Q3US54 (Q3US54_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAE24482.1

Gene names

Name:

Lrp6 MGI 1298218

Organism

Mus musculus (Mouse) EMBL BAE24482.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	682 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain SAAS SAAS000033 Repeat SAAS SAAS000033 Transmembrane Transmembrane helix SAAS SAAS000033
PTM	Disulfide bond SAAS SAAS000033
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway involved in dorsal/ventral axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt receptor signaling pathway involved in forebrain neuroblast division Inferred from mutant phenotype PubMed 16920270. Source: MGI Wnt receptor signaling pathway involved in somitogenesis Inferred from mutant phenotype PubMed 15469977. Source: MGI axis elongation involved in somitogenesis Inferred from genetic interaction PubMed 11029008. Source: MGI bone remodeling Inferred from genetic interaction PubMed 15537447. Source: MGI branching involved in mammary gland duct morphogenesis Inferred from mutant phenotype PubMed 19503830. Source: MGI canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development Inferred from mutant phenotype PubMed 19705442. Source: MGI canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Inferred from mutant phenotype PubMed 19705442. Source: MGI cell migration involved in gastrulation Inferred from genetic interaction PubMed 15142971. Source: MGI cellular response to cholesterol Inferred from electronic annotation. Source: Compara cerebellum morphogenesis Inferred from mutant phenotype PubMed 11029008. Source: MGI cerebral cortex cell migration Inferred from mutant phenotype PubMed 16920270. Source: MGI convergent extension Inferred from genetic interaction PubMed 19795512. Source: MGI dopaminergic neuron differentiation Inferred from mutant phenotype PubMed 19795519. Source: MGI embryonic camera-type eye morphogenesis Inferred from mutant phenotype PubMed 18985738PubMed 19653321. Source: MGI embryonic digit morphogenesis Inferred from mutant phenotype PubMed 19795512. Source: MGI embryonic forelimb morphogenesis Inferred from mutant phenotype PubMed 11029008PubMed 19653321. Source: MGI embryonic hindlimb morphogenesis Inferred from mutant phenotype PubMed 19653321. Source: MGI embryonic pattern specification Inferred from mutant phenotype PubMed 19653321. Source: MGI embryonic retina morphogenesis in camera-type eye Inferred from mutant phenotype PubMed 19653321. Source: MGI external genitalia morphogenesis Inferred from mutant phenotype PubMed 19653321. Source: MGI face morphogenesis Inferred from mutant phenotype PubMed 19653321PubMed 19700620. Source: MGI forebrain radial glial cell differentiation Inferred from genetic interaction PubMed 14715945. Source: MGI formation of radial glial scaffolds Inferred from genetic interaction PubMed 14715945. Source: MGI heart looping Inferred from genetic interaction PubMed 19795512. Source: MGI mammary placode formation Inferred from mutant phenotype PubMed 19503830. Source: MGI midbrain development Inferred from mutant phenotype PubMed 11029008. Source: MGI midbrain-hindbrain boundary development Inferred from mutant phenotype PubMed 11029008PubMed 19795512. Source: MGI negative regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 19700620. Source: MGI negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 17888405. Source: MGI negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Inferred from genetic interaction PubMed 19056682. Source: MGI negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Inferred from genetic interaction PubMed 19056682. Source: MGI negative regulation of planar cell polarity pathway involved in neural tube closure Inferred from genetic interaction PubMed 19056682. Source: MGI negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Inferred from genetic interaction PubMed 19056682. Source: MGI negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Inferred from genetic interaction PubMed 19056682. Source: MGI negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Inferred from genetic interaction PubMed 19056682. Source: MGI negative regulation of protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara negative regulation of smooth muscle cell apoptotic process Inferred from electronic annotation. Source: Compara neural crest formation Inferred from Biological aspect of Ancestor. Source: RefGenome neural tube closure Inferred from mutant phenotype PubMed 10545599PubMed 15469977PubMed 19653321. Source: MGI odontogenesis of dentin-containing tooth Inferred from mutant phenotype PubMed 5893447PubMed 591875. Source: MGI palate development Inferred from mutant phenotype PubMed 19653321PubMed 19700620. Source: MGI pericardium morphogenesis Inferred from genetic interaction PubMed 19795512. Source: MGI positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from mutant phenotype PubMed 19700620. Source: MGI positive regulation of bone resorption Inferred from mutant phenotype PubMed 18505367. Source: MGI positive regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of cell cycle Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from mutant phenotype PubMed 19700620. Source: MGI positive regulation of ossification Inferred from mutant phenotype PubMed 15469977. Source: MGI positive regulation of sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome post-anal tail morphogenesis Inferred from mutant phenotype PubMed 19653321PubMed 19795512. Source: MGI primitive streak formation Inferred from genetic interaction PubMed 19795512. Source: MGI receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Inferred from mutant phenotype PubMed 18948618. Source: MGI regulation of cell development Inferred from mutant phenotype PubMed 19795519. Source: MGI response to folic acid Inferred from mutant phenotype PubMed 17050573. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype PubMed 15469977. Source: MGI synaptic transmission Inferred from Biological aspect of Ancestor. Source: RefGenome thalamus development Inferred from mutant phenotype PubMed 15342729. Source: MGI trachea cartilage morphogenesis Inferred from genetic interaction PubMed 18256198. Source: MGI
Cellular_component	caveola Inferred from Biological aspect of Ancestor. Source: RefGenome cell surface Inferred from Biological aspect of Ancestor. Source: RefGenome cytoplasmic vesicle Inferred from electronic annotation. Source: Compara early endosome Inferred from direct assay PubMed 18948618. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body Inferred from Biological aspect of Ancestor. Source: RefGenome receptor complex Inferred from Biological aspect of Ancestor. Source: RefGenome synapse Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	Wnt-activated receptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome coreceptor activity Inferred from Biological aspect of Ancestor. Source: RefGenome coreceptor activity involved in Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara kinase inhibitor activity Inferred from electronic annotation. Source: Compara low-density lipoprotein receptor activity Inferred from sequence orthology PubMed 16263759. Source: MGI toxin transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE24482.1

Sequences

	Sequence		Length	Mass (Da)
	Q3US54 [UniParc]. Last modified October 11, 2005. Version 1. Checksum: 54254D0F7917B73D	FASTA	682	75,491
	10 20 30 40 50 60 PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW IDSRQNSIRK 70 80 90 100 110 120 AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT CEATNVIDVT RLDGRSVGVV 130 140 150 160 170 180 LKGEQDRPRA IVVNPEKGYM YFTNLQERSP KIERAALDGT EREVLFFSGL SKPIALALDS 190 200 210 220 230 240 KLGKLFWADS DLRRIESSDL SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID 250 260 270 280 290 300 MTGREGRTKV QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP 310 320 330 340 350 360 MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD ELNCPVCSES 370 380 390 400 410 420 QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF RCANGQCVGK HKKCDHSVDC 430 440 450 460 470 480 SDRSDELDCY PTEEPAPQAT NTVGSVIGVI VTIFVSGTIY FICQRMLCPR MKGDGETMTN 490 500 510 520 530 540 DYVVHSPASV PLGYVPHPSS LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS 550 560 570 580 590 600 SSSSTKGTYF PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP 610 620 630 640 650 660 CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE ENYESCPPSP 670 680 YTERSYSHHL YPPPPSPCTD SS

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[6]	Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAE24482.1. Tissue: Head EMBL BAE24482.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK140796 mRNA. Translation: BAE24482.1.
IPI	IPI00271594.
UniGene	Mm.321990.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3US54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc009ekk.2. mouse.
Organism-specific databases
MGI	MGI:1298218. Lrp6.
Phylogenomic databases
HOVERGEN	HBG101630.
InParanoid	Q3US54.
Gene expression databases
ArrayExpress	Q3US54.
Bgee	Q3US54.
Genevestigator	Q3US54.
Family and domain databases
Gene3D	2.120.10.30. 1 hit. 4.10.400.10. 3 hits.
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR000742. EG-like_dom. IPR023415. LDLR_class-A_CS. IPR000033. LDLR_classB_rpt. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Pfam	PF00057. Ldl_recept_a. 3 hits. PF00058. Ldl_recept_b. 2 hits. [Graphical view]
SMART	SM00181. EGF. 1 hit. SM00192. LDLa. 3 hits. SM00135. LY. 5 hits. [Graphical view]
SUPFAM	SSF57424. LDL_rcpt_classA_cys-rich. 3 hits.
PROSITE	PS01209. LDLRA_1. 3 hits. PS50068. LDLRA_2. 3 hits. PS51120. LDLRB. 5 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q3US54_MOUSE

Accession

Primary (citable) accession number: Q3US54

Entry history

Integrated into UniProtKB/TrEMBL:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)