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Protein

Zinc finger protein 48

Gene

Znf48

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri83 – 10523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri191 – 21323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 48
Alternative name(s):
Zinc finger protein 553
Gene namesi
Name:Znf48
Synonyms:Zfp48, Zfp553, Znf553
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2384725. Zfp553.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Zinc finger protein 48PRO_0000234587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei12 – 121PhosphoserineCombined sources
Cross-linki583 – 583Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ3US17.
PaxDbiQ3US17.
PeptideAtlasiQ3US17.
PRIDEiQ3US17.

PTM databases

iPTMnetiQ3US17.
PhosphoSiteiQ3US17.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045598.
CleanExiMM_ZFP553.
GenevisibleiQ3US17. MM.

Interactioni

Protein-protein interaction databases

BioGridi231466. 1 interaction.
STRINGi10090.ENSMUSP00000060967.

Structurei

3D structure databases

ProteinModelPortaliQ3US17.
SMRiQ3US17. Positions 85-566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi364 – 42663Pro-richAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri83 – 10523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri163 – 18523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri191 – 21323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115670.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3US17.
OMAiMEPQDFG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3US17.
TreeFamiTF338489.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3US17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASPGDEFE HSPQERDGPE IKEEEQLAPT LQVGNTSLKP DGIQCWDDLW
60 70 80 90 100
DRREGLGKRQ PRDPVPRILG EPRWGQGSND RAAVCGECGK SFRQMSDLVK
110 120 130 140 150
HQRTHTGEKP YKCGVCGKGF GDSSARIKHQ RTHTGEKAYR VRPPAPGPPK
160 170 180 190 200
MPRSRIPAGE RPTICGECGK SFRQSSDLVK HQRTHTGEKP YKCGICGKGF
210 220 230 240 250
GDSSARIKHQ RTHRGDQLPR PVVPRRQPSP AAPAAPHRPK AQDKPYICTD
260 270 280 290 300
CGKRFVLSCS LLSHQRSHLG PKPFGCDVCG KEFARGSDLV KHLRVHTGEK
310 320 330 340 350
PYLCPECGKG FADSSARVKH LRTHSGQRPH ACPECNRSFS LSSTLLRHRL
360 370 380 390 400
THVEPQDFSL AAYPVVPLIP SPPPPPLGTS PSLTPRSPSH SSDGPFGLPG
410 420 430 440 450
LEPEPGGPQA GEPPPPLAGD KPHKCPECGK GFRRSSDLVK HHRVHTGEKP
460 470 480 490 500
YLCPECGKGF ADSSARVKHL RTHQGERTRP PPPPSTLLRP HNPPGSVPIV
510 520 530 540 550
PQSRVQGRPS GPSQLHVCGF CGKEFPRSSD LVKHRRTHTG EKPYKCAECG
560 570 580 590
KGFGDSSARI KHQRGHLALK PFGVGDGPPR PLKEESPAGL E
Length:591
Mass (Da):64,599
Last modified:May 16, 2006 - v2
Checksum:iEE070D2692FA4A73
GO

Sequence cautioni

The sequence AAH12403 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → E in BAE24520 (PubMed:16141072).Curated
Sequence conflicti194 – 1941G → V in BAE28517 (PubMed:16141072).Curated
Sequence conflicti503 – 5031S → F in BAE28517 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049208 mRNA. Translation: BAC33610.1.
AK140924 mRNA. Translation: BAE24520.1.
AK146581 mRNA. Translation: BAE27277.1.
AK148378 mRNA. Translation: BAE28517.1.
BC012403 mRNA. Translation: AAH12403.1. Different initiation.
BC026401 mRNA. Translation: AAH26401.1.
CCDSiCCDS21860.1.
RefSeqiNP_666313.1. NM_146201.1.
XP_006507802.1. XM_006507739.1.
UniGeneiMm.258371.

Genome annotation databases

EnsembliENSMUST00000056232; ENSMUSP00000060967; ENSMUSG00000045598.
ENSMUST00000106312; ENSMUSP00000101919; ENSMUSG00000045598.
GeneIDi233887.
KEGGimmu:233887.
UCSCiuc009jur.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049208 mRNA. Translation: BAC33610.1.
AK140924 mRNA. Translation: BAE24520.1.
AK146581 mRNA. Translation: BAE27277.1.
AK148378 mRNA. Translation: BAE28517.1.
BC012403 mRNA. Translation: AAH12403.1. Different initiation.
BC026401 mRNA. Translation: AAH26401.1.
CCDSiCCDS21860.1.
RefSeqiNP_666313.1. NM_146201.1.
XP_006507802.1. XM_006507739.1.
UniGeneiMm.258371.

3D structure databases

ProteinModelPortaliQ3US17.
SMRiQ3US17. Positions 85-566.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231466. 1 interaction.
STRINGi10090.ENSMUSP00000060967.

PTM databases

iPTMnetiQ3US17.
PhosphoSiteiQ3US17.

Proteomic databases

MaxQBiQ3US17.
PaxDbiQ3US17.
PeptideAtlasiQ3US17.
PRIDEiQ3US17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056232; ENSMUSP00000060967; ENSMUSG00000045598.
ENSMUST00000106312; ENSMUSP00000101919; ENSMUSG00000045598.
GeneIDi233887.
KEGGimmu:233887.
UCSCiuc009jur.1. mouse.

Organism-specific databases

CTDi233887.
MGIiMGI:2384725. Zfp553.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115670.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3US17.
OMAiMEPQDFG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3US17.
TreeFamiTF338489.

Miscellaneous databases

PROiQ3US17.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045598.
CleanExiMM_ZFP553.
GenevisibleiQ3US17. MM.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF48_MOUSE
AccessioniPrimary (citable) accession number: Q3US17
Secondary accession number(s): Q3UFP3, Q8R0V0, Q921H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.