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Protein
Submitted name:

Putative uncharacterized protein

Gene

Lrp6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lrp6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi339 ↔ 354PROSITE-ProRule annotation
Disulfide bondi357 ↔ 369PROSITE-ProRule annotation
Disulfide bondi364 ↔ 382PROSITE-ProRule annotation
Disulfide bondi376 ↔ 391PROSITE-ProRule annotation
Disulfide bondi395 ↔ 407PROSITE-ProRule annotation
Disulfide bondi402 ↔ 420PROSITE-ProRule annotation
Disulfide bondi414 ↔ 429PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ3US54.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030201.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032322.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 94LDL-receptor class BPROSITE-ProRule annotationAdd BLAST49
Repeati95 – 137LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati138 – 182LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati183 – 225LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati226 – 267LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42

Sequence similaritiesi

Contains 3 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 5 LDL-receptor class B repeat.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IPT4. Eukaryota.
ENOG410XSY5. LUCA.
HOVERGENiHBG101630.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3US54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW
60 70 80 90 100
IDSRQNSIRK AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT
110 120 130 140 150
CEATNVIDVT RLDGRSVGVV LKGEQDRPRA IVVNPEKGYM YFTNLQERSP
160 170 180 190 200
KIERAALDGT EREVLFFSGL SKPIALALDS KLGKLFWADS DLRRIESSDL
210 220 230 240 250
SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID MTGREGRTKV
260 270 280 290 300
QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP
310 320 330 340 350
MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD
360 370 380 390 400
ELNCPVCSES QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF
410 420 430 440 450
RCANGQCVGK HKKCDHSVDC SDRSDELDCY PTEEPAPQAT NTVGSVIGVI
460 470 480 490 500
VTIFVSGTIY FICQRMLCPR MKGDGETMTN DYVVHSPASV PLGYVPHPSS
510 520 530 540 550
LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS SSSSTKGTYF
560 570 580 590 600
PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP
610 620 630 640 650
CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE
660 670 680
ENYESCPPSP YTERSYSHHL YPPPPSPCTD SS
Length:682
Mass (Da):75,491
Last modified:October 11, 2005 - v1
Checksum:i54254D0F7917B73D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032322.

Proteomic databases

PaxDbiQ3US54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Phylogenomic databases

eggNOGiENOG410IPT4. Eukaryota.
ENOG410XSY5. LUCA.
HOVERGENiHBG101630.

Miscellaneous databases

ChiTaRSiLrp6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030201.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ3US54_MOUSE
AccessioniPrimary (citable) accession number: Q3US54
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: January 18, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.