQ8-1]
GeneIDi382253
KEGGimmu:382253
UCSCiuc009utr.2 mouse [Q3UTQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCDKL5_MOUSE
AccessioniPrimary (citable) accession number: Q3UTQ8
Secondary accession number(s): Q05BK3, Q8BWI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

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