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Protein
Submitted name:

Insulin-like growth factor binding protein 5, isoform CRA_a

Gene

Igfbp5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor binding protein 5, isoform CRA_aImported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Igfbp5Imported
ORF Names:mCG_112978Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96440. Igfbp5.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500934299020 – 271Sequence analysisAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 262PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiQ3UQV0.
PeptideAtlasiQ3UQV0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026185.
ExpressionAtlasiQ3UQV0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027377.

Structurei

3D structure databases

SMRiQ3UQV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102IGFBP N-terminalInterPro annotationAdd BLAST81
Domaini188 – 262Thyroglobulin type-1InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
HOVERGENiHBG002631.
OMAiYREQAKI.
OrthoDBiEOG091G0EIN.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF17. PTHR11551:SF17. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UQV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESEQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Length:271
Mass (Da):30,372
Last modified:October 11, 2005 - v1
Checksum:iF55A58729861F6F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142108 mRNA. Translation: BAE24938.1.
CH466548 Genomic DNA. Translation: EDL00294.1.
RefSeqiNP_034648.2. NM_010518.2.
UniGeneiMm.405761.

Genome annotation databases

GeneIDi16011.
KEGGimmu:16011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142108 mRNA. Translation: BAE24938.1.
CH466548 Genomic DNA. Translation: EDL00294.1.
RefSeqiNP_034648.2. NM_010518.2.
UniGeneiMm.405761.

3D structure databases

SMRiQ3UQV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027377.

Proteomic databases

MaxQBiQ3UQV0.
PeptideAtlasiQ3UQV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16011.
KEGGimmu:16011.

Organism-specific databases

CTDi3488.
MGIiMGI:96440. Igfbp5.

Phylogenomic databases

eggNOGiENOG410IJJ2. Eukaryota.
ENOG4111GGG. LUCA.
HOVERGENiHBG002631.
OMAiYREQAKI.
OrthoDBiEOG091G0EIN.

Miscellaneous databases

ChiTaRSiIgfbp5. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026185.
ExpressionAtlasiQ3UQV0. baseline and differential.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF17. PTHR11551:SF17. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UQV0_MOUSE
AccessioniPrimary (citable) accession number: Q3UQV0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: March 15, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.