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Protein

Heparan-sulfate 6-O-sulfotransferase

Gene

Hs6st3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferaseUniRule annotation (EC:2.8.2.-UniRule annotation)
Gene namesi
Name:Hs6st3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1354960. Hs6st3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 26HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiQ3UTM4.

Expressioni

Gene expression databases

GenevisibleiQ3UTM4. MM.

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000007772.
HOVERGENiHBG083012.
KOiK08103.

Family and domain databases

InterProiView protein in InterPro
IPR010635. Heparan_SO4-6-sulfoTrfase.
IPR005331. Sulfotransferase.
PANTHERiPTHR12812. PTHR12812. 1 hit.
PfamiView protein in Pfam
PF03567. Sulfotransfer_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UTM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDERFNKWLL TPVLTLLFVV IMYQYVSPSC TSSCTNFGEQ LRSGEARPPA
60 70 80 90 100
VPSPARRAQA PLDEWERRPQ LPPPPRGPPE GSRGVAAPED EDEDPGDPEE
110 120 130 140 150
EEEEEEEEPD PEAPENGSLP RFVPRFNFTL KDLTRFVDFN IKGRDVIVFL
160 170 180 190 200
HIQKTGGTTF GRHLVKNIRL EQPCSCKAGQ KKCTCHRPGK KETWLFSRFS
210 220 230 240 250
TGWSCGLHAD WTELTNCVPA IMEKKDCPRN HSHTRYCPAS VGFLNPTPFP
260 270 280
QVLTPPVPRR APLAVWQWLS KGWAANLGEG
Length:280
Mass (Da):31,587
Last modified:October 11, 2005 - v1
Checksum:i24F411F7D412F34E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139324 mRNA. Translation: BAE23956.1.
RefSeqiNP_056635.2. NM_015820.3.
UniGeneiMm.445777.

Genome annotation databases

GeneIDi50787.
KEGGimmu:50787.

Similar proteinsi

Entry informationi

Entry nameiQ3UTM4_MOUSE
AccessioniPrimary (citable) accession number: Q3UTM4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)