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Q3UQK5

- Q3UQK5_MOUSE

UniProt

Q3UQK5 - Q3UQK5_MOUSE

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Protein
Submitted name: Putative uncharacterized protein
Gene
Axin2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. I-SMAD binding Source: MGI
  3. armadillo repeat domain binding Source: RefGenome
  4. beta-catenin binding Source: RefGenome
  5. protein binding Source: MGI
  6. protein kinase binding Source: RefGenome
  7. signal transducer activity Source: InterPro
  8. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. Wnt signaling pathway involved in somitogenesis Source: RefGenome
  2. bone mineralization Source: MGI
  3. cell death Source: RefGenome
  4. cell proliferation Source: MGI
  5. cellular protein localization Source: Ensembl
  6. cellular response to organic cyclic compound Source: RefGenome
  7. chondrocyte differentiation involved in endochondral bone morphogenesis Source: MGI
  8. dorsal/ventral axis specification Source: RefGenome
  9. intramembranous ossification Source: MGI
  10. mRNA stabilization Source: Ensembl
  11. maintenance of DNA repeat elements Source: Ensembl
  12. negative regulation of canonical Wnt signaling pathway Source: RefGenome
  13. negative regulation of catenin import into nucleus Source: Ensembl
  14. negative regulation of cell proliferation Source: MGI
  15. negative regulation of osteoblast differentiation Source: MGI
  16. odontogenesis Source: Ensembl
  17. positive regulation of GTPase activity Source: GOC
  18. positive regulation of cell death Source: Ensembl
  19. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  20. positive regulation of protein phosphorylation Source: Ensembl
  21. regulation of Wnt signaling pathway Source: MGI
  22. regulation of catenin import into nucleus Source: RefGenome
  23. regulation of centromeric sister chromatid cohesion Source: Ensembl
  24. regulation of chondrocyte development Source: MGI
  25. regulation of mismatch repair Source: Ensembl
  26. regulation of transcription, DNA-templated Source: RefGenome
  27. secondary heart field specification Source: MGI
  28. somitogenesis Source: MGI
  29. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Axin2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1270862. Axin2.

Subcellular locationi

GO - Cellular componenti

  1. beta-catenin destruction complex Source: RefGenome
  2. cell cortex Source: RefGenome
  3. centrosome Source: Ensembl
  4. cytoplasmic membrane-bounded vesicle Source: RefGenome
  5. cytoplasmic microtubule Source: RefGenome
  6. nucleus Source: MGI
  7. plasma membrane Source: RefGenome
  8. postsynaptic density Source: RefGenome
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ3UQK5.
BgeeiQ3UQK5.
GenevestigatoriQ3UQK5.

Family & Domainsi

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation
Contains RGS domain.SAAS annotations

Phylogenomic databases

HOVERGENiHBG004324.
InParanoidiQ3UQK5.
KOiK04385.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q3UQK5-1 [UniParc]FASTAAdd to Basket

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MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP    50
VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE 100
REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK 150
PATKTYIRDG IKKQQIGSVM FDQAQTEIQA VMEENAYQVF LTSDIYLEYV 200
RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK CKLSPTVVGL 250
SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 300
ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP 350
HFPRTHRLPK EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE 400
DEEKEGSEQA LSSRDGAPVQ HPLALLPSGS YEEDPQTILD DHLSRVLKTP 450
GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH TLLPTGGKLP PVAACPLLGG 500
KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL CPGGTDYYCY 550
SKCKSHPKAP EPLPGEQFCG SRGGTLPKRN AKGTEPGLAL SARDGGMSSA 600
AGAPQLPGEE GDRSQDVWQW MLESERQSKS KPHSAQSIRK SYPLESACAA 650
PGERVSRHHL LGASGHSRSV ARAHPFTQDP AMPPLTPPNT LAQLEEACRR 700
LAEVSKPQKQ RCCVASQQRD RNHSAAGQAG ASPFANPSLA PEDHKEPKKL 750
ASVHALQASE LVVTYFFCGE EIPYRRMLKA QSLTLGHFKE QLS 793
Length:793
Mass (Da):87,342
Last modified:October 11, 2005 - v1
Checksum:i14785708E16DC5EC
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei793 – 7931Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK142333 mRNA. Translation: BAE25034.1.
RefSeqiNP_056547.3. NM_015732.4.
UniGeneiMm.71710.

Genome annotation databases

GeneIDi12006.
KEGGimmu:12006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK142333 mRNA. Translation: BAE25034.1 .
RefSeqi NP_056547.3. NM_015732.4.
UniGenei Mm.71710.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12006.
KEGGi mmu:12006.

Organism-specific databases

CTDi 8313.
MGIi MGI:1270862. Axin2.

Phylogenomic databases

HOVERGENi HBG004324.
InParanoidi Q3UQK5.
KOi K04385.

Miscellaneous databases

NextBioi 280199.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q3UQK5.
Bgeei Q3UQK5.
Genevestigatori Q3UQK5.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: LungImported.

Entry informationi

Entry nameiQ3UQK5_MOUSE
AccessioniPrimary (citable) accession number: Q3UQK5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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