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Protein

Putative sodium-coupled neutral amino acid transporter 11

Gene

Slc38a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 11
Alternative name(s):
Solute carrier family 38 member 11
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443383. Slc38a11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003260611 – 453Putative sodium-coupled neutral amino acid transporter 11Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3USY0.
PRIDEiQ3USY0.

PTM databases

iPTMnetiQ3USY0.
PhosphoSitePlusiQ3USY0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061171.
CleanExiMM_SLC38A11.
ExpressionAtlasiQ3USY0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108039.

Structurei

3D structure databases

ProteinModelPortaliQ3USY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000188354.
HOVERGENiHBG106990.
InParanoidiQ3USY0.
KOiK14997.
OMAiHFQLTTQ.
OrthoDBiEOG091G086V.
PhylomeDBiQ3USY0.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3USY0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYQQPQLSG PLQRETDSSD RESLISGHEH GGKSSQSAAV FNVVNSVIGS
60 70 80 90 100
GIIGLPYSMK QAGFPLGILL LFLVSYITDF SLVLLIKGGA LSGTDSYQSL
110 120 130 140 150
VNKTFGFPGY LLLSTLQFMY PFIAMISYNI ITGDTLSKVF QRLPGVDPGG
160 170 180 190 200
WFISRHFIIV VSTVTCTLPL SLYRDIAKLG KISFISTILT TVILGIVMTR
210 220 230 240 250
AISLGPNIPK TDNAWVFAKP NAIQAIGVMS FAFICHHNCF LVYGSLEEPT
260 270 280 290 300
VAKWRRIIHT SILVSVFICV LFATCGYFTF TGFTQGDLFE NYCRSDDLVT
310 320 330 340 350
FGRFCYGITV ILTYPIECFV TREVIANVFF GGTLSSVFHT VLAVLIVTAA
360 370 380 390 400
TLVSLMIECL GIVLELNGVL CAAPLIFIIP SACYLKLSEE PRTHSDKIMA
410 420 430 440 450
CVMFPVGAVV MVVGFVMAIT NPQDCTHGQE MFYCFPENVS FTNTSWSHLQ

LTT
Length:453
Mass (Da):49,615
Last modified:March 18, 2008 - v2
Checksum:i77F6BAE153B7BAAF
GO
Isoform 2 (identifier: Q3USY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-78: Missing.

Note: No experimental confirmation available.
Show »
Length:428
Mass (Da):46,891
Checksum:i122609BD8921E684
GO
Isoform 3 (identifier: Q3USY0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-145: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):47,208
Checksum:i13A60FE05F1EC79D
GO

Sequence cautioni

The sequence BAE24200 differs from that shown. Reason: Frameshift at position 408.Curated
The sequence CAM23396 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM23397 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03253054 – 78Missing in isoform 2. CuratedAdd BLAST25
Alternative sequenceiVSP_032531124 – 145Missing in isoform 3. CuratedAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139966 mRNA. Translation: BAE24200.1. Frameshift.
AL928621, AL929132 Genomic DNA. Translation: CAM23396.1. Sequence problems.
AL928621, AL929132 Genomic DNA. Translation: CAM23397.1. Sequence problems.
CCDSiCCDS38129.1. [Q3USY0-1]
RefSeqiNP_796048.2. NM_177074.2. [Q3USY0-1]
UniGeneiMm.227703.

Genome annotation databases

EnsembliENSMUST00000112420; ENSMUSP00000108039; ENSMUSG00000061171. [Q3USY0-1]
GeneIDi320106.
KEGGimmu:320106.
UCSCiuc008jwj.1. mouse. [Q3USY0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139966 mRNA. Translation: BAE24200.1. Frameshift.
AL928621, AL929132 Genomic DNA. Translation: CAM23396.1. Sequence problems.
AL928621, AL929132 Genomic DNA. Translation: CAM23397.1. Sequence problems.
CCDSiCCDS38129.1. [Q3USY0-1]
RefSeqiNP_796048.2. NM_177074.2. [Q3USY0-1]
UniGeneiMm.227703.

3D structure databases

ProteinModelPortaliQ3USY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108039.

PTM databases

iPTMnetiQ3USY0.
PhosphoSitePlusiQ3USY0.

Proteomic databases

PaxDbiQ3USY0.
PRIDEiQ3USY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112420; ENSMUSP00000108039; ENSMUSG00000061171. [Q3USY0-1]
GeneIDi320106.
KEGGimmu:320106.
UCSCiuc008jwj.1. mouse. [Q3USY0-1]

Organism-specific databases

CTDi151258.
MGIiMGI:2443383. Slc38a11.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000188354.
HOVERGENiHBG106990.
InParanoidiQ3USY0.
KOiK14997.
OMAiHFQLTTQ.
OrthoDBiEOG091G086V.
PhylomeDBiQ3USY0.
TreeFamiTF328787.

Miscellaneous databases

PROiQ3USY0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061171.
CleanExiMM_SLC38A11.
ExpressionAtlasiQ3USY0. baseline and differential.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38AB_MOUSE
AccessioniPrimary (citable) accession number: Q3USY0
Secondary accession number(s): A2ASI0, A2ASI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.