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Protein

Testis-expressed protein 10

Gene

Tex10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity).By similarity1 Publication

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 10
Gene namesi
Name:Tex10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1344413 Tex10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003910001 – 928Testis-expressed protein 10Add BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3URQ0
MaxQBiQ3URQ0
PaxDbiQ3URQ0
PeptideAtlasiQ3URQ0
PRIDEiQ3URQ0

PTM databases

iPTMnetiQ3URQ0
PhosphoSitePlusiQ3URQ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000028345
ExpressionAtlasiQ3URQ0 baseline and differential
GenevisibleiQ3URQ0 MM

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148 (PubMed:22872859). Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi234665, 3 interactors
IntActiQ3URQ0, 5 interactors
STRINGi10090.ENSMUSP00000030030

Structurei

3D structure databases

ProteinModelPortaliQ3URQ0
SMRiQ3URQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 137HEATAdd BLAST39

Sequence similaritiesi

Belongs to the IPI1/TEX10 family.Curated

Phylogenomic databases

eggNOGiKOG2149 Eukaryota
ENOG410YR7T LUCA
GeneTreeiENSGT00390000012654
HOGENOMiHOG000133040
HOVERGENiHBG083741
InParanoidiQ3URQ0
KOiK14827
OMAiPLLIECW
OrthoDBiEOG091G0EBA
TreeFamiTF318197

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR024679 Ipi1_N
IPR037947 TEX10/Ipi1
PANTHERiPTHR16056:SF2 PTHR16056:SF2, 1 hit
PfamiView protein in Pfam
PF12333 Ipi1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q3URQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKRKRQDD FQKVKLKVGK KKPKLENATA TNFKTKAIHL PEQLKEDRTL
60 70 80 90 100
PTNNRKLNIK DLLSQMHHYS GGVKQSALLG LKDLLSQYPF IIDAHLSNIL
110 120 130 140 150
SEVTAVFTDR DANVRLAAVQ LLQFLAPKIR TEHISPFFPL VSAHLSSAMT
160 170 180 190 200
HITEGIQEDS LKVLDILLEH YPALITGRSS ILLKNFVELI SHQQLSKGLV
210 220 230 240 250
NRDRSQSWIL SVNPNRRVTS QQWRLKVLAR LSKFLQALAD GSSRLRESEG
260 270 280 290 300
LQEQKETPHA TSNSIFINWK DHANDQQQIQ VYENGGSQPN VSSQFRLRCL
310 320 330 340 350
GTLGTVDEDL SSPENLKGFI EIIIPLLIEC WIEALPPQLA ASVGSGVERE
360 370 380 390 400
PLQVMQQVLN VISLLWKLSK QQDETHTLES WLRKNYLTDF KHHFMSHFPY
410 420 430 440 450
ALKEITKQRK KDTNKSIKHC TVLSNNVDHL LLNLTLSDIM VSLANASTLQ
460 470 480 490 500
NDSSWIETIR KFVTETLKGG TRLNSKQLNR LLGVSWRLIQ MQPNRDATEN
510 520 530 540 550
LIKAVYTLYQ QRGLLLPVRT LLIKFFSKIY QKEELRSYRL RYRSKVLSRW
560 570 580 590 600
LAGLPLQLSY LGSRNPELST QLIDIIHTAA SQANKDLLKN LQAAALRIYD
610 620 630 640 650
PQEGAVVVLP AESQQRLVQL LYFLPTLPAD LLSQLSRCCI MGRLGSSLAV
660 670 680 690 700
TLIGILYMRS SFSGWSHSVN DCLMTDVDYL SFLFSTLTGF SKEELTWLQN
710 720 730 740 750
LRGVPHVVQT SLSPVLLYLT DLDQFLHHWD ITEAVCHSLL VIPARSQSFD
760 770 780 790 800
IMQSAISKHL VGLTVIPDST AGCIFGVMCK LLDHTCVVNE ALLPFLASCC
810 820 830 840 850
YSLLYFLLTL EKGDAEHLKK RDKLWEVCVS ILALLPRVLR LMLQSLRVNR
860 870 880 890 900
ASPEELPVVG QLLRLLLQHV PLRSHMLTNA ILVQQIIKNI TTLKSGSVQE
910 920
QWLTDLHYCF SVYISGHPQG PSILNALY
Length:928
Mass (Da):105,209
Last modified:October 11, 2005 - v1
Checksum:i05D38CBE5B3E8C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK132870 mRNA Translation: BAE21398.1
AK141288 mRNA Translation: BAE24638.1
AL807247 Genomic DNA Translation: CAM16567.1
CH466565 Genomic DNA Translation: EDL02335.1
BC151176 mRNA Translation: AAI51177.1
BC151177 mRNA Translation: AAI51178.1
CCDSiCCDS38760.1
RefSeqiNP_758508.2, NM_172304.3
XP_006538018.1, XM_006537955.3
XP_006538019.1, XM_006537956.2
UniGeneiMm.272025

Genome annotation databases

EnsembliENSMUST00000030030; ENSMUSP00000030030; ENSMUSG00000028345
ENSMUST00000164866; ENSMUSP00000132498; ENSMUSG00000028345
GeneIDi269536
KEGGimmu:269536
UCSCiuc008svd.1 mouse

Entry informationi

Entry nameiTEX10_MOUSE
AccessioniPrimary (citable) accession number: Q3URQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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