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Protein
Submitted name:

Insulin-like growth factor binding protein 5, isoform CRA_a

Gene

Igfbp5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor binding protein 5, isoform CRA_aImported
Gene namesi
Name:Igfbp5Imported
ORF Names:mCG_112978Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96440. Igfbp5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501109872920 – 271Sequence analysisAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000026185.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102IGFBP N-terminalInterPro annotationAdd BLAST81
Domaini188 – 262Thyroglobulin type-1InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
HOVERGENiHBG002631.
OMAiLPIDKHE.
OrthoDBiEOG091G0EIN.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
IPR036857. Thyroglobulin_1_sf.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UQV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESEQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,372
Last modified:October 11, 2005 - v1
Checksum:iF55A58729861F6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142108 mRNA. Translation: BAE24938.1.
CH466548 Genomic DNA. Translation: EDL00294.1.
RefSeqiNP_034648.2. NM_010518.2.
UniGeneiMm.405761.

Genome annotation databases

GeneIDi16011.
KEGGimmu:16011.

Similar proteinsi

Entry informationi

Entry nameiQ3UQV0_MOUSE
AccessioniPrimary (citable) accession number: Q3UQV0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation