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Protein

Testis-expressed sequence 10 protein

Gene

Tex10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 10 protein
Gene namesi
Name:Tex10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1344413. Tex10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Transmembranei790 – 810HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003910001 – 928Testis-expressed sequence 10 proteinAdd BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3URQ0.
MaxQBiQ3URQ0.
PaxDbiQ3URQ0.
PeptideAtlasiQ3URQ0.
PRIDEiQ3URQ0.

PTM databases

iPTMnetiQ3URQ0.
PhosphoSitePlusiQ3URQ0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028345.
ExpressionAtlasiQ3URQ0. baseline and differential.
GenevisibleiQ3URQ0. MM.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.By similarity1 Publication

Protein-protein interaction databases

BioGridi234665. 2 interactors.
IntActiQ3URQ0. 4 interactors.
STRINGi10090.ENSMUSP00000030030.

Structurei

3D structure databases

ProteinModelPortaliQ3URQ0.
SMRiQ3URQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 137HEATAdd BLAST39

Sequence similaritiesi

Contains 1 HEAT repeat.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2149. Eukaryota.
ENOG410YR7T. LUCA.
GeneTreeiENSGT00390000012654.
HOGENOMiHOG000133040.
HOVERGENiHBG083741.
InParanoidiQ3URQ0.
KOiK14827.
OMAiVELISHQ.
OrthoDBiEOG091G0EBA.
TreeFamiTF318197.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR024679. IPI1/TEX10.
[Graphical view]
PfamiPF12333. Ipi1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3URQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKRKRQDD FQKVKLKVGK KKPKLENATA TNFKTKAIHL PEQLKEDRTL
60 70 80 90 100
PTNNRKLNIK DLLSQMHHYS GGVKQSALLG LKDLLSQYPF IIDAHLSNIL
110 120 130 140 150
SEVTAVFTDR DANVRLAAVQ LLQFLAPKIR TEHISPFFPL VSAHLSSAMT
160 170 180 190 200
HITEGIQEDS LKVLDILLEH YPALITGRSS ILLKNFVELI SHQQLSKGLV
210 220 230 240 250
NRDRSQSWIL SVNPNRRVTS QQWRLKVLAR LSKFLQALAD GSSRLRESEG
260 270 280 290 300
LQEQKETPHA TSNSIFINWK DHANDQQQIQ VYENGGSQPN VSSQFRLRCL
310 320 330 340 350
GTLGTVDEDL SSPENLKGFI EIIIPLLIEC WIEALPPQLA ASVGSGVERE
360 370 380 390 400
PLQVMQQVLN VISLLWKLSK QQDETHTLES WLRKNYLTDF KHHFMSHFPY
410 420 430 440 450
ALKEITKQRK KDTNKSIKHC TVLSNNVDHL LLNLTLSDIM VSLANASTLQ
460 470 480 490 500
NDSSWIETIR KFVTETLKGG TRLNSKQLNR LLGVSWRLIQ MQPNRDATEN
510 520 530 540 550
LIKAVYTLYQ QRGLLLPVRT LLIKFFSKIY QKEELRSYRL RYRSKVLSRW
560 570 580 590 600
LAGLPLQLSY LGSRNPELST QLIDIIHTAA SQANKDLLKN LQAAALRIYD
610 620 630 640 650
PQEGAVVVLP AESQQRLVQL LYFLPTLPAD LLSQLSRCCI MGRLGSSLAV
660 670 680 690 700
TLIGILYMRS SFSGWSHSVN DCLMTDVDYL SFLFSTLTGF SKEELTWLQN
710 720 730 740 750
LRGVPHVVQT SLSPVLLYLT DLDQFLHHWD ITEAVCHSLL VIPARSQSFD
760 770 780 790 800
IMQSAISKHL VGLTVIPDST AGCIFGVMCK LLDHTCVVNE ALLPFLASCC
810 820 830 840 850
YSLLYFLLTL EKGDAEHLKK RDKLWEVCVS ILALLPRVLR LMLQSLRVNR
860 870 880 890 900
ASPEELPVVG QLLRLLLQHV PLRSHMLTNA ILVQQIIKNI TTLKSGSVQE
910 920
QWLTDLHYCF SVYISGHPQG PSILNALY
Length:928
Mass (Da):105,209
Last modified:October 11, 2005 - v1
Checksum:i05D38CBE5B3E8C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132870 mRNA. Translation: BAE21398.1.
AK141288 mRNA. Translation: BAE24638.1.
AL807247 Genomic DNA. Translation: CAM16567.1.
CH466565 Genomic DNA. Translation: EDL02335.1.
BC151176 mRNA. Translation: AAI51177.1.
BC151177 mRNA. Translation: AAI51178.1.
CCDSiCCDS38760.1.
RefSeqiNP_758508.2. NM_172304.3.
XP_006538018.1. XM_006537955.3.
XP_006538019.1. XM_006537956.2.
UniGeneiMm.272025.

Genome annotation databases

EnsembliENSMUST00000030030; ENSMUSP00000030030; ENSMUSG00000028345.
ENSMUST00000164866; ENSMUSP00000132498; ENSMUSG00000028345.
GeneIDi269536.
KEGGimmu:269536.
UCSCiuc008svd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132870 mRNA. Translation: BAE21398.1.
AK141288 mRNA. Translation: BAE24638.1.
AL807247 Genomic DNA. Translation: CAM16567.1.
CH466565 Genomic DNA. Translation: EDL02335.1.
BC151176 mRNA. Translation: AAI51177.1.
BC151177 mRNA. Translation: AAI51178.1.
CCDSiCCDS38760.1.
RefSeqiNP_758508.2. NM_172304.3.
XP_006538018.1. XM_006537955.3.
XP_006538019.1. XM_006537956.2.
UniGeneiMm.272025.

3D structure databases

ProteinModelPortaliQ3URQ0.
SMRiQ3URQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234665. 2 interactors.
IntActiQ3URQ0. 4 interactors.
STRINGi10090.ENSMUSP00000030030.

PTM databases

iPTMnetiQ3URQ0.
PhosphoSitePlusiQ3URQ0.

Proteomic databases

EPDiQ3URQ0.
MaxQBiQ3URQ0.
PaxDbiQ3URQ0.
PeptideAtlasiQ3URQ0.
PRIDEiQ3URQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030030; ENSMUSP00000030030; ENSMUSG00000028345.
ENSMUST00000164866; ENSMUSP00000132498; ENSMUSG00000028345.
GeneIDi269536.
KEGGimmu:269536.
UCSCiuc008svd.1. mouse.

Organism-specific databases

CTDi54881.
MGIiMGI:1344413. Tex10.

Phylogenomic databases

eggNOGiKOG2149. Eukaryota.
ENOG410YR7T. LUCA.
GeneTreeiENSGT00390000012654.
HOGENOMiHOG000133040.
HOVERGENiHBG083741.
InParanoidiQ3URQ0.
KOiK14827.
OMAiVELISHQ.
OrthoDBiEOG091G0EBA.
TreeFamiTF318197.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiTex10. mouse.
PROiQ3URQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028345.
ExpressionAtlasiQ3URQ0. baseline and differential.
GenevisibleiQ3URQ0. MM.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR024679. IPI1/TEX10.
[Graphical view]
PfamiPF12333. Ipi1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEX10_MOUSE
AccessioniPrimary (citable) accession number: Q3URQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.