Mre11a

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	129	Proton donorUniRule annotation		1

GO - Molecular functionⁱ

3'-5' exonuclease activity Source: Ensembl
ATP-dependent DNA helicase activity Source: Ensembl
cadherin binding Source: Ensembl
DNA binding Source: Ensembl
manganese ion binding Source: InterPro
protein C-terminus binding Source: Ensembl
single-stranded DNA endodeoxyribonuclease activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cell proliferation Source: Ensembl
double-strand break repair via nonhomologous end joining Source: Ensembl
intra-S DNA damage checkpoint Source: Ensembl
mitotic G2 DNA damage checkpoint Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of DNA endoreduplication Source: Ensembl
positive regulation of kinase activity Source: Ensembl
positive regulation of protein autophosphorylation Source: Ensembl
positive regulation of telomere maintenance Source: Ensembl
sister chromatid cohesion Source: Ensembl
synapsis Source: Ensembl
telomeric 3' overhang formation Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	EndonucleaseUniRule annotation, ExonucleaseUniRule annotation, Hydrolase, Nuclease
Biological process	DNA damage, DNA repairUniRule annotation, MeiosisUniRule annotation
Ligand	ManganeseUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_cImported Submitted name: Putative uncharacterized proteinImported
Gene namesⁱ	Name:Mre11aImported ORF Names:mCG_22656Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:1100512. Mre11a.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: Ensembl
Mre11 complex Source: Ensembl
nuclear chromosome, telomeric region Source: Ensembl
PML body Source: Ensembl
site of double-strand break Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031928.
ExpressionAtlasⁱ	Q3URU4. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

cadherin binding Source: Ensembl
protein C-terminus binding Source: Ensembl

Complete GO annotation...

Structureⁱ

3D structure databases

SMRⁱ	Q3URU4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	294 – 462	Mre11_DNA_bindInterPro annotationAdd BLAST		169

Sequence similaritiesⁱ

Belongs to the MRE11/RAD32 family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2310. Eukaryota. COG0420. LUCA.
HOVERGENⁱ	HBG052508.
KEGG Orthology (KO) More...KOⁱ	K10865.
OMAⁱ	IHFFRHR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06P4.

Family and domain databases

Gene3Dⁱ	3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR003701. Mre11. IPR007281. Mre11_DNA-bd.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit. PF04152. Mre11_DNA_bind. 1 hit.
PIRSFⁱ	PIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTⁱ	View protein in SMART SM01347. Mre11_DNA_bind. 1 hit.
SUPFAMⁱ	SSF56300. SSF56300. 2 hits.
TIGRFAMsⁱ	TIGR00583. mre11. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3URU4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN 
        60         70         80         90        100
EVDFILLGGD LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN 
       110        120        130        140        150
FGFSKFPWVN YQDGNLNISI PVFSIHGNHD DPTGADALCA LDVLSCAGFV 
       160        170        180        190        200
NHFGRSMSVE KVDISPVLLQ KGSTKLALYG LGSIPDERLY RMFVNKKVTM 
       210        220        230        240        250
LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL VIWGHEHECK 
       260        270        280        290        300
IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP 
       310        320        330        340        350
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE 
       360        370        380        390        400
RLGNPQQPGK PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR 
       410        420        430        440        450
HREQKGKTGE EINFGMLITK PASEGATLRV EDLVKQYFQT AEKNVQLSLL 
       460        470        480        490        500
TERGMGEAVQ EFVDKEEKDA IEELVKYQLE KTQRFLKERH IDALEDKIDE 
       510        520        530        540        550
EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA FSAEDLSFDT 
       560        570        580        590        600
SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI 
       610        620        630        640        650
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE 
       660        670        680        690        700
DDIFPTNSRA DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC 

PRRNRR

Length:706

Mass (Da):80,223

Last modified:October 11, 2005 - v1

Checksum:ⁱ0F12F51902FC179A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK141214 mRNA. Translation: BAE24593.1. CH466522 Genomic DNA. Translation: EDL25008.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_061206.1. NM_018736.3. XP_006510111.1. XM_006510048.2.
UniGeneⁱ	Mm.149071.

Genome annotation databases

GeneIDⁱ	17535.
KEGGⁱ	mmu:17535.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK141214 mRNA. Translation: BAE24593.1. CH466522 Genomic DNA. Translation: EDL25008.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_061206.1. NM_018736.3. XP_006510111.1. XM_006510048.2.
UniGeneⁱ	Mm.149071.

3D structure databases

SMRⁱ	Q3URU4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	17535.
KEGGⁱ	mmu:17535.

Organism-specific databases

CTDⁱ	17535.
MGIⁱ	MGI:1100512. Mre11a.

Phylogenomic databases

eggNOGⁱ	KOG2310. Eukaryota. COG0420. LUCA.
HOVERGENⁱ	HBG052508.
KEGG Orthology (KO) More...KOⁱ	K10865.
OMAⁱ	IHFFRHR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06P4.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031928.
ExpressionAtlasⁱ	Q3URU4. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.60.21.10. 1 hit.
InterProⁱ	View protein in InterPro IPR004843. Calcineurin-like_PHP_ApaH. IPR029052. Metallo-depent_PP-like. IPR003701. Mre11. IPR007281. Mre11_DNA-bd.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149. Metallophos. 1 hit. PF04152. Mre11_DNA_bind. 1 hit.
PIRSFⁱ	PIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTⁱ	View protein in SMART SM01347. Mre11_DNA_bind. 1 hit.
SUPFAMⁱ	SSF56300. SSF56300. 2 hits.
TIGRFAMsⁱ	TIGR00583. mre11. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q3URU4_MOUSE
Accessionⁱ	Q3URU4Primary (citable) accession number: Q3URU4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 11, 2005
	Last sequence update:	October 11, 2005
	Last modified:	July 5, 2017
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3URU4 (Q3URU4_MOUSE)

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Meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_c

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ