UniProtKB - Q3URU4 (Q3URU4_MOUSE)
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Protein
Submitted name:
Meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_c
Gene
Mre11a
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 129 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- 3'-5' exonuclease activity Source: Ensembl
- ATP-dependent DNA helicase activity Source: Ensembl
- cadherin binding Source: Ensembl
- DNA binding Source: Ensembl
- identical protein binding Source: Ensembl
- manganese ion binding Source: InterPro
- protein C-terminus binding Source: Ensembl
- single-stranded DNA endodeoxyribonuclease activity Source: Ensembl
GO - Biological processi
- cell proliferation Source: Ensembl
- double-strand break repair via nonhomologous end joining Source: Ensembl
- intra-S DNA damage checkpoint Source: Ensembl
- mitotic G2 DNA damage checkpoint Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of DNA endoreduplication Source: Ensembl
- positive regulation of kinase activity Source: Ensembl
- positive regulation of protein autophosphorylation Source: Ensembl
- positive regulation of telomere maintenance Source: Ensembl
- sister chromatid cohesion Source: Ensembl
- synapsis Source: Ensembl
- telomeric 3' overhang formation Source: Ensembl
Keywordsi
Molecular function | EndonucleaseUniRule annotation, ExonucleaseUniRule annotation, Hydrolase, Nuclease |
Biological process | DNA damage, DNA repairUniRule annotation, MeiosisUniRule annotation |
Ligand | ManganeseUniRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_cImported |
Gene namesi | Name:Mre11aImported ORF Names:mCG_22656Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1100512. Mre11a. |
Interactioni
GO - Molecular functioni
- cadherin binding Source: Ensembl
- identical protein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 294 – 462 | Mre11_DNA_bindInterPro annotationAdd BLAST | 169 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 491 – 511 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the MRE11/RAD32 family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG2310. Eukaryota. COG0420. LUCA. |
HOVERGENi | HBG052508. |
KOi | K10865. |
OMAi | IHFFRHR. |
OrthoDBi | EOG091G06P4. |
Family and domain databases
Gene3Di | 3.30.110.110. 1 hit. 3.60.21.10. 1 hit. |
InterProi | View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR003701. Mre11. IPR007281. Mre11_DNA-bd. IPR038487. Mre11_DNA-bd_sf. |
Pfami | View protein in Pfam PF00149. Metallophos. 1 hit. PF04152. Mre11_DNA_bind. 1 hit. |
PIRSFi | PIRSF000882. DSB_repair_MRE11. 1 hit. |
SMARTi | View protein in SMART SM01347. Mre11_DNA_bind. 1 hit. |
TIGRFAMsi | TIGR00583. mre11. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q3URU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN
60 70 80 90 100
EVDFILLGGD LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN
110 120 130 140 150
FGFSKFPWVN YQDGNLNISI PVFSIHGNHD DPTGADALCA LDVLSCAGFV
160 170 180 190 200
NHFGRSMSVE KVDISPVLLQ KGSTKLALYG LGSIPDERLY RMFVNKKVTM
210 220 230 240 250
LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL VIWGHEHECK
260 270 280 290 300
IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP
310 320 330 340 350
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE
360 370 380 390 400
RLGNPQQPGK PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR
410 420 430 440 450
HREQKGKTGE EINFGMLITK PASEGATLRV EDLVKQYFQT AEKNVQLSLL
460 470 480 490 500
TERGMGEAVQ EFVDKEEKDA IEELVKYQLE KTQRFLKERH IDALEDKIDE
510 520 530 540 550
EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA FSAEDLSFDT
560 570 580 590 600
SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI
610 620 630 640 650
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE
660 670 680 690 700
DDIFPTNSRA DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC
PRRNRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK141214 mRNA. Translation: BAE24593.1. CH466522 Genomic DNA. Translation: EDL25008.1. |
RefSeqi | NP_061206.1. NM_018736.3. XP_006510111.1. XM_006510048.2. |
UniGenei | Mm.149071. |
Genome annotation databases
GeneIDi | 17535. |
KEGGi | mmu:17535. |
Similar proteinsi
Entry informationi
Entry namei | Q3URU4_MOUSE | |
Accessioni | Q3URU4Primary (citable) accession number: Q3URU4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | March 28, 2018 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |