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Q3USJ8

- FCSD2_MOUSE

UniProt

Q3USJ8 - FCSD2_MOUSE

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Protein

FCH and double SH3 domains protein 2

Gene

Fchsd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FCH and double SH3 domains protein 2
Alternative name(s):
SH3 multiple domains protein 3
Gene namesi
Name:Fchsd2
Synonyms:Kiaa0769, Sh3md3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2448475. Fchsd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740FCH and double SH3 domains protein 2PRO_0000278215Add
BLAST

Proteomic databases

MaxQBiQ3USJ8.
PaxDbiQ3USJ8.
PRIDEiQ3USJ8.

PTM databases

PhosphoSiteiQ3USJ8.

Expressioni

Gene expression databases

BgeeiQ3USJ8.
CleanExiMM_FCHSD2.
ExpressionAtlasiQ3USJ8. baseline and differential.
GenevestigatoriQ3USJ8.

Interactioni

Subunit structurei

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032931.

Structurei

3D structure databases

ProteinModelPortaliQ3USJ8.
SMRiQ3USJ8. Positions 460-531, 564-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7467FCHPROSITE-ProRule annotationAdd
BLAST
Domaini469 – 53062SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 62963SH3 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili356 – 39742Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi718 – 7214Poly-Pro

Sequence similaritiesi

Contains 1 FCH domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327979.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
InParanoidiQ3USJ8.
OMAiQENSVFH.
OrthoDBiEOG722J81.
PhylomeDBiQ3USJ8.
TreeFamiTF324557.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3USJ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPPPRKVKV TQELRNIQGE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE
60 70 80 90 100
REYAQGIQKL ASQYLKRDWP GIKTDDRNDY RSMYPVWKSF LEGTMQVAQS
110 120 130 140 150
RINICENYKN FISEPARAVR SLKEQQLKRC VDQLTKIQTE LQETVKDLVK
160 170 180 190 200
GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC
210 220 230 240 250
NTKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI
260 270 280 290 300
AFSRTELETC QAIQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ
310 320 330 340 350
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN
360 370 380 390 400
ELECHGVALS EQSRAELEQK IDEARESIRK AEIIKLKAEA RLDLLKQIGV
410 420 430 440 450
SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD AEREEGEEFE
460 470 480 490 500
DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE
510 520 530 540 550
DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS
560 570 580 590 600
SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
610 620 630 640 650
NQDDDGFWEG EFSGRIGVFP SVLVEELSAS ENGDTPWTRE IQISPSPKPH
660 670 680 690 700
TSLPPLPLYD QPPSSPYPSP DKRSSQFFPR SPSANENSLH AESPGFSQAS
710 720 730 740
RQTPDTSYGK LRPVRAAPPP PTQNHRRTTE KMEDVEITLV
Length:740
Mass (Da):84,282
Last modified:February 20, 2007 - v2
Checksum:i31BB6275D922AE8E
GO
Isoform 2 (identifier: Q3USJ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-308: T → TSLKAAQLVDIELSPVSALRMTIAE

Show »
Length:764
Mass (Da):86,820
Checksum:i32DCC75608B05D12
GO
Isoform 3 (identifier: Q3USJ8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     308-308: T → TSLKAAQLVDIELSPVSALRMTIAE

Show »
Length:726
Mass (Da):82,406
Checksum:iB22E21BF00B07143
GO

Sequence cautioni

The sequence BAC65650.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501N → D in BAE24333. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838Missing in isoform 3. 1 PublicationVSP_023170Add
BLAST
Alternative sequencei308 – 3081T → TSLKAAQLVDIELSPVSALR MTIAE in isoform 2 and isoform 3. 2 PublicationsVSP_023171

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122368 mRNA. Translation: BAC65650.1. Different initiation.
AK140322 mRNA. Translation: BAE24333.1.
AK141949 mRNA. Translation: BAE24896.1.
BC060647 mRNA. Translation: AAH60647.1.
CCDSiCCDS52327.1. [Q3USJ8-2]
CCDS52328.1. [Q3USJ8-1]
RefSeqiNP_001139482.1. NM_001146010.1. [Q3USJ8-1]
NP_950177.2. NM_199012.2. [Q3USJ8-2]
UniGeneiMm.263041.

Genome annotation databases

EnsembliENSMUST00000032931; ENSMUSP00000032931; ENSMUSG00000030691. [Q3USJ8-2]
ENSMUST00000098250; ENSMUSP00000095850; ENSMUSG00000030691. [Q3USJ8-1]
GeneIDi207278.
KEGGimmu:207278.
UCSCiuc009ioc.2. mouse. [Q3USJ8-2]
uc009iod.2. mouse. [Q3USJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122368 mRNA. Translation: BAC65650.1 . Different initiation.
AK140322 mRNA. Translation: BAE24333.1 .
AK141949 mRNA. Translation: BAE24896.1 .
BC060647 mRNA. Translation: AAH60647.1 .
CCDSi CCDS52327.1. [Q3USJ8-2 ]
CCDS52328.1. [Q3USJ8-1 ]
RefSeqi NP_001139482.1. NM_001146010.1. [Q3USJ8-1 ]
NP_950177.2. NM_199012.2. [Q3USJ8-2 ]
UniGenei Mm.263041.

3D structure databases

ProteinModelPortali Q3USJ8.
SMRi Q3USJ8. Positions 460-531, 564-680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032931.

PTM databases

PhosphoSitei Q3USJ8.

Proteomic databases

MaxQBi Q3USJ8.
PaxDbi Q3USJ8.
PRIDEi Q3USJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032931 ; ENSMUSP00000032931 ; ENSMUSG00000030691 . [Q3USJ8-2 ]
ENSMUST00000098250 ; ENSMUSP00000095850 ; ENSMUSG00000030691 . [Q3USJ8-1 ]
GeneIDi 207278.
KEGGi mmu:207278.
UCSCi uc009ioc.2. mouse. [Q3USJ8-2 ]
uc009iod.2. mouse. [Q3USJ8-1 ]

Organism-specific databases

CTDi 9873.
MGIi MGI:2448475. Fchsd2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG327979.
GeneTreei ENSGT00510000046732.
HOGENOMi HOG000046016.
HOVERGENi HBG063540.
InParanoidi Q3USJ8.
OMAi QENSVFH.
OrthoDBi EOG722J81.
PhylomeDBi Q3USJ8.
TreeFami TF324557.

Miscellaneous databases

NextBioi 371920.
PROi Q3USJ8.
SOURCEi Search...

Gene expression databases

Bgeei Q3USJ8.
CleanExi MM_FCHSD2.
ExpressionAtlasi Q3USJ8. baseline and differential.
Genevestigatori Q3USJ8.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFCSD2_MOUSE
AccessioniPrimary (citable) accession number: Q3USJ8
Secondary accession number(s): Q3UQZ2, Q6P9R0, Q80TS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3