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Protein

Protein FAM188B

Gene

Fam188b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM188B
Gene namesi
Name:Fam188b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:3583959. Fam188b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Protein FAM188BPRO_0000320591Add
BLAST

Proteomic databases

MaxQBiQ3UQI9.
PaxDbiQ3UQI9.
PRIDEiQ3UQI9.

PTM databases

PhosphoSiteiQ3UQI9.

Expressioni

Gene expression databases

BgeeiQ3UQI9.
CleanExiMM_C330043M08RIK.
GenevestigatoriQ3UQI9.

Interactioni

Protein-protein interaction databases

BioGridi236942. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM188 family.Curated

Phylogenomic databases

eggNOGiNOG282176.
GeneTreeiENSGT00530000063283.
HOGENOMiHOG000111604.
InParanoidiQ3UQI9.
OMAiNWNGSDP.
OrthoDBiEOG7GJ6CM.
PhylomeDBiQ3UQI9.
TreeFamiTF323996.

Family and domain databases

InterProiIPR025257. DUF4205.
[Graphical view]
PfamiPF13898. DUF4205. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q3UQI9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLYVEEVA ASLVREFLSR KGLNKTFVTM DQERPRCELS INSRNDLRKV
60 70 80 90 100
LHLEFLYKEN KAKEKPLRTN LELITRYFLD NVGNTDNSES QEVPIPAIPV
110 120 130 140 150
PKKNNKLPLR HSETTLVNIY DLSDEDTGRR TSWSEAGKAR HDSLDGDILG
160 170 180 190 200
NFVSSKKPSH KSKAAHVDLG DSLPLVPAWE KVDQLHSSEP GIDVKKTMER
210 220 230 240 250
TRPKSGLIVR GMMAGPVASS PQDSFRKRSL RRSSALSRKL QTPEEIQQQS
260 270 280 290 300
EPFVHTPAYL GPQEVPDSSS DSVSRSPLGQ LNELSIEKPN VTSSSQGLSQ
310 320 330 340 350
RDRPRLRSVS EDSPLGYSHT EGNSRMAQDQ LERAFKRQGV QPPSLRKNQL
360 370 380 390 400
VSDRTDDKPD ALQLEDVEDE LIKEDIVLFP PPSMLKLQTV SKPIDLSLAK
410 420 430 440 450
EIKTLLFGST FCCFSEEWKL QNFSFNDIAS LKYGIVQNKG GPCGVLAAVQ
460 470 480 490 500
GCVLQKLLFE GDNRTNSNLR LQPSDAQRTR CLALAIADIL WRAGGKEQAV
510 520 530 540 550
VALASGTPHF SPTGKYKADG VLETLTLYSL TSSEDLVTFI QQSVHQFEAG
560 570 580 590 600
PYGCILLTLS AILSRSLELV RQDFDVPTSH LIGAHGYCTQ ELVNLLLTGR
610 620 630 640 650
AVSNVFNDVV ELDSGDGNIT LLRGIEARSD IGFLSLFEHY NVCQVGCFLK
660 670 680 690 700
TPRFPIWVVC SESHFSILFS LQPELLCDWR SERLFDLYYY DGLANQQEEI
710 720 730 740
RLTVDTTKTA PADSCSDLVP PLELCIRTKW KGASVNWNGS DPIL
Length:744
Mass (Da):82,937
Last modified:October 11, 2005 - v1
Checksum:i5AF10D14154B3241
GO
Isoform 2 (identifier: Q3UQI9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-744: Missing.

Note: No experimental confirmation available.

Show »
Length:505
Mass (Da):56,325
Checksum:i53793DA5EF2BF566
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei506 – 744239Missing in isoform 2. 1 PublicationVSP_031672Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082855 mRNA. Translation: BAC38655.1.
AK142385 mRNA. Translation: BAE25052.1.
CCDSiCCDS51782.1. [Q3UQI9-1]
RefSeqiNP_001136253.1. NM_001142781.1. [Q3UQI9-1]
NP_808551.2. NM_177883.4.
UniGeneiMm.268997.

Genome annotation databases

EnsembliENSMUST00000053094; ENSMUSP00000061221; ENSMUSG00000038022. [Q3UQI9-1]
GeneIDi330323.
KEGGimmu:330323.
UCSCiuc009cao.1. mouse. [Q3UQI9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK082855 mRNA. Translation: BAC38655.1.
AK142385 mRNA. Translation: BAE25052.1.
CCDSiCCDS51782.1. [Q3UQI9-1]
RefSeqiNP_001136253.1. NM_001142781.1. [Q3UQI9-1]
NP_808551.2. NM_177883.4.
UniGeneiMm.268997.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236942. 1 interaction.

PTM databases

PhosphoSiteiQ3UQI9.

Proteomic databases

MaxQBiQ3UQI9.
PaxDbiQ3UQI9.
PRIDEiQ3UQI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053094; ENSMUSP00000061221; ENSMUSG00000038022. [Q3UQI9-1]
GeneIDi330323.
KEGGimmu:330323.
UCSCiuc009cao.1. mouse. [Q3UQI9-1]

Organism-specific databases

CTDi84182.
MGIiMGI:3583959. Fam188b.

Phylogenomic databases

eggNOGiNOG282176.
GeneTreeiENSGT00530000063283.
HOGENOMiHOG000111604.
InParanoidiQ3UQI9.
OMAiNWNGSDP.
OrthoDBiEOG7GJ6CM.
PhylomeDBiQ3UQI9.
TreeFamiTF323996.

Miscellaneous databases

ChiTaRSiFam188b. mouse.
NextBioi399298.
PROiQ3UQI9.
SOURCEiSearch...

Gene expression databases

BgeeiQ3UQI9.
CleanExiMM_C330043M08RIK.
GenevestigatoriQ3UQI9.

Family and domain databases

InterProiIPR025257. DUF4205.
[Graphical view]
PfamiPF13898. DUF4205. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiF188B_MOUSE
AccessioniPrimary (citable) accession number: Q3UQI9
Secondary accession number(s): Q8C472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 11, 2005
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.