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Protein

FAD-dependent oxidoreductase domain-containing protein 2

Gene

Foxred2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity).By similarity

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
FAD-dependent oxidoreductase domain-containing protein 2
Gene namesi
Name:Foxred2Imported
Synonyms:D15Bwg0759e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:106315. Foxred2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000033769318 – 665FAD-dependent oxidoreductase domain-containing protein 2Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3USW5.
PaxDbiQ3USW5.
PeptideAtlasiQ3USW5.
PRIDEiQ3USW5.

PTM databases

PhosphoSitePlusiQ3USW5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016552.
GenevisibleiQ3USW5. MM.

Interactioni

Subunit structurei

Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016696.

Structurei

3D structure databases

ProteinModelPortaliQ3USW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi662 – 665Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the FOXRED2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1399. Eukaryota.
COG2072. LUCA.
GeneTreeiENSGT00640000091519.
HOGENOMiHOG000031485.
HOVERGENiHBG100868.
InParanoidiQ3USW5.
OMAiQAWNGHY.
OrthoDBiEOG091G08UJ.
PhylomeDBiQ3USW5.
TreeFamiTF324712.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
SUPFAMiSSF51905. SSF51905. 1 hit.
PROSITEiView protein in PROSITE
PS00014. ER_TARGET. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3USW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPSGLLVAL ALHLAVCSRP HRDYCVLGAG PAGLQMAAFL HRAGRDYEVF
60 70 80 90 100
ERESAPGSFF TRYPRHRKLI SINKRHTGKA NAEFNLRHDW NSLLSDDPHL
110 120 130 140 150
LFRHYSQAYF PDASDMVRYL GDFARRLGLH VLYNTNITHV TLDKDPQAWN
160 170 180 190 200
GHYFILTDQK GQVYQCSVLL VATGLAVPKL VDFPGSEYVE GYESVSVDPE
210 220 230 240 250
DFVGQNVLIL GHGNSAFETA ENILGVTNFV HMLSRSRVRL SWATHYVGDV
260 270 280 290 300
RAINNGLLDT YQLKSLDGLL ESDLEYLALV KDSKGKFHVT LKFLLENNSS
310 320 330 340 350
QSADSIPLPE DDNDNFAMRV AYDRVIRCLG WTFDFSIFDQ SLRLSSGTEF
360 370 380 390 400
SKKYPLIKAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH GFRYTVRAVH
410 420 430 440 450
RLLEHRHHGI PWPSTEYPIT QLTSSIIRRV NEASGLYQMF SVLADIILLK
460 470 480 490 500
ENATAFEYLE EFPMQMLAQL EMLTGRTARH GLFVINMEYG KNFSGPEKDV
510 520 530 540 550
FYYDRSVAHI EDAWMSNFLH PVIYYYRHLP TEQDMRFRPA QWPLPRPTAI
560 570 580 590 600
HHIVEDFLTD WTAPVGHILP LRRFLENCLD TDLRSFYAES CFLFTLTRQR
610 620 630 640 650
LPPFCQQGYL RMQGLSSTKS LWQHGVESRL LQDYTAMENS NRWLGDHSTA
660
PEPLTQSLDS NKEEL
Length:665
Mass (Da):76,004
Last modified:October 11, 2005 - v1
Checksum:i077E8266EB031C24
GO

Sequence cautioni

The sequence BAE42033 differs from that shown. Reason: Frameshift at position 535.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298N → S in BAE42033 (PubMed:16141072).Curated1
Sequence conflicti329L → P in AAH86662 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140027 mRNA. Translation: BAE24215.1.
AK170795 mRNA. Translation: BAE42033.1. Frameshift.
AL589650 Genomic DNA. Translation: CAP19080.1.
BC086662 mRNA. Translation: AAH86662.1.
CCDSiCCDS27607.1.
RefSeqiNP_001017983.2. NM_001017983.2.
NP_001161732.1. NM_001168260.1.
UniGeneiMm.295605.

Genome annotation databases

EnsembliENSMUST00000016696; ENSMUSP00000016696; ENSMUSG00000016552.
ENSMUST00000117725; ENSMUSP00000113403; ENSMUSG00000016552.
GeneIDi239554.
KEGGimmu:239554.
UCSCiuc007woj.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiFXRD2_MOUSE
AccessioniPrimary (citable) accession number: Q3USW5
Secondary accession number(s): Q3TCC4, Q5RJH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families