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Protein

Forkhead box protein R1

Gene

Foxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 248100Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein R1
Alternative name(s):
Forkhead box protein N5
Gene namesi
Name:Foxr1
Synonyms:Foxn5, Gm1115
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2685961. Foxr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Forkhead box protein R1PRO_0000253779Add
BLAST

Proteomic databases

PaxDbiQ3UTB7.
PRIDEiQ3UTB7.

PTM databases

iPTMnetiQ3UTB7.

Expressioni

Gene expression databases

BgeeiQ3UTB7.
CleanExiMM_FOXR1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096436.

Structurei

3D structure databases

ProteinModelPortaliQ3UTB7.
SMRiQ3UTB7. Positions 154-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00840000129742.
HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ3UTB7.
OrthoDBiEOG7J9VQ2.
PhylomeDBiQ3UTB7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UTB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNECFLTFT TTHLSEAEQK LALYRLQLVE PPKLPLEKKT NPDKDGPDIK
60 70 80 90 100
PNLWMWVNPN MVYPPGKLEV AVKEEDQSAL SAFQPALKEE EDSCSEASEV
110 120 130 140 150
QQPLPPCRQK RKQRRSTVPL PLAPGRRAPL ENPWRLPQAI SPEGRLWSRP
160 170 180 190 200
PLHYFHLIAL ALRNSPPCGL SVQQIYSFTR EHFPFFRTAP EAWKNTVRHN
210 220 230 240 250
LSFRDSFEKV PASRQGGAST GPRSCLWKLT EEGHRRFSKE ARTLASTQLQ
260
SIQQCMSQPG VKPFLFDL
Length:268
Mass (Da):30,579
Last modified:October 17, 2006 - v2
Checksum:iE944AC7A39C5B7B8
GO
Isoform 2 (identifier: Q3UTB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-223: EHFPFFRTAP...RQGGASTGPR → QNICLLSAQE...YSFSYPVPKD
     224-268: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):25,373
Checksum:iB5CF0C3045C87044
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei181 – 22343EHFPF…STGPR → QNICLLSAQEHNHSYPFATY NPAVPQIPILLGRYSFSYPV PKD in isoform 2. 1 PublicationVSP_021113Add
BLAST
Alternative sequencei224 – 26845Missing in isoform 2. 1 PublicationVSP_021114Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139562 mRNA. Translation: BAE24063.1.
AC122428 Genomic DNA. No translation available.
CCDSiCCDS23111.1. [Q3UTB7-2]
RefSeqiNP_001028641.1. NM_001033469.2. [Q3UTB7-2]
UniGeneiMm.335103.

Genome annotation databases

EnsembliENSMUST00000098837; ENSMUSP00000096436; ENSMUSG00000074397. [Q3UTB7-2]
GeneIDi382074.
KEGGimmu:382074.
UCSCiuc009pdr.1. mouse. [Q3UTB7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139562 mRNA. Translation: BAE24063.1.
AC122428 Genomic DNA. No translation available.
CCDSiCCDS23111.1. [Q3UTB7-2]
RefSeqiNP_001028641.1. NM_001033469.2. [Q3UTB7-2]
UniGeneiMm.335103.

3D structure databases

ProteinModelPortaliQ3UTB7.
SMRiQ3UTB7. Positions 154-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096436.

PTM databases

iPTMnetiQ3UTB7.

Proteomic databases

PaxDbiQ3UTB7.
PRIDEiQ3UTB7.

Protocols and materials databases

DNASUi382074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098837; ENSMUSP00000096436; ENSMUSG00000074397. [Q3UTB7-2]
GeneIDi382074.
KEGGimmu:382074.
UCSCiuc009pdr.1. mouse. [Q3UTB7-2]

Organism-specific databases

CTDi283150.
MGIiMGI:2685961. Foxr1.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00840000129742.
HOGENOMiHOG000004846.
HOVERGENiHBG080262.
InParanoidiQ3UTB7.
OrthoDBiEOG7J9VQ2.
PhylomeDBiQ3UTB7.

Miscellaneous databases

PROiQ3UTB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UTB7.
CleanExiMM_FOXR1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Egg.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFOXR1_MOUSE
AccessioniPrimary (citable) accession number: Q3UTB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.