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Q3US54 (Q3US54_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Lrp6 MGI 1298218
OrganismMus musculus (Mouse) EMBL BAE24482.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length682 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Cellular componentMembrane
   DomainEGF-like domain SAAS SAAS011042
Repeat SAAS SAAS011042
Transmembrane
Transmembrane helix SAAS SAAS000033
   PTMDisulfide bond SAAS SAAS011042
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from genetic interaction PubMed 11029008. Source: MGI

Wnt signaling pathway involved in dorsal/ventral axis specification

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt signaling pathway involved in forebrain neuroblast division

Inferred from mutant phenotype PubMed 16920270. Source: MGI

Wnt signaling pathway involved in somitogenesis

Inferred from mutant phenotype PubMed 15469977. Source: MGI

anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 16126904PubMed 19795512. Source: MGI

axis elongation

Inferred from mutant phenotype PubMed 19795512. Source: MGI

axis elongation involved in somitogenesis

Inferred from genetic interaction PubMed 11029008. Source: MGI

bone remodeling

Inferred from genetic interaction PubMed 15537447. Source: MGI

branching involved in mammary gland duct morphogenesis

Inferred from mutant phenotype PubMed 19503830. Source: MGI

canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 15064719PubMed 15469977PubMed 18505367PubMed 19700620PubMed 19795512. Source: MGI

canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development

Inferred from mutant phenotype PubMed 19705442. Source: MGI

canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation

Inferred from mutant phenotype PubMed 19705442. Source: MGI

cell migration involved in gastrulation

Inferred from genetic interaction PubMed 15142971. Source: MGI

cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

cellular response to cholesterol

Inferred from electronic annotation. Source: Ensembl

cerebellum morphogenesis

Inferred from mutant phenotype PubMed 11029008. Source: MGI

cerebral cortex cell migration

Inferred from mutant phenotype PubMed 16920270. Source: MGI

cerebral cortex development

Inferred from mutant phenotype PubMed 16920270. Source: MGI

convergent extension

Inferred from genetic interaction PubMed 19795512. Source: MGI

dopaminergic neuron differentiation

Inferred from mutant phenotype PubMed 19795519. Source: MGI

dorsal/ventral axis specification

Inferred from mutant phenotype PubMed 18985738. Source: MGI

embryonic camera-type eye morphogenesis

Inferred from mutant phenotype PubMed 18985738PubMed 19653321. Source: MGI

embryonic digit morphogenesis

Inferred from mutant phenotype PubMed 19795512. Source: MGI

embryonic forelimb morphogenesis

Inferred from mutant phenotype PubMed 11029008PubMed 19653321. Source: MGI

embryonic hindlimb morphogenesis

Inferred from mutant phenotype PubMed 19653321. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 20359476. Source: MGI

embryonic pattern specification

Inferred from mutant phenotype PubMed 19653321. Source: MGI

embryonic retina morphogenesis in camera-type eye

Inferred from mutant phenotype PubMed 19653321. Source: MGI

external genitalia morphogenesis

Inferred from mutant phenotype PubMed 19653321. Source: MGI

face morphogenesis

Inferred from mutant phenotype PubMed 19653321PubMed 19700620. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 15384171. Source: MGI

forebrain generation of neurons

Inferred from mutant phenotype PubMed 14715945. Source: MGI

forebrain radial glial cell differentiation

Inferred from genetic interaction PubMed 14715945. Source: MGI

formation of radial glial scaffolds

Inferred from genetic interaction PubMed 14715945. Source: MGI

gastrulation with mouth forming second

Inferred from genetic interaction PubMed 15142971. Source: MGI

generation of neurons

Inferred from mutant phenotype PubMed 15342729. Source: MGI

heart looping

Inferred from genetic interaction PubMed 19795512. Source: MGI

limb morphogenesis

Inferred from mutant phenotype PubMed 15469977. Source: MGI

mammary gland duct morphogenesis

Inferred from genetic interaction PubMed 19503830. Source: MGI

mammary placode formation

Inferred from mutant phenotype PubMed 19503830. Source: MGI

midbrain development

Inferred from mutant phenotype PubMed 11029008. Source: MGI

midbrain-hindbrain boundary development

Inferred from mutant phenotype PubMed 11029008PubMed 19795512. Source: MGI

negative regulation of Wnt signaling pathway

Inferred from genetic interaction PubMed 16126904. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 19700620. Source: MGI

negative regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 17888405. Source: MGI

negative regulation of non-canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of planar cell polarity pathway involved in neural tube closure

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of planar cell polarity pathway involved in pericardium morphogenesis

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis

Inferred from genetic interaction PubMed 19056682. Source: MGI

negative regulation of protein serine/threonine kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

neural crest formation

Inferred from Biological aspect of Ancestor. Source: RefGenome

neural tube closure

Inferred from mutant phenotype PubMed 10545599PubMed 15469977PubMed 19653321. Source: MGI

neural tube development

Inferred from genetic interaction PubMed 19795512. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 5893447PubMed 591875. Source: MGI

palate development

Inferred from mutant phenotype PubMed 19653321PubMed 19700620. Source: MGI

pericardium morphogenesis

Inferred from genetic interaction PubMed 19795512. Source: MGI

positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 19700620. Source: MGI

positive regulation of bone resorption

Inferred from mutant phenotype PubMed 18505367. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from mutant phenotype PubMed 19700620. Source: MGI

positive regulation of ossification

Inferred from mutant phenotype PubMed 15469977. Source: MGI

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

post-anal tail morphogenesis

Inferred from mutant phenotype PubMed 19653321PubMed 19795512. Source: MGI

primitive streak formation

Inferred from genetic interaction PubMed 19795512. Source: MGI

receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport

Inferred from mutant phenotype PubMed 18948618. Source: MGI

regulation of cell development

Inferred from mutant phenotype PubMed 19795519. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype PubMed 591875. Source: MGI

response to folic acid

Inferred from mutant phenotype PubMed 17050573. Source: MGI

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

retina morphogenesis in camera-type eye

Inferred from mutant phenotype PubMed 18985738. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 15469977. Source: MGI

somitogenesis

Inferred from genetic interaction PubMed 19795512. Source: MGI

synaptic transmission

Inferred from Biological aspect of Ancestor. Source: RefGenome

thalamus development

Inferred from mutant phenotype PubMed 15342729. Source: MGI

trachea cartilage morphogenesis

Inferred from genetic interaction PubMed 18256198. Source: MGI

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

caveola

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell surface

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from direct assay PubMed 18948618. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from direct assay PubMed 16126904. Source: MGI

neuronal cell body

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Inferred from direct assay PubMed 18948618. Source: MGI

receptor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

synapse

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionWnt-activated receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt-protein binding

Inferred from physical interaction PubMed 18606138. Source: MGI

coreceptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

coreceptor activity involved in Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

kinase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein receptor activity

Inferred from sequence orthology PubMed 16263759. Source: MGI

toxin transporter activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAE24482.1

Sequences

Sequence LengthMass (Da)Tools
Q3US54 [UniParc].

Last modified October 11, 2005. Version 1.
Checksum: 54254D0F7917B73D

FASTA68275,491
        10         20         30         40         50         60 
PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW IDSRQNSIRK 

        70         80         90        100        110        120 
AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT CEATNVIDVT RLDGRSVGVV 

       130        140        150        160        170        180 
LKGEQDRPRA IVVNPEKGYM YFTNLQERSP KIERAALDGT EREVLFFSGL SKPIALALDS 

       190        200        210        220        230        240 
KLGKLFWADS DLRRIESSDL SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID 

       250        260        270        280        290        300 
MTGREGRTKV QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP 

       310        320        330        340        350        360 
MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD ELNCPVCSES 

       370        380        390        400        410        420 
QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF RCANGQCVGK HKKCDHSVDC 

       430        440        450        460        470        480 
SDRSDELDCY PTEEPAPQAT NTVGSVIGVI VTIFVSGTIY FICQRMLCPR MKGDGETMTN 

       490        500        510        520        530        540 
DYVVHSPASV PLGYVPHPSS LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS 

       550        560        570        580        590        600 
SSSSTKGTYF PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP 

       610        620        630        640        650        660 
CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE ENYESCPPSP 

       670        680 
YTERSYSHHL YPPPPSPCTD SS 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[6]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAE24482.1.
Tissue: Head EMBL BAE24482.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK140796 mRNA. Translation: BAE24482.1.
UniGeneMm.321990.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1298218. Lrp6.

Phylogenomic databases

HOVERGENHBG101630.
InParanoidQ3US54.

Gene expression databases

ArrayExpressQ3US54.
BgeeQ3US54.
GenevestigatorQ3US54.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMSSF57424. SSF57424. 3 hits.
PROSITEPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ3US54_MOUSE
AccessionPrimary (citable) accession number: Q3US54
Entry history
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)