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Q3US54

- Q3US54_MOUSE

UniProt

Q3US54 - Q3US54_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Lrp6

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. coreceptor activity Source: RefGenome
    2. coreceptor activity involved in Wnt signaling pathway Source: Ensembl
    3. kinase inhibitor activity Source: Ensembl
    4. low-density lipoprotein receptor activity Source: MGI
    5. protein binding Source: MGI
    6. toxin transporter activity Source: Ensembl
    7. Wnt-activated receptor activity Source: RefGenome
    8. Wnt-protein binding Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. axis elongation Source: MGI
    3. axis elongation involved in somitogenesis Source: MGI
    4. bone remodeling Source: MGI
    5. branching involved in mammary gland duct morphogenesis Source: MGI
    6. canonical Wnt signaling pathway Source: MGI
    7. canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development Source: MGI
    8. canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: MGI
    9. cell migration involved in gastrulation Source: MGI
    10. cellular response to cholesterol Source: Ensembl
    11. cerebellum morphogenesis Source: MGI
    12. cerebral cortex cell migration Source: MGI
    13. cerebral cortex development Source: MGI
    14. convergent extension Source: MGI
    15. dopaminergic neuron differentiation Source: MGI
    16. dorsal/ventral axis specification Source: MGI
    17. embryonic camera-type eye morphogenesis Source: MGI
    18. embryonic digit morphogenesis Source: MGI
    19. embryonic forelimb morphogenesis Source: MGI
    20. embryonic hindlimb morphogenesis Source: MGI
    21. embryonic limb morphogenesis Source: MGI
    22. embryonic pattern specification Source: MGI
    23. embryonic retina morphogenesis in camera-type eye Source: MGI
    24. external genitalia morphogenesis Source: MGI
    25. face morphogenesis Source: MGI
    26. forebrain development Source: MGI
    27. forebrain generation of neurons Source: MGI
    28. forebrain radial glial cell differentiation Source: MGI
    29. formation of radial glial scaffolds Source: MGI
    30. gastrulation with mouth forming second Source: MGI
    31. generation of neurons Source: MGI
    32. heart looping Source: MGI
    33. limb morphogenesis Source: MGI
    34. mammary gland duct morphogenesis Source: MGI
    35. mammary placode formation Source: MGI
    36. midbrain development Source: MGI
    37. midbrain-hindbrain boundary development Source: MGI
    38. negative regulation of epithelial cell proliferation Source: MGI
    39. negative regulation of fat cell differentiation Source: MGI
    40. negative regulation of non-canonical Wnt signaling pathway Source: MGI
    41. negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: MGI
    42. negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: MGI
    43. negative regulation of planar cell polarity pathway involved in neural tube closure Source: MGI
    44. negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Source: MGI
    45. negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Source: MGI
    46. negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Source: MGI
    47. negative regulation of protein serine/threonine kinase activity Source: Ensembl
    48. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
    49. negative regulation of Wnt signaling pathway Source: MGI
    50. neural crest formation Source: RefGenome
    51. neural tube closure Source: MGI
    52. neural tube development Source: MGI
    53. odontogenesis of dentin-containing tooth Source: MGI
    54. palate development Source: MGI
    55. pericardium morphogenesis Source: MGI
    56. positive regulation of apoptotic process Source: MGI
    57. positive regulation of bone resorption Source: MGI
    58. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    59. positive regulation of cell cycle Source: Ensembl
    60. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    61. positive regulation of mesenchymal cell proliferation Source: MGI
    62. positive regulation of ossification Source: MGI
    63. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    64. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
    65. positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
    66. post-anal tail morphogenesis Source: MGI
    67. primitive streak formation Source: MGI
    68. receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Source: MGI
    69. regulation of cell development Source: MGI
    70. regulation of cell proliferation Source: MGI
    71. response to folic acid Source: MGI
    72. response to peptide hormone Source: Ensembl
    73. retina morphogenesis in camera-type eye Source: MGI
    74. single organismal cell-cell adhesion Source: Ensembl
    75. skeletal system morphogenesis Source: MGI
    76. somitogenesis Source: MGI
    77. synaptic transmission Source: RefGenome
    78. thalamus development Source: MGI
    79. trachea cartilage morphogenesis Source: MGI
    80. Wnt signaling pathway Source: MGI
    81. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome
    82. Wnt signaling pathway involved in forebrain neuroblast division Source: MGI
    83. Wnt signaling pathway involved in somitogenesis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Lrp6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1298218. Lrp6.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: RefGenome
    2. cell surface Source: RefGenome
    3. cytoplasmic vesicle Source: Ensembl
    4. early endosome Source: MGI
    5. Golgi apparatus Source: Ensembl
    6. integral component of membrane Source: UniProtKB-KW
    7. membrane Source: MGI
    8. neuronal cell body Source: RefGenome
    9. plasma membrane Source: MGI
    10. receptor complex Source: RefGenome
    11. synapse Source: RefGenome

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ3US54.
    BgeeiQ3US54.
    GenevestigatoriQ3US54.

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainSAAS annotation, RepeatSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG101630.
    InParanoidiQ3US54.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    4.10.400.10. 3 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view]
    PfamiPF00057. Ldl_recept_a. 3 hits.
    PF00058. Ldl_recept_b. 2 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00181. EGF. 1 hit.
    SM00192. LDLa. 3 hits.
    SM00135. LY. 5 hits.
    [Graphical view]
    SUPFAMiSSF57424. SSF57424. 3 hits.
    PROSITEiPS01209. LDLRA_1. 3 hits.
    PS50068. LDLRA_2. 3 hits.
    PS51120. LDLRB. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3US54-1 [UniParc]FASTAAdd to Basket

    « Hide

    PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW    50
    IDSRQNSIRK AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT 100
    CEATNVIDVT RLDGRSVGVV LKGEQDRPRA IVVNPEKGYM YFTNLQERSP 150
    KIERAALDGT EREVLFFSGL SKPIALALDS KLGKLFWADS DLRRIESSDL 200
    SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID MTGREGRTKV 250
    QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP 300
    MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD 350
    ELNCPVCSES QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF 400
    RCANGQCVGK HKKCDHSVDC SDRSDELDCY PTEEPAPQAT NTVGSVIGVI 450
    VTIFVSGTIY FICQRMLCPR MKGDGETMTN DYVVHSPASV PLGYVPHPSS 500
    LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS SSSSTKGTYF 550
    PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP 600
    CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE 650
    ENYESCPPSP YTERSYSHHL YPPPPSPCTD SS 682
    Length:682
    Mass (Da):75,491
    Last modified:October 11, 2005 - v1
    Checksum:i54254D0F7917B73D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK140796 mRNA. Translation: BAE24482.1.
    UniGeneiMm.321990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK140796 mRNA. Translation: BAE24482.1 .
    UniGenei Mm.321990.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1298218. Lrp6.

    Phylogenomic databases

    HOVERGENi HBG101630.
    InParanoidi Q3US54.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3US54.
    Bgeei Q3US54.
    Genevestigatori Q3US54.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    4.10.400.10. 3 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view ]
    Pfami PF00057. Ldl_recept_a. 3 hits.
    PF00058. Ldl_recept_b. 2 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00181. EGF. 1 hit.
    SM00192. LDLa. 3 hits.
    SM00135. LY. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57424. SSF57424. 3 hits.
    PROSITEi PS01209. LDLRA_1. 3 hits.
    PS50068. LDLRA_2. 3 hits.
    PS51120. LDLRB. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeadImported.

    Entry informationi

    Entry nameiQ3US54_MOUSE
    AccessioniPrimary (citable) accession number: Q3US54
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)