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Protein
Submitted name:

Putative uncharacterized protein

Gene

Lrp6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. coreceptor activity Source: GO_Central
  2. coreceptor activity involved in Wnt signaling pathway Source: MGI
  3. frizzled binding Source: MGI
  4. identical protein binding Source: MGI
  5. kinase inhibitor activity Source: MGI
  6. low-density lipoprotein receptor activity Source: MGI
  7. protein homodimerization activity Source: MGI
  8. receptor binding Source: MGI
  9. toxin transporter activity Source: Ensembl
  10. Wnt-activated receptor activity Source: GO_Central
  11. Wnt-protein binding Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. axis elongation Source: MGI
  3. axis elongation involved in somitogenesis Source: MGI
  4. bone remodeling Source: MGI
  5. branching involved in mammary gland duct morphogenesis Source: MGI
  6. canonical Wnt signaling pathway Source: MGI
  7. canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development Source: MGI
  8. canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: MGI
  9. cell migration involved in gastrulation Source: MGI
  10. cellular response to cholesterol Source: MGI
  11. cerebellum morphogenesis Source: MGI
  12. cerebral cortex cell migration Source: MGI
  13. cerebral cortex development Source: MGI
  14. convergent extension Source: MGI
  15. dopaminergic neuron differentiation Source: MGI
  16. dorsal/ventral axis specification Source: MGI
  17. embryonic camera-type eye morphogenesis Source: MGI
  18. embryonic digit morphogenesis Source: MGI
  19. embryonic forelimb morphogenesis Source: MGI
  20. embryonic hindlimb morphogenesis Source: MGI
  21. embryonic limb morphogenesis Source: MGI
  22. embryonic pattern specification Source: MGI
  23. embryonic retina morphogenesis in camera-type eye Source: MGI
  24. external genitalia morphogenesis Source: MGI
  25. face morphogenesis Source: MGI
  26. forebrain development Source: MGI
  27. forebrain generation of neurons Source: MGI
  28. forebrain radial glial cell differentiation Source: MGI
  29. formation of radial glial scaffolds Source: MGI
  30. gastrulation with mouth forming second Source: MGI
  31. generation of neurons Source: MGI
  32. heart looping Source: MGI
  33. limb morphogenesis Source: MGI
  34. mammary gland duct morphogenesis Source: MGI
  35. mammary placode formation Source: MGI
  36. midbrain development Source: MGI
  37. midbrain-hindbrain boundary development Source: MGI
  38. negative regulation of epithelial cell proliferation Source: MGI
  39. negative regulation of fat cell differentiation Source: MGI
  40. negative regulation of non-canonical Wnt signaling pathway Source: MGI
  41. negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: MGI
  42. negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: MGI
  43. negative regulation of planar cell polarity pathway involved in neural tube closure Source: MGI
  44. negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Source: MGI
  45. negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Source: MGI
  46. negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Source: MGI
  47. negative regulation of protein kinase activity Source: MGI
  48. negative regulation of protein phosphorylation Source: MGI
  49. negative regulation of protein serine/threonine kinase activity Source: MGI
  50. negative regulation of smooth muscle cell apoptotic process Source: MGI
  51. negative regulation of Wnt signaling pathway Source: MGI
  52. neural crest cell differentiation Source: MGI
  53. neural crest formation Source: MGI
  54. neural tube closure Source: MGI
  55. neural tube development Source: MGI
  56. odontogenesis of dentin-containing tooth Source: MGI
  57. palate development Source: MGI
  58. pericardium morphogenesis Source: MGI
  59. positive regulation of apoptotic process Source: MGI
  60. positive regulation of bone resorption Source: MGI
  61. positive regulation of canonical Wnt signaling pathway Source: MGI
  62. positive regulation of cell cycle Source: MGI
  63. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  64. positive regulation of mesenchymal cell proliferation Source: MGI
  65. positive regulation of ossification Source: MGI
  66. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  67. positive regulation of transcription, DNA-templated Source: MGI
  68. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  69. positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: MGI
  70. post-anal tail morphogenesis Source: MGI
  71. primitive streak formation Source: MGI
  72. receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Source: MGI
  73. regulation of cell development Source: MGI
  74. regulation of cell proliferation Source: MGI
  75. response to folic acid Source: MGI
  76. response to peptide hormone Source: Ensembl
  77. retina morphogenesis in camera-type eye Source: MGI
  78. single organismal cell-cell adhesion Source: Ensembl
  79. skeletal system morphogenesis Source: MGI
  80. somitogenesis Source: MGI
  81. synaptic transmission Source: GO_Central
  82. thalamus development Source: MGI
  83. toxin transport Source: MGI
  84. trachea cartilage morphogenesis Source: MGI
  85. Wnt signaling pathway Source: MGI
  86. Wnt signaling pathway involved in dorsal/ventral axis specification Source: MGI
  87. Wnt signaling pathway involved in forebrain neuroblast division Source: MGI
  88. Wnt signaling pathway involved in somitogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lrp6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: GO_Central
  2. cell surface Source: MGI
  3. cytoplasmic vesicle Source: MGI
  4. early endosome Source: MGI
  5. Golgi apparatus Source: Ensembl
  6. membrane Source: MGI
  7. neuronal cell body Source: GO_Central
  8. plasma membrane Source: MGI
  9. receptor complex Source: GO_Central
  10. synapse Source: GO_Central
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ3US54.
ExpressionAtlasiQ3US54. baseline and differential.
GenevestigatoriQ3US54.

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOVERGENiHBG101630.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3US54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW
60 70 80 90 100
IDSRQNSIRK AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT
110 120 130 140 150
CEATNVIDVT RLDGRSVGVV LKGEQDRPRA IVVNPEKGYM YFTNLQERSP
160 170 180 190 200
KIERAALDGT EREVLFFSGL SKPIALALDS KLGKLFWADS DLRRIESSDL
210 220 230 240 250
SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID MTGREGRTKV
260 270 280 290 300
QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP
310 320 330 340 350
MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD
360 370 380 390 400
ELNCPVCSES QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF
410 420 430 440 450
RCANGQCVGK HKKCDHSVDC SDRSDELDCY PTEEPAPQAT NTVGSVIGVI
460 470 480 490 500
VTIFVSGTIY FICQRMLCPR MKGDGETMTN DYVVHSPASV PLGYVPHPSS
510 520 530 540 550
LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS SSSSTKGTYF
560 570 580 590 600
PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP
610 620 630 640 650
CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE
660 670 680
ENYESCPPSP YTERSYSHHL YPPPPSPCTD SS
Length:682
Mass (Da):75,491
Last modified:October 11, 2005 - v1
Checksum:i54254D0F7917B73D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Phylogenomic databases

HOVERGENiHBG101630.

Miscellaneous databases

ChiTaRSiLrp6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3US54.
ExpressionAtlasiQ3US54. baseline and differential.
GenevestigatoriQ3US54.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.

Entry informationi

Entry nameiQ3US54_MOUSE
AccessioniPrimary (citable) accession number: Q3US54
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.