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Protein

Paternally-expressed gene 3 protein

Gene

Peg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri325 – 34723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri850 – 87223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1091 – 111323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1147 – 116923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1209 – 123123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1266 – 128924C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1317 – 133923C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1488 – 151023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1547 – 156923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Paternally-expressed gene 3 protein
Alternative name(s):
ASF-1
Gene namesi
Name:Peg3
Synonyms:Kiaa0287, Pw1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104748. Peg3.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15711571Paternally-expressed gene 3 proteinPRO_0000249229Add
BLAST

Proteomic databases

MaxQBiQ3URU2.
PaxDbiQ3URU2.
PRIDEiQ3URU2.

PTM databases

iPTMnetiQ3URU2.
PhosphoSiteiQ3URU2.

Expressioni

Tissue specificityi

Brain, glial cells, neurons, skeletal muscle, uterus and placenta. In the placenta it found in all trophoblast cells.4 Publications

Developmental stagei

Strongly expressed upon gastrulation and subsequently becomes restricted to skeletal muscle and subregions of the CNS. At E9.5, expressed in the branchial arches, somites and gut but little in the heart and neural tissues. At E12.5 strongly expressed in the cranial skeleton, tongue, vertebral cartilage, pituitary and the luminal epithelium.2 Publications

Inductioni

Induced during p53/TP53 mediated apoptosis. Up-regulated by DNA damage in cortical neurons in the presence of p53/TP53.2 Publications

Gene expression databases

BgeeiQ3URU2.
CleanExiMM_PEG3.
ExpressionAtlasiQ3URU2. baseline and differential.
GenevisibleiQ3URU2. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2.3 Publications

Protein-protein interaction databases

BioGridi202106. 1 interaction.
IntActiQ3URU2. 1 interaction.
MINTiMINT-4105070.
STRINGi10090.ENSMUSP00000050750.

Structurei

3D structure databases

ProteinModelPortaliQ3URU2.
SMRiQ3URU2. Positions 274-575, 1091-1296, 1477-1523, 1537-1571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati942 – 94651-1
Repeati967 – 97151-2
Repeati987 – 99152-1
Repeati992 – 99651-3
Repeati997 – 100152-2
Repeati1002 – 100651-4
Repeati1007 – 101152-3
Repeati1012 – 101651-5
Repeati1017 – 102151-6
Repeati1022 – 102651-7
Repeati1027 – 103151-8
Repeati1032 – 103651-9
Repeati1047 – 105151-10

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2656710 X 5 AA repeat of P-H-X-X-EAdd
BLAST
Regioni199 – 265673 X 5 AA repeat of P-H-D-D-KAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi228 – 2314Poly-Ser
Compositional biasi695 – 6984Poly-Ser
Compositional biasi771 – 7744Poly-Ser

Domaini

The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.By similarity

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri325 – 34723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri378 – 40023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri850 – 87223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1091 – 111323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1147 – 116923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1209 – 123123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1266 – 128924C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1317 – 133923C2H2-type 10; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1488 – 151023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1547 – 156923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123166.
HOVERGENiHBG079943.
InParanoidiQ3URU2.
KOiK09230.
OMAiDDKYFKC.
OrthoDBiEOG7P02H3.
PhylomeDBiQ3URU2.
TreeFamiTF337075.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3URU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYHHEDDTNS DMNSDDDMSR SGRETPPPRP SHAFGSERDL ERRGRSRDVE
60 70 80 90 100
PRDRWPYTRN PRSRLPQRDL SLPVMSRPHF GLDRDDDRRS MDYESRSQDA
110 120 130 140 150
ESYQNVVELK EDKKPQNPIQ DNLENYRKLL SLGVQLAEDD RHSHMTQGHS
160 170 180 190 200
SRSKRTAYPS TSRGLKPMPE AKKPSHRRGI CEDESSHGVI MEKFIKDVAR
210 220 230 240 250
NPKSGRAREL NERPPPRFPR PNDNWKDSSS SRRESVIQER GYEGSAFRGG
260 270 280 290 300
FRFNADLASR SRALERKRRY HFDSDERGSG HEHKSCVRKK PFECGAEMRQ
310 320 330 340 350
AMSMGNLNSP SFSESQSIDF GANPYVCDEC GRQFSVISEF VEHQIMHTRE
360 370 380 390 400
NLYEYGESFI HSVAVNEVQK GQGGGKRFEC KECGETFSRS AALAEHRQIH
410 420 430 440 450
AREYLAECRD QEDEETIMPS PTFSELQKMY GKDKFYECKV CKETFLHSSA
460 470 480 490 500
LIEHQKIHGR GNSDDRDNER ERERDRLRAR AREQRERERE RERERELGEP
510 520 530 540 550
FLTCPNFNEF RKMYRKDKIY ECKVCGESFL HLSSLREHQK IHTRGNPFEN
560 570 580 590 600
KSRMCEETFV PSQSLRRRQK TYREKLFDFN NARDALMGNS DSSEHQKNRS
610 620 630 640 650
RRNFFEGRGF EKPFVESQKS HTITRPPENK DDDKPFTISV NPNDKLKFPI
660 670 680 690 700
MENGSQGKSY ERSVIHSLGS AEAQKSHGGL GFSKPRPVAE SSTQSSSSIY
710 720 730 740 750
YPRAHSGGNT YEGKEYKDSI IHSLPAPRPL KRHRANDHIQ CDEGGESSIY
760 770 780 790 800
IPDIINKGRK IPAREDAYEG SSSSNYHTPN VSRAEPPSLS GESHDSKQDV
810 820 830 840 850
TFSVPSSSVR EHQKARAKKK YIEPRNNETS VIHSLPFGEL LAGHRRAKFF
860 870 880 890 900
ECQECGEAFA RRSELIEHQK IHDRERPSGS RHYERSVIRS LAPSDPQTSY
910 920 930 940 950
AQERFIQEQV RKFRAFGQRS TTSNNLSVQK IYAQETFNAE EPHDKETHGQ
960 970 980 990 1000
KIHDKEPYGK EPSGKEPHGD EPQDKEPLDQ EMRSEEPHDD KPHGQEPHDD
1010 1020 1030 1040 1050
KPHGQEPHDD KPHGQEPHGD EPHGQEPHGD EPHDKEPIDQ EMRSEEPHSE
1060 1070 1080 1090 1100
ESHGDEPHGE ESHGQEKVED ATIQASVSEE HQKDDAGDAI YECQDCGLGF
1110 1120 1130 1140 1150
TDLNDLTSHQ DTHSRKALVD SREYAHSEVH AHSVSEFEKK CSGEKLYECP
1160 1170 1180 1190 1200
KCGESFIHSS LLFEHQRVHE QDQLYSVKAC DDAFIALLPV RPRRNCTVER
1210 1220 1230 1240 1250
NPAVSGSAIR CRQCGQGFIH SSALNEHMRQ HRDNEIMEQS ELSDEIFIQG
1260 1270 1280 1290 1300
LALTEYQGSE TEEKLFECTI CGECFFTAKQ LGDHHTKVHK DEPYEYGPSY
1310 1320 1330 1340 1350
THASFLTEPL RKHIPLYECK DCGQSFLDDT VIAERMVFHP EREGGSEIVA
1360 1370 1380 1390 1400
ATAQEVEANV LIPQEVLRIQ GSNAEAAEPE VEAAEPEVEA AEPEVEAAEP
1410 1420 1430 1440 1450
NGEAEGPDGE AAEPDGEAEQ PNGEAEQPNG DADEPDGAGI EDPEERADEP
1460 1470 1480 1490 1500
EEDVEEPEGD ADEPDGADIE DPEEEGEDQE IEVEEPYYNC HECAETFASS
1510 1520 1530 1540 1550
SAFGEHLKSH ASVIIFEPAN APGECSGYIE RASTSAGGAE QADDKYFKCD
1560 1570
VCGQLFNDRL SLARHQNSHT G
Length:1,571
Mass (Da):178,932
Last modified:October 11, 2005 - v1
Checksum:i915E13EF0751C6EE
GO
Isoform 2 (identifier: Q3URU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1048: Missing.
     1202-1254: PAVSGSAIRC...EIFIQGLALT → ASSLPNSSGT...TNAKIAASPS
     1255-1571: Missing.

Show »
Length:1,194
Mass (Da):136,999
Checksum:i400EC6945BF9B923
GO

Sequence cautioni

The sequence AAC52770.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence BAB85589.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence BAC65520.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51E → G (PubMed:8563758).Curated
Sequence conflicti5 – 51E → G (PubMed:11260267).Curated
Sequence conflicti156 – 1561T → A in AAB96922 (PubMed:8563758).Curated
Sequence conflicti321 – 3211G → W in BAB85589 (PubMed:11260267).Curated
Sequence conflicti351 – 3511N → T (PubMed:10704281).Curated
Sequence conflicti370 – 3712KG → RS (PubMed:8563758).Curated
Sequence conflicti370 – 3712KG → RS (PubMed:11260267).Curated
Sequence conflicti382 – 3821E → V in BAB85589 (PubMed:11260267).Curated
Sequence conflicti403 – 4031E → R (PubMed:8806818).Curated
Sequence conflicti567 – 5682Missing (PubMed:8806818).Curated
Sequence conflicti570 – 5701K → E in BAB85589 (PubMed:11260267).Curated
Sequence conflicti608 – 6081R → G in BAB85589 (PubMed:11260267).Curated
Sequence conflicti614 – 6141F → S in BAB85589 (PubMed:11260267).Curated
Sequence conflicti645 – 6451K → E in BAB85589 (PubMed:11260267).Curated
Sequence conflicti648 – 6481F → L in AAB96922 (PubMed:8563758).Curated
Sequence conflicti660 – 6601Y → C in AAB96922 (PubMed:8563758).Curated
Sequence conflicti669 – 6691G → A (PubMed:8806818).Curated
Sequence conflicti712 – 7121E → K (PubMed:8806818).Curated
Sequence conflicti736 – 7372ND → MN in BAB85589 (PubMed:11260267).Curated
Sequence conflicti856 – 8561G → R (PubMed:8806818).Curated
Sequence conflicti979 – 9791D → V in AAB96922 (PubMed:8563758).Curated
Sequence conflicti1011 – 10111K → E (PubMed:8806818).Curated
Sequence conflicti1051 – 10511E → Q in AAH89344 (PubMed:15489334).Curated
Sequence conflicti1123 – 11231E → G (PubMed:8806818).Curated
Sequence conflicti1171 – 11711Missing in BAC65520 (PubMed:12693553).Curated
Sequence conflicti1181 – 11811D → Y (PubMed:8563758).Curated
Sequence conflicti1181 – 11811D → Y (PubMed:11260267).Curated
Sequence conflicti1401 – 14011N → I (PubMed:8563758).Curated
Sequence conflicti1401 – 14011N → I (PubMed:11260267).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei989 – 104860Missing in isoform 2. 1 PublicationVSP_020375Add
BLAST
Alternative sequencei1202 – 125453PAVSG…GLALT → ASSLPNSSGTTTPKFTRMSP MSMGPPTPMPPFSPSPSGST SHCTNAKIAASPS in isoform 2. 1 PublicationVSP_020376Add
BLAST
Alternative sequencei1255 – 1571317Missing in isoform 2. 1 PublicationVSP_020377Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038939 mRNA. Translation: AAB96922.1.
AB003040 mRNA. Translation: BAB85589.1. Frameshift.
AK141217 mRNA. Translation: BAE24595.1.
AK163845 mRNA. Translation: BAE37516.1.
AK122238 Transcribed RNA. Translation: BAC65520.2. Different initiation.
BC072661 mRNA. Translation: AAH72661.1.
BC085183 mRNA. Translation: AAH85183.1.
BC089344 mRNA. Translation: AAH89344.1.
AF105266, AF105264, AF105265 Genomic DNA. Translation: AAF16868.1.
U48804 Genomic DNA. Translation: AAC52770.1. Frameshift.
CCDSiCCDS20783.1. [Q3URU2-1]
PIRiT14155.
T30173.
RefSeqiNP_032843.2. NM_008817.2. [Q3URU2-1]
UniGeneiMm.389800.

Genome annotation databases

EnsembliENSMUST00000051209; ENSMUSP00000050750; ENSMUSG00000002265. [Q3URU2-1]
GeneIDi18616.
KEGGimmu:18616.
UCSCiuc009fbw.1. mouse. [Q3URU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038939 mRNA. Translation: AAB96922.1.
AB003040 mRNA. Translation: BAB85589.1. Frameshift.
AK141217 mRNA. Translation: BAE24595.1.
AK163845 mRNA. Translation: BAE37516.1.
AK122238 Transcribed RNA. Translation: BAC65520.2. Different initiation.
BC072661 mRNA. Translation: AAH72661.1.
BC085183 mRNA. Translation: AAH85183.1.
BC089344 mRNA. Translation: AAH89344.1.
AF105266, AF105264, AF105265 Genomic DNA. Translation: AAF16868.1.
U48804 Genomic DNA. Translation: AAC52770.1. Frameshift.
CCDSiCCDS20783.1. [Q3URU2-1]
PIRiT14155.
T30173.
RefSeqiNP_032843.2. NM_008817.2. [Q3URU2-1]
UniGeneiMm.389800.

3D structure databases

ProteinModelPortaliQ3URU2.
SMRiQ3URU2. Positions 274-575, 1091-1296, 1477-1523, 1537-1571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202106. 1 interaction.
IntActiQ3URU2. 1 interaction.
MINTiMINT-4105070.
STRINGi10090.ENSMUSP00000050750.

PTM databases

iPTMnetiQ3URU2.
PhosphoSiteiQ3URU2.

Proteomic databases

MaxQBiQ3URU2.
PaxDbiQ3URU2.
PRIDEiQ3URU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051209; ENSMUSP00000050750; ENSMUSG00000002265. [Q3URU2-1]
GeneIDi18616.
KEGGimmu:18616.
UCSCiuc009fbw.1. mouse. [Q3URU2-1]

Organism-specific databases

CTDi5178.
MGIiMGI:104748. Peg3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123166.
HOVERGENiHBG079943.
InParanoidiQ3URU2.
KOiK09230.
OMAiDDKYFKC.
OrthoDBiEOG7P02H3.
PhylomeDBiQ3URU2.
TreeFamiTF337075.

Miscellaneous databases

ChiTaRSiPeg3. mouse.
NextBioi294556.
PROiQ3URU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ3URU2.
CleanExiMM_PEG3.
ExpressionAtlasiQ3URU2. baseline and differential.
GenevisibleiQ3URU2. MM.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: B6C3H F1.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain and Head.
  6. "Organization and parent-of-origin-specific methylation of imprinted Peg3 gene on mouse proximal chromosome 7."
    Li L.-L., Szeto I.Y.-Y., Cattanach B.M., Ishino F., Surani M.A.
    Genomics 63:333-340(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-352 (ISOFORM 1).
  7. "Pw1, a novel zinc finger gene implicated in the myogenic and neuronal lineages."
    Relaix F., Weng X., Marazzi G., Yang E., Copeland N.G., Jenkins N., Spence S.E., Sassoon D.
    Dev. Biol. 177:383-396(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-1571 (ISOFORM 1), SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/Sv.
    Tissue: Limb bud.
  8. "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway."
    Relaix F., Wei X.-J., Wu X., Sassoon D.A.
    Nat. Genet. 18:287-291(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRAF2.
  9. "Regulation of maternal behavior and offspring growth by paternally expressed Peg3."
    Li L.-L., Keverne E.B., Aparicio S.A., Ishino F., Barton S.C., Surani M.A.
    Science 284:330-333(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis."
    Relaix F., Wei X., Li W., Pan J., Lin Y., Bowtell D.D., Sassoon D.A., Wu X.
    Proc. Natl. Acad. Sci. U.S.A. 97:2105-2110(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, INTERACTION WITH SIAH1A AND SIAH2.
  11. "Paternal monoallelic expression of PEG3 in the human placenta."
    Hiby S.E., Lough M., Keverne E.B., Surani M.A., Loke Y.W., King A.
    Hum. Mol. Genet. 10:1093-1100(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death."
    Johnson M.D., Wu X., Aithmitti N., Morrison R.S.
    J. Biol. Chem. 277:23000-23007(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiPEG3_MOUSE
AccessioniPrimary (citable) accession number: Q3URU2
Secondary accession number(s): O54978
, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 11, 2005
Last modified: March 16, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.