Sos1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: InterPro
protein heterodimerization activity Source: InterPro
Rho guanyl-nucleotide exchange factor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

regulation of Rho protein signal transduction Source: InterPro
small GTPase mediated signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Molecular function

Guanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Sos1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:98354. Sos1.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q3USK4.
PeptideAtlas More...PeptideAtlasⁱ	Q3USK4.
PRIDEⁱ	Q3USK4.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q3USK4. MM.

Genevisibleⁱ

Q3USK4. MM.

Interactionⁱ

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	200 – 390	DH (DBL-homology)InterPro annotationAdd BLAST	191
Domainⁱ	443 – 546	PHInterPro annotationAdd BLAST	104
Domainⁱ	597 – 741	N-terminal Ras-GEFInterPro annotationAdd BLAST	145
Domainⁱ	780 – 1019	Ras-GEFInterPro annotationAdd BLAST	240

Phylogenomic databases

eggNOGⁱ	KOG3417. Eukaryota. ENOG410XR96. LUCA.
HOVERGENⁱ	HBG017831.
KEGG Orthology (KO) More...KOⁱ	K03099.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155. RasGEF. 1 hit. cd06224. REM. 1 hit.
Gene3Dⁱ	1.10.840.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR009072. Histone-fold. IPR007125. Histone_H2A/H2B/H3. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125. Histone. 1 hit. PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit. SSF48065. SSF48065. 1 hit. SSF48366. SSF48366. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3USK4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE 
        60         70         80         90        100
LILQLLNMLC QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR 
       110        120        130        140        150
NPLSLPAERI HHLLREVLGY KIDHQVSVYI VAVLEYISAD ILKLVGNYVR 
       160        170        180        190        200
NIRHYEITKQ DIKVAMCADK VLMDMFHQDV EDINILSLTD EEPSTSGEQT 
       210        220        230        240        250
YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN DVENIFSRIV 
       260        270        280        290        300
DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 
       310        320        330        340        350
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC 
       360        370        380        390        400
LHYFELLKQL EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL 
       410        420        430        440        450
SESACRFYSQ QMKGKQLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGTL 
       460        470        480        490        500
TRVGAKHERH IFLFDGLMIC CKSNHGQPRL PGASSAEYRL KEKFFMRKVQ 
       510        520        530        540        550
INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA LISLQYRSTL 
       560        570        580        590        600
ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI 
       610        620        630        640        650
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI 
       660        670        680        690        700
PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH 
       710        720        730        740        750
FYDFERDADL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH 
       760        770        780        790        800
NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ 
       810        820        830        840        850
PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA 
       860        870        880        890        900
VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 
       910        920        930        940        950
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR 
       960        970        980        990       1000
HGKELINFSK RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS 
      1010       1020       1030       1040       1050
MEKEFTDYLF NKSLEIEPRH PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM 
      1060       1070       1080       1090       1100
RHPTPLQQEP RKISYSRIPE SETESTASAP NSPRTPLTPP PASGTSSNTD 
      1110 
VCSVFDSDHS ASPFHSSKC

Length:1,119

Mass (Da):129,228

Last modified:October 11, 2005 - v1

Checksum:ⁱF9439051E0E9200D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK140310 mRNA. Translation: BAE24327.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033257.2. NM_009231.2.
UniGeneⁱ	Mm.360004. Mm.60975.

Genome annotation databases

GeneIDⁱ	20662.
KEGGⁱ	mmu:20662.
UCSC genome browser More...UCSCⁱ	uc008drh.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK140310 mRNA. Translation: BAE24327.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033257.2. NM_009231.2.
UniGeneⁱ	Mm.360004. Mm.60975.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q3USK4.
PeptideAtlas More...PeptideAtlasⁱ	Q3USK4.
PRIDEⁱ	Q3USK4.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	20662.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	20662.
KEGGⁱ	mmu:20662.
UCSC genome browser More...UCSCⁱ	uc008drh.1. mouse.

Organism-specific databases

CTDⁱ	6654.
MGIⁱ	MGI:98354. Sos1.

Phylogenomic databases

eggNOGⁱ	KOG3417. Eukaryota. ENOG410XR96. LUCA.
HOVERGENⁱ	HBG017831.
KEGG Orthology (KO) More...KOⁱ	K03099.

Miscellaneous databases

ChiTaRSⁱ	Sos1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Genevisibleⁱ	Q3USK4. MM.

Genevisibleⁱ

Q3USK4. MM.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00155. RasGEF. 1 hit. cd06224. REM. 1 hit.
Gene3Dⁱ	1.10.840.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR009072. Histone-fold. IPR007125. Histone_H2A/H2B/H3. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR023578. Ras_GEF_dom. IPR001895. RASGEF_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00125. Histone. 1 hit. PF00169. PH. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit. SSF48065. SSF48065. 1 hit. SSF48366. SSF48366. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3USK4_MOUSE
Accessionⁱ	Q3USK4Primary (citable) accession number: Q3USK4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q3USK4 (Q3USK4_MOUSE)

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Putative uncharacterized protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3USK4 (Q3USK4_MOUSE)

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Putative uncharacterized protein

Sos1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ