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Q3USW5

- FXRD2_MOUSE

UniProt

Q3USW5 - FXRD2_MOUSE

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Protein

FAD-dependent oxidoreductase domain-containing protein 2

Gene

Foxred2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity).By similarity

Cofactori

FAD.By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB
  2. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
FAD-dependent oxidoreductase domain-containing protein 2
Gene namesi
Name:Foxred2
Synonyms:D15Bwg0759e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:106315. Foxred2.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 665648FAD-dependent oxidoreductase domain-containing protein 2PRO_0000337693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ3USW5.

PTM databases

PhosphoSiteiQ3USW5.

Expressioni

Gene expression databases

BgeeiQ3USW5.
ExpressionAtlasiQ3USW5. baseline and differential.
GenevestigatoriQ3USW5.

Interactioni

Subunit structurei

Interacts with SEL1L. May interact with OS9 and DNAJC10 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016696.

Structurei

3D structure databases

ProteinModelPortaliQ3USW5.
SMRiQ3USW5. Positions 23-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi662 – 6654Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the FOXRED2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG303889.
GeneTreeiENSGT00640000091519.
HOGENOMiHOG000031485.
HOVERGENiHBG100868.
InParanoidiQ3USW5.
OMAiQAWNGHY.
OrthoDBiEOG7M6D70.
PhylomeDBiQ3USW5.
TreeFamiTF324712.

Family and domain databases

PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3USW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPSGLLVAL ALHLAVCSRP HRDYCVLGAG PAGLQMAAFL HRAGRDYEVF
60 70 80 90 100
ERESAPGSFF TRYPRHRKLI SINKRHTGKA NAEFNLRHDW NSLLSDDPHL
110 120 130 140 150
LFRHYSQAYF PDASDMVRYL GDFARRLGLH VLYNTNITHV TLDKDPQAWN
160 170 180 190 200
GHYFILTDQK GQVYQCSVLL VATGLAVPKL VDFPGSEYVE GYESVSVDPE
210 220 230 240 250
DFVGQNVLIL GHGNSAFETA ENILGVTNFV HMLSRSRVRL SWATHYVGDV
260 270 280 290 300
RAINNGLLDT YQLKSLDGLL ESDLEYLALV KDSKGKFHVT LKFLLENNSS
310 320 330 340 350
QSADSIPLPE DDNDNFAMRV AYDRVIRCLG WTFDFSIFDQ SLRLSSGTEF
360 370 380 390 400
SKKYPLIKAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH GFRYTVRAVH
410 420 430 440 450
RLLEHRHHGI PWPSTEYPIT QLTSSIIRRV NEASGLYQMF SVLADIILLK
460 470 480 490 500
ENATAFEYLE EFPMQMLAQL EMLTGRTARH GLFVINMEYG KNFSGPEKDV
510 520 530 540 550
FYYDRSVAHI EDAWMSNFLH PVIYYYRHLP TEQDMRFRPA QWPLPRPTAI
560 570 580 590 600
HHIVEDFLTD WTAPVGHILP LRRFLENCLD TDLRSFYAES CFLFTLTRQR
610 620 630 640 650
LPPFCQQGYL RMQGLSSTKS LWQHGVESRL LQDYTAMENS NRWLGDHSTA
660
PEPLTQSLDS NKEEL
Length:665
Mass (Da):76,004
Last modified:October 11, 2005 - v1
Checksum:i077E8266EB031C24
GO

Sequence cautioni

The sequence BAE42033.1 differs from that shown. Reason: Frameshift at position 535.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981N → S in BAE42033. (PubMed:16141072)Curated
Sequence conflicti329 – 3291L → P in AAH86662. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140027 mRNA. Translation: BAE24215.1.
AK170795 mRNA. Translation: BAE42033.1. Frameshift.
AL589650 Genomic DNA. Translation: CAP19080.1.
BC086662 mRNA. Translation: AAH86662.1.
CCDSiCCDS27607.1.
RefSeqiNP_001017983.2. NM_001017983.2.
NP_001161732.1. NM_001168260.1.
UniGeneiMm.295605.

Genome annotation databases

EnsembliENSMUST00000016696; ENSMUSP00000016696; ENSMUSG00000016552.
ENSMUST00000117725; ENSMUSP00000113403; ENSMUSG00000016552.
GeneIDi239554.
KEGGimmu:239554.
UCSCiuc007woj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140027 mRNA. Translation: BAE24215.1 .
AK170795 mRNA. Translation: BAE42033.1 . Frameshift.
AL589650 Genomic DNA. Translation: CAP19080.1 .
BC086662 mRNA. Translation: AAH86662.1 .
CCDSi CCDS27607.1.
RefSeqi NP_001017983.2. NM_001017983.2.
NP_001161732.1. NM_001168260.1.
UniGenei Mm.295605.

3D structure databases

ProteinModelPortali Q3USW5.
SMRi Q3USW5. Positions 23-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000016696.

PTM databases

PhosphoSitei Q3USW5.

Proteomic databases

PRIDEi Q3USW5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016696 ; ENSMUSP00000016696 ; ENSMUSG00000016552 .
ENSMUST00000117725 ; ENSMUSP00000113403 ; ENSMUSG00000016552 .
GeneIDi 239554.
KEGGi mmu:239554.
UCSCi uc007woj.2. mouse.

Organism-specific databases

CTDi 80020.
MGIi MGI:106315. Foxred2.

Phylogenomic databases

eggNOGi NOG303889.
GeneTreei ENSGT00640000091519.
HOGENOMi HOG000031485.
HOVERGENi HBG100868.
InParanoidi Q3USW5.
OMAi QAWNGHY.
OrthoDBi EOG7M6D70.
PhylomeDBi Q3USW5.
TreeFami TF324712.

Miscellaneous databases

NextBioi 384169.
PROi Q3USW5.
SOURCEi Search...

Gene expression databases

Bgeei Q3USW5.
ExpressionAtlasi Q3USW5. baseline and differential.
Genevestigatori Q3USW5.

Family and domain databases

PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye.

Entry informationi

Entry nameiFXRD2_MOUSE
AccessioniPrimary (citable) accession number: Q3USW5
Secondary accession number(s): Q3TCC4, Q5RJH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 11, 2005
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3