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Protein
Submitted name:

Corticotropin-releasing factor receptor 2

Gene

Crhr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Corticotropin-releasing factor receptor 2Imported
Gene namesi
Name:Crhr2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:894312. Crhr2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei134 – 160HelicalSequence analysisAdd BLAST27
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Transmembranei211 – 232HelicalSequence analysisAdd BLAST22
Transmembranei244 – 267HelicalSequence analysisAdd BLAST24
Transmembranei287 – 306HelicalSequence analysisAdd BLAST20
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei359 – 381HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501097329827 – 430Sequence analysisAdd BLAST404

Expressioni

Gene expression databases

BgeeiENSMUSG00000003476.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 122G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST79
Domaini135 – 382G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST248

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230719.
HOVERGENiHBG106921.
KOiK04579.
OrthoDBiEOG091G0BBY.
TreeFamiTF315710.

Family and domain databases

Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR003053. GPCR_2_CRF2_rcpt.
IPR003051. GPCR_2_CRF_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR01279. CRFRECEPTOR.
PR01281. CRFRECEPTOR2.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3UQP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPGSLPSA QLLLCLFSLL PVLQVAQPGQ APQDQPLWTL LEQYCHRTTT
60 70 80 90 100
GNFSGPYTYC NTTLDQIGTC WPQSAPGALV ERPCPEYFNG IKYNTTRNAY
110 120 130 140 150
RECLENGTWA SRVNYSHCEP ILDDKRKYDL HYRIALIVNY LGHCVSVVAL
160 170 180 190 200
VAAFLLFLVL RSIRCLRNVI HWNLITTFIL RNIAWFLLQL IDHEVHEGNE
210 220 230 240 250
VWCRCITTIF NYFVVTNFFW MFVEGCYLHT AIVMTYSTEH LRKWLFLFIG
260 270 280 290 300
WCIPCPIIIA WAVGKLYYEN EQCWFGKEAG DLVDYIYQGP VMLVLLINFV
310 320 330 340 350
FLFNIVRILM TKLRASTTSE TIQYRKAVKA TLVLLPLLGI TYMLFFVNPG
360 370 380 390 400
EDDLSQIVFI YFNSFLQSFQ GFFVSVFYCF FNGEVRAALR KRWHRWQDHH
410 420 430
ALRVPVARAM SIPTSPTRIS FHSIKQTAAV
Length:430
Mass (Da):49,783
Last modified:October 11, 2005 - v1
Checksum:i1F4E3B8872D89E9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079243 Genomic DNA. No translation available.
AK142261 mRNA. Translation: BAE24999.1.
RefSeqiNP_001275547.1. NM_001288618.1.
NP_001275548.1. NM_001288619.1.
NP_001275549.1. NM_001288620.1.
NP_034083.2. NM_009953.4.
UniGeneiMm.236081.

Genome annotation databases

EnsembliENSMUST00000003568; ENSMUSP00000003568; ENSMUSG00000003476.
GeneIDi12922.
KEGGimmu:12922.
UCSCiuc009cak.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ3UQP0_MOUSE
AccessioniPrimary (citable) accession number: Q3UQP0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 27, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported