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Protein

Kelch repeat and BTB domain-containing protein 8

Gene

Kbtbd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 8
Gene namesi
Name:Kbtbd8
Synonyms:Kiaa1842
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2661430. Kbtbd8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Kelch repeat and BTB domain-containing protein 8PRO_0000278221Add
BLAST

Proteomic databases

EPDiQ3UQV5.
MaxQBiQ3UQV5.
PaxDbiQ3UQV5.
PeptideAtlasiQ3UQV5.
PRIDEiQ3UQV5.

PTM databases

iPTMnetiQ3UQV5.
PhosphoSiteiQ3UQV5.

Expressioni

Gene expression databases

BgeeiQ3UQV5.
CleanExiMM_KBTBD8.
ExpressionAtlasiQ3UQV5. baseline and differential.
GenevisibleiQ3UQV5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032107.

Structurei

3D structure databases

ProteinModelPortaliQ3UQV5.
SMRiQ3UQV5. Positions 29-252, 335-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 11769BTBPROSITE-ProRule annotationAdd
BLAST
Domaini152 – 254103BACKAdd
BLAST
Repeati334 – 38855Kelch 1Add
BLAST
Repeati389 – 43951Kelch 2Add
BLAST
Repeati441 – 47939Kelch 3Add
BLAST
Repeati481 – 53050Kelch 4Add
BLAST
Repeati540 – 58647Kelch 5Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129730.
HOGENOMiHOG000113200.
HOVERGENiHBG100857.
InParanoidiQ3UQV5.
KOiK10475.
OMAiRWFEHEQ.
OrthoDBiEOG75TMBB.
PhylomeDBiQ3UQV5.
TreeFamiTF332672.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR028764. KBTBD8.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF24. PTHR24412:SF24. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3UQV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASADLSKS SPTPNGIPSS DTANDTMDPF HACSILKQLK TMYDEGQLTD
60 70 80 90 100
IVVEVDHGKT FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIIGVEAES
110 120 130 140 150
MDLVLNYAYT SRVILTEANV QALFTTASIF QIPSIQDQCA KYMISHLDPQ
160 170 180 190 200
NSIGVFIFAD HYGHQELGDR SKEYIRKKFL CVTKEQEFLQ LTKDQLISIL
210 220 230 240 250
DSDDLNVDRE EHVYESIIRW FEHEQSEREV HLPEIFAKCI RFPLMEDTFI
260 270 280 290 300
EKIPPQFAQA IVKSCGEPSN TSGCTQRLGM TASEMIICFD AAHKHSGKKQ
310 320 330 340 350
TVPCLDIVTG RVFKLCKPPN DLREVGILVS PDNDIYIAGG YRPSSSEVSI
360 370 380 390 400
DHKAENDFWM YDHSTNRWLS KPSLLRARIG CKLVYCCGKM YAIGGRVYEG
410 420 430 440 450
DGRNSLKSVE CYDSRENCWM TVCAMPVAME FHNAVEHKEK IYVLQGEFFL
460 470 480 490 500
FYEPQKDYWG FLTPMTVPRI QGLAAVYKDS IYYIAGTCGN HQRVFTVEAY
510 520 530 540 550
DIELNKWTRK KDFPCDQSIN PYLKLVLFQN KLHLFVRATQ VTVEEHIFRT
560 570 580 590
SRKNSLYQYD DIADQWMKVY ETPDRLWDLG RHFECAVAKL YPQCLQKVL
Length:599
Mass (Da):68,660
Last modified:October 11, 2005 - v1
Checksum:i822093A49ECF9960
GO
Isoform 2 (identifier: Q3UQV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):60,347
Checksum:i4A45733C947A405A
GO

Sequence cautioni

The sequence AAH88734.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti420 – 4201M → V in BAE39583 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 2. 1 PublicationVSP_023186Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142080 mRNA. Translation: BAE24933.1.
AK167507 mRNA. Translation: BAE39583.1.
BC088734 mRNA. Translation: AAH88734.1. Different initiation.
AB093302 mRNA. Translation: BAC41484.1.
CCDSiCCDS51856.1. [Q3UQV5-1]
CCDS51857.1. [Q3UQV5-2]
RefSeqiNP_001008785.2. NM_001008785.5. [Q3UQV5-1]
NP_001096140.1. NM_001102670.2. [Q3UQV5-2]
UniGeneiMm.333275.

Genome annotation databases

EnsembliENSMUST00000032107; ENSMUSP00000032107; ENSMUSG00000030031. [Q3UQV5-1]
ENSMUST00000119582; ENSMUSP00000113739; ENSMUSG00000030031. [Q3UQV5-2]
GeneIDi243574.
KEGGimmu:243574.
UCSCiuc009czw.3. mouse. [Q3UQV5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142080 mRNA. Translation: BAE24933.1.
AK167507 mRNA. Translation: BAE39583.1.
BC088734 mRNA. Translation: AAH88734.1. Different initiation.
AB093302 mRNA. Translation: BAC41484.1.
CCDSiCCDS51856.1. [Q3UQV5-1]
CCDS51857.1. [Q3UQV5-2]
RefSeqiNP_001008785.2. NM_001008785.5. [Q3UQV5-1]
NP_001096140.1. NM_001102670.2. [Q3UQV5-2]
UniGeneiMm.333275.

3D structure databases

ProteinModelPortaliQ3UQV5.
SMRiQ3UQV5. Positions 29-252, 335-507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032107.

PTM databases

iPTMnetiQ3UQV5.
PhosphoSiteiQ3UQV5.

Proteomic databases

EPDiQ3UQV5.
MaxQBiQ3UQV5.
PaxDbiQ3UQV5.
PeptideAtlasiQ3UQV5.
PRIDEiQ3UQV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032107; ENSMUSP00000032107; ENSMUSG00000030031. [Q3UQV5-1]
ENSMUST00000119582; ENSMUSP00000113739; ENSMUSG00000030031. [Q3UQV5-2]
GeneIDi243574.
KEGGimmu:243574.
UCSCiuc009czw.3. mouse. [Q3UQV5-1]

Organism-specific databases

CTDi84541.
MGIiMGI:2661430. Kbtbd8.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00840000129730.
HOGENOMiHOG000113200.
HOVERGENiHBG100857.
InParanoidiQ3UQV5.
KOiK10475.
OMAiRWFEHEQ.
OrthoDBiEOG75TMBB.
PhylomeDBiQ3UQV5.
TreeFamiTF332672.

Miscellaneous databases

PROiQ3UQV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UQV5.
CleanExiMM_KBTBD8.
ExpressionAtlasiQ3UQV5. baseline and differential.
GenevisibleiQ3UQV5. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR028764. KBTBD8.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PANTHERiPTHR24412:SF24. PTHR24412:SF24. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Eye and Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-599 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryonic germ cell.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 337-599 (ISOFORMS 1/2).
    Tissue: Brain.

Entry informationi

Entry nameiKBTB8_MOUSE
AccessioniPrimary (citable) accession number: Q3UQV5
Secondary accession number(s): Q3TJB2, Q5M7B2, Q8CH97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2005
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.