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Protein

BTB/POZ domain-containing protein KCTD21

Gene

Kctd21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD21
Alternative name(s):
KCASH2 protein1 Publication
Potassium channel tetramerization domain-containing protein 21
Gene namesi
Name:Kctd21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3643121. Kctd21.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811521 – 260BTB/POZ domain-containing protein KCTD21Add BLAST260

Proteomic databases

MaxQBiQ3URF8.
PaxDbiQ3URF8.
PRIDEiQ3URF8.

PTM databases

PhosphoSitePlusiQ3URF8.

Expressioni

Tissue specificityi

Highly expressed in cerebellum and brain. Expressed in adult cerebellum (at protein level).1 Publication

Interactioni

Subunit structurei

Homopentamer. Interacts with KCTD11; KCTD21 and KCTD11 may associate in pentameric assemblies. Interacts (via BTB domain) with CUL3; indicative for a participation in a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:21472142).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051316.

Structurei

3D structure databases

ProteinModelPortaliQ3URF8.
SMRiQ3URF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 72BTBPROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili88 – 112Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi135 – 140Poly-Ser6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
HOGENOMiHOG000231837.
HOVERGENiHBG080457.
InParanoidiQ3URF8.
KOiK21922.
PhylomeDBiQ3URF8.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3URF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID
60 70 80 90 100
RDGKVFRYIL NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE
110 120 130 140 150
VELSKAEKNA MLNITLKQRV QTVHFTVREA PQIYSLSSSS MEVFNANIFS
160 170 180 190 200
TSCLFLKLLG SKLLYCSNGN LSSITSHLQD PNHLTLDWVA NVEGLPEEEY
210 220 230 240 250
TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS SHPHALDFMN
260
NKIIRLIRYR
Length:260
Mass (Da):29,623
Last modified:October 11, 2005 - v1
Checksum:i61A8F5FCCCF8D622
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK141547 mRNA. Translation: BAE24730.1.
CCDSiCCDS21456.1.
RefSeqiNP_001034128.2. NM_001039039.3.
UniGeneiMm.334029.

Genome annotation databases

GeneIDi622320.
KEGGimmu:622320.

Similar proteinsi

Entry informationi

Entry nameiKCD21_MOUSE
AccessioniPrimary (citable) accession number: Q3URF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome