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Q3USJ8

- FCSD2_MOUSE

UniProt

Q3USJ8 - FCSD2_MOUSE

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Protein
FCH and double SH3 domains protein 2
Gene
Fchsd2, Kiaa0769, Sh3md3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
FCH and double SH3 domains protein 2
Alternative name(s):
SH3 multiple domains protein 3
Gene namesi
Name:Fchsd2
Synonyms:Kiaa0769, Sh3md3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2448475. Fchsd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740FCH and double SH3 domains protein 2
PRO_0000278215Add
BLAST

Proteomic databases

PaxDbiQ3USJ8.
PRIDEiQ3USJ8.

PTM databases

PhosphoSiteiQ3USJ8.

Expressioni

Gene expression databases

ArrayExpressiQ3USJ8.
BgeeiQ3USJ8.
CleanExiMM_FCHSD2.
GenevestigatoriQ3USJ8.

Interactioni

Subunit structurei

Interacts with CASK and MAGI1. CASK inhibits interaction with MAGI1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032931.

Structurei

3D structure databases

ProteinModelPortaliQ3USJ8.
SMRiQ3USJ8. Positions 460-531, 564-680.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7467FCH
Add
BLAST
Domaini469 – 53062SH3 1
Add
BLAST
Domaini567 – 62963SH3 2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili356 – 39742 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi718 – 7214Poly-Pro

Sequence similaritiesi

Contains 1 FCH domain.
Contains 2 SH3 domains.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG327979.
GeneTreeiENSGT00510000046732.
HOGENOMiHOG000046016.
HOVERGENiHBG063540.
OMAiQENSVFH.
OrthoDBiEOG722J81.
PhylomeDBiQ3USJ8.
TreeFamiTF324557.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3USJ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQPPPRKVKV TQELRNIQGE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE    50
REYAQGIQKL ASQYLKRDWP GIKTDDRNDY RSMYPVWKSF LEGTMQVAQS 100
RINICENYKN FISEPARAVR SLKEQQLKRC VDQLTKIQTE LQETVKDLVK 150
GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC 200
NTKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI 250
AFSRTELETC QAIQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ 300
FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN 350
ELECHGVALS EQSRAELEQK IDEARESIRK AEIIKLKAEA RLDLLKQIGV 400
SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD AEREEGEEFE 450
DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE 500
DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS 550
SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE 600
NQDDDGFWEG EFSGRIGVFP SVLVEELSAS ENGDTPWTRE IQISPSPKPH 650
TSLPPLPLYD QPPSSPYPSP DKRSSQFFPR SPSANENSLH AESPGFSQAS 700
RQTPDTSYGK LRPVRAAPPP PTQNHRRTTE KMEDVEITLV 740
Length:740
Mass (Da):84,282
Last modified:February 20, 2007 - v2
Checksum:i31BB6275D922AE8E
GO
Isoform 2 (identifier: Q3USJ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-308: T → TSLKAAQLVDIELSPVSALRMTIAE

Show »
Length:764
Mass (Da):86,820
Checksum:i32DCC75608B05D12
GO
Isoform 3 (identifier: Q3USJ8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     308-308: T → TSLKAAQLVDIELSPVSALRMTIAE

Show »
Length:726
Mass (Da):82,406
Checksum:iB22E21BF00B07143
GO

Sequence cautioni

The sequence BAC65650.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838Missing in isoform 3.
VSP_023170Add
BLAST
Alternative sequencei308 – 3081T → TSLKAAQLVDIELSPVSALR MTIAE in isoform 2 and isoform 3.
VSP_023171

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501N → D in BAE24333. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122368 mRNA. Translation: BAC65650.1. Different initiation.
AK140322 mRNA. Translation: BAE24333.1.
AK141949 mRNA. Translation: BAE24896.1.
BC060647 mRNA. Translation: AAH60647.1.
CCDSiCCDS52327.1. [Q3USJ8-2]
CCDS52328.1. [Q3USJ8-1]
RefSeqiNP_001139482.1. NM_001146010.1. [Q3USJ8-1]
NP_950177.2. NM_199012.2. [Q3USJ8-2]
UniGeneiMm.263041.

Genome annotation databases

EnsembliENSMUST00000032931; ENSMUSP00000032931; ENSMUSG00000030691. [Q3USJ8-2]
ENSMUST00000098250; ENSMUSP00000095850; ENSMUSG00000030691. [Q3USJ8-1]
GeneIDi207278.
KEGGimmu:207278.
UCSCiuc009ioc.2. mouse. [Q3USJ8-2]
uc009iod.2. mouse. [Q3USJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122368 mRNA. Translation: BAC65650.1 . Different initiation.
AK140322 mRNA. Translation: BAE24333.1 .
AK141949 mRNA. Translation: BAE24896.1 .
BC060647 mRNA. Translation: AAH60647.1 .
CCDSi CCDS52327.1. [Q3USJ8-2 ]
CCDS52328.1. [Q3USJ8-1 ]
RefSeqi NP_001139482.1. NM_001146010.1. [Q3USJ8-1 ]
NP_950177.2. NM_199012.2. [Q3USJ8-2 ]
UniGenei Mm.263041.

3D structure databases

ProteinModelPortali Q3USJ8.
SMRi Q3USJ8. Positions 460-531, 564-680.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000032931.

PTM databases

PhosphoSitei Q3USJ8.

Proteomic databases

PaxDbi Q3USJ8.
PRIDEi Q3USJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032931 ; ENSMUSP00000032931 ; ENSMUSG00000030691 . [Q3USJ8-2 ]
ENSMUST00000098250 ; ENSMUSP00000095850 ; ENSMUSG00000030691 . [Q3USJ8-1 ]
GeneIDi 207278.
KEGGi mmu:207278.
UCSCi uc009ioc.2. mouse. [Q3USJ8-2 ]
uc009iod.2. mouse. [Q3USJ8-1 ]

Organism-specific databases

CTDi 9873.
MGIi MGI:2448475. Fchsd2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG327979.
GeneTreei ENSGT00510000046732.
HOGENOMi HOG000046016.
HOVERGENi HBG063540.
OMAi QENSVFH.
OrthoDBi EOG722J81.
PhylomeDBi Q3USJ8.
TreeFami TF324557.

Miscellaneous databases

NextBioi 371920.
PROi Q3USJ8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3USJ8.
Bgeei Q3USJ8.
CleanExi MM_FCHSD2.
Genevestigatori Q3USJ8.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 13:749-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiFCSD2_MOUSE
AccessioniPrimary (citable) accession number: Q3USJ8
Secondary accession number(s): Q3UQZ2, Q6P9R0, Q80TS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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