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Protein

Bromodomain-containing protein 9

Gene

Brd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169Histone H4K5ac H4K8ac and histone H4K5bu H4K8buBy similarity1
Binding sitei222Histone H4K5ac H4K8ac and histone H4K5bu H4K8buBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 9
Gene namesi
Name:Brd9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145317. Brd9.

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3822347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392201 – 596Bromodomain-containing protein 9Add BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei372N6-acetyllysine; alternateBy similarity1
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei565PhosphoserineBy similarity1
Modified residuei587PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3UQU0.
MaxQBiQ3UQU0.
PaxDbiQ3UQU0.
PeptideAtlasiQ3UQU0.
PRIDEiQ3UQU0.

PTM databases

iPTMnetiQ3UQU0.
PhosphoSitePlusiQ3UQU0.

Expressioni

Gene expression databases

CleanExiMM_BRD9.
ExpressionAtlasiQ3UQU0. baseline and differential.

Interactioni

Subunit structurei

Binds acetylated histones H3 and H4. Binds butyrylated histone H4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222796. 2 interactors.
IntActiQ3UQU0. 1 interactor.
STRINGi10090.ENSMUSP00000096982.

Structurei

3D structure databases

ProteinModelPortaliQ3UQU0.
SMRiQ3UQU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 223BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 216Histone H4K5ac H4K8ac and histone H4K5bu H4K8buBy similarity3

Domaini

The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions. Also recognizes and binds histones that are butyrylated.By similarity

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiKOG1828. Eukaryota.
ENOG410XRRI. LUCA.
GeneTreeiENSGT00530000063939.
HOGENOMiHOG000070022.
HOVERGENiHBG107536.
InParanoidiQ3UQU0.
KOiK22184.
PhylomeDBiQ3UQU0.
TreeFamiTF106439.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
InterProiView protein in InterPro
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR021900. DUF3512.
PfamiView protein in Pfam
PF00439. Bromodomain. 1 hit.
PF12024. DUF3512. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00297. BROMO. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
PROSITEiView protein in PROSITE
PS50014. BROMODOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UQU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKHKKHKA EWRSSYEDYT DTPLEKPLKL VLKVGGSEVT ELSGSGHDSS
60 70 80 90 100
YYDDRSDHER ERHREKKKKK KKKSEKEKHL DEEERRKRKE EKKRKREKEH
110 120 130 140 150
CDSEGEADAF DPGKKVEVEP PPDRPVRACR TQPAENESTP IQRLLEHFLR
160 170 180 190 200
QLQRKDPHGF FAFPVTDAIA PGYSMIIKHP MDFGTMKDKI VANEYKSVTE
210 220 230 240 250
FKADFKLMCD NAMTYNRPDT VYYKLAKKIL HAGFKMMSKA ALLGSEDPAA
260 270 280 290 300
EEPVPEVVPV QVETTKKSKK PSREVISCMF EPEGNACSLT DSTAEEHVLA
310 320 330 340 350
LVEHAADEAR DRINRFLPGG KMGYLKKLGD GSLLYSVVNA PEPDADEEET
360 370 380 390 400
HPVDLSSLSS KLLPGFTTLG FKDERRNKVT FLSSASTALS MQNNSVFGDL
410 420 430 440 450
KSDEMELLYS AYGDETGVQC ALSLQEFVKD AGSYSKKMVD DLLDQITGGD
460 470 480 490 500
HSRMIFQLKQ RRSIPMRPAD EMKVGDPLGE SGGPVLDFMS MKQYPDVSLD
510 520 530 540 550
VSMLSSLGKV KKELDHEDSH LNLDETARLL QDLHEAQAER GGSRPSSNLS
560 570 580 590
SLSTASEREH PPPGSPSRLS VGEQPDVAHD PYEFLQSPEP AAPAKN
Length:596
Mass (Da):66,840
Last modified:October 11, 2005 - v1
Checksum:iCC7DEEBEBF47F5DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239K → KQ in AAH31484 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142152 mRNA. Translation: BAE24949.1.
BC031484 mRNA. Translation: AAH31484.1.
BC046438 mRNA. Translation: AAH46438.1.
RefSeqiNP_001019679.2. NM_001024508.3.
NP_001294970.1. NM_001308041.1.
UniGeneiMm.278509.

Genome annotation databases

EnsembliENSMUST00000222399; ENSMUSP00000152390; ENSMUSG00000057649.
GeneIDi105246.
KEGGimmu:105246.
UCSCiuc007rej.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiBRD9_MOUSE
AccessioniPrimary (citable) accession number: Q3UQU0
Secondary accession number(s): Q0P669, Q5FWH1, Q811F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2005
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot