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Q3USJ8 (FCSD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FCH and double SH3 domains protein 2
Alternative name(s):
SH3 multiple domains protein 3
Gene names
Name:Fchsd2
Synonyms:Kiaa0769, Sh3md3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length740 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1 By similarity.

Sequence similarities

Contains 1 FCH domain.

Contains 2 SH3 domains.

Sequence caution

The sequence BAC65650.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
SH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q3USJ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q3USJ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     308-308: T → TSLKAAQLVDIELSPVSALRMTIAE
Isoform 3 (identifier: Q3USJ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     308-308: T → TSLKAAQLVDIELSPVSALRMTIAE

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 740740FCH and double SH3 domains protein 2
PRO_0000278215

Regions

Domain8 – 7467FCH
Domain469 – 53062SH3 1
Domain567 – 62963SH3 2
Coiled coil356 – 39742 Potential
Compositional bias718 – 7214Poly-Pro

Natural variations

Alternative sequence1 – 3838Missing in isoform 3.
VSP_023170
Alternative sequence3081T → TSLKAAQLVDIELSPVSALR MTIAE in isoform 2 and isoform 3.
VSP_023171

Experimental info

Sequence conflict3501N → D in BAE24333. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 31BB6275D922AE8E

FASTA74084,282
        10         20         30         40         50         60 
MQPPPRKVKV TQELRNIQGE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGIQKL 

        70         80         90        100        110        120 
ASQYLKRDWP GIKTDDRNDY RSMYPVWKSF LEGTMQVAQS RINICENYKN FISEPARAVR 

       130        140        150        160        170        180 
SLKEQQLKRC VDQLTKIQTE LQETVKDLVK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF 

       190        200        210        220        230        240 
QSRISLQKAS VKLKARRSEC NTKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN 

       250        260        270        280        290        300 
VYDHLKDYLI AFSRTELETC QAIQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 

       310        320        330        340        350        360 
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN ELECHGVALS 

       370        380        390        400        410        420 
EQSRAELEQK IDEARESIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE 

       430        440        450        460        470        480 
RWARPPAVTS NGTLHSLNAD AEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY 

       490        500        510        520        530        540 
KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL 

       550        560        570        580        590        600 
AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 

       610        620        630        640        650        660 
NQDDDGFWEG EFSGRIGVFP SVLVEELSAS ENGDTPWTRE IQISPSPKPH TSLPPLPLYD 

       670        680        690        700        710        720 
QPPSSPYPSP DKRSSQFFPR SPSANENSLH AESPGFSQAS RQTPDTSYGK LRPVRAAPPP 

       730        740 
PTQNHRRTTE KMEDVEITLV 

« Hide

Isoform 2 [UniParc].

Checksum: 32DCC75608B05D12
Show »

FASTA76486,820
Isoform 3 [UniParc].

Checksum: B22E21BF00B07143
Show »

FASTA72682,406

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Adipose tissue and Spinal ganglion.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6.
Tissue: Brain.
[4]"Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
Katoh M., Katoh M.
Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK122368 mRNA. Translation: BAC65650.1. Different initiation.
AK140322 mRNA. Translation: BAE24333.1.
AK141949 mRNA. Translation: BAE24896.1.
BC060647 mRNA. Translation: AAH60647.1.
CCDSCCDS52327.1. [Q3USJ8-2]
CCDS52328.1. [Q3USJ8-1]
RefSeqNP_001139482.1. NM_001146010.1. [Q3USJ8-1]
NP_950177.2. NM_199012.2. [Q3USJ8-2]
UniGeneMm.263041.

3D structure databases

ProteinModelPortalQ3USJ8.
SMRQ3USJ8. Positions 460-531, 564-680.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000032931.

PTM databases

PhosphoSiteQ3USJ8.

Proteomic databases

PaxDbQ3USJ8.
PRIDEQ3USJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032931; ENSMUSP00000032931; ENSMUSG00000030691. [Q3USJ8-2]
ENSMUST00000098250; ENSMUSP00000095850; ENSMUSG00000030691. [Q3USJ8-1]
GeneID207278.
KEGGmmu:207278.
UCSCuc009ioc.2. mouse. [Q3USJ8-2]
uc009iod.2. mouse. [Q3USJ8-1]

Organism-specific databases

CTD9873.
MGIMGI:2448475. Fchsd2.
RougeSearch...

Phylogenomic databases

eggNOGNOG327979.
GeneTreeENSGT00510000046732.
HOGENOMHOG000046016.
HOVERGENHBG063540.
OMAQENSVFH.
OrthoDBEOG722J81.
PhylomeDBQ3USJ8.
TreeFamTF324557.

Gene expression databases

ArrayExpressQ3USJ8.
BgeeQ3USJ8.
CleanExMM_FCHSD2.
GenevestigatorQ3USJ8.

Family and domain databases

InterProIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
PROSITEPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio371920.
PROQ3USJ8.
SOURCESearch...

Entry information

Entry nameFCSD2_MOUSE
AccessionPrimary (citable) accession number: Q3USJ8
Secondary accession number(s): Q3UQZ2, Q6P9R0, Q80TS2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot