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Protein
Submitted name:

Putative uncharacterized protein

Gene

Lrp6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • axis elongation Source: MGI
  • axis elongation involved in somitogenesis Source: MGI
  • bone remodeling Source: MGI
  • branching involved in mammary gland duct morphogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development Source: MGI
  • canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation Source: MGI
  • cell migration involved in gastrulation Source: MGI
  • cellular response to cholesterol Source: MGI
  • cerebellum morphogenesis Source: MGI
  • cerebral cortex cell migration Source: MGI
  • cerebral cortex development Source: MGI
  • convergent extension Source: MGI
  • dopaminergic neuron differentiation Source: MGI
  • dorsal/ventral axis specification Source: MGI
  • embryonic camera-type eye morphogenesis Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic pattern specification Source: MGI
  • embryonic retina morphogenesis in camera-type eye Source: MGI
  • external genitalia morphogenesis Source: MGI
  • face morphogenesis Source: MGI
  • forebrain development Source: MGI
  • forebrain generation of neurons Source: MGI
  • forebrain radial glial cell differentiation Source: MGI
  • formation of radial glial scaffolds Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • generation of neurons Source: MGI
  • heart looping Source: MGI
  • limb morphogenesis Source: MGI
  • mammary gland duct morphogenesis Source: MGI
  • mammary placode formation Source: MGI
  • midbrain development Source: MGI
  • midbrain-hindbrain boundary development Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of non-canonical Wnt signaling pathway Source: MGI
  • negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: MGI
  • negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: MGI
  • negative regulation of planar cell polarity pathway involved in neural tube closure Source: MGI
  • negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis Source: MGI
  • negative regulation of planar cell polarity pathway involved in pericardium morphogenesis Source: MGI
  • negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis Source: MGI
  • negative regulation of protein kinase activity Source: MGI
  • negative regulation of protein phosphorylation Source: MGI
  • negative regulation of protein serine/threonine kinase activity Source: MGI
  • negative regulation of smooth muscle cell apoptotic process Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • neural crest cell differentiation Source: MGI
  • neural crest formation Source: MGI
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • palate development Source: MGI
  • pericardium morphogenesis Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of bone resorption Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cell cycle Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: Ensembl
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of ossification Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Source: MGI
  • post-anal tail morphogenesis Source: MGI
  • primitive streak formation Source: MGI
  • receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Source: MGI
  • regulation of cell development Source: MGI
  • regulation of cell proliferation Source: MGI
  • response to folic acid Source: MGI
  • response to peptide hormone Source: Ensembl
  • retina morphogenesis in camera-type eye Source: MGI
  • single organismal cell-cell adhesion Source: Ensembl
  • skeletal system morphogenesis Source: MGI
  • somitogenesis Source: MGI
  • synaptic transmission Source: GO_Central
  • thalamus development Source: MGI
  • toxin transport Source: MGI
  • trachea cartilage morphogenesis Source: MGI
  • Wnt signaling pathway Source: MGI
  • Wnt signaling pathway involved in dorsal/ventral axis specification Source: MGI
  • Wnt signaling pathway involved in forebrain neuroblast division Source: MGI
  • Wnt signaling pathway involved in somitogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lrp6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Subcellular locationi

GO - Cellular componenti

  • caveola Source: GO_Central
  • cell surface Source: MGI
  • cytoplasmic vesicle Source: MGI
  • cytosol Source: GOC
  • early endosome Source: MGI
  • Golgi apparatus Source: Ensembl
  • membrane Source: MGI
  • neuronal cell body Source: GO_Central
  • plasma membrane Source: MGI
  • receptor complex Source: GO_Central
  • synapse Source: GO_Central
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ3US54.
ExpressionAtlasiQ3US54. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032322.

Family & Domainsi

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOVERGENiHBG101630.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3US54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PTTFLLFSQK SAINRMVIDE QQSPDIILPI HSLRNVRAID YDPLDKQLYW
60 70 80 90 100
IDSRQNSIRK AHEDGGQGFN VVANSVANQN LEIQPYDLSI DIYSRYIYWT
110 120 130 140 150
CEATNVIDVT RLDGRSVGVV LKGEQDRPRA IVVNPEKGYM YFTNLQERSP
160 170 180 190 200
KIERAALDGT EREVLFFSGL SKPIALALDS KLGKLFWADS DLRRIESSDL
210 220 230 240 250
SGANRIVLED SNILQPVGLT VFENWLYWID KQQQMIEKID MTGREGRTKV
260 270 280 290 300
QARIAQLSDI HAVKELNLQE YRQHPCAQDN GGCSHICLVK GDGTTRCSCP
310 320 330 340 350
MHLVLLQDEL SCGEPPTCSP QQFTCFTGDI DCIPVAWRCD GFTECEDHSD
360 370 380 390 400
ELNCPVCSES QFQCASGQCI DGALRCNGDA NCQDKSDEKN CEVLCLIDQF
410 420 430 440 450
RCANGQCVGK HKKCDHSVDC SDRSDELDCY PTEEPAPQAT NTVGSVIGVI
460 470 480 490 500
VTIFVSGTIY FICQRMLCPR MKGDGETMTN DYVVHSPASV PLGYVPHPSS
510 520 530 540 550
LSGSLPGMSR GKSMISSLSI MGGSSGPPYD RAHVTGASSS SSSSTKGTYF
560 570 580 590 600
PAILNPPPSP ATERSHYTME FGYSSNSPST HRSYSYRPYS YRHFAPPTTP
610 620 630 640 650
CSTDVCDSDY APSRRMTSVA TAKGYTSDVN YDSEPVPPPP TPRSQYLSAE
660 670 680
ENYESCPPSP YTERSYSHHL YPPPPSPCTD SS
Length:682
Mass (Da):75,491
Last modified:October 11, 2005 - v1
Checksum:i54254D0F7917B73D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140796 mRNA. Translation: BAE24482.1.
UniGeneiMm.321990.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1298218. Lrp6.

Phylogenomic databases

HOVERGENiHBG101630.

Miscellaneous databases

ChiTaRSiLrp6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ3US54.
ExpressionAtlasiQ3US54. baseline and differential.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 3 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 3 hits.
PF00058. Ldl_recept_b. 2 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 1 hit.
SM00192. LDLa. 3 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 3 hits.
PROSITEiPS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 3 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.

Entry informationi

Entry nameiQ3US54_MOUSE
AccessioniPrimary (citable) accession number: Q3US54
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 24, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.