Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Splicing factor, suppressor of white-apricot homolog

Gene

Sfswap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor, suppressor of white-apricot homolog
Alternative name(s):
Splicing factor, arginine/serine-rich 8
Suppressor of white apricot protein homolog
Gene namesi
Name:Sfswap
Synonyms:Sfrs8, Srsf8, Swap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:101760. Sfswap.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Splicing factor, suppressor of white-apricot homologPRO_0000413023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831PhosphoserineCombined sources
Modified residuei315 – 3151N6-acetyllysineBy similarity
Modified residuei601 – 6011PhosphoserineCombined sources
Modified residuei621 – 6211PhosphoserineCombined sources
Modified residuei639 – 6391PhosphothreonineCombined sources
Modified residuei829 – 8291PhosphoserineBy similarity
Modified residuei831 – 8311PhosphoserineBy similarity
Modified residuei899 – 8991PhosphoserineCombined sources
Modified residuei903 – 9031PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3USH5.
MaxQBiQ3USH5.
PaxDbiQ3USH5.
PeptideAtlasiQ3USH5.
PRIDEiQ3USH5.

PTM databases

iPTMnetiQ3USH5.

Expressioni

Gene expression databases

BgeeiQ3USH5.
ExpressionAtlasiQ3USH5. baseline and differential.
GenevisibleiQ3USH5. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156373EBI-8387273,EBI-744603From a different organism.

Protein-protein interaction databases

IntActiQ3USH5. 2 interactions.
MINTiMINT-4115248.
STRINGi10090.ENSMUSP00000062413.

Structurei

3D structure databases

ProteinModelPortaliQ3USH5.
SMRiQ3USH5. Positions 189-280, 454-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati211 – 25343SURP motif 1Add
BLAST
Repeati458 – 49841SURP motif 2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili632 – 68655Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi101 – 18686Glu-richAdd
BLAST
Compositional biasi382 – 45776Pro-richAdd
BLAST
Compositional biasi737 – 856120Arg-richAdd
BLAST
Compositional biasi762 – 920159Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 SURP motif repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1847. Eukaryota.
ENOG410ZQGI. LUCA.
GeneTreeiENSGT00730000111096.
HOGENOMiHOG000168244.
HOVERGENiHBG079184.
InParanoidiQ3USH5.
OMAiPPCVVVE.
OrthoDBiEOG786H2Z.
TreeFamiTF106264.

Family and domain databases

InterProiIPR000061. Surp.
IPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50128. SURP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3USH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGAGGGRAK PERKGGVKEE AGPGGTGTGG NRVELLVFGY ACKLFRDDER
60 70 80 90 100
ALAQEQGQHL IPWMGDPKIL IDRYDGRGHL HDLSAYDAEY ATWNRDYQLS
110 120 130 140 150
EEEARVEALC DEERYLALHT DLLEEEARQE EEYKRLSEAL AEDGNYSAVG
160 170 180 190 200
FTYGSDYYDP SEPTEEEEPS KQREKNEAEN LEENEEPFIA PLGLSVPSDV
210 220 230 240 250
ELPPTAKMHA IIERTANFVC KQGAQFEIML KAKQARNSQF DFLRFDHYLN
260 270 280 290 300
PYYKFIQKAM KEGRYTVLAE SKNEEKKKSG PTSDNEEEDD EEDGSYLHPS
310 320 330 340 350
LFASKKSSRL EELMKPLKVV DPDHPLAALV RKAQADSSAP APPTADGTPA
360 370 380 390 400
QPSQVEYTAD STVAAMYYSY YMLPDGTYCL APPPPGIDVA TYYSTLPAGV
410 420 430 440 450
TVSSSPGVTT TVPPPPGTTP PPPPTTAEPS SGVTSTTTTT SALAPVAIIP
460 470 480 490 500
PPPDIQPVID KLAEYVARNG LKFETSVRAK NDQRFEFLQP WHQYNAYYEF
510 520 530 540 550
KKQFFLQKEG GGSTQAASTA EEAPTETAVE ESGEAGEDGA PEGMAETGGR
560 570 580 590 600
GSGKKEAGSS KSTVDGKLVK ASFAPISFAI KAKENDLLPL EKNRVKLDDD
610 620 630 640 650
SEEDEESREC QESTSSVANP SPAAAPPSVA VEEKKPQLTQ EELEAKQAKQ
660 670 680 690 700
KLEDRLAAAA REKLAQASKE SKEKQLQAER KRKAALFLQT LKNPLPEAEV
710 720 730 740 750
GKLEESTFGV EDTGVMPCPL LVGGRTLPIL EGKPPERPSN RCRDPPREEE
760 770 780 790 800
REKKKKKHKK RSRTRSRSPK YHSSSKPRSR SHSKAKHSLP SAYRTVRRSR
810 820 830 840 850
SRSRSPRRRA HSPERRREER SVPTAYRMSG SPGVSRKRTR SRSPHEKKKK
860 870 880 890 900
RRSRSRTKAK ARSQSTSPSK QAAQRPSAHS AHSASISPVE SRGSSQERSR
910 920 930 940
GVSQEKDGQI SSAIVSSVQS KITQDLMAKV RAMLAASKNL QTSAS
Length:945
Mass (Da):104,190
Last modified:October 19, 2011 - v2
Checksum:i7B2CBDCB63A89AA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114614 Genomic DNA. No translation available.
AC114657 Genomic DNA. No translation available.
AK031872 mRNA. Translation: BAC27586.1.
AK140369 mRNA. Translation: BAE24357.1.
CCDSiCCDS19694.1.
RefSeqiNP_758480.2. NM_172276.3.
UniGeneiMm.288714.

Genome annotation databases

EnsembliENSMUST00000053737; ENSMUSP00000062413; ENSMUSG00000029439.
GeneIDi231769.
KEGGimmu:231769.
UCSCiuc008zsu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114614 Genomic DNA. No translation available.
AC114657 Genomic DNA. No translation available.
AK031872 mRNA. Translation: BAC27586.1.
AK140369 mRNA. Translation: BAE24357.1.
CCDSiCCDS19694.1.
RefSeqiNP_758480.2. NM_172276.3.
UniGeneiMm.288714.

3D structure databases

ProteinModelPortaliQ3USH5.
SMRiQ3USH5. Positions 189-280, 454-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3USH5. 2 interactions.
MINTiMINT-4115248.
STRINGi10090.ENSMUSP00000062413.

PTM databases

iPTMnetiQ3USH5.

Proteomic databases

EPDiQ3USH5.
MaxQBiQ3USH5.
PaxDbiQ3USH5.
PeptideAtlasiQ3USH5.
PRIDEiQ3USH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053737; ENSMUSP00000062413; ENSMUSG00000029439.
GeneIDi231769.
KEGGimmu:231769.
UCSCiuc008zsu.1. mouse.

Organism-specific databases

CTDi6433.
MGIiMGI:101760. Sfswap.

Phylogenomic databases

eggNOGiKOG1847. Eukaryota.
ENOG410ZQGI. LUCA.
GeneTreeiENSGT00730000111096.
HOGENOMiHOG000168244.
HOVERGENiHBG079184.
InParanoidiQ3USH5.
OMAiPPCVVVE.
OrthoDBiEOG786H2Z.
TreeFamiTF106264.

Miscellaneous databases

PROiQ3USH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3USH5.
ExpressionAtlasiQ3USH5. baseline and differential.
GenevisibleiQ3USH5. MM.

Family and domain databases

InterProiIPR000061. Surp.
IPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
PF01805. Surp. 2 hits.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
SM00648. SWAP. 2 hits.
[Graphical view]
SUPFAMiSSF109905. SSF109905. 2 hits.
PROSITEiPS50128. SURP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-845.
    Strain: C57BL/6J.
    Tissue: Adipose tissue and Medulla oblongata.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-601; SER-621; SER-899 AND SER-903, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSFSWA_MOUSE
AccessioniPrimary (citable) accession number: Q3USH5
Secondary accession number(s): Q8CCZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: July 6, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.