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Q3US54

- Q3US54_MOUSE

UniProt

Q3US54 - Q3US54_MOUSE

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Protein
Submitted name: Putative uncharacterized protein
Gene
Lrp6
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: RefGenome
  2. Wnt-protein binding Source: MGI
  3. coreceptor activity Source: RefGenome
  4. coreceptor activity involved in Wnt signaling pathway Source: Ensembl
  5. kinase inhibitor activity Source: Ensembl
  6. low-density lipoprotein receptor activity Source: MGI
  7. protein binding Source: MGI
  8. toxin transporter activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. Wnt signaling pathway Source: MGI
  2. Wnt signaling pathway involved in dorsal/ventral axis specification Source: RefGenome
  3. Wnt signaling pathway involved in forebrain neuroblast division Source: MGI
  4. Wnt signaling pathway involved in somitogenesis Source: MGI
  5. anterior/posterior pattern specification Source: MGI
  6. axis elongation Source: MGI
  7. axis elongation involved in somitogenesis Source: MGI
  8. bone remodeling Source: MGI
  9. branching involved in mammary gland duct morphogenesis Source: MGI
  10. canonical Wnt signaling pathway Source: MGI
  11. canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development Source: MGI
  12. canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: MGI
  13. cell migration involved in gastrulation Source: MGI
  14. cellular response to cholesterol Source: Ensembl
  15. cerebellum morphogenesis Source: MGI
  16. cerebral cortex cell migration Source: MGI
  17. cerebral cortex development Source: MGI
  18. convergent extension Source: MGI
  19. dopaminergic neuron differentiation Source: MGI
  20. dorsal/ventral axis specification Source: MGI
  21. embryonic camera-type eye morphogenesis Source: MGI
  22. embryonic digit morphogenesis Source: MGI
  23. embryonic forelimb morphogenesis Source: MGI
  24. embryonic hindlimb morphogenesis Source: MGI
  25. embryonic limb morphogenesis Source: MGI
  26. embryonic pattern specification Source: MGI
  27. embryonic retina morphogenesis in camera-type eye Source: MGI
  28. external genitalia morphogenesis Source: MGI
  29. face morphogenesis Source: MGI
  30. forebrain development Source: MGI
  31. forebrain generation of neurons Source: MGI
  32. forebrain radial glial cell differentiation Source: MGI
  33. formation of radial glial scaffolds Source: MGI
  34. gastrulation with mouth forming second Source: MGI
  35. generation of neurons Source: MGI
  36. heart looping Source: MGI
  37. limb morphogenesis Source: MGI
  38. mammary gland duct morphogenesis Source: MGI
  39. mammary placode formation Source: MGI
  40. midbrain development Source: MGI
  41. midbrain-hindbrain boundary development Source: MGI
  42. negative regulation of Wnt signaling pathway Source: MGI
  43. negative regulation of epithelial cell proliferation Source: MGI
  44. negative regulation of fat cell differentiation Source: MGI
  45. negative regulation of non-canonical Wnt signaling pathway Source: MGI
  46. negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: MGI
  47. negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: MGI
  48. negative regulation of planar cell polarity pathway involved in neural tube closure Source: MGI
  49. negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Source: MGI
  50. negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Source: MGI
  51. negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Source: MGI
  52. negative regulation of protein serine/threonine kinase activity Source: Ensembl
  53. negative regulation of smooth muscle cell apoptotic process Source: Ensembl
  54. neural crest formation Source: RefGenome
  55. neural tube closure Source: MGI
  56. neural tube development Source: MGI
  57. odontogenesis of dentin-containing tooth Source: MGI
  58. palate development Source: MGI
  59. pericardium morphogenesis Source: MGI
  60. positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: Ensembl
  61. positive regulation of apoptotic process Source: MGI
  62. positive regulation of bone resorption Source: MGI
  63. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  64. positive regulation of cell cycle Source: Ensembl
  65. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  66. positive regulation of mesenchymal cell proliferation Source: MGI
  67. positive regulation of ossification Source: MGI
  68. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  69. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  70. post-anal tail morphogenesis Source: MGI
  71. primitive streak formation Source: MGI
  72. receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Source: MGI
  73. regulation of cell development Source: MGI
  74. regulation of cell proliferation Source: MGI
  75. response to folic acid Source: MGI
  76. response to peptide hormone Source: Ensembl
  77. retina morphogenesis in camera-type eye Source: MGI
  78. single organismal cell-cell adhesion Source: Ensembl
  79. skeletal system morphogenesis Source: MGI
  80. somitogenesis Source: MGI
  81. synaptic transmission Source: RefGenome
  82. thalamus development Source: MGI
  83. trachea cartilage morphogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lrp6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. caveola Source: RefGenome
  3. cell surface Source: RefGenome
  4. cytoplasmic vesicle Source: Ensembl
  5. early endosome Source: MGI
  6. integral component of membrane Source: UniProtKB-KW
  7. membrane Source: MGI
  8. neuronal cell body Source: RefGenome
  9. plasma membrane Source: MGI
  10. receptor complex Source: RefGenome
  11. synapse Source: RefGenome
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ3US54.
BgeeiQ3US54.
GenevestigatoriQ3US54.

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotations, RepeatSAAS annotations

Phylogenomic databases

HOVERGENiHBG101630.
InParanoidiQ3US54.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3US54-1 [UniParc]FASTAAdd to Basket

« Hide

PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW    50
IDSRQNSIRK AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT 100
CEATNVIDVT RLDGRSVGVV LKGEQDRPRA IVVNPEKGYM YFTNLQERSP 150
KIERAALDGT EREVLFFSGL SKPIALALDS KLGKLFWADS DLRRIESSDL 200
SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID MTGREGRTKV 250
QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP 300
MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD 350
ELNCPVCSES QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF 400
RCANGQCVGK HKKCDHSVDC SDRSDELDCY PTEEPAPQAT NTVGSVIGVI 450
VTIFVSGTIY FICQRMLCPR MKGDGETMTN DYVVHSPASV PLGYVPHPSS 500
LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS SSSSTKGTYF 550
PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP 600
CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE 650
ENYESCPPSP YTERSYSHHL YPPPPSPCTD SS 682
Length:682
Mass (Da):75,491
Last modified:October 11, 2005 - v1
Checksum:i54254D0F7917B73D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140796 mRNA. Translation: BAE24482.1 .
UniGenei Mm.321990.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1298218. Lrp6.

Phylogenomic databases

HOVERGENi HBG101630.
InParanoidi Q3US54.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q3US54.
Bgeei Q3US54.
Genevestigatori Q3US54.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view ]
SUPFAMi SSF57424. SSF57424. 3 hits.
PROSITEi PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.

Entry informationi

Entry nameiQ3US54_MOUSE
AccessioniPrimary (citable) accession number: Q3US54
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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