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Q3UR32

- P2RX3_MOUSE

UniProt

Q3UR32 - P2RX3_MOUSE

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Protein
P2X purinoceptor 3
Gene
P2rx3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel By similarity.1 Publication

GO - Molecular functioni

  1. ATP binding Source: Ensembl
  2. extracellular ATP-gated cation channel activity Source: MGI
  3. purinergic nucleotide receptor activity Source: RefGenome

GO - Biological processi

  1. behavioral response to pain Source: MGI
  2. cation transport Source: MGI
  3. ion transport Source: MGI
  4. neuromuscular synaptic transmission Source: MGI
  5. neuronal action potential Source: Ensembl
  6. peristalsis Source: MGI
  7. protein homooligomerization Source: Ensembl
  8. purinergic nucleotide receptor signaling pathway Source: GOC
  9. regulation of synaptic plasticity Source: MGI
  10. response to ATP Source: MGI
  11. response to carbohydrate Source: MGI
  12. response to cold Source: MGI
  13. response to heat Source: MGI
  14. response to hypoxia Source: MGI
  15. response to mechanical stimulus Source: MGI
  16. response to organic substance Source: MGI
  17. response to temperature stimulus Source: MGI
  18. sensory perception of taste Source: MGI
  19. synaptic transmission Source: MGI
  20. urinary bladder smooth muscle contraction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 3
Short name:
P2X3
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1097160. P2rx3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei23 – 4321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini44 – 317274Extracellular Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini339 – 39759Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. axon Source: MGI
  3. dendritic spine Source: Ensembl
  4. integral component of nuclear inner membrane Source: RefGenome
  5. integral component of plasma membrane Source: MGI
  6. membrane raft Source: Ensembl
  7. neuron projection Source: MGI
  8. neuronal cell body Source: Ensembl
  9. receptor complex Source: MGI
  10. rough endoplasmic reticulum Source: Ensembl
  11. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Simultaneous knockout of P2rx2 and P2rx3 results in reduced pain-related behaviors in response to intraplantar injection of formalin and reduced urinary bladder reflexes and decreased pelvic afferent nerve activity in response to bladder distension. Neurons have minimal to no response to ATP (1 Publication). Simultaneous knockout of P2rx2 and P2rx3 results in defects in taste responses in the taste nerves and reduced behavioral responses to sweeteners, glutamate and bitter substances (1 Publication).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397P2X purinoceptor 3
PRO_0000269195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 153 By similarity
Disulfide bondi116 ↔ 137 By similarity
Disulfide bondi122 ↔ 147 By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi203 ↔ 213 By similarity
Disulfide bondi247 ↔ 256 By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ3UR32.

PTM databases

PhosphoSiteiQ3UR32.

Expressioni

Gene expression databases

BgeeiQ3UR32.
GenevestigatoriQ3UR32.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ3UR32.
SMRiQ3UR32. Positions 24-344.

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40178.
GeneTreeiENSGT00740000115538.
HOGENOMiHOG000232042.
HOVERGENiHBG053086.
InParanoidiA2AW02.
KOiK05217.
OMAiVGWVFLH.
OrthoDBiEOG78PV92.
PhylomeDBiQ3UR32.
TreeFamiTF328633.

Family and domain databases

Gene3Di2.60.490.10. 1 hit.
InterProiIPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view]
PANTHERiPTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
PfamiPF00864. P2X_receptor. 1 hit.
[Graphical view]
PRINTSiPR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsiTIGR00863. P2X. 1 hit.
PROSITEiPS01212. P2X_RECEPTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3UR32-1 [UniParc]FASTAAdd to Basket

« Hide

MNCISDFFTY ETTKSVVVKS WTIGIINRAV QLLIISYFVG WVFLHEKAYQ    50
VRDTAIESSV VTKVKGFGRY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE 100
NQMQGFCPEN EEKYRCVSDS QCGPERFPGG GILTGRCVNY SSVRRTCEIQ 150
GWCPTEVDTV EMPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTDKDI 200
KKCRFHPEKA PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD 250
KAWDQCIPKY SFTRLDGVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 300
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA 350
DHYKARKFEE VTETTLKGTA STNPVFTSDQ ATVEKQSTDS GAYSIGH 397
Length:397
Mass (Da):44,437
Last modified:October 11, 2005 - v1
Checksum:iBFB90C740E5DD910
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951R → P in AAH23089. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140283 mRNA. Translation: BAE24316.1.
AK141847 mRNA. Translation: BAE24856.1.
AL935159 Genomic DNA. Translation: CAM18192.1.
BC023089 mRNA. Translation: AAH23089.1.
CCDSiCCDS16200.1.
RefSeqiNP_663501.2. NM_145526.2.
UniGeneiMm.440375.
Mm.448935.

Genome annotation databases

EnsembliENSMUST00000028465; ENSMUSP00000028465; ENSMUSG00000027071.
GeneIDi228139.
KEGGimmu:228139.
UCSCiuc008kjr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK140283 mRNA. Translation: BAE24316.1 .
AK141847 mRNA. Translation: BAE24856.1 .
AL935159 Genomic DNA. Translation: CAM18192.1 .
BC023089 mRNA. Translation: AAH23089.1 .
CCDSi CCDS16200.1.
RefSeqi NP_663501.2. NM_145526.2.
UniGenei Mm.440375.
Mm.448935.

3D structure databases

ProteinModelPortali Q3UR32.
SMRi Q3UR32. Positions 24-344.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2401608.
GuidetoPHARMACOLOGYi 480.

PTM databases

PhosphoSitei Q3UR32.

Proteomic databases

PRIDEi Q3UR32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028465 ; ENSMUSP00000028465 ; ENSMUSG00000027071 .
GeneIDi 228139.
KEGGi mmu:228139.
UCSCi uc008kjr.1. mouse.

Organism-specific databases

CTDi 5024.
MGIi MGI:1097160. P2rx3.

Phylogenomic databases

eggNOGi NOG40178.
GeneTreei ENSGT00740000115538.
HOGENOMi HOG000232042.
HOVERGENi HBG053086.
InParanoidi A2AW02.
KOi K05217.
OMAi VGWVFLH.
OrthoDBi EOG78PV92.
PhylomeDBi Q3UR32.
TreeFami TF328633.

Miscellaneous databases

NextBioi 378939.
PROi Q3UR32.
SOURCEi Search...

Gene expression databases

Bgeei Q3UR32.
Genevestigatori Q3UR32.

Family and domain databases

Gene3Di 2.60.490.10. 1 hit.
InterProi IPR003046. P2X3_purnocptor.
IPR027309. P2X_extracellular_dom.
IPR001429. P2X_purnocptor.
[Graphical view ]
PANTHERi PTHR10125. PTHR10125. 1 hit.
PTHR10125:SF8. PTHR10125:SF8. 1 hit.
Pfami PF00864. P2X_receptor. 1 hit.
[Graphical view ]
PRINTSi PR01310. P2X3RECEPTOR.
PR01307. P2XRECEPTOR.
TIGRFAMsi TIGR00863. P2X. 1 hit.
PROSITEi PS01212. P2X_RECEPTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina and Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP."
    Cockayne D.A., Dunn P.M., Zhong Y., Rong W., Hamilton S.G., Knight G.E., Ruan H.Z., Ma B., Yip P., Nunn P., McMahon S.B., Burnstock G., Ford A.P.
    J. Physiol. (Lond.) 567:621-639(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "ATP signaling is crucial for communication from taste buds to gustatory nerves."
    Finger T.E., Danilova V., Barrows J., Bartel D.L., Vigers A.J., Stone L., Hellekant G., Kinnamon S.C.
    Science 310:1495-1499(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiP2RX3_MOUSE
AccessioniPrimary (citable) accession number: Q3UR32
Secondary accession number(s): A2AW02, Q8R1U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 11, 2005
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi