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Q3USW5

- FXRD2_MOUSE

UniProt

Q3USW5 - FXRD2_MOUSE

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Protein

FAD-dependent oxidoreductase domain-containing protein 2

Gene
Foxred2, D15Bwg0759e
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation By similarity.

Cofactori

FAD By similarity.

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB
  2. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
FAD-dependent oxidoreductase domain-containing protein 2
Gene namesi
Name:Foxred2
Synonyms:D15Bwg0759e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:106315. Foxred2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 665648FAD-dependent oxidoreductase domain-containing protein 2PRO_0000337693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3USW5.

PTM databases

PhosphoSiteiQ3USW5.

Expressioni

Gene expression databases

ArrayExpressiQ3USW5.
BgeeiQ3USW5.
GenevestigatoriQ3USW5.

Interactioni

Subunit structurei

Interacts with SEL1L. May interact with OS9 and DNAJC10 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016696.

Structurei

3D structure databases

ProteinModelPortaliQ3USW5.
SMRiQ3USW5. Positions 19-223.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi662 – 6654Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the FOXRED2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG303889.
GeneTreeiENSGT00640000091519.
HOGENOMiHOG000031485.
HOVERGENiHBG100868.
InParanoidiQ3USW5.
OMAiQAWNGHY.
OrthoDBiEOG7M6D70.
PhylomeDBiQ3USW5.
TreeFamiTF324712.

Family and domain databases

PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3USW5-1 [UniParc]FASTAAdd to Basket

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MGPSGLLVAL ALHLAVCSRP HRDYCVLGAG PAGLQMAAFL HRAGRDYEVF    50
ERESAPGSFF TRYPRHRKLI SINKRHTGKA NAEFNLRHDW NSLLSDDPHL 100
LFRHYSQAYF PDASDMVRYL GDFARRLGLH VLYNTNITHV TLDKDPQAWN 150
GHYFILTDQK GQVYQCSVLL VATGLAVPKL VDFPGSEYVE GYESVSVDPE 200
DFVGQNVLIL GHGNSAFETA ENILGVTNFV HMLSRSRVRL SWATHYVGDV 250
RAINNGLLDT YQLKSLDGLL ESDLEYLALV KDSKGKFHVT LKFLLENNSS 300
QSADSIPLPE DDNDNFAMRV AYDRVIRCLG WTFDFSIFDQ SLRLSSGTEF 350
SKKYPLIKAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH GFRYTVRAVH 400
RLLEHRHHGI PWPSTEYPIT QLTSSIIRRV NEASGLYQMF SVLADIILLK 450
ENATAFEYLE EFPMQMLAQL EMLTGRTARH GLFVINMEYG KNFSGPEKDV 500
FYYDRSVAHI EDAWMSNFLH PVIYYYRHLP TEQDMRFRPA QWPLPRPTAI 550
HHIVEDFLTD WTAPVGHILP LRRFLENCLD TDLRSFYAES CFLFTLTRQR 600
LPPFCQQGYL RMQGLSSTKS LWQHGVESRL LQDYTAMENS NRWLGDHSTA 650
PEPLTQSLDS NKEEL 665
Length:665
Mass (Da):76,004
Last modified:October 11, 2005 - v1
Checksum:i077E8266EB031C24
GO

Sequence cautioni

The sequence BAE42033.1 differs from that shown. Reason: Frameshift at position 535.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981N → S in BAE42033. 1 Publication
Sequence conflicti329 – 3291L → P in AAH86662. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140027 mRNA. Translation: BAE24215.1.
AK170795 mRNA. Translation: BAE42033.1. Frameshift.
AL589650 Genomic DNA. Translation: CAP19080.1.
BC086662 mRNA. Translation: AAH86662.1.
CCDSiCCDS27607.1.
RefSeqiNP_001017983.2. NM_001017983.2.
NP_001161732.1. NM_001168260.1.
UniGeneiMm.295605.

Genome annotation databases

EnsembliENSMUST00000016696; ENSMUSP00000016696; ENSMUSG00000016552.
ENSMUST00000117725; ENSMUSP00000113403; ENSMUSG00000016552.
GeneIDi239554.
KEGGimmu:239554.
UCSCiuc007woj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140027 mRNA. Translation: BAE24215.1 .
AK170795 mRNA. Translation: BAE42033.1 . Frameshift.
AL589650 Genomic DNA. Translation: CAP19080.1 .
BC086662 mRNA. Translation: AAH86662.1 .
CCDSi CCDS27607.1.
RefSeqi NP_001017983.2. NM_001017983.2.
NP_001161732.1. NM_001168260.1.
UniGenei Mm.295605.

3D structure databases

ProteinModelPortali Q3USW5.
SMRi Q3USW5. Positions 19-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000016696.

PTM databases

PhosphoSitei Q3USW5.

Proteomic databases

PRIDEi Q3USW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016696 ; ENSMUSP00000016696 ; ENSMUSG00000016552 .
ENSMUST00000117725 ; ENSMUSP00000113403 ; ENSMUSG00000016552 .
GeneIDi 239554.
KEGGi mmu:239554.
UCSCi uc007woj.2. mouse.

Organism-specific databases

CTDi 80020.
MGIi MGI:106315. Foxred2.

Phylogenomic databases

eggNOGi NOG303889.
GeneTreei ENSGT00640000091519.
HOGENOMi HOG000031485.
HOVERGENi HBG100868.
InParanoidi Q3USW5.
OMAi QAWNGHY.
OrthoDBi EOG7M6D70.
PhylomeDBi Q3USW5.
TreeFami TF324712.

Miscellaneous databases

NextBioi 384169.
PROi Q3USW5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3USW5.
Bgeei Q3USW5.
Genevestigatori Q3USW5.

Family and domain databases

PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiFXRD2_MOUSE
AccessioniPrimary (citable) accession number: Q3USW5
Secondary accession number(s): Q3TCC4, Q5RJH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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