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Protein

Deleted in autism protein 1 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Deleted in autism protein 1 homolog
Alternative name(s):
Golgi Protein of 49 kDa
Short name:
GoPro49
Hypoxia and AKT-induced stem cell factor
Short name:
HASF
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916111. 1190002N15Rik.

Subcellular locationi

GO - Cellular componenti

  • COPI-coated vesicle Source: MGI
  • COPI vesicle coat Source: MGI
  • extracellular space Source: UniProtKB
  • Golgi membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence analysisAdd
BLAST
Chaini36 – 430395Deleted in autism protein 1 homologPRO_0000226038Add
BLAST

Proteomic databases

EPDiQ3USZ8.
MaxQBiQ3USZ8.
PaxDbiQ3USZ8.
PRIDEiQ3USZ8.

PTM databases

PhosphoSiteiQ3USZ8.

Expressioni

Tissue specificityi

Expressed in heart, brain, liver, spleen, kidney, lung, thymus, testis, ovary and muscle.1 Publication

Developmental stagei

As early as 12.5 dpc to 16.5 dpc, intense expression is restricted to mesenchymal condensations, which form the different cartilage elements of the developing skeleton. At 12.5 dpc, strongly expressed in all vertebrae, heart ventricle, dental follicle, interdigital tissue, tongue and cartilages of the basioccipital bone, maxilla, mandible and the region of the future nasal septum. At 14.5 and 16.5 dpc, expressed in ribs, long bones, interdigital tissue, metatarsals, dental follicle, cartilages of the mandible and nasal septum as well as vertebrae with stronger expression in posterior vertebrae. At 16.5 dpc, also expressed in paw bones and, in vertebrae, the expression is limited to mainly columnar, proliferating chondrocytes. At 4 days postnatal, intense expression in nasal cartilages, hair, dental and vibrissa follicles.2 Publications

Gene expression databases

CleanExiMM_1190002N15RIK.
GenevisibleiQ3USZ8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108651.

Structurei

3D structure databases

ProteinModelPortaliQ3USZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DIA1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKM0. Eukaryota.
ENOG410XR52. LUCA.
GeneTreeiENSGT00520000055625.
HOGENOMiHOG000234327.
HOVERGENiHBG058913.
InParanoidiQ3USZ8.
OMAiSRYATWR.
OrthoDBiEOG7DRJ40.
TreeFamiTF313319.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR020519. UPF0672.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
[Graphical view]
ProDomiPD307452. UPF0672. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3USZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLVPLKLG RLSRALKLAA LGSLLVLMLL HSPSLLASWQ RNELADRRFL
60 70 80 90 100
QLNKCPACFG TSWCRRFLNG QVGFETWGRL RLLDFLNVKN VYFAQYGEPR
110 120 130 140 150
EGGRRRVVLK RLGSQRELAQ LDQSICKRAT GRPRCDLLQA MPRTEFARLN
160 170 180 190 200
GDVRLLTPEA VEGWSDLVHC PSQRLLDRLV RRYAETKDSG SFLLRNLKDS
210 220 230 240 250
ERMQLLLTLA FNPEPLVLQS FPSDEGWPFA KYLGACGRMV AVNYVGEELW
260 270 280 290 300
SYFNAPWEKR VDLAWQLMEI AEQLTNNDFE FALYLLDVSF DNFAVGPRDG
310 320 330 340 350
KVIIVDAENV LVADKRLIRQ NKPENWDVWY ESKFDDCDKE ACLSFSKEIL
360 370 380 390 400
CARVTVDHNY YAVCQNLLSR HATWRGTSGG LLHDPPSEIA KDGRLEALLD
410 420 430
ECTNPKKRYG RFQAAKELRG YLAQLSHNVR
Length:430
Mass (Da):49,463
Last modified:September 18, 2013 - v2
Checksum:i4A63FFC4E13379D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 2220RLVPL…LAALG → MAVVLRMSNI in BAE24182 (PubMed:16141072).CuratedAdd
BLAST
Sequence conflicti426 – 4305SHNVR → KSQCEVVSSDLYIFFAEKAL TKLNHQKNCLE in BAE24182 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139920 mRNA. Translation: BAE24182.1.
AC160129 Genomic DNA. No translation available.
CCDSiCCDS40725.1.
RefSeqiNP_001028317.2. NM_001033145.2.
UniGeneiMm.258746.

Genome annotation databases

EnsembliENSMUST00000113028; ENSMUSP00000108651; ENSMUSG00000045414.
GeneIDi68861.
KEGGimmu:68861.
UCSCiuc009rax.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139920 mRNA. Translation: BAE24182.1.
AC160129 Genomic DNA. No translation available.
CCDSiCCDS40725.1.
RefSeqiNP_001028317.2. NM_001033145.2.
UniGeneiMm.258746.

3D structure databases

ProteinModelPortaliQ3USZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108651.

PTM databases

PhosphoSiteiQ3USZ8.

Proteomic databases

EPDiQ3USZ8.
MaxQBiQ3USZ8.
PaxDbiQ3USZ8.
PRIDEiQ3USZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113028; ENSMUSP00000108651; ENSMUSG00000045414.
GeneIDi68861.
KEGGimmu:68861.
UCSCiuc009rax.1. mouse.

Organism-specific databases

MGIiMGI:1916111. 1190002N15Rik.

Phylogenomic databases

eggNOGiENOG410IKM0. Eukaryota.
ENOG410XR52. LUCA.
GeneTreeiENSGT00520000055625.
HOGENOMiHOG000234327.
HOVERGENiHBG058913.
InParanoidiQ3USZ8.
OMAiSRYATWR.
OrthoDBiEOG7DRJ40.
TreeFamiTF313319.

Miscellaneous databases

NextBioi328073.
PROiQ3USZ8.

Gene expression databases

CleanExiMM_1190002N15RIK.
GenevisibleiQ3USZ8. MM.

Family and domain databases

InterProiIPR022049. FAM69_kinase_dom.
IPR020519. UPF0672.
[Graphical view]
PfamiPF12260. PIP49_C. 1 hit.
[Graphical view]
ProDomiPD307452. UPF0672. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Expression of the novel Golgi protein GoPro49 is developmentally regulated during mesenchymal differentiation."
    Takatalo M., Jaervinen E., Laitinen S., Thesleff I., Roennholm R.
    Dev. Dyn. 237:2243-2255(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. "Novel Golgi protein, GoPro49, is a specific dental follicle marker."
    Takatalo M.S., Tummers M., Thesleff I., Roennholm R.
    J. Dent. Res. 88:534-538(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  5. "C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway."
    Beigi F., Schmeckpeper J., Pow-Anpongkul P., Payne J.A., Zhang L., Zhang Z., Huang J., Mirotsou M., Dzau V.J.
    Circ. Res. 113:372-380(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CARDIOMYOCYTE PROLIFERATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDIA1_MOUSE
AccessioniPrimary (citable) accession number: Q3USZ8
Secondary accession number(s): E9Q9E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 18, 2013
Last modified: March 16, 2016
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.