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Q3UQK5

- Q3UQK5_MOUSE

UniProt

Q3UQK5 - Q3UQK5_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Axin2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: RefGenome
    3. GTPase activator activity Source: RefGenome
    4. I-SMAD binding Source: MGI
    5. protein binding Source: MGI
    6. protein kinase binding Source: RefGenome
    7. signal transducer activity Source: InterPro
    8. ubiquitin protein ligase binding Source: MGI

    GO - Biological processi

    1. bone mineralization Source: MGI
    2. cell death Source: RefGenome
    3. cell proliferation Source: MGI
    4. cellular protein localization Source: Ensembl
    5. cellular response to organic cyclic compound Source: RefGenome
    6. chondrocyte differentiation involved in endochondral bone morphogenesis Source: MGI
    7. dorsal/ventral axis specification Source: RefGenome
    8. intramembranous ossification Source: MGI
    9. maintenance of DNA repeat elements Source: Ensembl
    10. mRNA stabilization Source: Ensembl
    11. negative regulation of canonical Wnt signaling pathway Source: RefGenome
    12. negative regulation of catenin import into nucleus Source: Ensembl
    13. negative regulation of cell proliferation Source: MGI
    14. negative regulation of osteoblast differentiation Source: MGI
    15. odontogenesis Source: Ensembl
    16. positive regulation of cell death Source: Ensembl
    17. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    18. positive regulation of GTPase activity Source: GOC
    19. positive regulation of protein phosphorylation Source: Ensembl
    20. regulation of catenin import into nucleus Source: RefGenome
    21. regulation of centromeric sister chromatid cohesion Source: Ensembl
    22. regulation of chondrocyte development Source: MGI
    23. regulation of mismatch repair Source: Ensembl
    24. regulation of transcription, DNA-templated Source: RefGenome
    25. regulation of Wnt signaling pathway Source: MGI
    26. secondary heart field specification Source: MGI
    27. somitogenesis Source: MGI
    28. termination of G-protein coupled receptor signaling pathway Source: InterPro
    29. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Axin2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1270862. Axin2.

    Subcellular locationi

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: RefGenome
    2. cell cortex Source: RefGenome
    3. centrosome Source: Ensembl
    4. cytoplasmic membrane-bounded vesicle Source: RefGenome
    5. cytoplasmic microtubule Source: RefGenome
    6. nucleus Source: MGI
    7. plasma membrane Source: RefGenome
    8. postsynaptic density Source: RefGenome

    Expressioni

    Gene expression databases

    ArrayExpressiQ3UQK5.
    BgeeiQ3UQK5.
    GenevestigatoriQ3UQK5.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RGS domain.UniRule annotation
    Contains RGS domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG004324.
    InParanoidiQ3UQK5.
    KOiK04385.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q3UQK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP    50
    VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE 100
    REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK 150
    PATKTYIRDG IKKQQIGSVM FDQAQTEIQA VMEENAYQVF LTSDIYLEYV 200
    RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK CKLSPTVVGL 250
    SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 300
    ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP 350
    HFPRTHRLPK EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE 400
    DEEKEGSEQA LSSRDGAPVQ HPLALLPSGS YEEDPQTILD DHLSRVLKTP 450
    GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH TLLPTGGKLP PVAACPLLGG 500
    KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL CPGGTDYYCY 550
    SKCKSHPKAP EPLPGEQFCG SRGGTLPKRN AKGTEPGLAL SARDGGMSSA 600
    AGAPQLPGEE GDRSQDVWQW MLESERQSKS KPHSAQSIRK SYPLESACAA 650
    PGERVSRHHL LGASGHSRSV ARAHPFTQDP AMPPLTPPNT LAQLEEACRR 700
    LAEVSKPQKQ RCCVASQQRD RNHSAAGQAG ASPFANPSLA PEDHKEPKKL 750
    ASVHALQASE LVVTYFFCGE EIPYRRMLKA QSLTLGHFKE QLS 793
    Length:793
    Mass (Da):87,342
    Last modified:October 11, 2005 - v1
    Checksum:i14785708E16DC5EC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei793 – 7931Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK142333 mRNA. Translation: BAE25034.1.
    RefSeqiNP_056547.3. NM_015732.4.
    UniGeneiMm.71710.

    Genome annotation databases

    GeneIDi12006.
    KEGGimmu:12006.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK142333 mRNA. Translation: BAE25034.1 .
    RefSeqi NP_056547.3. NM_015732.4.
    UniGenei Mm.71710.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12006.
    KEGGi mmu:12006.

    Organism-specific databases

    CTDi 8313.
    MGIi MGI:1270862. Axin2.

    Phylogenomic databases

    HOVERGENi HBG004324.
    InParanoidi Q3UQK5.
    KOi K04385.

    Miscellaneous databases

    NextBioi 280199.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q3UQK5.
    Bgeei Q3UQK5.
    Genevestigatori Q3UQK5.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: LungImported.

    Entry informationi

    Entry nameiQ3UQK5_MOUSE
    AccessioniPrimary (citable) accession number: Q3UQK5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2005
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)